DK0646115T3 - Heterocykliske/cykliske aminderivater - Google Patents

Heterocykliske/cykliske aminderivater

Info

Publication number
DK0646115T3
DK0646115T3 DK92921695T DK92921695T DK0646115T3 DK 0646115 T3 DK0646115 T3 DK 0646115T3 DK 92921695 T DK92921695 T DK 92921695T DK 92921695 T DK92921695 T DK 92921695T DK 0646115 T3 DK0646115 T3 DK 0646115T3
Authority
DK
Denmark
Prior art keywords
heterocyclic
cyclic amine
amine derivatives
compounds
formula
Prior art date
Application number
DK92921695T
Other languages
Danish (da)
English (en)
Inventor
Anabella Villalobos
Arthur Adam Nagel
Yuhpyng Liang Chen
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of DK0646115T3 publication Critical patent/DK0646115T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DK92921695T 1991-03-28 1992-03-09 Heterocykliske/cykliske aminderivater DK0646115T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67691891A 1991-03-28 1991-03-28
PCT/US1992/001605 WO1992017475A1 (en) 1991-03-28 1992-03-09 Heterocyclic-cyclic amine derivatives

Publications (1)

Publication Number Publication Date
DK0646115T3 true DK0646115T3 (da) 2003-04-22

Family

ID=24716559

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92921695T DK0646115T3 (da) 1991-03-28 1992-03-09 Heterocykliske/cykliske aminderivater

Country Status (29)

Country Link
EP (1) EP0646115B1 (cs)
JP (3) JP2659107B2 (cs)
KR (1) KR0179054B1 (cs)
CN (1) CN1044242C (cs)
AT (1) ATE231505T1 (cs)
AU (2) AU658194B2 (cs)
BR (1) BR9205811A (cs)
CA (2) CA2195129C (cs)
CZ (1) CZ289756B6 (cs)
DE (1) DE69232907T2 (cs)
DK (1) DK0646115T3 (cs)
EG (1) EG20281A (cs)
ES (1) ES2188584T3 (cs)
FI (1) FI934223A7 (cs)
HU (1) HU225047B1 (cs)
IE (1) IE920980A1 (cs)
IL (3) IL116122A0 (cs)
MX (1) MX9201419A (cs)
MY (1) MY108885A (cs)
NO (1) NO304071B1 (cs)
NZ (3) NZ248946A (cs)
PL (3) PL171915B1 (cs)
PT (1) PT100300B (cs)
RU (1) RU2119920C1 (cs)
SG (1) SG49055A1 (cs)
UA (1) UA45944C2 (cs)
WO (1) WO1992017475A1 (cs)
YU (1) YU31392A (cs)
ZA (1) ZA922239B (cs)

