ATE218533T1 - Verfahren zur reinigung von (rr-ss)-2- dimethylaminomethyl-1-(3- methoxyphenyl)cyclohexanol hydrochlorid - Google Patents
Verfahren zur reinigung von (rr-ss)-2- dimethylaminomethyl-1-(3- methoxyphenyl)cyclohexanol hydrochloridInfo
- Publication number
- ATE218533T1 ATE218533T1 AT97306305T AT97306305T ATE218533T1 AT E218533 T1 ATE218533 T1 AT E218533T1 AT 97306305 T AT97306305 T AT 97306305T AT 97306305 T AT97306305 T AT 97306305T AT E218533 T1 ATE218533 T1 AT E218533T1
- Authority
- AT
- Austria
- Prior art keywords
- dimethylaminomethyl
- methoxyphenyl
- tramadol
- purifying
- cyclohexanol hydrochloride
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229960004380 tramadol Drugs 0.000 abstract 4
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- TVYLLZQTGLZFBW-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol Chemical compound COC1=CC=CC(C2(O)C(CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-UHFFFAOYSA-N 0.000 abstract 1
- PPKXEPBICJTCRU-UHFFFAOYSA-N [2-hydroxy-2-(3-methoxyphenyl)cyclohexyl]methyl-dimethylazanium;chloride Chemical compound Cl.COC1=CC=CC(C2(O)C(CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11912196A IL119121A (en) | 1996-08-22 | 1996-08-22 | Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE218533T1 true ATE218533T1 (de) | 2002-06-15 |
Family
ID=11069225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97306305T ATE218533T1 (de) | 1996-08-22 | 1997-08-19 | Verfahren zur reinigung von (rr-ss)-2- dimethylaminomethyl-1-(3- methoxyphenyl)cyclohexanol hydrochlorid |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5874620A (de) |
| EP (1) | EP0831082B1 (de) |
| AT (1) | ATE218533T1 (de) |
| DE (1) | DE69713014T2 (de) |
| ES (1) | ES2176625T3 (de) |
| IL (1) | IL119121A (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2295884A1 (en) | 1997-07-15 | 1999-01-28 | Russinsky Limited | Tramadol, salts thereof and process for their preparation |
| IT1298597B1 (it) | 1998-03-06 | 2000-01-12 | Secifarma Spa | Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino) |
| HK1045301A1 (zh) * | 1999-06-22 | 2002-11-22 | Grunenthal Gmbh | 2-[(二甲基氨基)甲基]-1-(3-甲氧苯基)-環己醇的非對映異構體碱的分離方法 |
| CA2758923A1 (en) | 2001-03-16 | 2002-09-26 | Dmi Biosciences, Inc. | Use of tramadol to delay ejaculation |
| US6649783B2 (en) * | 2001-10-03 | 2003-11-18 | Euro-Celtique, S.A. | Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols |
| DE10218862A1 (de) | 2002-04-26 | 2003-11-06 | Gruenenthal Gmbh | Verfahren zur Chlorierung tertiärer Alkohole |
| US8487002B2 (en) * | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
| TWI319713B (en) * | 2002-10-25 | 2010-01-21 | Sustained-release tramadol formulations with 24-hour efficacy | |
| US20060172006A1 (en) * | 2003-10-10 | 2006-08-03 | Vincent Lenaerts | Sustained-release tramadol formulations with 24-hour clinical efficacy |
| PT1931346E (pt) * | 2005-09-09 | 2012-08-14 | Angelini Labopharm Llc | Composição de trazodona para administração uma vez por dia |
| JP2009507047A (ja) * | 2005-09-09 | 2009-02-19 | ラボファーム インコーポレイテッド | 持続性薬物放出組成物 |
| EP1785412A1 (de) * | 2005-11-14 | 2007-05-16 | IPCA Laboratories Limited | Verfahren zur Rückgewinnung von Tramadol |
| NZ579170A (en) | 2007-02-12 | 2012-05-25 | Dmi Biosciences Inc | Reducing side effects of tramadol |
| BRPI0807282A2 (pt) | 2007-02-12 | 2014-04-29 | Dmi Biosciences Inc | Tratamento de ejaculação precoce e disfunção erétil co-mórbidas |
| EP2978739A1 (de) | 2013-03-26 | 2016-02-03 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Extraktion von tramadol aus nauclea latifolia smith |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| IL103096A (en) * | 1992-09-08 | 1996-12-05 | Chemagis Ltd | Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts. |
| IL116281A (en) * | 1995-12-07 | 1999-06-20 | Chemagis Ltd | Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts |
-
1996
- 1996-08-22 IL IL11912196A patent/IL119121A/xx not_active IP Right Cessation
-
1997
- 1997-08-14 US US08/911,518 patent/US5874620A/en not_active Expired - Lifetime
- 1997-08-19 EP EP97306305A patent/EP0831082B1/de not_active Expired - Lifetime
- 1997-08-19 AT AT97306305T patent/ATE218533T1/de not_active IP Right Cessation
- 1997-08-19 DE DE69713014T patent/DE69713014T2/de not_active Expired - Fee Related
- 1997-08-19 ES ES97306305T patent/ES2176625T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69713014T2 (de) | 2003-01-02 |
| US5874620A (en) | 1999-02-23 |
| ES2176625T3 (es) | 2002-12-01 |
| EP0831082B1 (de) | 2002-06-05 |
| EP0831082A1 (de) | 1998-03-25 |
| DE69713014D1 (de) | 2002-07-11 |
| IL119121A (en) | 2000-11-21 |
| IL119121A0 (en) | 1996-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE218533T1 (de) | Verfahren zur reinigung von (rr-ss)-2- dimethylaminomethyl-1-(3- methoxyphenyl)cyclohexanol hydrochlorid | |
| DE69625026D1 (de) | Verfahren zur Entfernung von Kohlensäure aus Gasen | |
| ATE392430T1 (de) | Verfahren zur herstellung von dipeptiden | |
| ATE179411T1 (de) | Verfahren zur herstellung von aromatischen carbamaten | |
| DE69429758D1 (de) | Verfahren zur Herstellung eines Polypeptides | |
| DE69611663D1 (de) | Verfahren zur Reinigung von (RR-SS)-2-Dimethyl-Aminomethyl-1-(3-Methoxyphenyl)Cyclohexanol und dessen Salzen | |
| DE59601745D1 (de) | Verfahren zur Herstellung von 3-Aminomethyl-3,5,5-trimethylcyclohexylamin | |
| DE69502675D1 (de) | Verfahren zur Herstellung von Bis(Aminomethyl)Cyclohexan | |
| DE59602847D1 (de) | Verfahren zur Herstellung von d,I-Menthol aus d-Menthol | |
| DE69607344D1 (de) | Verfahren zur herstellung von n,n'-disubstituierten cyclischen harnstoffen | |
| DE69709127D1 (de) | Verfahren zur herstellung von iohexol | |
| DE69513152D1 (de) | Verfahren zur trennung von pentafluorethan aus einer mischung, die halogenierte kohlenwasserstoffe und chlorpentafluorethan enthält | |
| ATE179697T1 (de) | Verfahren zur herstellung von aromatischen urethanen | |
| DE59907526D1 (de) | Verfahren zur Herstellung von 3-Cyano-3,5,5-trimethyl-cyclohexanon | |
| EP0839796A3 (de) | Verfahren zur Herstellung von 1.4 Bis(aminomethyl) cyclohexan | |
| DE59802794D1 (de) | Verfahren zur abtrennung eines imins aus einer mischung enthaltend ein amin und ein imin | |
| DE69821053T2 (de) | Verfahren zur Herstellung von 2,2,6,6-Tetramethyl-4-piperidyl-Gruppen enthaltenden Polytriazinen | |
| DE59705787D1 (de) | Verfahren zur herstellung von n,n'-dialkylperylen-3,4,9,10-tetracarbonsäurediimiden | |
| DE69514122D1 (de) | Lösungsmittelfreies verfahren zur herstellung von 2,6 difluorbenzonitril | |
| DE59710180D1 (de) | Verfahren zur abtrennung von 2-aminomethylcyclopentylamin aus einer mischung enthaltend hexamethylendiamin und 2-aminomethylcyclopentylamin | |
| ATE243675T1 (de) | Verfahren zur abtrennung des (rr,ss)-2- (dimethylamino)methyl-1-(3-methoxyphenyl)- cyclohexanolisomers von dem (rs,sr) isomer durch selektive ausfällung | |
| DE69811677D1 (de) | Verfahren zur präparation von enantiomer-angereicherten, n-derivatisierten laktamen. | |
| DE59802484D1 (de) | Verfahren zur Herstellung von Aminen aus Olefinen an NU-85 Zeolithen | |
| DE59703263D1 (de) | Verfahren zur extraktiven Abtrennung von Diarylcarbonaten und den zugrundeliegenden aromatischen Hydroxyverbindungen aus Reaktionslösungen | |
| DE59603989D1 (de) | Verfahren zur herstellung von aminen aus olefinen an bor-beta-zeolithen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |