DK0496314T3 - Substituerede 1,2,3,4-tetrahydrocyclopenta(b)indoler, 1,2,3,3a,4,8a-hexahydrocyclopenta(b)indoler og beslægtede forbindelser, mellemprodukter og en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler - Google Patents

Substituerede 1,2,3,4-tetrahydrocyclopenta(b)indoler, 1,2,3,3a,4,8a-hexahydrocyclopenta(b)indoler og beslægtede forbindelser, mellemprodukter og en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Info

Publication number
DK0496314T3
DK0496314T3 DK92100816.5T DK92100816T DK0496314T3 DK 0496314 T3 DK0496314 T3 DK 0496314T3 DK 92100816 T DK92100816 T DK 92100816T DK 0496314 T3 DK0496314 T3 DK 0496314T3
Authority
DK
Denmark
Prior art keywords
indoles
intermediates
preparation
tetrahydrocyclopenta
hexahydrocyclopenta
Prior art date
Application number
DK92100816.5T
Other languages
Danish (da)
English (en)
Inventor
Helen Hu Ong
Gerard Joseph Omalley
Michael Clayton Merriman
Mark Gabriel Palermo
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of DK0496314T3 publication Critical patent/DK0496314T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK92100816.5T 1991-01-18 1992-01-18 Substituerede 1,2,3,4-tetrahydrocyclopenta(b)indoler, 1,2,3,3a,4,8a-hexahydrocyclopenta(b)indoler og beslægtede forbindelser, mellemprodukter og en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler DK0496314T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/642,952 US5100891A (en) 1991-01-18 1991-01-18 Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds

Publications (1)

Publication Number Publication Date
DK0496314T3 true DK0496314T3 (da) 1998-05-18

Family

ID=24578739

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92100816.5T DK0496314T3 (da) 1991-01-18 1992-01-18 Substituerede 1,2,3,4-tetrahydrocyclopenta(b)indoler, 1,2,3,3a,4,8a-hexahydrocyclopenta(b)indoler og beslægtede forbindelser, mellemprodukter og en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Country Status (26)

Country Link
US (1) US5100891A (fr)
EP (1) EP0496314B1 (fr)
JP (1) JP2665422B2 (fr)
KR (1) KR100230881B1 (fr)
AT (1) ATE158790T1 (fr)
AU (1) AU650315B2 (fr)
BR (1) BR9200171A (fr)
CA (1) CA2059610C (fr)
CZ (1) CZ282732B6 (fr)
DE (1) DE69222444T2 (fr)
DK (1) DK0496314T3 (fr)
ES (1) ES2109953T3 (fr)
FI (2) FI102174B (fr)
GR (1) GR3025318T3 (fr)
HU (1) HUT67027A (fr)
IE (1) IE920149A1 (fr)
IL (1) IL100693A0 (fr)
MX (1) MX9200206A (fr)
NO (1) NO178397C (fr)
NZ (1) NZ241305A (fr)
PH (1) PH31429A (fr)
PL (2) PL169417B1 (fr)
RO (1) RO112505B1 (fr)
RU (1) RU2077530C1 (fr)
TW (1) TW198024B (fr)
ZA (1) ZA92341B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298626A (en) * 1991-01-18 1994-03-29 Hoechst-Roussel Pharmaceuticals Incorporated Select cyclopent[b]indoles
US5350762A (en) * 1993-03-08 1994-09-27 Hoechst-Roussel Pharmaceuticals Incorporated Tetrahydrocyclopent[B]indole methanamines and related compounds
CA2296104A1 (fr) * 1997-07-03 1999-01-14 Asahi Kasei Kogyo Kabushiki Kaisha Nouveaux composes tricycliques presentant des noyaux satures et compositions medicinales les contenant
WO2000020423A1 (fr) * 1998-10-06 2000-04-13 Janssen Pharmaceutica N.V. Piperidines δ3 tricycliques comme produits pharmaceutiques
UA70334C2 (en) * 1998-10-06 2004-10-15 Janssen Pharmaceutica N V Jans BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS
UA69420C2 (uk) * 1998-10-06 2004-09-15 Янссен Фармацевтика Н.В. ТРИЦИКЛІЧНІ <font face="Symbol">D3</font>-ПІПЕРИДИНИ ЯК <font face="Symbol">a<sub></font>2</sub>-АНТАГОНІСТИ
IT1317926B1 (it) * 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Derivati triciclici dell'indolo ad attivita' antiangiogenica.
CA2528321A1 (fr) 2003-06-10 2004-12-23 Smithkline Beecham Corporation Derives de tetrahydrocarbazole et leur utilisation pharmaceutique
DE602004022169D1 (de) * 2003-06-12 2009-09-03 Smithkline Beecham Corp Tetrahydrocarbazolderivate und deren pharmazeutische verwendung
MX2007006179A (es) * 2004-11-23 2007-06-20 Ptc Therapeutics Inc Tetrahidrocarbazoles como agentes activos para inhibir la produccion del factor de crecimiento endotelial vascular por control de la traduccion.
GB2422828A (en) * 2005-02-03 2006-08-09 Hunter Fleming Ltd Tricyclic cytoprotective compounds comprising an indole residue
WO2013139929A1 (fr) * 2012-03-22 2013-09-26 Ludwig-Maximilians-Universität München Nouveaux moyens et méthodes pour le traitement de maladies du système nerveux central, de maladies cardiaques et métaboliques et du vieillissement
KR20140013471A (ko) 2012-07-24 2014-02-05 주식회사 쎄코 진공증착용 발열조립체 및 이를 구비하는 진공증착장치
US10882821B1 (en) 2017-09-26 2021-01-05 The Board Of Trustees Of The Leland Stanford Junior University Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3514462A (en) * 1966-10-21 1970-05-26 Upjohn Co 1 and 2 ethoxy 3,4,5,10 - tetrahydroazepino(3,4-b) and (2,3-b)indoles and corresponding amino derivatives thereof
US3595874A (en) * 1969-02-28 1971-07-27 Upjohn Co 3,4,5,10-tetrahydroazepino(2,3-b)indol-5a (2h)-ols
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
SU482086A1 (ru) * 1973-11-30 1976-03-15 Всесоюзный Научно-Исследовательски% Химико-Фармацевтический Институт Им.С.Орджоникидзе Способ получени производных 1- -амино1,2,3,4-тетрагидрокарбазола
FR2275202A1 (fr) * 1974-06-18 1976-01-16 Ayerst Mckenna & Harrison Derives tricycliques d'alcoylamines et preparation de ceux-ci
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles

Also Published As

Publication number Publication date
TW198024B (fr) 1993-01-11
PH31429A (en) 1998-11-03
RU2077530C1 (ru) 1997-04-20
PL293209A1 (en) 1993-04-05
PL296651A1 (en) 1993-07-26
FI20001775A (fi) 2000-08-10
AU650315B2 (en) 1994-06-16
FI920192A0 (fi) 1992-01-16
NO920235D0 (no) 1992-01-17
CS12992A3 (en) 1992-08-12
FI102174B1 (fi) 1998-10-30
JP2665422B2 (ja) 1997-10-22
KR100230881B1 (ko) 1999-11-15
EP0496314B1 (fr) 1997-10-01
FI920192A (fi) 1992-07-19
CA2059610C (fr) 2002-04-02
CA2059610A1 (fr) 1992-07-19
IL100693A0 (en) 1992-09-06
NO178397C (no) 1996-03-20
PL169417B1 (pl) 1996-07-31
DE69222444T2 (de) 1998-06-04
ES2109953T3 (es) 1998-02-01
MX9200206A (es) 1992-08-01
AU1027992A (en) 1992-07-23
NO178397B (no) 1995-12-11
BR9200171A (pt) 1992-10-06
FI102174B (fi) 1998-10-30
JPH04334367A (ja) 1992-11-20
NZ241305A (en) 1994-10-26
PL167465B1 (pl) 1995-09-30
EP0496314A1 (fr) 1992-07-29
US5100891A (en) 1992-03-31
FI107919B (fi) 2001-10-31
RO112505B1 (ro) 1997-10-30
HU9200172D0 (en) 1992-04-28
NO920235L (no) 1992-07-20
ATE158790T1 (de) 1997-10-15
KR920014777A (ko) 1992-08-25
ZA92341B (en) 1992-09-30
IE920149A1 (en) 1992-07-29
GR3025318T3 (en) 1998-02-27
HUT67027A (en) 1995-01-30
CZ282732B6 (cs) 1997-09-17
DE69222444D1 (de) 1997-11-06

Similar Documents

Publication Publication Date Title
DK0496314T3 (da) Substituerede 1,2,3,4-tetrahydrocyclopenta(b)indoler, 1,2,3,3a,4,8a-hexahydrocyclopenta(b)indoler og beslægtede forbindelser, mellemprodukter og en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
DK0669920T3 (da) Substituerede 3-(aminoalkylamino)-1,2-benzisoxazoler og beslægtede forbindelser
DK0513543T3 (da) Amidinophenylalaninderivater, fremgangsmåde til deres fremstilling, deres anvendelse og antikoagulationsmidler med indehold deraf
DK0773943T3 (da) Forbindelser, der er anvendelige som antiproliferative midler og garft-inhibitorer
FI925415A (fi) Framstaellning av substituerade piperidiner
NZ228065A (en) 1,2,4-triazinediones and parasiticidal compositions; processes for preparation
DK0517221T3 (da) ((Arylalkylpiperidin-4-yl)-methyl)-2alfa,3,4,5-tetrahydro-1(2H)-acenaphthylen-1-oner og beslægtede forbindelser, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
DK0614888T3 (da) Tetrahydrocyclopentab indol-methanaminer og beslægtede forbindelser, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler.
DE69533214D1 (de) 2,3-Dihydro-1H-isoindolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Hemmer der Serotoninwiederaufnahme
BR9707004A (pt) Composto processo para preparar o mesmo composição farmacêutica utilização do composto e processos para tratamento de doenças do sistema endocinológico e para a manufatura de um medicamento
DK0709378T3 (da) Aminoalkyloximer, en fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og mellemproduktforbindelser
DK378885A (da) 1-(n-(alfa-amino-alfa-methylacetyl)aminophenyl)-2-aminopropanonderivater, fremgangsmaade til deres fremstilling og deres anvendelse i terapien