DE69908994D1 - Verfahren zur Abtrennung des (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanolisomers von dem (RS,SR) Isomer durch selektive Ausfällung - Google Patents
Verfahren zur Abtrennung des (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanolisomers von dem (RS,SR) Isomer durch selektive AusfällungInfo
- Publication number
- DE69908994D1 DE69908994D1 DE69908994T DE69908994T DE69908994D1 DE 69908994 D1 DE69908994 D1 DE 69908994D1 DE 69908994 T DE69908994 T DE 69908994T DE 69908994 T DE69908994 T DE 69908994T DE 69908994 D1 DE69908994 D1 DE 69908994D1
- Authority
- DE
- Germany
- Prior art keywords
- isomer
- methoxyphenyl
- dimethylamino
- methyl
- cyclohexanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT98MI000457A IT1298597B1 (it) | 1998-03-06 | 1998-03-06 | Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino) |
ITMI980457 | 1998-03-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69908994D1 true DE69908994D1 (de) | 2003-07-31 |
DE69908994T2 DE69908994T2 (de) | 2004-05-19 |
Family
ID=11379210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69908994T Expired - Fee Related DE69908994T2 (de) | 1998-03-06 | 1999-03-03 | Verfahren zur Abtrennung des (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanolisomers von dem (RS,SR) Isomer durch selektive Ausfällung |
Country Status (8)
Country | Link |
---|---|
US (1) | US6169205B1 (de) |
EP (1) | EP0940385B1 (de) |
AT (1) | ATE243675T1 (de) |
DE (1) | DE69908994T2 (de) |
DK (1) | DK0940385T3 (de) |
ES (1) | ES2201581T3 (de) |
IT (1) | IT1298597B1 (de) |
PT (1) | PT940385E (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19758576C2 (de) * | 1997-12-22 | 2002-01-24 | Gruenenthal Gmbh | Verfahren zur Diastereomerentrennung für substituierte Aminoalkohole |
US6649783B2 (en) | 2001-10-03 | 2003-11-18 | Euro-Celtique, S.A. | Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols |
EP1346978A1 (de) * | 2002-03-21 | 2003-09-24 | Jubilant Organosys Limited | Verfahren zur Herstellung von Tramadol-Hydrochloride und/oder Tramadol-Monohydrat |
EP1785412A1 (de) | 2005-11-14 | 2007-05-16 | IPCA Laboratories Limited | Verfahren zur Rückgewinnung von Tramadol |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
IL103096A (en) * | 1992-09-08 | 1996-12-05 | Chemagis Ltd | Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts. |
IL116281A (en) * | 1995-12-07 | 1999-06-20 | Chemagis Ltd | Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts |
IL119121A (en) * | 1996-08-22 | 2000-11-21 | Chemagis Ltd | Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride |
-
1998
- 1998-03-06 IT IT98MI000457A patent/IT1298597B1/it active IP Right Grant
-
1999
- 1999-03-03 DE DE69908994T patent/DE69908994T2/de not_active Expired - Fee Related
- 1999-03-03 EP EP99104275A patent/EP0940385B1/de not_active Expired - Lifetime
- 1999-03-03 ES ES99104275T patent/ES2201581T3/es not_active Expired - Lifetime
- 1999-03-03 DK DK99104275T patent/DK0940385T3/da active
- 1999-03-03 PT PT99104275T patent/PT940385E/pt unknown
- 1999-03-03 AT AT99104275T patent/ATE243675T1/de not_active IP Right Cessation
- 1999-03-04 US US09/262,043 patent/US6169205B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ITMI980457A1 (it) | 1999-09-06 |
DK0940385T3 (da) | 2003-10-20 |
US6169205B1 (en) | 2001-01-02 |
PT940385E (pt) | 2003-10-31 |
IT1298597B1 (it) | 2000-01-12 |
ES2201581T3 (es) | 2004-03-16 |
EP0940385A1 (de) | 1999-09-08 |
EP0940385B1 (de) | 2003-06-25 |
ATE243675T1 (de) | 2003-07-15 |
DE69908994T2 (de) | 2004-05-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |