DE69908994D1 - Verfahren zur Abtrennung des (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanolisomers von dem (RS,SR) Isomer durch selektive Ausfällung - Google Patents

Verfahren zur Abtrennung des (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanolisomers von dem (RS,SR) Isomer durch selektive Ausfällung

Info

Publication number
DE69908994D1
DE69908994D1 DE69908994T DE69908994T DE69908994D1 DE 69908994 D1 DE69908994 D1 DE 69908994D1 DE 69908994 T DE69908994 T DE 69908994T DE 69908994 T DE69908994 T DE 69908994T DE 69908994 D1 DE69908994 D1 DE 69908994D1
Authority
DE
Germany
Prior art keywords
isomer
methoxyphenyl
dimethylamino
methyl
cyclohexanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69908994T
Other languages
English (en)
Other versions
DE69908994T2 (de
Inventor
Walter Cabri
Domenico Magrone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dipharma Francis SRL
Original Assignee
Dinamite Dipharma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dinamite Dipharma SpA filed Critical Dinamite Dipharma SpA
Publication of DE69908994D1 publication Critical patent/DE69908994D1/de
Application granted granted Critical
Publication of DE69908994T2 publication Critical patent/DE69908994T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69908994T 1998-03-06 1999-03-03 Verfahren zur Abtrennung des (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanolisomers von dem (RS,SR) Isomer durch selektive Ausfällung Expired - Fee Related DE69908994T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI980457 1998-03-06
IT98MI000457A IT1298597B1 (it) 1998-03-06 1998-03-06 Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)

Publications (2)

Publication Number Publication Date
DE69908994D1 true DE69908994D1 (de) 2003-07-31
DE69908994T2 DE69908994T2 (de) 2004-05-19

Family

ID=11379210

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69908994T Expired - Fee Related DE69908994T2 (de) 1998-03-06 1999-03-03 Verfahren zur Abtrennung des (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanolisomers von dem (RS,SR) Isomer durch selektive Ausfällung

Country Status (8)

Country Link
US (1) US6169205B1 (de)
EP (1) EP0940385B1 (de)
AT (1) ATE243675T1 (de)
DE (1) DE69908994T2 (de)
DK (1) DK0940385T3 (de)
ES (1) ES2201581T3 (de)
IT (1) IT1298597B1 (de)
PT (1) PT940385E (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19758576C2 (de) * 1997-12-22 2002-01-24 Gruenenthal Gmbh Verfahren zur Diastereomerentrennung für substituierte Aminoalkohole
US6649783B2 (en) 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
EP1346978A1 (de) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Verfahren zur Herstellung von Tramadol-Hydrochloride und/oder Tramadol-Monohydrat
EP1785412A1 (de) 2005-11-14 2007-05-16 IPCA Laboratories Limited Verfahren zur Rückgewinnung von Tramadol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL103096A (en) * 1992-09-08 1996-12-05 Chemagis Ltd Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts.
IL116281A (en) * 1995-12-07 1999-06-20 Chemagis Ltd Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts
IL119121A (en) * 1996-08-22 2000-11-21 Chemagis Ltd Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride

Also Published As

Publication number Publication date
US6169205B1 (en) 2001-01-02
IT1298597B1 (it) 2000-01-12
EP0940385A1 (de) 1999-09-08
PT940385E (pt) 2003-10-31
EP0940385B1 (de) 2003-06-25
DK0940385T3 (da) 2003-10-20
ATE243675T1 (de) 2003-07-15
ITMI980457A1 (it) 1999-09-06
DE69908994T2 (de) 2004-05-19
ES2201581T3 (es) 2004-03-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee