US5260421A
(en)
*
|
1987-12-21 |
1993-11-09 |
Applied Research Systems Ars Holding N.V. |
Site-directed mutagenesis modified glycoprotein hormones
|
US5705478A
(en)
*
|
1989-02-21 |
1998-01-06 |
Washington University |
Covalently linked β subunits of the glycoprotein hormones as antagonists
|
US6225449B1
(en)
*
|
1991-10-04 |
2001-05-01 |
Washington University |
Hormone analogs with multiple CTP extensions
|
US5792460A
(en)
*
|
1989-02-21 |
1998-08-11 |
Washington University |
Modified glycoprotein hormones having a CTP at the amino terminus
|
US5240832A
(en)
*
|
1989-06-20 |
1993-08-31 |
Genzyme Corporation |
Heteropolymeric protein production methods
|
EP0673383B1
(fr)
*
|
1991-06-18 |
2000-05-31 |
University Of Medicine & Dentistry Of New Jersey |
Analogues des hormones glycoproteiques presentant une specificite et une activite de liaison avec les recepteurs modifiees, et procedes de preparation et d'utilisation de ces analogues
|
US6028177A
(en)
*
|
1991-10-04 |
2000-02-22 |
Washington University |
Methods of detecting single-chain forms of the glycoprotein hormone quartet
|
US5985611A
(en)
*
|
1992-04-30 |
1999-11-16 |
Washington University |
Recombinant production of gonadotropins in secretory cells
|
CA2160800C
(fr)
*
|
1993-04-20 |
2010-06-01 |
Irving Boime |
Proteines gonadotropes modifiees par l'adjonction de sequences ctp
|
US5683899A
(en)
|
1994-02-03 |
1997-11-04 |
University Of Hawaii |
Methods and compositions for combinatorial-based discovery of new multimeric molecules
|
US5643745A
(en)
*
|
1994-02-03 |
1997-07-01 |
University Of Hawaii |
Heterologous dimeric proteins produced in heterokaryons
|
US6238890B1
(en)
|
1994-02-18 |
2001-05-29 |
Washington University |
Single chain forms of the glycoprotein hormone quartet
|
GB9403600D0
(en)
*
|
1994-02-24 |
1994-04-13 |
Univ Glasgow |
Three dimensional hormone structure
|
AU2603995A
(en)
*
|
1994-05-25 |
1995-12-18 |
University Of Nebraska Board Of Regents |
Biologically active glycoprotein hormones produced in procaryotic cells
|
BR9506313A
(pt)
*
|
1994-08-12 |
1997-08-05 |
Univ Washington |
Formas de cadeia simples do quarteto de hormônio de glicoproteína
|
ATE257843T1
(de)
*
|
1994-08-12 |
2004-01-15 |
Univ Washington |
Einzelkettenformen des clycoprotein-hormon- quartetts
|
US5733735A
(en)
*
|
1996-06-11 |
1998-03-31 |
Washington University |
Assay system to determine receptor antagonist target site
|
IL122732A0
(en)
*
|
1997-01-15 |
1998-08-16 |
Akzo Nobel Nv |
Liquid gonadotropin-containing formulation its preparation and a device containing same
|
US5883073A
(en)
*
|
1997-04-03 |
1999-03-16 |
Washington University |
Single-chain double-alpha peptide
|
WO1999015665A2
(fr)
*
|
1997-09-22 |
1999-04-01 |
University Of Maryland, Baltimore |
Mutants de thyrotropine et methodes fondees sur ces mutants
|
US6103501A
(en)
*
|
1997-11-17 |
2000-08-15 |
Washington University |
Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
|
US6635256B1
(en)
|
1998-10-19 |
2003-10-21 |
Washington University |
Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
|
WO2000015224A1
(fr)
|
1998-09-17 |
2000-03-23 |
Eli Lilly And Company |
Preparation a base de proteines