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EP0535496A1 (en) * 1991-09-25 1993-04-07 Hoechst-Roussel Pharmaceuticals Incorporated (1-Indanon-2yl)methylpiperidines, intermediates and a process for their preparation and their use as medicaments
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
AU690529B2 (en) * 1992-11-23 1998-04-30 Hoechst Marion Roussel, Inc. Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
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EP0809642A1 (en) * 1995-02-15 1997-12-03 PHARMACIA & UPJOHN COMPANY Imidazo 1,2-a]pyridines for the treatment of cns and cardiac diseases
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US5916902A (en) * 1995-09-13 1999-06-29 Pfizer Inc. Processes and intermediates for preparing 5, 7-dihydro-3- 2-(1-benzylpiperidin-4-yl)ethyl-!6H-pyrrolo- 4, 5-F!-1, 2-benzisoxazol-6-one
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EP1050303A3 (en) * 1999-04-27 2003-01-15 Pfizer Products Inc. Methods and compositions for treating age-related behavioral disorders in companion animals
US6951873B1 (en) 1999-04-27 2005-10-04 Pfizer Inc. Methods for treating age-related behavioral disorders in companion animals
AU767726B2 (en) * 1999-04-30 2003-11-20 Pfizer Products Inc. Radiotracers for in vivo study of acetylcholinesterase and Alzheimer's disease
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
ES2284519T3 (es) 1999-09-01 2007-11-16 EISAI R&D MANAGEMENT CO., LTD. Derivados de piperidina 4-sustituida.
DE60139781D1 (de) 2000-06-21 2009-10-15 Eisai R&D Man Co Ltd 4-substituierte piperidinverbindung
ATE360629T1 (de) * 2001-10-17 2007-05-15 Ciba Sc Holding Ag Photoaktivierbare stickstoffbasen
US7226915B2 (en) * 2003-05-15 2007-06-05 Hoffmann-La Roche Inc. Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors
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EP1609783A1 (en) * 2004-06-17 2005-12-28 Neuropharma S.A.U. Marine compounds with calcium channel blocking properties for Alzheimer's disease treatment
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
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JPWO2007126041A1 (ja) 2006-04-28 2009-09-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 ベンゾイソオキサゾール化合物
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US8008327B2 (en) 2008-04-29 2011-08-30 Boehringer Ingelheim International Gmbh Indazole compounds as CCR1 receptor antagonists
CA2722811C (en) 2008-05-06 2016-07-05 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
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EA021015B1 (ru) 2009-10-21 2015-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Индазолы и пиразолопиридины в качестве антагонистов рецептора ccr1
US8927550B2 (en) 2009-10-27 2015-01-06 Boehringer Ingelheim International Gmbh Heterocyclic compounds as CCR1 receptor antagonists
CA2789014C (en) 2010-02-09 2019-01-15 Michela Gallagher Methods and compositions for improving cognitive function
EP2563787B1 (en) 2010-04-30 2014-11-26 Boehringer Ingelheim International GmbH Azaindazole amide compounds as ccr1 receptor antagonists
US8546442B2 (en) 2010-12-23 2013-10-01 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as CCR1 receptor antagonists
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
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Also Published As

Publication number Publication date
JPH06500794A (ja) 1994-01-27
ES2188584T3 (es) 2003-07-01
CA2195129C (en) 2002-09-10
NZ248946A (en) 1995-04-27
NZ250987A (en) 1997-06-24
EP0646115A1 (en) 1995-04-05
PL170567B1 (pl) 1997-01-31
EP0646115B1 (en) 2003-01-22
MX9201419A (es) 1992-10-01
PT100300B (pt) 1999-09-30
FI934223L (fi) 1993-09-27
IL116122A (en) 1998-10-30
CN1065267A (zh) 1992-10-14
RU2119920C1 (ru) 1998-10-10
HUT68357A (en) 1995-06-28
AU1878292A (en) 1992-11-02
IL116122A0 (en) 1996-01-31
DE69232907T2 (de) 2003-05-15
NO304071B1 (no) 1998-10-19
AU658194B2 (en) 1995-04-06
EG20281A (en) 1998-07-30
AU674477B2 (en) 1996-12-19
HU9302733D0 (en) 1993-12-28
ATE231505T1 (de) 2003-02-15
CZ395892A3 (en) 1994-04-13
KR0179054B1 (en) 1999-03-20
SG49055A1 (en) 1998-05-18
PT100300A (pt) 1993-08-31
NO933445D0 (no) 1993-09-27
DE69232907D1 (de) 2003-02-27
HU225047B1 (en) 2006-05-29
JPH10158264A (ja) 1998-06-16
CA2107105C (en) 2003-10-07
PL171915B1 (pl) 1997-06-30
JP2000154185A (ja) 2000-06-06
CA2195129A1 (en) 1992-09-29
MY108885A (en) 1996-11-30
UA45944C2 (uk) 2002-05-15
NO933445L (no) 1993-09-27
NZ242151A (en) 1994-10-26
FI934223A0 (fi) 1993-09-27
PL171914B1 (pl) 1997-06-30
JP3051076B2 (ja) 2000-06-12
IL101327A (en) 1998-06-15
AU2178895A (en) 1995-09-07
CZ289756B6 (cs) 2002-04-17
BR9205811A (pt) 1994-06-28
CA2107105A1 (en) 1992-09-29
YU31392A (sh) 1994-12-28
IL101327A0 (en) 1992-11-15
FI934223A7 (fi) 1993-09-27
ZA922239B (en) 1993-09-27
WO1992017475A1 (en) 1992-10-15
IE920980A1 (en) 1992-10-07
JP2659107B2 (ja) 1997-09-30
CN1044242C (zh) 1999-07-21

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