DK0584903T3 - Fremgangsmåde til fremstilling af arylpiperazinyl-heterocykliske forbindelser - Google Patents
Fremgangsmåde til fremstilling af arylpiperazinyl-heterocykliske forbindelserInfo
- Publication number
- DK0584903T3 DK0584903T3 DK93303576T DK93303576T DK0584903T3 DK 0584903 T3 DK0584903 T3 DK 0584903T3 DK 93303576 T DK93303576 T DK 93303576T DK 93303576 T DK93303576 T DK 93303576T DK 0584903 T3 DK0584903 T3 DK 0584903T3
- Authority
- DK
- Denmark
- Prior art keywords
- chem
- formula
- arylpiperazinyl
- preparation
- heterocyclic compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Lubricants (AREA)
- Eye Examination Apparatus (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/936,179 US5206366A (en) | 1992-08-26 | 1992-08-26 | Process for preparing aryl piperazinyl-heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0584903T3 true DK0584903T3 (da) | 2001-12-03 |
Family
ID=25468285
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00201940T DK1029861T3 (da) | 1992-08-26 | 1993-05-07 | Benzisothiazol-piperazinylderivat og dets anvendelse som neuroleptikum |
| DK93303576T DK0584903T3 (da) | 1992-08-26 | 1993-05-07 | Fremgangsmåde til fremstilling af arylpiperazinyl-heterocykliske forbindelser |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00201940T DK1029861T3 (da) | 1992-08-26 | 1993-05-07 | Benzisothiazol-piperazinylderivat og dets anvendelse som neuroleptikum |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5206366A (fi) |
| EP (2) | EP1029861B1 (fi) |
| JP (1) | JP2742370B2 (fi) |
| KR (1) | KR0123441B1 (fi) |
| CN (1) | CN1033089C (fi) |
| AT (2) | ATE273976T1 (fi) |
| AU (1) | AU642836B1 (fi) |
| BR (1) | BR9302065A (fi) |
| CZ (1) | CZ281893B6 (fi) |
| DE (2) | DE69333597T2 (fi) |
| DK (2) | DK1029861T3 (fi) |
| EG (1) | EG20214A (fi) |
| ES (2) | ES2161703T3 (fi) |
| FI (1) | FI111641B (fi) |
| HU (1) | HU223312B1 (fi) |
| IL (1) | IL105622A (fi) |
| MX (1) | MX9302813A (fi) |
| MY (1) | MY109731A (fi) |
| NO (1) | NO300685B1 (fi) |
| NZ (1) | NZ247539A (fi) |
| PL (1) | PL173840B1 (fi) |
| PT (2) | PT584903E (fi) |
| RU (1) | RU2061695C1 (fi) |
| SI (1) | SI9300287A (fi) |
| SK (1) | SK280584B6 (fi) |
| YU (1) | YU48964B (fi) |
| ZA (1) | ZA936225B (fi) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206366A (en) * | 1992-08-26 | 1993-04-27 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds |
| US5338846A (en) * | 1992-08-26 | 1994-08-16 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds with a piperazine salt |
| US5359068A (en) * | 1993-06-28 | 1994-10-25 | Pfizer Inc. | Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one |
| MX9709451A (es) * | 1995-06-06 | 1998-02-28 | Hoechst Marion Roussel Inc | Derivados de benzisoxazol e indazol como agentes antipsicoticos. |
| IL126590A (en) * | 1996-05-07 | 2001-11-25 | Pfizer | Trihydrate salt of -5 (-2 (-4 (1 (2, 2-benzothiazole - 3yl) -1-piperazinyl) ethyl) - 6-chloro-1, 3-dihydro-2 (1H) - indole - 2On (= Ziprasidone) and pharmaceutical preparations containing it |
| TW491847B (en) | 1996-05-07 | 2002-06-21 | Pfizer | Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one |
| US5945421A (en) * | 1997-08-11 | 1999-08-31 | Warner-Lambert Company | Dopamine D4 receptor antagonists |
| US6040448A (en) * | 1997-10-24 | 2000-03-21 | Neurogen Corporation | Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands |
| IL127497A (en) * | 1997-12-18 | 2002-07-25 | Pfizer Prod Inc | Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders |
| CN100391455C (zh) * | 1998-03-06 | 2008-06-04 | 阿斯特拉曾尼卡有限公司 | 靛红和羟吲哚衍生物的制药用途 |
| US6150366A (en) * | 1998-06-15 | 2000-11-21 | Pfizer Inc. | Ziprasidone formulations |
| US6660858B2 (en) | 2001-03-28 | 2003-12-09 | Lion Bioscience Ag | 2-aminobenzoxazole derivatives and combinatorial libraries thereof |
| UY27668A1 (es) * | 2002-02-20 | 2003-10-31 | Pfizer Prod Inc | Composición de ziprasidona y controles sintéticos |
