FI934223A0 - Heterocykliscykliska aminderivat - Google Patents

Heterocykliscykliska aminderivat

Info

Publication number
FI934223A0
FI934223A0 FI934223A FI934223A FI934223A0 FI 934223 A0 FI934223 A0 FI 934223A0 FI 934223 A FI934223 A FI 934223A FI 934223 A FI934223 A FI 934223A FI 934223 A0 FI934223 A0 FI 934223A0
Authority
FI
Finland
Prior art keywords
heterocycliscycliska
aminderivat
compounds
formula
dementia
Prior art date
Application number
FI934223A
Other languages
English (en)
Other versions
FI934223A (fi
Inventor
Anabella Villalobos
Arthur Adam Nagel
Yuhpyng Liang Chen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI934223A0 publication Critical patent/FI934223A0/fi
Publication of FI934223A publication Critical patent/FI934223A/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
FI934223A 1991-03-28 1993-09-27 Heterocykliscykliska aminderivat FI934223A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67691891A 1991-03-28 1991-03-28
PCT/US1992/001605 WO1992017475A1 (en) 1991-03-28 1992-03-09 Heterocyclic-cyclic amine derivatives

Publications (2)

Publication Number Publication Date
FI934223A0 true FI934223A0 (fi) 1993-09-27
FI934223A FI934223A (fi) 1993-09-27

Family

ID=24716559

Family Applications (1)

Application Number Title Priority Date Filing Date
FI934223A FI934223A (fi) 1991-03-28 1993-09-27 Heterocykliscykliska aminderivat

Country Status (29)

Country Link
EP (1) EP0646115B1 (fi)
JP (3) JP2659107B2 (fi)
KR (1) KR0179054B1 (fi)
CN (1) CN1044242C (fi)
AT (1) ATE231505T1 (fi)
AU (2) AU658194B2 (fi)
BR (1) BR9205811A (fi)
CA (2) CA2107105C (fi)
CZ (1) CZ289756B6 (fi)
DE (1) DE69232907T2 (fi)
DK (1) DK0646115T3 (fi)
EG (1) EG20281A (fi)
ES (1) ES2188584T3 (fi)
FI (1) FI934223A (fi)
HU (1) HU225047B1 (fi)
IE (1) IE920980A1 (fi)
IL (3) IL116122A0 (fi)
MX (1) MX9201419A (fi)
MY (1) MY108885A (fi)
NO (1) NO304071B1 (fi)
NZ (3) NZ250987A (fi)
PL (3) PL170567B1 (fi)
PT (1) PT100300B (fi)
RU (1) RU2119920C1 (fi)
SG (1) SG49055A1 (fi)
UA (1) UA45944C2 (fi)
WO (1) WO1992017475A1 (fi)
YU (1) YU31392A (fi)
ZA (1) ZA922239B (fi)

