RU93028444A - Способ получения алкилпиперазинил-гетероциклических соединений - Google Patents

Способ получения алкилпиперазинил-гетероциклических соединений

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Publication number
RU93028444A
RU93028444A RU93028444/04A RU93028444A RU93028444A RU 93028444 A RU93028444 A RU 93028444A RU 93028444/04 A RU93028444/04 A RU 93028444/04A RU 93028444 A RU93028444 A RU 93028444A RU 93028444 A RU93028444 A RU 93028444A
Authority
RU
Russia
Prior art keywords
obtaining
alkylpiperasinyl
heterocyclic compounds
formula
containing compound
Prior art date
Application number
RU93028444/04A
Other languages
English (en)
Other versions
RU2061695C1 (ru
Inventor
Боулс Поль
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/936,179 external-priority patent/US5206366A/en
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of RU93028444A publication Critical patent/RU93028444A/ru
Application granted granted Critical
Publication of RU2061695C1 publication Critical patent/RU2061695C1/ru

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Claims (1)

  1. Способ получения соединения формулы
    Figure 00000001

    или его фармацевтически приемлемой кислотно-аддитивной соли, включающей взаимодействие пиперазина формулы
    Figure 00000002

    с алкилгалогенид-содержащим соединением формулы
    Figure 00000003

    в воде с реагентом нейтрализации галоидводородной кислоты и нагревание смеси в условиях, подходящих для реакции сочетания указанного пиперазина с алкилгалогенид-содержащим соединением.
RU9393028444A 1992-08-26 1993-05-28 Способ получения арилпиперазинил-гетероциклических соединений или их фармацевтически приемлемой кислотно-аддитивной соли RU2061695C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US936179 1992-08-26
US936,179 1992-08-26
US07/936,179 US5206366A (en) 1992-08-26 1992-08-26 Process for preparing aryl piperazinyl-heterocyclic compounds

Publications (2)

Publication Number Publication Date
RU93028444A true RU93028444A (ru) 1996-01-27
RU2061695C1 RU2061695C1 (ru) 1996-06-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU9393028444A RU2061695C1 (ru) 1992-08-26 1993-05-28 Способ получения арилпиперазинил-гетероциклических соединений или их фармацевтически приемлемой кислотно-аддитивной соли

Country Status (27)

Country Link
US (1) US5206366A (ru)
EP (2) EP1029861B1 (ru)
JP (1) JP2742370B2 (ru)
KR (1) KR0123441B1 (ru)
CN (1) CN1033089C (ru)
AT (2) ATE273976T1 (ru)
AU (1) AU642836B1 (ru)
BR (1) BR9302065A (ru)
CZ (1) CZ281893B6 (ru)
DE (2) DE69333597T2 (ru)
DK (2) DK1029861T3 (ru)
EG (1) EG20214A (ru)
ES (2) ES2225015T3 (ru)
FI (1) FI111641B (ru)
HU (1) HU223312B1 (ru)
IL (1) IL105622A (ru)
MX (1) MX9302813A (ru)
MY (1) MY109731A (ru)
NO (1) NO300685B1 (ru)
NZ (1) NZ247539A (ru)
PL (1) PL173840B1 (ru)
PT (2) PT1029861E (ru)
RU (1) RU2061695C1 (ru)
SI (1) SI9300287A (ru)
SK (1) SK280584B6 (ru)
YU (1) YU48964B (ru)
ZA (1) ZA936225B (ru)

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US7678799B2 (en) * 2003-06-03 2010-03-16 Teva Pharmaceutical Industries Ltd. Crystalline ziprasidone HCl and processes for preparation thereof
US20050049295A1 (en) * 2003-06-12 2005-03-03 Dr. Reddy's Laboratories Limited Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
EP1628973A2 (en) 2003-10-24 2006-03-01 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
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DE602005018171D1 (de) * 2004-02-27 2010-01-21 Ranbaxy Lab Ltd Verfahren zur herstellung von ziprasidon
ITMI20040944A1 (it) * 2004-05-11 2004-08-11 Dinamite Dipharma S P A In For Polimorfo di ziprasidone cloridrato e procedimento per la sua preparazione
CA2467538C (en) * 2004-05-14 2010-08-24 Apotex Pharmachem Inc. New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same
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US7728136B2 (en) 2004-06-18 2010-06-01 Lupin Limited Method for the preparation of aryl piperazinyl-heterocyclic compounds
US9044503B2 (en) * 2004-08-27 2015-06-02 University Of Kentucky Research Foundation Amyloid peptide inactivating enzyme to treat alzheimer's disease peripherally
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US7777037B2 (en) * 2004-10-27 2010-08-17 Dr. Reddy's Laboratories Limited Ziprasidone process
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CA2599391A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of ziprasidone mesylate
JP4109709B1 (ja) * 2005-04-01 2008-07-02 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 統合失調症の治療のためのテトラヒドロ−ピリドアゼピン−８−オン及び関連化合物
HU230479B1 (hu) * 2006-05-02 2016-07-28 Richter Gedeon Nyrt. Eljárás 5-{2-[4-(1,2-benzizotiazol-3-il)-1-piperazinil]-etil}-6-klór-1,3-dihidro-2H-indol-2-on (Ziprasidon) előállítására
HUP0600868A3 (en) * 2006-11-24 2009-03-30 Richter Gedeon Nyrt 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation
US8410268B2 (en) * 2008-03-11 2013-04-02 Alkem Laboratories Limited Process for the preparation of ziprasidone
JP2013526542A (ja) 2010-05-12 2013-06-24 アッヴィ・インコーポレイテッド キナーゼのインダゾール阻害薬
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