DK0778262T3 - Fremgangsmåde til oprensning af (RR,SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol og dets salte - Google Patents

Fremgangsmåde til oprensning af (RR,SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol og dets salte

Info

Publication number
DK0778262T3
DK0778262T3 DK96308347T DK96308347T DK0778262T3 DK 0778262 T3 DK0778262 T3 DK 0778262T3 DK 96308347 T DK96308347 T DK 96308347T DK 96308347 T DK96308347 T DK 96308347T DK 0778262 T3 DK0778262 T3 DK 0778262T3
Authority
DK
Denmark
Prior art keywords
methoxyphenyl
isomer
dimethylaminomethyl
cyclohexanol
purification
Prior art date
Application number
DK96308347T
Other languages
English (en)
Inventor
Ori Lerman
Michael Tennenbaum
Erez Gal
Joseph Kaspi
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Application granted granted Critical
Publication of DK0778262T3 publication Critical patent/DK0778262T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK96308347T 1995-12-07 1996-11-19 Fremgangsmåde til oprensning af (RR,SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol og dets salte DK0778262T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11628195A IL116281A (en) 1995-12-07 1995-12-07 Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts

Publications (1)

Publication Number Publication Date
DK0778262T3 true DK0778262T3 (da) 2001-03-05

Family

ID=11068279

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96308347T DK0778262T3 (da) 1995-12-07 1996-11-19 Fremgangsmåde til oprensning af (RR,SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol og dets salte

Country Status (12)

Country Link
US (1) US5672755A (da)
EP (1) EP0778262B1 (da)
AT (1) ATE198879T1 (da)
AU (1) AU713304B2 (da)
CA (1) CA2192155C (da)
DE (1) DE69611663T2 (da)
DK (1) DK0778262T3 (da)
ES (1) ES2154792T3 (da)
GR (1) GR3035602T3 (da)
IL (1) IL116281A (da)
PT (1) PT778262E (da)
SK (1) SK282179B6 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119121A (en) * 1996-08-22 2000-11-21 Chemagis Ltd Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride
WO1999003820A1 (en) * 1997-07-15 1999-01-28 Russinsky Limited Tramadol, salts thereof and process for their preparation
US5877351A (en) * 1997-12-24 1999-03-02 Wyckoff Chemical Company, Inc. Preparation and purification process for 2- (dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts
IT1298597B1 (it) 1998-03-06 2000-01-12 Secifarma Spa Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)
ATE257147T1 (de) * 1998-05-22 2004-01-15 Mallinckrodt Inc Ein verbessertes synthese- und reinigungsverfahren für (r*,r*)-2- ((dimethylamino)methyl)-1-(3-methoxyphenyl) cyclohexanol hydrochlorid
EP1082300B1 (en) * 1998-05-29 2003-09-10 PHARMACIA & UPJOHN COMPANY 3-[(1'-n-methylamino)ethyl-n-benzyl]pyrrolidine monomethanesulfonate
AU4775699A (en) * 1999-06-22 2001-01-09 Grunenthal Gmbh Method for separating the diastereomer bases of 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-cyclohexanol
GB0010437D0 (en) * 2000-04-28 2000-06-14 Darwin Discovery Ltd Process
DE10108308A1 (de) * 2001-02-21 2002-08-29 Gruenenthal Gmbh Verfahren zur Isolierung und Reinigung von (1RS,2RS)-2[(Dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
US6780891B2 (en) 2001-11-30 2004-08-24 Sepracor Inc. Tramadol analogs and uses thereof
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
DE102005031041A1 (de) * 2005-07-02 2007-01-04 Palitzsch, Peter Verfahren zur Isomerisierung von Tramadol
RU2008113439A (ru) 2005-09-09 2009-10-20 Лабофарм Инк. (CA) Композиции с замедленным высвобождением лекарственного средства
EP1785412A1 (en) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1219503B (de) 1960-08-20 1966-06-23 Firth Cleveland Ltd Heiz- und/oder Kuehlgeraet
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3653589A (en) 1970-07-27 1972-04-04 Carrier Corp Air conditioning system
IL103096A (en) * 1992-09-08 1996-12-05 Chemagis Ltd Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts.

Also Published As

Publication number Publication date
DE69611663T2 (de) 2001-06-13
US5672755A (en) 1997-09-30
PT778262E (pt) 2001-05-31
CA2192155A1 (en) 1997-06-08
IL116281A0 (en) 1996-03-31
CA2192155C (en) 2005-06-14
ATE198879T1 (de) 2001-02-15
DE69611663D1 (de) 2001-03-01
IL116281A (en) 1999-06-20
EP0778262B1 (en) 2001-01-24
AU7181896A (en) 1997-06-12
EP0778262A2 (en) 1997-06-11
GR3035602T3 (en) 2001-06-29
SK150396A3 (en) 1997-07-09
SK282179B6 (sk) 2001-11-06
ES2154792T3 (es) 2001-04-16
AU713304B2 (en) 1999-11-25
EP0778262A3 (en) 1998-04-29

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