PT100300B - Derivados de aminas heterociclicas-ciclicas, nomeadamente derivados de benzisoxazole-piperidina - Google Patents
Derivados de aminas heterociclicas-ciclicas, nomeadamente derivados de benzisoxazole-piperidinaInfo
- Publication number
- PT100300B PT100300B PT100300A PT10030092A PT100300B PT 100300 B PT100300 B PT 100300B PT 100300 A PT100300 A PT 100300A PT 10030092 A PT10030092 A PT 10030092A PT 100300 B PT100300 B PT 100300B
- Authority
- PT
- Portugal
- Prior art keywords
- derivatives
- benzisoxazole
- heterocyclic
- namely
- cyclic amines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67691891A | 1991-03-28 | 1991-03-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
PT100300A PT100300A (pt) | 1993-08-31 |
PT100300B true PT100300B (pt) | 1999-09-30 |
Family
ID=24716559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT100300A PT100300B (pt) | 1991-03-28 | 1992-03-26 | Derivados de aminas heterociclicas-ciclicas, nomeadamente derivados de benzisoxazole-piperidina |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP0646115B1 (pt) |
JP (3) | JP2659107B2 (pt) |
KR (1) | KR0179054B1 (pt) |
CN (1) | CN1044242C (pt) |
AT (1) | ATE231505T1 (pt) |
AU (2) | AU658194B2 (pt) |
BR (1) | BR9205811A (pt) |
CA (2) | CA2195129C (pt) |
CZ (1) | CZ289756B6 (pt) |
DE (1) | DE69232907T2 (pt) |
DK (1) | DK0646115T3 (pt) |
EG (1) | EG20281A (pt) |
ES (1) | ES2188584T3 (pt) |
FI (1) | FI934223A0 (pt) |
HU (1) | HU225047B1 (pt) |
IE (1) | IE920980A1 (pt) |
IL (3) | IL101327A (pt) |
MX (1) | MX9201419A (pt) |
MY (1) | MY108885A (pt) |
NO (1) | NO304071B1 (pt) |
NZ (3) | NZ242151A (pt) |
PL (3) | PL170567B1 (pt) |
PT (1) | PT100300B (pt) |
RU (1) | RU2119920C1 (pt) |
SG (1) | SG49055A1 (pt) |
UA (1) | UA45944C2 (pt) |
WO (1) | WO1992017475A1 (pt) |
YU (1) | YU31392A (pt) |
ZA (1) | ZA922239B (pt) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5750542A (en) | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
EP0602242A4 (en) * | 1991-08-22 | 1994-06-29 | Yoshitomi Pharmaceutical | Benzisoxazole compound and use thereof. |
EP0535496A1 (en) * | 1991-09-25 | 1993-04-07 | Hoechst-Roussel Pharmaceuticals Incorporated | (1-Indanon-2yl)methylpiperidines, intermediates and a process for their preparation and their use as medicaments |
JP3462501B2 (ja) * | 1992-11-23 | 2003-11-05 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 置換された3−(アミノアルキルアミノ)−1,2−ベンゾイソキサゾールおよび関連化合物 |
US5494908A (en) * | 1992-11-23 | 1996-02-27 | Hoechst-Roussel Pharmaceutical Incorporated | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
GB9305623D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
ATE260922T1 (de) * | 1994-10-26 | 2004-03-15 | Pfizer | Verfahren und zwischenprodukte zur herstellung von 5,7-dihydro-3-(2 1-benzylpiperidin-4-yl |
EP0809642A1 (en) * | 1995-02-15 | 1997-12-03 | PHARMACIA & UPJOHN COMPANY | Imidazo 1,2-a]pyridines for the treatment of cns and cardiac diseases |
KR19980703192A (ko) * | 1995-03-22 | 1998-10-15 | 우에하라아끼라 | 티아졸 유도체 |
WO1996039405A1 (en) * | 1995-06-06 | 1996-12-12 | Hoechst Marion Roussel, Inc. | Pyridiniminyl-1,2-benzisoxazoles and- benzisothiazoles as antipsychotic agents |
