DK0559019T3 - 14-beta-hydroxy-10-deacetyl-baccatin III og derivater deraf som antitumormidler - Google Patents

14-beta-hydroxy-10-deacetyl-baccatin III og derivater deraf som antitumormidler

Info

Publication number
DK0559019T3
DK0559019T3 DK93102633T DK93102633T DK0559019T3 DK 0559019 T3 DK0559019 T3 DK 0559019T3 DK 93102633 T DK93102633 T DK 93102633T DK 93102633 T DK93102633 T DK 93102633T DK 0559019 T3 DK0559019 T3 DK 0559019T3
Authority
DK
Denmark
Prior art keywords
deacetyl
beta
hydroxy
derivatives
antitumor agents
Prior art date
Application number
DK93102633T
Other languages
Danish (da)
English (en)
Inventor
Ezio Bombardelli
Bruno Gabetta
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of DK0559019T3 publication Critical patent/DK0559019T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
DK93102633T 1992-03-06 1993-02-19 14-beta-hydroxy-10-deacetyl-baccatin III og derivater deraf som antitumormidler DK0559019T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920528A IT1254517B (it) 1992-03-06 1992-03-06 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico

Publications (1)

Publication Number Publication Date
DK0559019T3 true DK0559019T3 (da) 2000-03-27

Family

ID=11362321

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93102633T DK0559019T3 (da) 1992-03-06 1993-02-19 14-beta-hydroxy-10-deacetyl-baccatin III og derivater deraf som antitumormidler

Country Status (19)

Country Link
US (2) US5264591A (el)
EP (1) EP0559019B1 (el)
JP (1) JP2708346B2 (el)
KR (1) KR100255525B1 (el)
CN (1) CN1051082C (el)
AT (1) ATE184599T1 (el)
CA (1) CA2091001C (el)
CZ (1) CZ284265B6 (el)
DE (1) DE69326369T2 (el)
DK (1) DK0559019T3 (el)
ES (1) ES2136096T3 (el)
FI (1) FI109904B (el)
GR (1) GR3031280T3 (el)
HK (1) HK1011686A1 (el)
HU (2) HU218665B (el)
IT (1) IT1254517B (el)
NO (1) NO305080B1 (el)
PL (1) PL171982B1 (el)
SK (1) SK279257B6 (el)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US6011056A (en) * 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5698712A (en) * 1992-03-06 1997-12-16 Indena S.P.A. Baccatine III derivatives
US5481007A (en) * 1992-06-23 1996-01-02 The Scripps Research Institute Taxoid synthesis
US5281727A (en) 1992-11-27 1994-01-25 Napro Biotherapeutics, Inc. Method of using ion exchange media to increase taxane yields
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
WO1994020485A1 (en) * 1993-03-05 1994-09-15 Florida State University Process for the preparation of 9-desoxotaxanes
US6710191B2 (en) * 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
FR2711370B1 (fr) * 1993-10-18 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2712289B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2714053B1 (fr) * 1993-12-22 1996-03-08 Pf Medicament Procédé d'extraction et d'isolement de la 10-désacétylbaccatine III.
CN1112433A (zh) * 1994-05-24 1995-11-29 郭明 红豆杉属植物提取物及其应用
IT1269862B (it) * 1994-05-30 1997-04-15 Indena Spa Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono
US5763477A (en) * 1994-07-22 1998-06-09 Dr. Reddy's Research Foundation Taxane derivatives from 14-β-hydroxy-10 deacetylbaccatin III
FR2723094A1 (fr) * 1994-07-26 1996-02-02 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
FR2732341A1 (fr) * 1995-03-27 1996-10-04 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
IT1275435B (it) * 1995-05-19 1997-08-07 Indena Spa Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono
EP0747372A1 (en) * 1995-06-06 1996-12-11 Dr. Reddy's Research Foundation Taxane derivatives from 14-beta-hydroxy-10 deacetybaccatin III
US5919815A (en) * 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
JP4172726B2 (ja) * 1996-05-22 2008-10-29 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド シス―ドコサヘキサエン酸とドセタキセルとの共有複合体を含有する製剤
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US5750736A (en) * 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US5856532A (en) * 1996-08-14 1999-01-05 Council Of Scientific & Industrial Research Process for the production of taxol
WO1998008833A1 (en) * 1996-08-26 1998-03-05 Bristol-Myers Squibb Company Sulfenamide taxane derivatives
EP0868422A1 (de) * 1996-09-24 1998-10-07 Marigen S.A. Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
EP1068192B1 (en) * 1998-01-14 2002-06-12 Bristol-Myers Squibb Company Novel crystalline complexes of baccatin iii with imidazole, 2-methylimidazole or isopropanol
US6002024A (en) * 1998-07-27 1999-12-14 Dabur Research Foundation Process for the isolation of 14β-hydroxy-10-deacetyl baccatin-III
US6124482A (en) * 1998-07-27 2000-09-26 Dabur Research Foundation Process for isolation of 10-deacetyl baccatin-III
US7235583B1 (en) * 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CZ2003837A3 (cs) 2000-09-22 2004-12-15 Bristol-Myers Squibb Company Způsob pro snížení toxicity při kombinovaných chemoterapiích
EP1423107B1 (en) * 2001-03-23 2012-05-09 Luitpold Pharmaceuticals, Inc. Fatty alcohol drug conjugates
US8552054B2 (en) 2001-03-23 2013-10-08 Luitpold Pharmaceuticals, Inc. Fatty amine drug conjugates
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
ITMI20050614A1 (it) * 2005-04-12 2006-10-13 Indena Spa Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
WO2008035928A1 (en) * 2006-09-20 2008-03-27 Lg Chem, Ltd. Additive for non-aqueous electrolyte and secondary battery using the same
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol

Also Published As

Publication number Publication date
US5453520A (en) 1995-09-26
EP0559019B1 (en) 1999-09-15
US5264591A (en) 1993-11-23
HU211824A9 (en) 1995-12-28
SK279257B6 (sk) 1998-08-05
ATE184599T1 (de) 1999-10-15
CA2091001C (en) 2003-11-04
HU218665B (hu) 2000-10-28
ITMI920528A1 (it) 1993-09-06
CZ33693A3 (en) 1994-01-19
KR930019654A (ko) 1993-10-18
ES2136096T3 (es) 1999-11-16
NO930774D0 (no) 1993-03-03
NO930774L (no) 1993-09-07
IT1254517B (it) 1995-09-25
CA2091001A1 (en) 1993-09-07
CN1076695A (zh) 1993-09-29
DE69326369T2 (de) 2000-03-23
SK15293A3 (en) 1993-12-08
PL171982B1 (pl) 1997-07-31
HU9300594D0 (en) 1993-05-28
FI930978A0 (fi) 1993-03-04
ITMI920528A0 (it) 1992-03-06
JP2708346B2 (ja) 1998-02-04
GR3031280T3 (en) 1999-12-31
FI930978A (fi) 1993-09-07
HK1011686A1 (en) 1999-07-16
KR100255525B1 (ko) 2000-05-01
DE69326369D1 (de) 1999-10-21
CZ284265B6 (cs) 1998-10-14
JPH069599A (ja) 1994-01-18
FI109904B (fi) 2002-10-31
PL297940A1 (en) 1993-11-15
EP0559019A1 (en) 1993-09-08
HUT64317A (en) 1993-12-28
NO305080B1 (no) 1999-03-29
CN1051082C (zh) 2000-04-05

Similar Documents

Publication Publication Date Title
DK0559019T3 (da) 14-beta-hydroxy-10-deacetyl-baccatin III og derivater deraf som antitumormidler
NO302359B1 (no) 7-(substituerte)-9-£(substituerte glycyl)amido|-6-demetyl-6-deoksy-tetracykliner, farmasöytiske preparater inneholdende dem, og mellomprodukter
ES2038664T3 (es) Briostatinas.
AU6329794A (en) Nitrogen-containing spirocycles
NO943002L (no) Fosfono-oksymetyletere av taxanderivater
NO180679C (no) Pyranylcyanoguanidin-derivater, preparater som inneholder dem og anvendelse derav
MX9203032A (es) Una solucion farmaceutica.
DE69511424D1 (de) Antifungale sordaridinderivate
NO952207L (no) Anvendelse av 2-amino-6-A-propylamino-4,5,6,7-tetrahydrobenzotiazol (pramipexol) som et antidepresivt legemiddel
NO902394D0 (no) Fremgangsmaate for fremstilling av pyranyl-cyanoguanidin-derivater.
DK0736009T3 (da) N-oxider af 4-arylpiperaziner og 4-arylpiperidiner som antipsykotiske medikamenter
FI901277A0 (fi) 2,5,6,7-tetranor-4,8-inter-m-fenylen pg1z-derivativ.
ES2129053T3 (es) Nuevos derivados de fosfolipidos.
FI934468A0 (fi) Bensenborsyraderivat, foerfarande foer deras framstaellning och deras anvaendning som sytesmellanprodukter
ES2134971T3 (es) Derivado de acido octahidro-2-naftaleno-carboxilico, su produccion y uso.
DK0673913T3 (da) Calcium-alkalimetalcitratforbindelser samt deres anvendelse som lægemidler
ES2175228T3 (es) Metilsulfomicina i, un procedimiento para su produccion y su uso.
ES2039270T3 (es) Derivados de gamma-l-glutamil-4-nitroanilida y procedimiento para determinar actividad de gamma-gtp utilizandolos.
ECSP972237A (es) Derivados de 6,5 heterobiciclicos sustituidos