IT1298597B1 - Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino) - Google Patents

Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)

Info

Publication number
IT1298597B1
IT1298597B1 IT98MI000457A ITMI980457A IT1298597B1 IT 1298597 B1 IT1298597 B1 IT 1298597B1 IT 98MI000457 A IT98MI000457 A IT 98MI000457A IT MI980457 A ITMI980457 A IT MI980457A IT 1298597 B1 IT1298597 B1 IT 1298597B1
Authority
IT
Italy
Prior art keywords
dimethylamino
cyclohexanol
methoxyphenyl
methyl
purification
Prior art date
Application number
IT98MI000457A
Other languages
English (en)
Inventor
Walter Cabri
Domenico Magrone
Original Assignee
Secifarma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Secifarma Spa filed Critical Secifarma Spa
Priority to IT98MI000457A priority Critical patent/IT1298597B1/it
Priority to PT99104275T priority patent/PT940385E/pt
Priority to DK99104275T priority patent/DK0940385T3/da
Priority to ES99104275T priority patent/ES2201581T3/es
Priority to EP99104275A priority patent/EP0940385B1/en
Priority to DE69908994T priority patent/DE69908994T2/de
Priority to AT99104275T priority patent/ATE243675T1/de
Priority to US09/262,043 priority patent/US6169205B1/en
Publication of ITMI980457A1 publication Critical patent/ITMI980457A1/it
Application granted granted Critical
Publication of IT1298597B1 publication Critical patent/IT1298597B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT98MI000457A 1998-03-06 1998-03-06 Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino) IT1298597B1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT98MI000457A IT1298597B1 (it) 1998-03-06 1998-03-06 Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)
PT99104275T PT940385E (pt) 1998-03-06 1999-03-03 Processo para a separacao do isomero do (rr,ss)-2-(dimetilamino)-metil-1-(3-metoxifenil)-ciclo-hexanol a partir do isomero (rs,sr) mediante precipitacao selectiva
DK99104275T DK0940385T3 (da) 1998-03-06 1999-03-03 Fremgangsmåde til separation af (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanol-isomeren fra (RS,SR)-isomeren ved selektiv udfældning
ES99104275T ES2201581T3 (es) 1998-03-06 1999-03-03 Procedimiento de separacion del (rr,ss)-2-(dimetilamino)metil-1-(3-metoxifennil)-ciclohexanol de isomero (rs,sr) por preecipitacion selectiva.
EP99104275A EP0940385B1 (en) 1998-03-06 1999-03-03 Process for the separation of the (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanol isomer from the (RS,SR) isomer by selective precipitation
DE69908994T DE69908994T2 (de) 1998-03-06 1999-03-03 Verfahren zur Abtrennung des (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanolisomers von dem (RS,SR) Isomer durch selektive Ausfällung
AT99104275T ATE243675T1 (de) 1998-03-06 1999-03-03 Verfahren zur abtrennung des (rr,ss)-2- (dimethylamino)methyl-1-(3-methoxyphenyl)- cyclohexanolisomers von dem (rs,sr) isomer durch selektive ausfällung
US09/262,043 US6169205B1 (en) 1998-03-06 1999-03-04 Process for the purification of (RR,SS)-2-(dimethylamino) methyl-1-(3-methoxyphenyl)-cyclohexanol from (RS,SR)-2-(dimethylamino)methyl-1-(3-methoxyphenyl) cyclohexanol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT98MI000457A IT1298597B1 (it) 1998-03-06 1998-03-06 Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)

Publications (2)

Publication Number Publication Date
ITMI980457A1 ITMI980457A1 (it) 1999-09-06
IT1298597B1 true IT1298597B1 (it) 2000-01-12

Family

ID=11379210

Family Applications (1)

Application Number Title Priority Date Filing Date
IT98MI000457A IT1298597B1 (it) 1998-03-06 1998-03-06 Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)

Country Status (8)

Country Link
US (1) US6169205B1 (it)
EP (1) EP0940385B1 (it)
AT (1) ATE243675T1 (it)
DE (1) DE69908994T2 (it)
DK (1) DK0940385T3 (it)
ES (1) ES2201581T3 (it)
IT (1) IT1298597B1 (it)
PT (1) PT940385E (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19758576C2 (de) * 1997-12-22 2002-01-24 Gruenenthal Gmbh Verfahren zur Diastereomerentrennung für substituierte Aminoalkohole
US6649783B2 (en) 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
EP1346978A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Process for preparing tramadol hydrochloride and/or tramadol monohydrate
EP1785412A1 (en) 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL103096A (en) * 1992-09-08 1996-12-05 Chemagis Ltd Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts.
IL116281A (en) * 1995-12-07 1999-06-20 Chemagis Ltd Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts
IL119121A (en) * 1996-08-22 2000-11-21 Chemagis Ltd Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride

Also Published As

Publication number Publication date
DE69908994D1 (de) 2003-07-31
ITMI980457A1 (it) 1999-09-06
DK0940385T3 (da) 2003-10-20
US6169205B1 (en) 2001-01-02
PT940385E (pt) 2003-10-31
ES2201581T3 (es) 2004-03-16
EP0940385A1 (en) 1999-09-08
EP0940385B1 (en) 2003-06-25
ATE243675T1 (de) 2003-07-15
DE69908994T2 (de) 2004-05-19

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