|
CA2369262A1
(fr)
|
1999-04-13 |
2000-10-19 |
Sudha Nagarajan |
Administration pulmonaire de formulations de poudre seche pour le traitement de l'infecondite
|
UA78676C2
(en)
*
|
2000-02-22 |
2007-04-25 |
Applied Research Systems |
Purified lh
|
CA2399020A1
(fr)
*
|
2000-02-22 |
2001-08-30 |
Applied Research Systems Ars Holding N.V. |
Procede de purification de hcg et hcg recombinee purifiee par cette methode
|
US7514239B2
(en)
*
|
2000-03-28 |
2009-04-07 |
Amgen Inc. |
Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
|
JP2001333772A
(ja)
|
2000-04-25 |
2001-12-04 |
Washington Univ |
可変性の活性を有する単鎖稔性ホルモン
|
US20040005554A1
(en)
*
|
2000-05-08 |
2004-01-08 |
Tayar Nabil El |
Novel glycoproteins and methods of use thereof
|
US6493964B1
(en)
|
2000-05-25 |
2002-12-17 |
Tousimis Research Corp. |
Supercritical point drying apparatus for semiconductor device manufacturing and bio-medical sample processing
|
KR101229995B1
(ko)
*
|
2000-12-11 |
2013-02-06 |
씨제이 주식회사 |
생체내 에리스로포이에틴 활성이 증진된 융합단백질
|
AU2002222740A1
(en)
*
|
2000-12-11 |
2002-06-24 |
Cheil Jedang Corporation |
Fusion protein having the enhanced in vivo activity of erythropoietin
|
US6987172B2
(en)
|
2001-03-05 |
2006-01-17 |
Washington University In St. Louis |
Multifunctional single chain glycoprotein hormones comprising three or more β subunits
|
US6573237B2
(en)
|
2001-03-16 |
2003-06-03 |
Eli Lilly And Company |
Protein formulations
|
MXPA04004289A
(es)
*
|
2001-11-08 |
2005-03-31 |
William R Moyle |
Proteina knobs.
|
KR100467750B1
(ko)
*
|
2001-11-29 |
2005-01-24 |
씨제이 주식회사 |
생체내 에리스로포이에틴 활성이 증진된 융합단백질
|
KR100467751B1
(ko)
*
|
2001-12-03 |
2005-01-24 |
씨제이 주식회사 |
생체내 에리스로포이에틴 활성이 증진된 융합단백질
|
US7173113B2
(en)
*
|
2002-01-31 |
2007-02-06 |
The Trustees Of Columbia University In The City Of New York |
Long-acting hormone and growth factor compositions and uses thereof
|
US7081446B2
(en)
*
|
2002-01-31 |
2006-07-25 |
The Trustees Of Columbia University In The City Of New York |
Long-acting follicle stimulating hormone analogues and uses thereof
|
US20040009902A1
(en)
*
|
2002-05-13 |
2004-01-15 |
Irving Boime |
CTP extended erythropoietin
|
US20060177894A1
(en)
*
|
2002-11-08 |
2006-08-10 |
Moyle William R |
Protein knobs
|
DE602004030546D1
(de)
|
2003-03-04 |
2011-01-27 |
Aspenbio Pharma Inc |
LH zur Verwendung der Erhaltung einer oder mehreren Schwangerschaften durch Induktion der Bildung des sekundären Gelbkörpers.
|
EP1673105B1
(fr)
*
|
2003-07-25 |
2007-05-02 |
Laboratoires Serono S.A. |
Utilisation de l'hormone de stimulation folliculaire pour reduire les aberrations chromosomiques des spermatozoides masculines
|
UA88879C2
(en)
*
|
2003-09-02 |
2009-12-10 |
Эплайд Рисерч Системз Эрс Холдинг Н.В. |
Fsh glycosylation mutant
|
WO2005044851A1
(fr)
*
|
2003-11-06 |
2005-05-19 |
Compugen Ltd. |
Variants de la chaine alpha de l'hormone glycoproteine humaine, compositions et utilisations associees
|
JP4412989B2
(ja)
*
|
2003-12-15 |
2010-02-10 |
株式会社日立製作所 |
複数の記憶システムを有するデータ処理システム
|
US20050220640A1
(en)
*
|
2004-04-02 |
2005-10-06 |
Finkenbinder David B |
Fan motor assembly with noise suppression
|
EP1781320A2
(fr)
*
|
2004-07-27 |
2007-05-09 |
Genzyme Corporation |
Utilisation de thyrotropine pour la regeneration des os
|
CN103172747A
(zh)
|
2005-01-25 |
2013-06-26 |
细胞治疗学公司 |
体内半衰期改变的生物活性蛋白质偶联物
|
US20080039372A1
(en)
*
|
2005-07-21 |
2008-02-14 |
The Trustees Of Columbia University In The City Of New York |
Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation
|
CN101282990B
(zh)
*
|
2005-08-26 |
2013-04-03 |
阿雷斯贸易股份有限公司 |
糖基化干扰素-β的制备方法
|
JP5199112B2
(ja)
*
|
2005-12-09 |
2013-05-15 |
アレス トレーディング ソシエテ アノニム |
Fsh又はfsh変異体を精製するための方法
|
US20150038413A1
(en)
|
2006-02-03 |
2015-02-05 |
Opko Biologics Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
US9458444B2
(en)
|
2006-02-03 |
2016-10-04 |
Opko Biologics Ltd. |
Long-acting coagulation factors and methods of producing same
|
US8304386B2
(en)
*
|
2006-02-03 |
2012-11-06 |
Prolor Biotech, Inc. |
Long-acting growth hormone and methods of producing same
|
US7553941B2
(en)
|
2006-02-03 |
2009-06-30 |
Modigene Inc |
Long-acting polypeptides and methods of producing same
|
US8048849B2
(en)
|
2006-02-03 |
2011-11-01 |
Modigene, Inc. |
Long-acting polypeptides and methods of producing same
|
US9249407B2
(en)
|
2006-02-03 |
2016-02-02 |
Opko Biologics Ltd. |
Long-acting coagulation factors and methods of producing same
|
US10221228B2
(en)
|
2006-02-03 |
2019-03-05 |
Opko Biologics Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
US8946155B2
(en)
|
2006-02-03 |
2015-02-03 |
Opko Biologics Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
US10351615B2
(en)
|
2006-02-03 |
2019-07-16 |
Opko Biologics Ltd. |
Methods of treatment with long-acting growth hormone
|
US8450269B2
(en)
|
2006-02-03 |
2013-05-28 |
Prolor Biotech Ltd. |
Long-acting growth hormone and methods of producing same
|
US8759292B2
(en)
|
2006-02-03 |
2014-06-24 |
Prolor Biotech, Llc |
Long-acting coagulation factors and methods of producing same
|
US20140113860A1
(en)
|
2006-02-03 |
2014-04-24 |
Prolor Biotech Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
US8476234B2
(en)
|
2006-02-03 |
2013-07-02 |
Prolor Biotech Inc. |
Long-acting coagulation factors and methods of producing same
|
US8048848B2
(en)
|
2006-02-03 |
2011-11-01 |
Prolor Biotech Ltd. |
Long-acting interferons and derivatives thereof and methods thereof
|
US20070281883A1
(en)
*
|
2006-06-05 |
2007-12-06 |
Hanna Rosenfeld |
Development of follicle stimulating hormone agonists and antagonists in fish
|
WO2009053360A1
(fr)
*
|
2007-10-22 |
2009-04-30 |
Merck Serono S.A. |
Procédé de purification d'une protéine contenant fc
|
AU2008314687A1
(en)
*
|
2007-10-22 |
2009-04-30 |
Merck Serono S.A. |
Method for purifying Fc-fusion proteins
|
US9663778B2
(en)
|
2009-07-09 |
2017-05-30 |
OPKO Biologies Ltd. |
Long-acting coagulation factors and methods of producing same
|
US20120263701A1
(en)
|
2009-08-24 |
2012-10-18 |
Volker Schellenberger |
Coagulation factor vii compositions and methods of making and using same
|
AR081755A1
(es)
|
2010-04-02 |
2012-10-17 |
Hanmi Holdings Co Ltd |
Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo
|
EP2717898B1
(fr)
|
2011-06-10 |
2018-12-19 |
Bioverativ Therapeutics Inc. |
Composés pro-coagulants et leurs procédés d'utilisation