| US20040048876A1 (en) * | 2002-02-20 | 2004-03-11 | Pfizer Inc. | Ziprasidone composition and synthetic controls |
| BR0314393A (pt) * | 2002-09-17 | 2005-07-19 | Warner Lambert Co | Piperazinas heterocìclicas substituìdas para o tratamento de esquizofrenia |
| ES2297200T3 (es) * | 2002-10-24 | 2008-05-01 | Pfizer Products Inc. | Derivados de acilo de 5-(2-(4-(1,2 bencisotiazol-3-il)-1-piperazinil)etil)-6-cloro-1,3-dihidro-2h-indol-2-ona que presentan actividad neuroleptica. |
| WO2004041793A1 (en) * | 2002-11-08 | 2004-05-21 | Warner-Lambert Company Llc | Phenylalkyl and pyridylalkyl piperazine derivatives |
| US7488729B2 (en) | 2002-12-04 | 2009-02-10 | Dr. Reddy's Laboratories Limited | Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof |
| WO2004050655A1 (en) * | 2002-12-04 | 2004-06-17 | Dr. Reddy's Laboratories Limited | Polymorphic forms of ziprasidone and its hydrochloride |
| CN1255105C (zh) * | 2002-12-17 | 2006-05-10 | 上海医药工业研究院 | 齐拉西酮及其盐的水溶性包合物及其制备方法 |
| US20050143396A1 (en) * | 2003-04-11 | 2005-06-30 | Hertero Drugs Limited | Novel crystalline forms of ziprasidone hydrochloride |
| CA2528192A1 (en) * | 2003-06-03 | 2005-02-24 | Teva Pharmaceutical Industries Ltd | Cristalline ziprasidone hcl and processes for preparation thereof |
| US20050049295A1 (en) * | 2003-06-12 | 2005-03-03 | Dr. Reddy's Laboratories Limited | Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate |
| US7160888B2 (en) * | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
| US7667037B2 (en) | 2003-10-24 | 2010-02-23 | Teva Pharmaceutical Industries Ltd. | Processes for preparation of ziprasidone |
| EP1592688A2 (en) * | 2003-12-18 | 2005-11-09 | Teva Pharmaceutical Industries Ltd. | Polymorphic form b2 of ziprasidone base |
| ES2334800T3 (es) * | 2004-02-27 | 2010-03-16 | Ranbaxy Laboratories Limited | Proceso para la preparacion de ziprasidona. |
| ITMI20040944A1 (it) * | 2004-05-11 | 2004-08-11 | Dinamite Dipharma S P A In For | Polimorfo di ziprasidone cloridrato e procedimento per la sua preparazione |
| CA2467538C (en) * | 2004-05-14 | 2010-08-24 | Apotex Pharmachem Inc. | New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same |
| CA2471219A1 (en) * | 2004-06-14 | 2005-12-14 | Apotex Pharmachem Inc. | Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) |
| US7728136B2 (en) | 2004-06-18 | 2010-06-01 | Lupin Limited | Method for the preparation of aryl piperazinyl-heterocyclic compounds |
| US9044503B2 (en) * | 2004-08-27 | 2015-06-02 | University Of Kentucky Research Foundation | Amyloid peptide inactivating enzyme to treat alzheimer's disease peripherally |
| ES2250000B1 (es) * | 2004-09-29 | 2007-06-01 | Medichem, S.A. | Procedimiento para la preparacion de ziprasidona. |
| ES2250001B1 (es) * | 2004-09-29 | 2007-06-01 | Medichem, S.A. | Proceso para la purificacion de ziprasidona. |
| US7777037B2 (en) * | 2004-10-27 | 2010-08-17 | Dr. Reddy's Laboratories Limited | Ziprasidone process |
| CA2593497A1 (en) * | 2005-02-11 | 2006-08-17 | Judith Aronhime | Amorphous ziprasidone mesylate |
| EP1858891A2 (en) * | 2005-03-14 | 2007-11-28 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of ziprasidone mesylate |
| EP1858892A1 (en) * | 2005-03-14 | 2007-11-28 | Teva Pharmaceutical Industries Ltd | Anhydrous ziprasidone mesylate and a process for its preparation |
| JP4109709B1 (ja) * | 2005-04-01 | 2008-07-02 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 統合失調症の治療のためのテトラヒドロ−ピリドアゼピン−８−オン及び関連化合物 |
| HU230479B1 (hu) * | 2006-05-02 | 2016-07-28 | Richter Gedeon Nyrt. | Eljárás 5-{2-[4-(1,2-benzizotiazol-3-il)-1-piperazinil]-etil}-6-klór-1,3-dihidro-2H-indol-2-on (Ziprasidon) előállítására |
| HUP0600868A3 (en) * | 2006-11-24 | 2009-03-30 | Richter Gedeon Nyrt | 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation |
| US8410268B2 (en) * | 2008-03-11 | 2013-04-02 | Alkem Laboratories Limited | Process for the preparation of ziprasidone |
