DK0428376T3 - Fremgangsmåde til fremstilling af taxol under anvendelse af en oxazinon - Google Patents

Fremgangsmåde til fremstilling af taxol under anvendelse af en oxazinon

Info

Publication number
DK0428376T3
DK0428376T3 DK90312366.9T DK90312366T DK0428376T3 DK 0428376 T3 DK0428376 T3 DK 0428376T3 DK 90312366 T DK90312366 T DK 90312366T DK 0428376 T3 DK0428376 T3 DK 0428376T3
Authority
DK
Denmark
Prior art keywords
heteroaryl
alkynyl
aryl
alkenyl
alkyl
Prior art date
Application number
DK90312366.9T
Other languages
Danish (da)
English (en)
Inventor
Robert A Holton
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/436,235 external-priority patent/US5015744A/en
Application filed by Univ Florida State filed Critical Univ Florida State
Application granted granted Critical
Publication of DK0428376T3 publication Critical patent/DK0428376T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/84—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing rings with more than eight members
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DK90312366.9T 1989-11-14 1990-11-13 Fremgangsmåde til fremstilling af taxol under anvendelse af en oxazinon DK0428376T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/436,235 US5015744A (en) 1989-11-14 1989-11-14 Method for preparation of taxol using an oxazinone
US07/603,041 US5136060A (en) 1989-11-14 1990-10-30 Method for preparation of taxol using an oxazinone

Publications (1)

Publication Number Publication Date
DK0428376T3 true DK0428376T3 (da) 1996-02-05

Family

ID=27030868

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90312366.9T DK0428376T3 (da) 1989-11-14 1990-11-13 Fremgangsmåde til fremstilling af taxol under anvendelse af en oxazinon

Country Status (28)

Country Link
US (3) US5136060A (el)
EP (1) EP0428376B1 (el)
JP (1) JP2507830B2 (el)
KR (1) KR0161499B1 (el)
CN (1) CN1043528C (el)
AT (1) ATE132860T1 (el)
AU (1) AU633375B2 (el)
BG (1) BG60478B1 (el)
CA (2) CA2029787C (el)
CZ (2) CZ283581B6 (el)
DE (1) DE69024757T2 (el)
DK (1) DK0428376T3 (el)
EG (1) EG19641A (el)
ES (1) ES2083438T3 (el)
FI (1) FI104487B (el)
GR (1) GR3019192T3 (el)
HU (1) HU209299B (el)
IE (2) IE76279B1 (el)
IL (3) IL96304A (el)
MY (1) MY106071A (el)
NO (1) NO177902C (el)
NZ (1) NZ235993A (el)
OA (1) OA09327A (el)
PL (1) PL167898B1 (el)
PT (1) PT95870B (el)
RO (1) RO110491B1 (el)
RU (1) RU2033994C1 (el)
YU (1) YU48232B (el)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5475120A (en) * 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
CA2071160A1 (en) * 1991-07-31 1993-02-01 Vittorio Farina Asymmetric synthesis of taxol side chain
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5274124A (en) * 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
ATE258171T1 (de) * 1991-09-23 2004-02-15 Univ Florida State Metallalkoxide
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6005138A (en) 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
SG46582A1 (en) * 1991-09-23 1998-02-20 Univ Florida State 10-Desacetoxytaxol derivatives
US6521660B2 (en) 1991-09-23 2003-02-18 Florida State University 3′-alkyl substituted taxanes and pharmaceutical compositions containing them
US7074945B2 (en) * 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
US6335362B1 (en) * 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
DK1001036T3 (da) * 1992-01-15 2004-11-29 Squibb & Sons Inc Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fremstillingen af taxaner
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5254703A (en) * 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
FR2696463B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2696458B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696462B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2697752B1 (fr) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
EP1500393A1 (en) 1992-11-27 2005-01-26 Mayne Pharma (USA) Inc. Injectable composition containing taxol
NZ258044A (en) * 1992-11-27 1995-12-21 Faulding F H & Co Ltd Pharmaceutical composition comprising taxol, solubilising agent, an acid and an organic solvent
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
MX9307777A (es) 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
US6339164B1 (en) 1993-01-29 2002-01-15 Florida State University C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them
US6187916B1 (en) * 1993-02-01 2001-02-13 Research Foundation Of State University Of New York Process for the preparation of taxane derivatives and β-lactam intermediates therefor
US6593482B2 (en) 1993-02-01 2003-07-15 Aventis Pharma S.A. Methods for preparing new taxoids and pharmaceutical compositions containing them
CA2155304C (en) * 1993-02-05 2010-07-20 Charles Swindell Syntheses of paclitaxel, analogs and intermediates with variable a-ring side chains
US5684175A (en) * 1993-02-05 1997-11-04 Napro Biotherapeutics, Inc. C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor
EP0687260B1 (en) * 1993-03-05 2003-02-19 Florida State University Process for the preparation of 9-desoxotaxanes
US6710191B2 (en) 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
IL109052A (en) * 1993-03-22 2009-07-20 Univ Florida State Taxanes having a furyl or thienyl substituted side-chain and pharmaceutical compositions containing them
DK0703909T3 (da) * 1993-06-11 2000-09-11 Upjohn Co Delta6,7-taxoler, antineoplastisk anvendelse og farmaceutiske præparater indeholdende dem
TW397866B (en) * 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
US5442065A (en) * 1993-09-09 1995-08-15 Board Of Regents, The University Of Texas System Synthesis of tetrahydroquinoline enediyne core analogs of dynemicin
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
AU8052194A (en) * 1993-10-20 1995-05-08 Enzon, Inc. 2'- and/or 7- substituted taxoids
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US6441026B1 (en) 1993-11-08 2002-08-27 Aventis Pharma S.A. Antitumor compositions containing taxane derivatives
IL112412A (en) * 1994-01-28 2000-02-29 Upjohn Co Delta 12,13-iso-taxol analogs and antineoplastic pharmaceutical compositions containing them
US5508447A (en) * 1994-05-24 1996-04-16 Board Of Regents, The University Of Texas System Short synthetic route to taxol and taxol derivatives
CA2170661A1 (en) 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
US5560872A (en) * 1995-05-18 1996-10-01 Lever Brothers Company Compositions comprising oxazolidine and tetrahydrooxazine amide surfactants
US5675025A (en) * 1995-06-07 1997-10-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
US5840748A (en) * 1995-10-02 1998-11-24 Xechem International, Inc. Dihalocephalomannine and methods of use therefor
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
US5854278A (en) * 1995-12-13 1998-12-29 Xechem International, Inc. Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
US6107497A (en) * 1996-02-29 2000-08-22 Napro Biotherapeutics, Inc. Intermediate for use in docetaxel synthesis and production method therefor
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
FR2745814B1 (fr) * 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
AU724499B2 (en) * 1996-05-06 2000-09-21 Florida State University 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
US5750737A (en) * 1996-09-25 1998-05-12 Sisti; Nicholas J. Method for paclitaxel synthesis
DE19726146A1 (de) * 1997-06-19 1998-12-24 Basf Ag Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
DE69812395T2 (de) 1997-08-21 2004-02-05 Florida State University, Tallahassee Verfahren zur synthese von taxanen
US6150537A (en) * 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
US6025516A (en) * 1998-10-14 2000-02-15 Chiragene, Inc. Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
MXPA03002494A (es) 2000-09-22 2004-05-24 Bristol Myers Squibb Co Metodo para reducir toxicidad de quimio terapias combinadas.
JP2004536026A (ja) 2000-11-28 2004-12-02 トランスフォーム ファーマシューティカルズ，インコーポレーティッド． パクリタキセル、その誘導体、および薬剤として許容される塩を含む医薬品製剤
US6479679B1 (en) 2001-04-25 2002-11-12 Napro Biotherapeutics, Inc. Two-step conversion of protected taxane ester to paclitaxel
US6452025B1 (en) 2001-04-25 2002-09-17 Napro Biotherapeutics, Inc. Three-step conversion of protected taxane ester to paclitaxel
CN1596250A (zh) * 2001-11-30 2005-03-16 布里斯托尔-迈尔斯斯奎布公司 紫杉醇溶剂化物
WO2004033442A2 (en) * 2002-10-09 2004-04-22 Chatham Biotec Ltd. Novel taxanes and methods related to use and preparation thereof
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
WO2006116532A2 (en) * 2005-04-28 2006-11-02 University Of Massachusetts Lowell Synthesis of oligo/poly(catechins) and methods of use
US7847111B2 (en) 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
WO2007143839A1 (en) * 2006-06-12 2007-12-21 6570763 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel and 10-deacetylbaccatin iii from 9-dihydro-13-acetylbaccatin iii
US20090292131A1 (en) * 2008-05-07 2009-11-26 Ladislav Cvak Processes for preparation of taxanes and intermediates thereof
KR101014438B1 (ko) * 2008-09-26 2011-02-14 동아제약주식회사 탁산 유도체의 제조방법
EP2588490B1 (en) 2010-07-02 2017-02-22 Angiochem Inc. Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4521599A (en) * 1983-07-11 1985-06-04 The Upjohn Company Process for the preparation of 1,3-oxazine-4-ones
US4631340A (en) * 1984-09-06 1986-12-23 Pennwalt Corporation 1,4-oxazinone derivatives
US4549014A (en) * 1984-09-06 1985-10-22 Pennwalt Corporation Adamantyl containing 1,4-oxazinone derivatives
US4552585A (en) * 1984-10-04 1985-11-12 Fmc Corporation Herbicidal 2-(aminophenyl)methyl derivatives of 3-isoxazolidinones or 3-oxazinones
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
GB8803114D0 (en) * 1988-02-11 1988-03-09 Bp Chem Int Ltd Bleach activators in detergent compositions
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone

