NO304071B1 - Heterocyklisk-cykliske amin-derivater - Google Patents

Heterocyklisk-cykliske amin-derivater

Info

Publication number
NO304071B1
NO304071B1 NO933445A NO933445A NO304071B1 NO 304071 B1 NO304071 B1 NO 304071B1 NO 933445 A NO933445 A NO 933445A NO 933445 A NO933445 A NO 933445A NO 304071 B1 NO304071 B1 NO 304071B1
Authority
NO
Norway
Prior art keywords
heterocyclic
cyclic amine
amine derivatives
compounds
formula
Prior art date
Application number
NO933445A
Other languages
English (en)
Other versions
NO933445D0 (no
NO933445L (no
Inventor
Anabella Villalobos
Arthur Adam Nagel
Yuhpyng Liang Chen
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO933445D0 publication Critical patent/NO933445D0/no
Publication of NO933445L publication Critical patent/NO933445L/no
Publication of NO304071B1 publication Critical patent/NO304071B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
NO933445A 1991-03-28 1993-09-27 Heterocyklisk-cykliske amin-derivater NO304071B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67691891A 1991-03-28 1991-03-28
PCT/US1992/001605 WO1992017475A1 (en) 1991-03-28 1992-03-09 Heterocyclic-cyclic amine derivatives

Publications (3)

Publication Number Publication Date
NO933445D0 NO933445D0 (no) 1993-09-27
NO933445L NO933445L (no) 1993-09-27
NO304071B1 true NO304071B1 (no) 1998-10-19

Family

ID=24716559

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933445A NO304071B1 (no) 1991-03-28 1993-09-27 Heterocyklisk-cykliske amin-derivater

Country Status (29)

Country Link
EP (1) EP0646115B1 (no)
JP (3) JP2659107B2 (no)
KR (1) KR0179054B1 (no)
CN (1) CN1044242C (no)
AT (1) ATE231505T1 (no)
AU (2) AU658194B2 (no)
BR (1) BR9205811A (no)
CA (2) CA2195129C (no)
CZ (1) CZ289756B6 (no)
DE (1) DE69232907T2 (no)
DK (1) DK0646115T3 (no)
EG (1) EG20281A (no)
ES (1) ES2188584T3 (no)
FI (1) FI934223A (no)
HU (1) HU225047B1 (no)
IE (1) IE920980A1 (no)
IL (3) IL116122A (no)
MX (1) MX9201419A (no)
MY (1) MY108885A (no)
NO (1) NO304071B1 (no)
NZ (3) NZ248946A (no)
PL (3) PL171915B1 (no)
PT (1) PT100300B (no)
RU (1) RU2119920C1 (no)
SG (1) SG49055A1 (no)
UA (1) UA45944C2 (no)
WO (1) WO1992017475A1 (no)
YU (1) YU31392A (no)
ZA (1) ZA922239B (no)

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EP0535496A1 (en) * 1991-09-25 1993-04-07 Hoechst-Roussel Pharmaceuticals Incorporated (1-Indanon-2yl)methylpiperidines, intermediates and a process for their preparation and their use as medicaments
DE69332691T2 (de) * 1992-11-23 2003-12-18 Aventis Pharma Inc Substituierte 3-(aminoalkylamino)-1,2-benzisoxazole und verwandte verbindungen
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
DK0788500T3 (da) * 1994-10-26 2004-06-07 Pfizer Fremgangsmåder og mellemprodukter til fremstilling af 5,7-dihydro-3-[2-(1-benzylpiperidin-4-yl)ethyl]-6H-pyrrolo-[4,5-f],2-benzisoxazol-6-on
US5912246A (en) * 1995-02-15 1999-06-15 Pharmacia & Upjohn Company Imidazo 1,2-a!pyridines for the treatment of CNS and cardiac diseases
CN1184478A (zh) * 1995-03-22 1998-06-10 大正制药株式会社 噻唑衍生物
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US5916902A (en) * 1995-09-13 1999-06-29 Pfizer Inc. Processes and intermediates for preparing 5, 7-dihydro-3- 2-(1-benzylpiperidin-4-yl)ethyl-!6H-pyrrolo- 4, 5-F!-1, 2-benzisoxazol-6-one
US5998415A (en) * 1995-11-02 1999-12-07 Merck Sharp & Dohme Ltd. Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors
FR2751412B3 (fr) * 1996-07-17 1998-09-25 Valbiofrance Methodes de diagnostic in vitro de maladies neurodegeneratives et trousses pour la mise en oeuvre de ces methodes
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CN1535682A (zh) 1998-09-30 2004-10-13 ����ҩƷ��ҵ��ʽ���� 改善膀胱排泄能力的药物
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US6951873B1 (en) 1999-04-27 2005-10-04 Pfizer Inc. Methods for treating age-related behavioral disorders in companion animals
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GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
PT1209151E (pt) 1999-09-01 2007-05-31 Eisai R&D Man Co Ltd Derivados piperidina 4-substituídos.
WO2001098271A1 (fr) 2000-06-21 2001-12-27 Eisai Co., Ltd. Compose piperidine 4-substitue
EP1609783A1 (en) * 2004-06-17 2005-12-28 Neuropharma S.A.U. Marine compounds with calcium channel blocking properties for Alzheimer's disease treatment
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
WO2007003961A2 (en) * 2005-06-30 2007-01-11 Prosidion Limited Gpcr agonists
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US20090318690A1 (en) 2006-04-28 2009-12-24 Eisai R&D Management Co., Ltd. Benzisoxazole Compound
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BRPI0919844A2 (pt) 2008-09-26 2019-09-24 Boehringer Ingelheim Int compostos de azaindazol como antagonistas do receptor ccr1
MX2011005905A (es) * 2008-12-12 2011-06-20 Actelion Pharmaceuticals Ltd Derivados de 5-amino-2-(1-hidroxi-etil)-tetrahidropirano.
MX2012004644A (es) 2009-10-21 2012-05-08 Boehringer Ingelheim Int Compuestos de indazol y pirazolopiridina como antagonistas del receptor de ccr1.
US8927550B2 (en) 2009-10-27 2015-01-06 Boehringer Ingelheim International Gmbh Heterocyclic compounds as CCR1 receptor antagonists
JP6082250B2 (ja) 2010-02-09 2017-02-15 ザ・ジョンズ・ホプキンス・ユニバーシティー 認知機能を改善するための方法および組成物
JP5793182B2 (ja) 2010-04-30 2015-10-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしてのアザインダゾールアミド化合物
JP5684406B2 (ja) 2010-12-23 2015-03-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしてのピラゾロピペリジン化合物
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Also Published As

Publication number Publication date
DK0646115T3 (da) 2003-04-22
WO1992017475A1 (en) 1992-10-15
ATE231505T1 (de) 2003-02-15
CA2195129C (en) 2002-09-10
PT100300B (pt) 1999-09-30
RU2119920C1 (ru) 1998-10-10
DE69232907T2 (de) 2003-05-15
AU2178895A (en) 1995-09-07
JPH10158264A (ja) 1998-06-16
HU225047B1 (en) 2006-05-29
EP0646115B1 (en) 2003-01-22
UA45944C2 (uk) 2002-05-15
AU674477B2 (en) 1996-12-19
CN1065267A (zh) 1992-10-14
CN1044242C (zh) 1999-07-21
JP3051076B2 (ja) 2000-06-12
CA2107105C (en) 2003-10-07
NZ250987A (en) 1997-06-24
CA2107105A1 (en) 1992-09-29
PL171914B1 (pl) 1997-06-30
AU1878292A (en) 1992-11-02
JPH06500794A (ja) 1994-01-27
KR0179054B1 (en) 1999-03-20
PL170567B1 (pl) 1997-01-31
IL116122A (en) 1998-10-30
MX9201419A (es) 1992-10-01
IE920980A1 (en) 1992-10-07
EP0646115A1 (en) 1995-04-05
DE69232907D1 (de) 2003-02-27
FI934223A0 (fi) 1993-09-27
CZ289756B6 (cs) 2002-04-17
SG49055A1 (en) 1998-05-18
CA2195129A1 (en) 1992-09-29
FI934223A (fi) 1993-09-27
CZ395892A3 (en) 1994-04-13
EG20281A (en) 1998-07-30
NZ248946A (en) 1995-04-27
BR9205811A (pt) 1994-06-28
HUT68357A (en) 1995-06-28
IL101327A0 (en) 1992-11-15
HU9302733D0 (en) 1993-12-28
YU31392A (sh) 1994-12-28
IL101327A (en) 1998-06-15
PL171915B1 (pl) 1997-06-30
JP2659107B2 (ja) 1997-09-30
ES2188584T3 (es) 2003-07-01
PT100300A (pt) 1993-08-31
ZA922239B (en) 1993-09-27
AU658194B2 (en) 1995-04-06
NO933445D0 (no) 1993-09-27
NO933445L (no) 1993-09-27
NZ242151A (en) 1994-10-26
MY108885A (en) 1996-11-30
JP2000154185A (ja) 2000-06-06
IL116122A0 (en) 1996-01-31

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