DE69713014T2 - Verfahren zur Reinigung von (RR-SS)-2-Dimethylaminomethyl-1-(3-Methoxyphenyl)Cyclohexanol Hydrochlorid - Google Patents

Verfahren zur Reinigung von (RR-SS)-2-Dimethylaminomethyl-1-(3-Methoxyphenyl)Cyclohexanol Hydrochlorid

Info

Publication number
DE69713014T2
DE69713014T2 DE69713014T DE69713014T DE69713014T2 DE 69713014 T2 DE69713014 T2 DE 69713014T2 DE 69713014 T DE69713014 T DE 69713014T DE 69713014 T DE69713014 T DE 69713014T DE 69713014 T2 DE69713014 T2 DE 69713014T2
Authority
DE
Germany
Prior art keywords
dimethylaminomethyl
methoxyphenyl
tramadol
purification
cyclohexanol hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69713014T
Other languages
English (en)
Other versions
DE69713014D1 (de
Inventor
Ori Lerman
Joseph Kaspi
Dov Brenner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wavelength Pharmaceuticals Ltd
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Application granted granted Critical
Publication of DE69713014D1 publication Critical patent/DE69713014D1/de
Publication of DE69713014T2 publication Critical patent/DE69713014T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69713014T 1996-08-22 1997-08-19 Verfahren zur Reinigung von (RR-SS)-2-Dimethylaminomethyl-1-(3-Methoxyphenyl)Cyclohexanol Hydrochlorid Expired - Fee Related DE69713014T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11912196A IL119121A (en) 1996-08-22 1996-08-22 Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride

Publications (2)

Publication Number Publication Date
DE69713014D1 DE69713014D1 (de) 2002-07-11
DE69713014T2 true DE69713014T2 (de) 2003-01-02

Family

ID=11069225

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69713014T Expired - Fee Related DE69713014T2 (de) 1996-08-22 1997-08-19 Verfahren zur Reinigung von (RR-SS)-2-Dimethylaminomethyl-1-(3-Methoxyphenyl)Cyclohexanol Hydrochlorid

Country Status (6)

Country Link
US (1) US5874620A (de)
EP (1) EP0831082B1 (de)
AT (1) ATE218533T1 (de)
DE (1) DE69713014T2 (de)
ES (1) ES2176625T3 (de)
IL (1) IL119121A (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001510180A (ja) 1997-07-15 2001-07-31 ラシンスキィ・リミテッド トラマドール、その塩酸塩、及びそれらの製造方法
IT1298597B1 (it) * 1998-03-06 2000-01-12 Secifarma Spa Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)
AU4775699A (en) * 1999-06-22 2001-01-09 Grunenthal Gmbh Method for separating the diastereomer bases of 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-cyclohexanol
WO2002074241A2 (en) * 2001-03-16 2002-09-26 Dmi Biosciences Inc. Method of delaying ejaculation
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
DE10218862A1 (de) * 2002-04-26 2003-11-06 Gruenenthal Gmbh Verfahren zur Chlorierung tertiärer Alkohole
US8487002B2 (en) * 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
DK1940467T3 (da) * 2005-09-09 2017-02-13 Paladin Labs Inc Lægemiddelsammensætning med langvarig frigivelse
EP1785412A1 (de) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Verfahren zur Rückgewinnung von Tramadol
NZ579170A (en) 2007-02-12 2012-05-25 Dmi Biosciences Inc Reducing side effects of tramadol
EP2120570B1 (de) 2007-02-12 2012-05-16 DMI Biosciences, Inc. Behandlung frühzeitiger comorbid-ejakulation und erektiler dysfunktion
US20160039742A1 (en) 2013-03-26 2016-02-11 Universite Joseph Fourier - Grenoble 1 Extraction of tramadol from nauclea latifolia smith

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL103096A (en) * 1992-09-08 1996-12-05 Chemagis Ltd Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts.
IL116281A (en) * 1995-12-07 1999-06-20 Chemagis Ltd Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts

Also Published As

Publication number Publication date
EP0831082A1 (de) 1998-03-25
ES2176625T3 (es) 2002-12-01
ATE218533T1 (de) 2002-06-15
IL119121A (en) 2000-11-21
DE69713014D1 (de) 2002-07-11
EP0831082B1 (de) 2002-06-05
US5874620A (en) 1999-02-23
IL119121A0 (en) 1996-11-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee