DK0660936T3 - Op-konverterende reportermolekyle til biologiske og andre assays under anvendelse af laserexcitationsteknik - Google Patents

Op-konverterende reportermolekyle til biologiske og andre assays under anvendelse af laserexcitationsteknik

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Publication number
DK0660936T3
DK0660936T3 DK93921595T DK93921595T DK0660936T3 DK 0660936 T3 DK0660936 T3 DK 0660936T3 DK 93921595 T DK93921595 T DK 93921595T DK 93921595 T DK93921595 T DK 93921595T DK 0660936 T3 DK0660936 T3 DK 0660936T3
Authority
DK
Denmark
Prior art keywords
biological
assays
analytes
reporter molecule
laser excitation
Prior art date
Application number
DK93921595T
Other languages
English (en)
Inventor
David A Zarling
Michel J Rossi
Norman A Peppers
James Kane
Gregory W Faris
Mark J Dyer
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
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Publication of DK0660936T3 publication Critical patent/DK0660936T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00583—Features relative to the processes being carried out
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    • B01J2219/00583—Features relative to the processes being carried out
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
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    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00583—Features relative to the processes being carried out
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    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Materials Engineering (AREA)
  • Transplantation (AREA)
  • Optics & Photonics (AREA)
DK93921595T 1992-09-14 1993-09-14 Op-konverterende reportermolekyle til biologiske og andre assays under anvendelse af laserexcitationsteknik DK0660936T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94606892A 1992-09-14 1992-09-14
PCT/US1993/008712 WO1994007142A1 (en) 1992-09-14 1993-09-14 Up-converting reporters for biological and other assays using laser excitation techniques

Publications (1)

Publication Number Publication Date
DK0660936T3 true DK0660936T3 (da) 1999-05-25

Family

ID=25483910

Family Applications (2)

Application Number Title Priority Date Filing Date
DK96200682T DK0723146T3 (da) 1992-09-14 1993-09-14 Opkonverterende reportermolekyler til biologiske og andre assays ved anvendelse af laser-excitationsteknikker
DK93921595T DK0660936T3 (da) 1992-09-14 1993-09-14 Op-konverterende reportermolekyle til biologiske og andre assays under anvendelse af laserexcitationsteknik

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK96200682T DK0723146T3 (da) 1992-09-14 1993-09-14 Opkonverterende reportermolekyler til biologiske og andre assays ved anvendelse af laser-excitationsteknikker

Country Status (8)

