DK0426468T3 - Stabil polymorfisk form for (E)-N,N-diethyl-2-(3,4-dihydroxy-5-nitrophenyl)acrylamid og fremgangsmåde til fremstilling deraf - Google Patents
Stabil polymorfisk form for (E)-N,N-diethyl-2-(3,4-dihydroxy-5-nitrophenyl)acrylamid og fremgangsmåde til fremstilling derafInfo
- Publication number
- DK0426468T3 DK0426468T3 DK90311963.4T DK90311963T DK0426468T3 DK 0426468 T3 DK0426468 T3 DK 0426468T3 DK 90311963 T DK90311963 T DK 90311963T DK 0426468 T3 DK0426468 T3 DK 0426468T3
- Authority
- DK
- Denmark
- Prior art keywords
- dihydroxy
- acrylamide
- diethyl
- polymorphic form
- nitrophenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8924838A GB2238047B (en) | 1989-11-03 | 1989-11-03 | Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0426468T3 true DK0426468T3 (da) | 1995-10-23 |
Family
ID=10665678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90311963.4T DK0426468T3 (da) | 1989-11-03 | 1990-11-01 | Stabil polymorfisk form for (E)-N,N-diethyl-2-(3,4-dihydroxy-5-nitrophenyl)acrylamid og fremgangsmåde til fremstilling deraf |
Country Status (13)
Country | Link |
---|---|
US (1) | US5135950A (da) |
EP (1) | EP0426468B1 (da) |
JP (1) | JP2823680B2 (da) |
AT (1) | ATE127447T1 (da) |
BR (1) | BR1100289A (da) |
DE (2) | DE69022166T2 (da) |
DK (1) | DK0426468T3 (da) |
ES (1) | ES2075885T3 (da) |
FI (1) | FI107149B (da) |
GB (1) | GB2238047B (da) |
GR (1) | GR3017526T3 (da) |
LU (1) | LU91071I2 (da) |
NL (1) | NL300147I1 (da) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5283352A (en) * | 1986-11-28 | 1994-02-01 | Orion-Yhtyma Oy | Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same |
GB9113431D0 (en) * | 1991-06-20 | 1991-08-07 | Orion Yhytma Oy | Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde |
CA2080554A1 (en) * | 1991-10-15 | 1993-04-16 | Mitsubishi Chemical Corporation | Styrene derivatives |
JPH05301838A (ja) * | 1991-10-15 | 1993-11-16 | Mitsubishi Kasei Corp | スチレン誘導体 |
US7094427B2 (en) * | 2002-05-29 | 2006-08-22 | Impax Laboratories, Inc. | Combination immediate release controlled release levodopa/carbidopa dosage forms |
US20060013875A1 (en) * | 2002-05-29 | 2006-01-19 | Impax Laboratories, Inc. | Combination immediate release controlled release levodopa/carbidopa dosage forms |
RU2354655C2 (ru) * | 2003-12-19 | 2009-05-10 | Ф.Хоффманн-Ля Рош Аг | Ингибиторы сомт |
WO2005070881A1 (en) * | 2003-12-24 | 2005-08-04 | Wockhardt Limited | An efficient process for the manufacture of (e)-entacapone polymorphic form a |
CA2551791A1 (en) * | 2003-12-29 | 2005-07-21 | Wockhardt Limited | Stable polymorphs of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide |
AU2003287844A1 (en) * | 2003-12-31 | 2005-07-21 | Cilag Ag | Novel crystalline forms of entacapone, and production thereof |
WO2005063696A2 (de) * | 2003-12-31 | 2005-07-14 | Cilag Ag | Neue kristalline formen von entacapone und deren herstellung |
EP1577289A1 (en) | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
US20060003966A1 (en) * | 2004-06-16 | 2006-01-05 | Jack Arbiser | Carbazole formulations for the treatment of psoriasis and angiogenesis |
JP2008519811A (ja) | 2004-11-10 | 2008-06-12 | オリオン コーポレーション | 下肢静止不能症候群の治療 |
EA013161B1 (ru) | 2005-06-08 | 2010-02-26 | Орион Корпорейшн | Дозированная форма для перорального применения |
US20070003621A1 (en) * | 2005-06-23 | 2007-01-04 | Spherics, Inc. | Dosage forms for movement disorder treatment |
EP1764096A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
EP1764095A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
EP1764093A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
ATE445591T1 (de) * | 2005-11-09 | 2009-10-15 | Usv Ltd | Verfahren zur herstellung von hochreinem (e)-n,n- diethyl-2-cyano-3-(3,4-dihydro-5- nitrophenyl)acrylamid (entacapon) |
US20080300420A1 (en) * | 2006-01-02 | 2008-12-04 | Sanmar Speciality Chemicals Ltd. | Process for the Preparation of Entacapone Form-A |
JP5232015B2 (ja) * | 2006-02-06 | 2013-07-10 | オリオン コーポレーション | エンタカポンの製造方法 |
WO2007094007A1 (en) * | 2006-02-13 | 2007-08-23 | Suven Life Sciences Ltd., | An improved process for the preparation of entacapone |
WO2007113845A1 (en) * | 2006-04-03 | 2007-10-11 | Alembic Limited | A process for the preparation of (e)-2-cyano-3-(3, 4-dihydroxy-5-nitrophenyl)-n, n-diethyl-2-propenamide (entacapone) |