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EP0535496A1 (en) * 1991-09-25 1993-04-07 Hoechst-Roussel Pharmaceuticals Incorporated (1-Indanon-2yl)methylpiperidines, intermediates and a process for their preparation and their use as medicaments
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
JP3462501B2 (ja) * 1992-11-23 2003-11-05 アベンティス・ファーマスーティカルズ・インコーポレイテツド 置換された3−(アミノアルキルアミノ)−1,2−ベンゾイソキサゾールおよび関連化合物
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ES2214506T3 (es) * 1994-10-26 2004-09-16 Pfizer Inc. Procedimientos y compuestos intermedios para la preparacion de 5,7-dihidro-3-(2-(1-bencilpiperidin-4-il)etil)-6h-pirrolo-(4,5-f)-1,2-bencisoxazol-6-ona.
EP0809642A1 (en) * 1995-02-15 1997-12-03 PHARMACIA & UPJOHN COMPANY Imidazo 1,2-a]pyridines for the treatment of cns and cardiac diseases
JP3884477B2 (ja) * 1995-03-22 2007-02-21 大正製薬株式会社 チアゾール誘導体
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FR2751412B3 (fr) * 1996-07-17 1998-09-25 Valbiofrance Methodes de diagnostic in vitro de maladies neurodegeneratives et trousses pour la mise en oeuvre de ces methodes
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CN1572299A (zh) 1998-09-30 2005-02-02 武田药品工业株式会社 改善膀胱排泄能力的药物
US6951873B1 (en) 1999-04-27 2005-10-04 Pfizer Inc. Methods for treating age-related behavioral disorders in companion animals
EP1050303A3 (en) * 1999-04-27 2003-01-15 Pfizer Products Inc. Methods and compositions for treating age-related behavioral disorders in companion animals
EP1048302A3 (en) * 1999-04-30 2002-07-17 Pfizer Products Inc. Radiotracers for in vivo study of acetylcholinesterase and Alzheimer's disease
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
CA2382117C (en) 1999-09-01 2009-11-10 Eisai Co., Ltd. 4-substituted piperidine compound
EP1300395B1 (en) 2000-06-21 2009-09-02 Eisai R&D Management Co., Ltd. 4-substituted piperidine compound
EP1609783A1 (en) * 2004-06-17 2005-12-28 Neuropharma S.A.U. Marine compounds with calcium channel blocking properties for Alzheimer's disease treatment
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
EP1907384A2 (en) * 2005-06-30 2008-04-09 Prosidion Limited Gpcr agonists
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AU2008263206A1 (en) 2007-06-01 2008-12-18 Schering Corporation Gamma secretase modulators
US8008327B2 (en) 2008-04-29 2011-08-30 Boehringer Ingelheim International Gmbh Indazole compounds as CCR1 receptor antagonists
CA2722811C (en) 2008-05-06 2016-07-05 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
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MX2011005905A (es) * 2008-12-12 2011-06-20 Actelion Pharmaceuticals Ltd Derivados de 5-amino-2-(1-hidroxi-etil)-tetrahidropirano.
RS53130B (en) 2009-10-21 2014-06-30 Boehringer Ingelheim International Gmbh INDASOL AND PYRAZOLOPYRIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS
EP2493875B1 (en) 2009-10-27 2014-08-06 Boehringer Ingelheim International GmbH Heterocyclic compounds as ccr1 receptor antagonists
EP2533645B1 (en) 2010-02-09 2016-07-27 The Johns Hopkins University Methods and compositions for improving cognitive function
US8871786B2 (en) 2010-04-30 2014-10-28 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as CCR1 receptor antagonists
WO2012087782A1 (en) 2010-12-23 2012-06-28 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as ccr1 receptor antagonists
EP2919788A4 (en) 2012-11-14 2016-05-25 Univ Johns Hopkins METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA
CA2890861C (en) 2012-11-21 2021-03-30 Raqualia Pharma Inc. Polymorphic forms of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2h-pyran-4-carboxylic acid
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
DK2968220T3 (da) 2013-03-15 2021-06-14 Agenebio Inc Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion
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Also Published As

Publication number Publication date
JP3051076B2 (ja) 2000-06-12
WO1992017475A1 (en) 1992-10-15
CN1044242C (zh) 1999-07-21
PL171915B1 (pl) 1997-06-30
CA2107105C (en) 2003-10-07
CZ289756B6 (cs) 2002-04-17
ES2188584T3 (es) 2003-07-01
IE920980A1 (en) 1992-10-07
CZ395892A3 (en) 1994-04-13
IL101327A (en) 1998-06-15
IL116122A0 (en) 1996-01-31
HU225047B1 (en) 2006-05-29
PL170567B1 (pl) 1997-01-31
JP2000154185A (ja) 2000-06-06
IL101327A0 (en) 1992-11-15
DE69232907T2 (de) 2003-05-15
YU31392A (sh) 1994-12-28
AU1878292A (en) 1992-11-02
BR9205811A (pt) 1994-06-28
CA2195129C (en) 2002-09-10
EP0646115B1 (en) 2003-01-22
PT100300A (pt) 1993-08-31
PT100300B (pt) 1999-09-30
HU9302733D0 (en) 1993-12-28
NZ250987A (en) 1997-06-24
RU2119920C1 (ru) 1998-10-10
JP2659107B2 (ja) 1997-09-30
DK0646115T3 (da) 2003-04-22
PL171914B1 (pl) 1997-06-30
DE69232907D1 (de) 2003-02-27
ATE231505T1 (de) 2003-02-15
AU674477B2 (en) 1996-12-19
ZA922239B (en) 1993-09-27
EP0646115A1 (en) 1995-04-05
MY108885A (en) 1996-11-30
HUT68357A (en) 1995-06-28
NZ248946A (en) 1995-04-27
JPH10158264A (ja) 1998-06-16
NO933445D0 (no) 1993-09-27
CN1065267A (zh) 1992-10-14
UA45944C2 (uk) 2002-05-15
MX9201419A (es) 1992-10-01
JPH06500794A (ja) 1994-01-27
CA2195129A1 (en) 1992-09-29
NO933445L (no) 1993-09-27
NZ242151A (en) 1994-10-26
AU658194B2 (en) 1995-04-06
CA2107105A1 (en) 1992-09-29
FI934223A (fi) 1993-09-27
AU2178895A (en) 1995-09-07
KR0179054B1 (en) 1999-03-20
EG20281A (en) 1998-07-30
IL116122A (en) 1998-10-30
NO304071B1 (no) 1998-10-19
SG49055A1 (en) 1998-05-18

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Owner name: EISAI CO., LTD.

FD Application lapsed