|
CA2841066C
(fr)
|
2011-07-08 |
2023-09-26 |
Biogen Idec Hemophilia Inc. |
Polypeptides chimeriques et hybrides du facteur viii et leurs procedes d'utilisation
|
KR20140053991A
(ko)
|
2011-07-18 |
2014-05-08 |
아츠 바이올로직스 에이/에스 |
장기간 작용하는 황체 형성 호르몬 (lh) 화합물
|
AU2013219935B2
(en)
|
2012-02-14 |
2016-02-04 |
Opko Biologics Ltd. |
Long-acting coagulation factors and methods of producing same
|
AU2013204636B2
(en)
|
2012-02-15 |
2016-04-14 |
Bioverativ Therapeutics Inc. |
Recombinant Factor VIII proteins
|
PL3564260T3
(pl)
|
2012-02-15 |
2023-03-06 |
Bioverativ Therapeutics Inc. |
Kompozycje czynnika viii oraz sposoby ich wytwarzania i stosowania
|
WO2013157002A1
(fr)
|
2012-04-19 |
2013-10-24 |
Prolor Biotech Inc. |
Variants d'oxyntomoduline à action prolongée et procédés pour les produire
|
CA2875246A1
(fr)
|
2012-06-08 |
2013-12-12 |
Biogen Idec Ma Inc. |
Composes pro-coagulants
|
JP2015525222A
(ja)
|
2012-06-08 |
2015-09-03 |
バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. |
キメラ性凝固因子
|
EP2870250B2
(fr)
|
2012-07-06 |
2022-06-29 |
Bioverativ Therapeutics Inc. |
Lignée cellulaire exprimant des polypeptides de facteur viii à une seule chaîne et ses utilisations
|
US10391152B2
(en)
|
2012-10-18 |
2019-08-27 |
Bioverativ Therapeutics Inc. |
Methods of using a fixed dose of a clotting factor
|
EP3943102A1
(fr)
|
2012-10-30 |
2022-01-26 |
Bioverativ Therapeutics Inc. |
Procédé d'utilisation de polypeptide du facteur viii
|
CN112661863A
(zh)
|
2012-11-20 |
2021-04-16 |
奥普科生物制品有限公司 |
通过连接至促性腺激素羧基端肽来增加多肽的流体动力学体积的方法
|
CN103509121B
(zh)
|
2012-11-22 |
2015-01-28 |
苏州康宁杰瑞生物科技有限公司 |
一种fsh融合蛋白及其制备方法和用途
|
WO2014088836A1
(fr)
|
2012-12-03 |
2014-06-12 |
Merck Sharp & Dohme Corp. |
Insuline et analogues d'insuline à base de peptide à partie terminale carboxy (ptc) o-glycosylée
|
PT3889173T
(pt)
|
2013-02-15 |
2023-10-10 |
Bioverativ Therapeutics Inc |
Gene do fator viii otimizado
|
WO2014159813A1
(fr)
|
2013-03-13 |
2014-10-02 |
Moderna Therapeutics, Inc. |
Molécules polynucléotidiques à longue durée de vie
|
TWI828269B
(zh)
|
2013-03-15 |
2024-01-01 |
美商百歐維拉提夫治療公司 |
因子ix多肽調配物
|
EP4122487A1
(fr)
|
2013-03-15 |
2023-01-25 |
Bioverativ Therapeutics Inc. |
Formulations de polypeptide de facteur viii
|
TW202003554A
(zh)
|
2013-08-14 |
2020-01-16 |
美商百歐維拉提夫治療公司 |
因子viii-xten融合物及其用途
|
WO2015023894A1
(fr)
|
2013-08-14 |
2015-02-19 |
Biogen Idec Ma Inc. |
Protéines de facteur viii de recombinaison
|
EP3763733A1
(fr)
|
2013-10-21 |
2021-01-13 |
OPKO Biologics Ltd. |
Polypeptides à action prolongée et procédés de production et d'administration associés
|
US20150158926A1
(en)
|
2013-10-21 |
2015-06-11 |
Opko Biologics, Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
CN103539860B
(zh)
*
|
2013-11-01 |
2014-12-03 |
广州优联康医药科技有限公司 |
一种长效重组人促卵泡激素融合蛋白
|
US10584147B2
(en)
|
2013-11-08 |
2020-03-10 |
Biovertiv Therapeutics Inc. |
Procoagulant fusion compound
|
ES2967617T3
(es)
|
2013-12-06 |
2024-05-03 |
Bioverativ Therapeutics Inc |
Herramientas de farmacocinética poblacional y sus usos
|
AU2015236340B2
(en)
|
2014-03-24 |
2020-02-06 |
Bioverativ Therapeutics Inc. |
Lyophilized factor IX formulations
|