JPH09124643A (ja) * | 1995-08-14 | 1997-05-13 | Bristol Myers Squibb Co | 抗うつ作用を有する1−アリールアルキル−4−(アルコキシピリジニル)−又は4−(アルコキシピリミジニル)ピペラジン誘導体 |
US5916902A (en) * | 1995-09-13 | 1999-06-29 | Pfizer Inc. | Processes and intermediates for preparing 5, 7-dihydro-3- 2-(1-benzylpiperidin-4-yl)ethyl-!6H-pyrrolo- 4, 5-F!-1, 2-benzisoxazol-6-one |
AU7319096A (en) * | 1995-11-02 | 1997-05-22 | Merck Sharp & Dohme Limited | Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation and their use as selective agonists of 5-ht1-like receptors |
FR2751412B3 (fr) * | 1996-07-17 | 1998-09-25 | Valbiofrance | Methodes de diagnostic in vitro de maladies neurodegeneratives et trousses pour la mise en oeuvre de ces methodes |
US6013654A (en) * | 1997-08-14 | 2000-01-11 | Pharmacia & Upjohn Company | Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases |
EP0976404A3 (en) * | 1998-07-30 | 2001-06-27 | Pfizer Products Inc. | A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal |
EP1891954A3 (en) | 1998-09-30 | 2009-01-14 | Takeda Pharmaceutical Company Limited | Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder |
US6951873B1 (en) | 1999-04-27 | 2005-10-04 | Pfizer Inc. | Methods for treating age-related behavioral disorders in companion animals |
EP1050303A3 (en) * | 1999-04-27 | 2003-01-15 | Pfizer Products Inc. | Methods and compositions for treating age-related behavioral disorders in companion animals |
AU767726B2 (en) * | 1999-04-30 | 2003-11-20 | Pfizer Products Inc. | Radiotracers for in vivo study of acetylcholinesterase and Alzheimer's disease |
GB9914486D0 (en) | 1999-06-21 | 1999-08-18 | Smithkline Beecham Plc | Medicaments |
GB9917406D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
GB9917408D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
DK1209151T3 (da) | 1999-09-01 | 2007-08-20 | Eisai R&D Man Co Ltd | 4-substituerede piperidinderivativer |
US6906083B2 (en) | 2000-06-21 | 2005-06-14 | Eisai Co., Ltd. | 4-substituted piperidine compound |
EP1609783A1 (en) * | 2004-06-17 | 2005-12-28 | Neuropharma S.A.U. | Marine compounds with calcium channel blocking properties for Alzheimer's disease treatment |
DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
WO2007003961A2 (en) * | 2005-06-30 | 2007-01-11 | Prosidion Limited | Gpcr agonists |
GB0519879D0 (en) | 2005-09-30 | 2005-11-09 | Astrazeneca Ab | Chemical process |
WO2007126041A1 (ja) | 2006-04-28 | 2007-11-08 | Eisai R & D Management Co., Ltd. | ベンゾイソオキサゾール化合物 |
PE20090319A1 (es) * | 2007-06-01 | 2009-03-27 | Schering Corp | Moduladores de gamma secretasa |
US8008327B2 (en) | 2008-04-29 | 2011-08-30 | Boehringer Ingelheim International Gmbh | Indazole compounds as CCR1 receptor antagonists |
WO2009137338A1 (en) | 2008-05-06 | 2009-11-12 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as ccr1 antagonists |
CN102227425A (zh) | 2008-09-26 | 2011-10-26 | 贝林格尔·英格海姆国际有限公司 | 作为ccr1受体拮抗剂的氮杂吲唑化合物 |
EP2376497B1 (en) * | 2008-12-12 | 2013-09-18 | Actelion Pharmaceuticals Ltd. | 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives |
SI2491028T1 (sl) | 2009-10-21 | 2014-03-31 | Boehringer Ingelheim International Gmbh | Indazolne in pirazolopiridinske spojine kot antagonisti receptorja CCR1 |
US8927550B2 (en) | 2009-10-27 | 2015-01-06 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as CCR1 receptor antagonists |
CN102905532A (zh) | 2010-02-09 | 2013-01-30 | 约翰斯.霍普金斯大学 | 用于改善认知功能的方法和组合物 |
EP2563787B1 (en) | 2010-04-30 | 2014-11-26 | Boehringer Ingelheim International GmbH | Azaindazole amide compounds as ccr1 receptor antagonists |
JP5684406B2 (ja) | 2010-12-23 | 2015-03-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr1受容体アンタゴニストとしてのピラゾロピペリジン化合物 |
CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
CA2890861C (en) * | 2012-11-21 | 2021-03-30 | Raqualia Pharma Inc. | Polymorphic forms of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2h-pyran-4-carboxylic acid |
WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
WO2014144801A1 (en) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Methods and compositions for improving cognitive function |
EA034167B8 (ru) | 2015-05-22 | 2021-04-27 | Эйджинбайо, Инк. | Фармацевтические композиции леветирацетама пролонгированного высвобождения |
RU2638155C1 (ru) * | 2016-02-29 | 2017-12-12 | Общество С Ограниченной Ответственностью "Сай Фарма" | Производные бензо[d]изоксазола и их применение |
TW202321263A (zh) * | 2021-08-10 | 2023-06-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 磺醯胺衍生物、其製備方法及其在醫藥上的應用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3488353A (en) | 1967-05-29 | 1970-01-06 | Sterling Drug Inc | New 1-((2-azaindolyl)-lower-alkyl) 4-substituted-piperazines |
JPS51136666A (en) * | 1975-05-19 | 1976-11-26 | Dainippon Pharmaceut Co Ltd | Process for preparing 3-aminoalkyl-1,2-benzisoxazole derivatives. |
US4396770A (en) * | 1982-04-09 | 1983-08-02 | Hoechst-Roussel Pharmaceuticals Inc. | 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines |
IL66866A (en) * | 1982-04-09 | 1987-08-31 | Hoechst Roussel Pharma | 1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and-piperidines,a process for the preparation thereof,and pharmaceutical compositions containing them |
US4489075A (en) * | 1982-05-15 | 1984-12-18 | Pfizer Inc. | Cyclic sulfonamidoalkyl substituted 4-piperidinoquinazoline cardiac stimulants |
PH22302A (en) * | 1985-02-11 | 1988-07-22 | Fujisawa Pharmaceutical Co | Piperidine compounds |
DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
JPS63234065A (ja) * | 1987-03-23 | 1988-09-29 | Mitsubishi Rayon Co Ltd | 包接能を有する高分子組成物 |
JPH0657707B2 (ja) * | 1987-05-25 | 1994-08-03 | 吉富製薬株式会社 | ピペリジン化合物 |
FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
US4980365A (en) * | 1987-07-13 | 1990-12-25 | Hoechst-Roussel Pharmaceuticals Inc. | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents |
ATE87918T1 (de) * | 1988-02-19 | 1993-04-15 | Lilly Co Eli | Tetrazolverbindungen als antagonisten der excitatorischen aminosaeurerezeptoren. |
JPH0283375A (ja) * | 1988-09-21 | 1990-03-23 | Dainippon Pharmaceut Co Ltd | 2−置換ピペラジニル−2−(1,2−ベンズイソキサゾール−3−イル)酢酸誘導体 |
FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