GB0610207D0 (en) * | 2006-05-23 | 2006-07-05 | Pliva Istrazivanje I Razvoj D | New forms of active pharmaceutical ingredient |
US20080131492A1 (en) * | 2006-06-23 | 2008-06-05 | Spherics, Inc. | Dosage forms for movement disorder treatment |
US20080004343A1 (en) * | 2006-06-29 | 2008-01-03 | Wockhardt Limited | Stable polymorphs of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide |
GB0613826D0 (en) * | 2006-07-12 | 2006-08-23 | Pliva Istrazivanje I Razvoj D | Process and product |
ES2306587B1 (es) * | 2006-11-15 | 2009-08-07 | Quimica Sintetica, S.A. | Nueva forma cristalina de entacapona y procedimiento para su obtencion. |
ITMI20062450A1 (it) | 2006-12-19 | 2008-06-20 | Dipharma Spa | Procedimento per la preparazione di entacapone |
CA2673511A1 (en) * | 2006-12-22 | 2008-07-03 | Combinatorx, Incorporated | Pharmaceutical compositions for treatment of parkinson's disease and related disorders |
ES2319024B1 (es) * | 2007-02-13 | 2009-12-11 | Quimica Sintetica, S.A. | Procedimiento para la obtencion de entacapona sustancialmente libre de isomero z, sus intermedios de sintesis y nueva forma cristalina. |
WO2009084031A2 (en) * | 2007-12-03 | 2009-07-09 | Neuland Laboratories Ltd | An improved process for preparation of (2e)-2-cyano-3-(3,4- dihydroxy-5-nitrophenyl)n,n-diethyl-2-propenamide polymorphic form a |
EP2251323B1 (en) | 2009-05-14 | 2014-04-23 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Method for the purification of entacapone |
EA026419B1 (ru) | 2010-03-04 | 2017-04-28 | Орион Корпорейшн | Применение леводопы, карбидопы и энтакапона для лечения болезни паркинсона |
CN103845317B (zh) | 2012-11-28 | 2018-05-08 | 北京生命科学研究所 | 恩他卡朋在预防或治疗肥胖等代谢综合征中的应用 |
US10098845B2 (en) | 2013-10-07 | 2018-10-16 | Impax Laboratories, Llc | Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof |
US10987313B2 (en) | 2013-10-07 | 2021-04-27 | Impax Laboratories, Llc | Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof |
CN104402764A (zh) * | 2014-11-26 | 2015-03-11 | 千辉药业(安徽)有限责任公司 | 一种恩他卡朋的制备方法 |
US11986449B2 (en) | 2020-12-22 | 2024-05-21 | Amneal Pharmaceuticals Llc | Levodopa dosing regimen |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU213587A (en) * | 1986-11-28 | 1989-06-30 | Orion Yhtymae Oy | Process for obtaining new pharmacologic active cateholic derivatives |
EP0304493B1 (en) * | 1987-03-11 | 1992-09-02 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Hydroxystyrene derivatives |
KR900016098A (ko) * | 1988-04-28 | 1990-11-12 | 사하루 게이 죠오 | 카페인산의 유도체 및 이를 함유하는 약제학적 조성물 |
JP2535058B2 (ja) * | 1988-07-29 | 1996-09-18 | 富士通株式会社 | 半導体装置の製造方法 |
-
1989
- 1989-11-03 GB GB8924838A patent/GB2238047B/en not_active Revoked
-
1990
- 1990-10-23 FI FI905198A patent/FI107149B/fi not_active IP Right Cessation
- 1990-10-31 US US07/606,717 patent/US5135950A/en not_active Expired - Lifetime
- 1990-11-01 ES ES90311963T patent/ES2075885T3/es not_active Expired - Lifetime
- 1990-11-01 DE DE69022166T patent/DE69022166T2/de not_active Expired - Lifetime
- 1990-11-01 AT AT90311963T patent/ATE127447T1/de active
- 1990-11-01 EP EP90311963A patent/EP0426468B1/en not_active Expired - Lifetime
- 1990-11-01 DE DE200412000014 patent/DE122004000014I1/de active Pending
- 1990-11-01 DK DK90311963.4T patent/DK0426468T3/da active
- 1990-11-02 JP JP2298708A patent/JP2823680B2/ja not_active Expired - Lifetime
-
1995
- 1995-09-26 GR GR950402644T patent/GR3017526T3/el unknown
-
1997
- 1997-04-15 BR BR1100289-1A patent/BR1100289A/pt active IP Right Grant
-
2004
- 2004-04-09 LU LU91071C patent/LU91071I2/fr unknown
- 2004-04-16 NL NL300147C patent/NL300147I1/nl unknown
Also Published As
Publication number | Publication date |
---|---|
EP0426468A2 (en) | 1991-05-08 |
BR1100289A (pt) | 1999-10-05 |
ATE127447T1 (de) | 1995-09-15 |
GB2238047B (en) | 1993-02-10 |
JPH03169844A (ja) | 1991-07-23 |
EP0426468B1 (en) | 1995-09-06 |
FI107149B (fi) | 2001-06-15 |
GB2238047A (en) | 1991-05-22 |
GR3017526T3 (en) | 1995-12-31 |
DE122004000014I1 (de) | 2004-08-12 |
US5135950A (en) | 1992-08-04 |
ES2075885T3 (es) | 1995-10-16 |
EP0426468A3 (en) | 1992-05-06 |
GB8924838D0 (en) | 1989-12-20 |
NL300147I1 (nl) | 2004-07-01 |
DE69022166T2 (de) | 1996-02-15 |
FI905198A0 (fi) | 1990-10-23 |
DE69022166D1 (de) | 1995-10-12 |
JP2823680B2 (ja) | 1998-11-11 |
LU91071I2 (fr) | 2005-06-21 |
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