ATE198879T1 - Verfahren zur reinigung von (rr-ss)-2-dimethyl- aminomethyl-1-(3-methoxyphenyl)cyclohexanol und dessen salzen - Google Patents

Verfahren zur reinigung von (rr-ss)-2-dimethyl- aminomethyl-1-(3-methoxyphenyl)cyclohexanol und dessen salzen

Info

Publication number
ATE198879T1
ATE198879T1 AT96308347T AT96308347T ATE198879T1 AT E198879 T1 ATE198879 T1 AT E198879T1 AT 96308347 T AT96308347 T AT 96308347T AT 96308347 T AT96308347 T AT 96308347T AT E198879 T1 ATE198879 T1 AT E198879T1
Authority
AT
Austria
Prior art keywords
methoxyphenyl
isomer
cyclohexanol
dimethyl
aminomethyl
Prior art date
Application number
AT96308347T
Other languages
English (en)
Inventor
Ori Lerman
Michael Tennenbaum
Erez Gal
Joseph Kaspi
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Application granted granted Critical
Publication of ATE198879T1 publication Critical patent/ATE198879T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT96308347T 1995-12-07 1996-11-19 Verfahren zur reinigung von (rr-ss)-2-dimethyl- aminomethyl-1-(3-methoxyphenyl)cyclohexanol und dessen salzen ATE198879T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11628195A IL116281A (en) 1995-12-07 1995-12-07 Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts

Publications (1)

Publication Number Publication Date
ATE198879T1 true ATE198879T1 (de) 2001-02-15

Family

ID=11068279

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96308347T ATE198879T1 (de) 1995-12-07 1996-11-19 Verfahren zur reinigung von (rr-ss)-2-dimethyl- aminomethyl-1-(3-methoxyphenyl)cyclohexanol und dessen salzen

Country Status (12)

Country Link
US (1) US5672755A (de)
EP (1) EP0778262B1 (de)
AT (1) ATE198879T1 (de)
AU (1) AU713304B2 (de)
CA (1) CA2192155C (de)
DE (1) DE69611663T2 (de)
DK (1) DK0778262T3 (de)
ES (1) ES2154792T3 (de)
GR (1) GR3035602T3 (de)
IL (1) IL116281A (de)
PT (1) PT778262E (de)
SK (1) SK282179B6 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119121A (en) * 1996-08-22 2000-11-21 Chemagis Ltd Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride
JP2001510180A (ja) 1997-07-15 2001-07-31 ラシンスキィ・リミテッド トラマドール、その塩酸塩、及びそれらの製造方法
US5877351A (en) * 1997-12-24 1999-03-02 Wyckoff Chemical Company, Inc. Preparation and purification process for 2- (dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts
IT1298597B1 (it) * 1998-03-06 2000-01-12 Secifarma Spa Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)
DE69913955T2 (de) * 1998-05-22 2004-12-16 Mallinckrodt, Inc. Ein verbessertes synthese- und reinigungsverfahren für (r*,r*)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochlorid
AU4211799A (en) * 1998-05-29 1999-12-13 Pharmacia & Upjohn Company 3-[(1--n-methylamino)ethyl-n-benzyl] pyrrolidine monomethanesulfonate
AU4775699A (en) * 1999-06-22 2001-01-09 Grunenthal Gmbh Method for separating the diastereomer bases of 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-cyclohexanol
GB0010437D0 (en) * 2000-04-28 2000-06-14 Darwin Discovery Ltd Process
DE10108308A1 (de) * 2001-02-21 2002-08-29 Gruenenthal Gmbh Verfahren zur Isolierung und Reinigung von (1RS,2RS)-2[(Dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
WO2003048113A1 (en) 2001-11-30 2003-06-12 Sepracor Inc. Tramadol analogs and uses thereof
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
DE102005031041A1 (de) * 2005-07-02 2007-01-04 Palitzsch, Peter Verfahren zur Isomerisierung von Tramadol
DK1940467T3 (da) 2005-09-09 2017-02-13 Paladin Labs Inc Lægemiddelsammensætning med langvarig frigivelse
EP1785412A1 (de) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Verfahren zur Rückgewinnung von Tramadol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1219503B (de) 1960-08-20 1966-06-23 Firth Cleveland Ltd Heiz- und/oder Kuehlgeraet
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3653589A (en) 1970-07-27 1972-04-04 Carrier Corp Air conditioning system
IL103096A (en) 1992-09-08 1996-12-05 Chemagis Ltd Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts.

Also Published As

Publication number Publication date
US5672755A (en) 1997-09-30
AU7181896A (en) 1997-06-12
GR3035602T3 (en) 2001-06-29
DE69611663D1 (de) 2001-03-01
EP0778262A3 (de) 1998-04-29
ES2154792T3 (es) 2001-04-16
CA2192155A1 (en) 1997-06-08
SK150396A3 (en) 1997-07-09
EP0778262B1 (de) 2001-01-24
IL116281A (en) 1999-06-20
EP0778262A2 (de) 1997-06-11
IL116281A0 (en) 1996-03-31
AU713304B2 (en) 1999-11-25
PT778262E (pt) 2001-05-31
CA2192155C (en) 2005-06-14
SK282179B6 (sk) 2001-11-06
DE69611663T2 (de) 2001-06-13
DK0778262T3 (da) 2001-03-05

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Legal Events

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