Also Published As

Publication number Publication date
HUT57200A (en) 1991-11-28
IL109246A0 (en) 1994-07-31
BG93228A (bg) 1993-12-24
PT95870A (pt) 1991-09-30
BG60478B1 (bg) 1995-05-31
CN1053427A (zh) 1991-07-31
YU216090A (sh) 1993-10-20
NO904923L (no) 1991-05-15
OA09327A (en) 1992-09-15
NO904923D0 (no) 1990-11-13
YU48232B (sh) 1997-08-22
CZ563490A3 (cs) 1998-01-14
ATE132860T1 (de) 1996-01-15
DE69024757D1 (de) 1996-02-22
CA2029787A1 (en) 1991-05-15
ES2083438T3 (es) 1996-04-16
PL287757A1 (en) 1991-12-16
CZ283581B6 (cs) 1998-05-13
HU209299B (en) 1994-04-28
US5136060A (en) 1992-08-04
FI905609A0 (fi) 1990-11-13
MY106071A (en) 1995-03-31
IL109246A (en) 1998-01-04
EG19641A (en) 1995-08-30
IL96304A (en) 1995-06-29
EP0428376A1 (en) 1991-05-22
JP2507830B2 (ja) 1996-06-19
JPH03232869A (ja) 1991-10-16
NZ235993A (en) 1992-10-28
GR3019192T3 (en) 1996-06-30
EP0428376B1 (en) 1996-01-10
IE76279B1 (en) 1997-10-08
AU633375B2 (en) 1993-01-28
HU907131D0 (en) 1991-05-28
FI104487B (fi) 2000-02-15
KR910009681A (ko) 1991-06-28
IL96304A0 (en) 1991-08-16
RO110491B1 (ro) 1996-01-30
CA2029787C (en) 2001-10-09
NO177902C (no) 1995-12-13
RU2033994C1 (ru) 1995-04-30
CA2347588C (en) 2005-08-16
CZ313695A3 (en) 1997-11-12
US5532363A (en) 1996-07-02
CA2347588A1 (en) 1991-05-15
DE69024757T2 (de) 1996-05-15
KR0161499B1 (ko) 1998-12-01
AU6590490A (en) 1991-05-23
US5384399A (en) 1995-01-24
NO177902B (no) 1995-09-04
IE74154B1 (en) 1997-07-02
IE904061A1 (en) 1991-05-22
PT95870B (pt) 1997-04-30
PL167898B1 (pl) 1995-12-30
CN1043528C (zh) 1999-06-02
CZ283539B6 (cs) 1998-04-15

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