Country Link
EP (3) EP0660936B1 (da)
JP (3) JP3420765B2 (da)
AT (3) ATE463744T1 (da)
CA (1) CA2144527C (da)
DE (3) DE69334326D1 (da)
DK (2) DK0723146T3 (da)
ES (2) ES2123063T3 (da)
WO (1) WO1994007142A1 (da)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994007138A1 (en) 1992-09-14 1994-03-31 Fodstad Oystein Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
NO180658C (no) 1994-03-10 1997-05-21 Oeystein Fodstad Fremgangsmåte og anordning for deteksjon av spesifikke målceller i spesialiserte eller blandede cellepopulasjoner og opplösninger som inneholder blandede cellepopulasjoner
FI98765C (fi) 1995-01-16 1997-08-11 Erkki Soini Virtaussytometrinen menetelmä ja laite
FI101829B1 (fi) * 1995-03-07 1998-08-31 Erkki Juhani Soini Biospesifinen määritysmenetelmä
EP0804732B1 (en) * 1995-01-16 2001-10-10 SOINI, Erkki A biospecific multiparameter assay method
US5912257A (en) * 1995-09-06 1999-06-15 The Research Foundation Of State University Of New York Two-photon upconverting dyes and applications
NO961031D0 (no) 1996-03-13 1996-03-13 Det Norske Radiumshospital Tum Fremgangsmåte til å drepe uönskede målceller
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US7144119B2 (en) 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
DE69732510T2 (de) * 1996-10-31 2005-08-25 Fuji Photo Film Co., Ltd., Minami-Ashigara Bilderzeugende Vorrichtung
US6310354B1 (en) 1996-12-03 2001-10-30 Erkki Soini Method and a device for monitoring nucleic acid amplification reactions
WO1998025143A1 (en) * 1996-12-03 1998-06-11 Erkki Soini Biospecific, two photon excitation, fluorescence detection and device
NO308755B1 (no) * 1996-12-20 2000-10-23 Iystein Fodstad FremgangsmÕte til karakterisering av unormale celler, anvendelse og sett for utførelse av fremgangsmÕten
US5827748A (en) * 1997-01-24 1998-10-27 The United States Of America As Represented By The Secretary Of The Navy Chemical sensor using two-dimensional lens array
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
WO1998043072A1 (en) * 1997-03-25 1998-10-01 Photonic Research Systems Limited Luminescence assays
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
EP1003904B1 (en) 1997-05-23 2007-07-11 BioArray Solutions Ltd. Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
DE19725050C2 (de) * 1997-06-13 1999-06-24 Fraunhofer Ges Forschung Anordnung zur Detektion biochemischer oder chemischer Substanzen mittels Fluoreszenzlichtanregung und Verfahren zu deren Herstellung
GB9718477D0 (en) * 1997-09-02 1997-11-05 Photonic Research Systems Limi Luminescence detection
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US7115884B1 (en) * 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US6607829B1 (en) 1997-11-13 2003-08-19 Massachusetts Institute Of Technology Tellurium-containing nanocrystalline materials
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
GB9811483D0 (en) * 1998-05-29 1998-07-29 Photonic Research Systems Limi Luminescence assay using cyclical excitation wavelength sequence
GB9811480D0 (en) * 1998-05-29 1998-07-29 Photonic Research Systems Limi Evanescent-wave excitation of upconverting labels
US6342397B1 (en) 1998-06-04 2002-01-29 Erkki Soini Homogeneous biospecific assay using a solid phase, two-photon excitation and confocal fluorescence detection
EP2045334A1 (en) 1998-06-24 2009-04-08 Illumina, Inc. Decoding of array sensors with microspheres
DE59915204D1 (de) * 1998-08-28 2010-10-28 Febit Holding Gmbh Verfahren zur herstellung von biochemischen reaktionsträgern
AU2149300A (en) * 1998-11-13 2000-06-05 Bangs Laboratories, Inc. Labeling microparticles capable of absorbing infrared light and methods of making and using the same
US7510841B2 (en) 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6846460B1 (en) 1999-01-29 2005-01-25 Illumina, Inc. Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses
GB9906929D0 (en) * 1999-03-26 1999-05-19 Univ Glasgow Assay system
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
EP2360270B1 (en) 1999-05-20 2016-11-09 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US7604996B1 (en) 1999-08-18 2009-10-20 Illumina, Inc. Compositions and methods for preparing oligonucleotide solutions
US6942968B1 (en) 1999-08-30 2005-09-13 Illumina, Inc. Array compositions for improved signal detection
US7332344B2 (en) 1999-12-01 2008-02-19 Photonic Research Systems Limited Luminescence assays
US6235483B1 (en) 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
AU2001238068A1 (en) 2000-02-07 2001-08-14 Illumina, Inc. Nucleic acid detection methods using universal priming
WO2001057268A2 (en) 2000-02-07 2001-08-09 Illumina, Inc. Nucleic acid detection methods using universal priming
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
CA2398029A1 (en) * 2000-02-08 2001-08-16 Cornell Research Foundation, Inc. Multiphoton excitation through optical fibers for fluorescence spectroscopy
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US7285384B2 (en) 2000-02-16 2007-10-23 Illuminia, Inc. Parallel genotyping of multiple patient samples
US7057704B2 (en) 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US20030045005A1 (en) 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
WO2002062201A2 (en) * 2001-02-02 2002-08-15 Dana-Farber Cancer Institute, Inc. Rare event detection system
DE10123439A1 (de) * 2001-05-14 2002-11-21 Bernhard Trier Fluoreszenzmikroskop
US7336988B2 (en) 2001-08-08 2008-02-26 Lucent Technologies Inc. Multi-photon endoscopy
CA2474036C (en) * 2001-11-07 2012-09-25 S3I, Llc System and method for detecting and classifying biological particles
US6643071B2 (en) 2001-12-21 2003-11-04 Lucent Technologies Inc. Graded-index lens microscopes
US6750266B2 (en) 2001-12-28 2004-06-15 3M Innovative Properties Company Multiphoton photosensitization system
DE10200499A1 (de) * 2002-01-03 2003-07-10 Zeiss Carl Jena Gmbh Verfahren und/oder Anordnung zur Identifikation von fluoreszierenden, lumineszierenden und/oder absorbierenden Substanzen auf und/oder in Probenträgern
AU2003215240A1 (en) 2002-02-14 2003-09-04 Illumina, Inc. Automated information processing in randomly ordered arrays
JP4526004B2 (ja) * 2002-03-05 2010-08-18 大日本印刷株式会社 希土類元素含有微粒子およびそれを用いた蛍光プローブ
CN1157462C (zh) 2002-04-15 2004-07-14 清华大学 一种制备纳米级氟化物基质上转换荧光材料的方法
WO2004017374A2 (en) * 2002-08-16 2004-02-26 Clinical Microarrays, Inc. Reading of fluorescent arrays
DE10245432A1 (de) 2002-09-27 2004-04-08 Micronas Gmbh Verfahren und Vorrichtung zum Detektieren mindestens eines Lumineszenz-Stoffs
DE10245435B4 (de) 2002-09-27 2006-03-16 Micronas Gmbh Vorrichtung zur Detektion mindestens eines in einer zu untersuchenden Probe enthaltenen Liganden
US7091500B2 (en) 2003-06-20 2006-08-15 Lucent Technologies Inc. Multi-photon endoscopic imaging system
US7323696B2 (en) 2004-01-09 2008-01-29 Applera Corporation Phosphor particle coded beads
CA2554423A1 (en) * 2004-01-26 2005-08-11 Anticancer, Inc. Whole body imaging using portable observation systems
CN1280623C (zh) 2004-07-16 2006-10-18 北京博奥生物芯片有限责任公司 一种用于荧光仪器校准测量的校准基片及其制备方法
JP4653983B2 (ja) * 2004-08-23 2011-03-16 菊治 山下 遠赤外線を放射する癌治療器具
WO2006080556A1 (ja) * 2005-01-27 2006-08-03 Nippon Sheet Glass Company, Limited 検出方法、当該検出方法を用いたマイクロ化学システム、信号検出方法、熱レンズ分光分析システム、蛍光検出システム、信号検出装置、信号検出システム、信号検出プログラム、及び記憶媒体
JP2006234794A (ja) * 2005-01-27 2006-09-07 Nippon Sheet Glass Co Ltd 信号検出方法、熱レンズ分光分析システム、蛍光検出システム、信号検出装置、信号検出システム、信号検出プログラム、及び記憶媒体
JP2007071729A (ja) * 2005-09-07 2007-03-22 Nippon Sheet Glass Co Ltd 検出方法及び当該検出方法を用いたマイクロ化学システム
GB2424946A (en) * 2005-04-05 2006-10-11 Stratec Biomedical Systems Ag A detection system for substance binding using up-converting fluorescent probes
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
FR2884920B1 (fr) * 2005-04-21 2007-08-10 Horiba Abx Sa Sa Dispositif et procede d'analyse multiparametrique d'elements microscopiques
US7635594B2 (en) 2005-05-09 2009-12-22 Theranos, Inc. Point-of-care fluidic systems and uses thereof
WO2007011854A2 (en) * 2005-07-15 2007-01-25 Biovigilant Systems, Inc. Pathogen and particle detector system and method
US20070160175A1 (en) * 2005-09-23 2007-07-12 Lang Matthew J Systems and methods for force-fluorescence microscopy
EP1801593A1 (en) * 2005-12-22 2007-06-27 Koninklijke Philips Electronics N.V. A method of imaging biological specimens using inorganic nanoparticles as label agents
WO2007078262A1 (en) * 2006-01-06 2007-07-12 National University Of Singapore Method of preparing nano-structured material(s) and uses thereof
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
WO2008066054A1 (fr) * 2006-11-28 2008-06-05 Nippon Sheet Glass Company, Limited Système de détection et sa sonde
DE102006056949B4 (de) * 2006-11-30 2011-12-22 Ruprecht-Karls-Universität Heidelberg Verfahren und Vorrichtung zur Detektion mindestens einer Eigenschaft von mindestens einem Objekt mit einem Mikrochip
US8110816B2 (en) 2007-02-28 2012-02-07 Nippon Sheet Glass Company, Limited Fluorescence detection system
WO2008110974A1 (en) * 2007-03-13 2008-09-18 Koninklijke Philips Electronics N. V. Analyzing biological cell material based on different interactions between illumination light and cell components
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
CA2934220C (en) 2007-10-02 2019-11-05 Theranos, Inc. Modular point-of-care devices and uses thereof