EP0641320B1 (en) * | 1991-04-17 | 2001-05-30 | PHARMACIA & UPJOHN COMPANY | Substituted (s)-3-phenylpiperidine derivatives, their preparation and their use as dopamine autoreceptor antagonists |
-
1992
- 1992-03-09 DE DE69232907T patent/DE69232907T2/de not_active Expired - Fee Related
- 1992-03-09 WO PCT/US1992/001605 patent/WO1992017475A1/en active IP Right Grant
- 1992-03-09 RU RU93055137A patent/RU2119920C1/ru not_active IP Right Cessation
- 1992-03-09 HU HU9302733A patent/HU225047B1/hu not_active IP Right Cessation
- 1992-03-09 PL PL92300711A patent/PL170567B1/pl not_active IP Right Cessation
- 1992-03-09 ES ES92921695T patent/ES2188584T3/es not_active Expired - Lifetime
- 1992-03-09 PL PL92313811A patent/PL171915B1/pl not_active IP Right Cessation
- 1992-03-09 EP EP92921695A patent/EP0646115B1/en not_active Expired - Lifetime
- 1992-03-09 CA CA002195129A patent/CA2195129C/en not_active Expired - Fee Related
- 1992-03-09 CZ CS19923958A patent/CZ289756B6/cs not_active IP Right Cessation
- 1992-03-09 AU AU18782/92A patent/AU658194B2/en not_active Ceased
- 1992-03-09 SG SG1996005572A patent/SG49055A1/en unknown
- 1992-03-09 JP JP4510182A patent/JP2659107B2/ja not_active Expired - Fee Related
- 1992-03-09 UA UA93004393A patent/UA45944C2/uk unknown
- 1992-03-09 BR BR9205811A patent/BR9205811A/pt not_active Application Discontinuation
- 1992-03-09 PL PL92313812A patent/PL171914B1/pl not_active IP Right Cessation
- 1992-03-09 AT AT92921695T patent/ATE231505T1/de not_active IP Right Cessation
- 1992-03-09 DK DK92921695T patent/DK0646115T3/da active
- 1992-03-09 CA CA002107105A patent/CA2107105C/en not_active Expired - Fee Related
- 1992-03-22 IL IL101327A patent/IL101327A/en active IP Right Grant
- 1992-03-22 IL IL11612295A patent/IL116122A0/xx unknown
- 1992-03-22 IL IL11612292A patent/IL116122A/en active IP Right Grant
- 1992-03-26 EG EG15592A patent/EG20281A/xx active
- 1992-03-26 PT PT100300A patent/PT100300B/pt not_active IP Right Cessation
- 1992-03-27 NZ NZ242151A patent/NZ242151A/en not_active IP Right Cessation
- 1992-03-27 MY MYPI92000531A patent/MY108885A/en unknown
- 1992-03-27 CN CN92102178A patent/CN1044242C/zh not_active Expired - Fee Related
- 1992-03-27 ZA ZA922239A patent/ZA922239B/xx unknown
- 1992-03-27 NZ NZ248946A patent/NZ248946A/en not_active IP Right Cessation
- 1992-03-27 NZ NZ250987A patent/NZ250987A/en not_active IP Right Cessation
- 1992-03-27 YU YU31392A patent/YU31392A/sh unknown
- 1992-03-27 IE IE098092A patent/IE920980A1/en not_active IP Right Cessation
- 1992-03-30 MX MX9201419A patent/MX9201419A/es not_active IP Right Cessation
-
1993
- 1993-09-27 NO NO933445A patent/NO304071B1/no unknown
- 1993-09-27 FI FI934223A patent/FI934223A0/fi not_active Application Discontinuation
- 1993-09-27 KR KR1019930702929A patent/KR0179054B1/ko not_active IP Right Cessation
-
1995
- 1995-06-20 AU AU21788/95A patent/AU674477B2/en not_active Ceased
-
1997
- 1997-03-06 JP JP9052097A patent/JP3051076B2/ja not_active Expired - Fee Related
-
1999
- 1999-12-24 JP JP11368302A patent/JP2000154185A/ja active Pending
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