EP3160478A4
(fr)
|
2014-06-30 |
2018-05-16 |
Bioverativ Therapeutics Inc. |
Gène du facteur ix optimisé
|
KR102122463B1
(ko)
|
2014-10-14 |
2020-06-15 |
할로자임, 아이엔씨 |
아데노신 디아미네이즈-2(ada2)의 조성물, 이의 변이체 및 이를 사용하는 방법
|
MA40835A
(fr)
|
2014-10-23 |
2017-08-29 |
Biogen Ma Inc |
Anticorps anti-gpiib/iiia et leurs utilisations
|
MA40861A
(fr)
|
2014-10-31 |
2017-09-05 |
Biogen Ma Inc |
Anticorps anti-glycoprotéines iib/iiia
|
WO2016092550A2
(fr)
|
2014-12-10 |
2016-06-16 |
Opko Biologics Ltd. |
Méthodes de production de polypeptides modifiés par des ctp à action prolongée
|
EP3988113A1
(fr)
|
2015-06-19 |
2022-04-27 |
OPKO Biologics Ltd. |
Facteurs de coagulation à action prolongée et ses procédés de production
|
CN108472337B
(zh)
|
2015-08-03 |
2022-11-25 |
比奥贝拉蒂治疗公司 |
因子ix融合蛋白以及其制备和使用方法
|
RS63548B1
(sr)
|
2016-02-01 |
2022-09-30 |
Bioverativ Therapeutics Inc |
Optimizovani geni faktora viii
|
BR112019000610A2
(pt)
|
2016-07-11 |
2019-07-02 |
Opko Biologics Ltd |
fator vii de coagulação de longa ação e métodos de produção do mesmo
|
CN110520150A
(zh)
|
2016-12-02 |
2019-11-29 |
比奥维拉迪维治疗股份有限公司 |
使用嵌合凝血因子治疗血友病性关节病的方法
|
AU2017368328A1
(en)
|
2016-12-02 |
2019-07-18 |
Bioverativ Therapeutics Inc. |
Methods of inducing immune tolerance to clotting factors
|
MA47163A
(fr)
|
2016-12-16 |
2019-11-06 |
Biogen Ma Inc |
Facteur 11 de différenciation de croissance activé protéolytiquement stabilisé
|
JP2020505424A
(ja)
|
2017-01-31 |
2020-02-20 |
バイオベラティブ セラピューティクス インコーポレイテッド |
因子ix融合タンパク質ならびにその製造および使用方法
|
SG11202000764RA
(en)
|
2017-08-09 |
2020-02-27 |
Bioverativ Therapeutics Inc |
Nucleic acid molecules and uses thereof
|
MX2020008152A
(es)
|
2018-02-01 |
2020-11-24 |
Bioverativ Therapeutics Inc |
Uso de vectores lentivirales que expresan el factor viii.
|
WO2019211842A1
(fr)
|
2018-04-30 |
2019-11-07 |
Opko Biologics Ltd. |
Antagonistes de l'hormone de croissance humaine à action prolongée et leurs procédés de production
|
SG11202010767SA
(en)
|
2018-05-18 |
2020-11-27 |
Bioverativ Therapeutics Inc |
Methods of treating hemophilia a
|
CN108676096B
(zh)
*
|
2018-05-22 |
2022-03-29 |
北京伟杰信生物科技有限公司 |
重组猪fsh-ctp融合蛋白及其制备方法与应用
|
CN113227385A
(zh)
|
2018-08-09 |
2021-08-06 |
比奥维拉迪维治疗股份有限公司 |
核酸分子及其用于非病毒基因疗法的用途
|
TW202039855A
(zh)
|
2018-12-06 |
2020-11-01 |
美商百歐維拉提夫治療公司 |
表現因子ix之慢病毒載體的用途
|
US11254530B2
(en)
*
|
2019-03-26 |
2022-02-22 |
Toshiba Tec Kabushiki Kaisha |
Sheet aligning mechanism
|
BR112021022860A2
(pt)
|
2019-05-16 |
2022-01-18 |
Ceva Sante Animale |
Composições e métodos para aumentar o desempenho da reprodução em mamíferos não humanos com uso de hormônio luteinizante recombinante
|
WO2021005604A1
(fr)
|
2019-07-11 |
2021-01-14 |
Opko Biologics Ltd. |
Igf-1 ou variants d'igf-1 à action prolongée et procédés de production associés
|
WO2021067389A1
(fr)
|
2019-09-30 |
2021-04-08 |
Bioverativ Therapeutics Inc. |
Formulations de vecteur lentiviral
|
EP4192495A1
(fr)
|
2020-08-07 |
2023-06-14 |
Bristol-Myers Squibb Company |
Fgf21 combiné à des antagonistes de ccr2/5 pour le traitement de la fibrose
|
US20240123031A1
(en)
|
2020-11-25 |
2024-04-18 |
Bristol-Myers Squibb Company |
Methods of treating liver diseases
|