KR20180078345A (ko) 2009-10-19 2018-07-09 테라노스, 인코포레이티드 통합형 건강 정보 취득 및 분석 시스템
DE102010019095B4 (de) 2010-04-30 2016-12-08 Deutsches Zentrum für Luft- und Raumfahrt e.V. Verfahren und Vorrichtung zur Fluoreszenzlebensdauermessung
AR085087A1 (es) 2011-01-21 2013-09-11 Theranos Inc Sistemas y metodos para maximizar el uso de muestras
JP5487150B2 (ja) * 2011-03-31 2014-05-07 富士フイルム株式会社 光学的測定方法および光学的測定装置
US9588113B2 (en) 2012-02-22 2017-03-07 Church & Dwight Co., Inc. Methods for electronic analyte assaying
SG193046A1 (en) * 2012-02-23 2013-09-30 Histoindex Pte Ltd A digital imaging system for biopsy inspection
DE102012007862A1 (de) * 2012-04-18 2013-10-24 Heribert Broicher Vorrichtung zur Identifizierung und Qualitätskontrolle von Material
KR101364649B1 (ko) 2012-04-27 2014-02-20 한국과학기술연구원 코어/쉘 구조의 다기능성 자성 나노형광체 및 그 제조방법
ES2791279T3 (es) 2013-08-19 2020-11-03 Univ Houston Indicadores fosforescentes
EP3123172B1 (en) * 2014-03-24 2021-01-13 Instrumentation Laboratory Company Bioassay system and method for detecting analytes in body fluids
US10379046B2 (en) * 2015-04-08 2019-08-13 Molecular Devices, Llc Method and system for multiplexed time-resolved fluorescence detection
DE102015117939A1 (de) * 2015-10-21 2017-04-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Bestimmung einer Strahlendosis und Produkt
CN109073555A (zh) * 2016-04-28 2018-12-21 国立大学法人名古屋大学 流式细胞术用荧光探针和荧光标记细胞的分选方法
JP6633978B2 (ja) * 2016-06-17 2020-01-22 積水化学工業株式会社 検査キット及び検査方法
DE102017105159B4 (de) 2017-03-10 2020-09-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Validierung einer Bestrahlungsanlage
US20180364150A1 (en) * 2017-06-14 2018-12-20 Cypress Semiconductor Corporation Optical monitoring of target characteristics
RU195925U1 (ru) * 2019-11-19 2020-02-11 Федеральное государственное бюджетное образовательное учреждение высшего образования "Рязанский государственный радиотехнический университет имени В.Ф. Уткина" Сканирующий зонд атомно-силового микроскопа с отделяемым телеуправляемым нанокомпозитным излучающим элементом, легированным квантовыми точками, апконвертирующими и магнитными наночастицами структуры ядро-оболочка
CN113637048B (zh) * 2020-04-27 2023-07-25 中国科学院理化技术研究所 一种γ-谷氨酰转肽酶的双光子荧光探针及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US634278A (en) 1899-06-03 1899-10-03 Leon Stilmant Speed-changing gear for cycles.
US4100416A (en) * 1977-03-02 1978-07-11 Block Engineering, Inc. Serum fluorescence suppression
US4172227A (en) 1978-07-21 1979-10-23 Becton, Dickinson And Company Flow microfluorometer
US4347935A (en) 1979-05-16 1982-09-07 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for electrostatically sorting biological cells
US4667830A (en) 1981-06-15 1987-05-26 The Board Of Trustees Of The Leland Stanford Junior University Method and means for sorting individual particles into containers for culturing, cloning, analysis, or the like
US4724217A (en) * 1983-10-31 1988-02-09 The United States Of America As Represented By The United States Department Of Energy Ultratrace analysis of transuranic actinides by laser-induced fluorescence
US4661913A (en) 1984-09-11 1987-04-28 Becton, Dickinson And Company Apparatus and method for the detection and classification of articles using flow cytometry techniques
US5093234A (en) 1984-12-24 1992-03-03 Caribbean Microparticles Corporation Method of aligning, compensating, and calibrating a flow cytometer for analysis of samples, and microbead standards kit therefor
DE3677364D1 (de) * 1985-08-05 1991-03-07 Univ Leiden Markierte makromolekuele; verfahren zu ihrer herstellung und ihre verwendung in immunologischen oder immunocytochemischen testen.
DE3541033A1 (de) 1985-11-19 1987-05-21 Boehringer Mannheim Gmbh Verfahren zur quantifizierung von zellpopulationen bzw. subpopulationen sowie hierfuer geeignetes reagenz
US5132242A (en) * 1987-07-15 1992-07-21 Cheung Sau W Fluorescent microspheres and methods of using them
EP0476556A3 (en) * 1990-09-18 1992-11-19 Takeda Chemical Industries, Ltd. Method for determination of a light sensitive substance
US5144224A (en) 1991-04-01 1992-09-01 Larsen Lawrence E Millimeter wave flow cytometer

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CA2144527C (en) 2010-08-17
ATE170004T1 (de) 1998-09-15
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EP1333274B1 (en) 2010-04-07
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JP3636705B2 (ja) 2005-04-06
DE69320484D1 (de) 1998-09-24
WO1994007142A1 (en) 1994-03-31
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ATE266195T1 (de) 2004-05-15
ATE463744T1 (de) 2010-04-15
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