| CA2799154A1 (en) | 2010-05-12 | 2011-11-17 | Abbvie Inc. | Indazole inhibitors of kinase |
| PL391810A1 (pl) | 2010-07-14 | 2012-01-16 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Nowe sole ziprasidonu oraz sposoby ich otrzymywania |
| WO2012020424A1 (en) | 2010-08-12 | 2012-02-16 | Arch Pharmalabs Limited | A short process for the preparation of ziprasidone and intermediates thereof |
| SI23610A (sl) | 2011-01-13 | 2012-07-31 | Diagen@d@o@o | Nove adicijske soli ziprasidona postopek za njihovo pripravo in njihova uporaba v terapiji |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4610988A (en) * | 1982-04-09 | 1986-09-09 | Hoechst-Roussel Pharmaceuticals Inc. | 1-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(substituted)piperazines useful for alleviating pain |
| FR2536749A1 (fr) * | 1982-11-25 | 1984-06-01 | Cerm Cent Europ Rech Mauvernay | (amino-2 ethyl)-6 benzoxazolinones substituees, leur preparation et leurs applications en therapeutique |
| MX173362B (es) * | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
| US4883795A (en) * | 1988-01-22 | 1989-11-28 | Pfizer Inc. | Piperazinyl-heterocyclic compounds |
| US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
| US5206366A (en) * | 1992-08-26 | 1993-04-27 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds |
| US5312925A (en) * | 1992-09-01 | 1994-05-17 | Pfizer Inc. | Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride |
-
1992
- 1992-08-26 US US07/936,179 patent/US5206366A/en not_active Expired - Lifetime
-
1993
- 1993-05-03 NZ NZ247539A patent/NZ247539A/xx not_active IP Right Cessation
- 1993-05-04 HU HU9301291A patent/HU223312B1/hu not_active IP Right Cessation
- 1993-05-04 FI FI932012A patent/FI111641B/fi active Protection Beyond IP Right Term
- 1993-05-05 AU AU38403/93A patent/AU642836B1/en not_active Ceased
- 1993-05-06 IL IL105622A patent/IL105622A/en not_active IP Right Cessation
- 1993-05-06 NO NO931656A patent/NO300685B1/no unknown
- 1993-05-07 DK DK00201940T patent/DK1029861T3/da active
- 1993-05-07 DK DK93303576T patent/DK0584903T3/da active
- 1993-05-07 PT PT93303576T patent/PT584903E/pt unknown
- 1993-05-07 AT AT00201940T patent/ATE273976T1/de active
- 1993-05-07 DE DE69333597T patent/DE69333597T2/de not_active Expired - Lifetime
- 1993-05-07 DE DE69330853T patent/DE69330853T2/de not_active Expired - Fee Related
- 1993-05-07 ES ES93303576T patent/ES2161703T3/es not_active Expired - Lifetime
- 1993-05-07 AT AT93303576T patent/ATE206422T1/de not_active IP Right Cessation
- 1993-05-07 EP EP00201940A patent/EP1029861B1/en not_active Expired - Lifetime
- 1993-05-07 ES ES00201940T patent/ES2225015T3/es not_active Expired - Lifetime
- 1993-05-07 MY MYPI93000857A patent/MY109731A/en unknown
- 1993-05-07 EP EP93303576A patent/EP0584903B1/en not_active Expired - Lifetime
- 1993-05-07 PT PT00201940T patent/PT1029861E/pt unknown
- 1993-05-12 CZ CZ93877A patent/CZ281893B6/cs not_active IP Right Cessation
- 1993-05-13 MX MX9302813A patent/MX9302813A/es not_active IP Right Cessation
- 1993-05-13 EG EG27793A patent/EG20214A/xx active
- 1993-05-14 SK SK485-93A patent/SK280584B6/sk not_active IP Right Cessation
- 1993-05-19 PL PL93299002A patent/PL173840B1/pl not_active IP Right Cessation
- 1993-05-26 BR BR9302065A patent/BR9302065A/pt not_active Application Discontinuation
- 1993-05-28 SI SI9300287A patent/SI9300287A/sl not_active IP Right Cessation
- 1993-05-28 RU RU9393028444A patent/RU2061695C1/ru not_active IP Right Cessation
- 1993-06-04 CN CN93106669A patent/CN1033089C/zh not_active Expired - Fee Related
- 1993-07-20 KR KR1019930013678A patent/KR0123441B1/ko not_active IP Right Cessation
- 1993-08-13 JP JP5201542A patent/JP2742370B2/ja not_active Expired - Lifetime
- 1993-08-25 YU YU56593A patent/YU48964B/sh unknown
- 1993-08-25 ZA ZA936225A patent/ZA936225B/xx unknown
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