ATE127447T1 - Stabile polymorphe form von (e)-n,n-diethyl-2- cyano-3-(3,4-dihydroxy-5-nitrophenyl)-acrylamid und verfahren zu ihrer herstellung. - Google Patents

Stabile polymorphe form von (e)-n,n-diethyl-2- cyano-3-(3,4-dihydroxy-5-nitrophenyl)-acrylamid und verfahren zu ihrer herstellung.

Info

Publication number
ATE127447T1
ATE127447T1 AT90311963T AT90311963T ATE127447T1 AT E127447 T1 ATE127447 T1 AT E127447T1 AT 90311963 T AT90311963 T AT 90311963T AT 90311963 T AT90311963 T AT 90311963T AT E127447 T1 ATE127447 T1 AT E127447T1
Authority
AT
Austria
Prior art keywords
dihydroxy
acrylamide
cyano
diethyl
nitrophenyl
Prior art date
Application number
AT90311963T
Other languages
English (en)
Inventor
Aino Kyllikki Pippuri
Erkki Juhani Honkanen
Jorma Veikko Haarala
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10665678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE127447(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Application granted granted Critical
Publication of ATE127447T1 publication Critical patent/ATE127447T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
AT90311963T 1989-11-03 1990-11-01 Stabile polymorphe form von (e)-n,n-diethyl-2- cyano-3-(3,4-dihydroxy-5-nitrophenyl)-acrylamid und verfahren zu ihrer herstellung. ATE127447T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8924838A GB2238047B (en) 1989-11-03 1989-11-03 Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation

Publications (1)

Publication Number Publication Date
ATE127447T1 true ATE127447T1 (de) 1995-09-15

Family

ID=10665678

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90311963T ATE127447T1 (de) 1989-11-03 1990-11-01 Stabile polymorphe form von (e)-n,n-diethyl-2- cyano-3-(3,4-dihydroxy-5-nitrophenyl)-acrylamid und verfahren zu ihrer herstellung.

Country Status (13)

Country Link
US (1) US5135950A (de)
EP (1) EP0426468B1 (de)
JP (1) JP2823680B2 (de)
AT (1) ATE127447T1 (de)
BR (1) BR1100289A (de)
DE (2) DE69022166T2 (de)
DK (1) DK0426468T3 (de)
ES (1) ES2075885T3 (de)
FI (1) FI107149B (de)
GB (1) GB2238047B (de)
GR (1) GR3017526T3 (de)
LU (1) LU91071I2 (de)
NL (1) NL300147I1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283352A (en) * 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB9113431D0 (en) * 1991-06-20 1991-08-07 Orion Yhytma Oy Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde
CA2080554A1 (en) * 1991-10-15 1993-04-16 Mitsubishi Chemical Corporation Styrene derivatives
JPH05301838A (ja) * 1991-10-15 1993-11-16 Mitsubishi Kasei Corp スチレン誘導体
US20060013875A1 (en) * 2002-05-29 2006-01-19 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
US7094427B2 (en) * 2002-05-29 2006-08-22 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
BRPI0417799A (pt) * 2003-12-19 2007-04-17 Hoffmann La Roche inibidores de comt
AU2003296838A1 (en) * 2003-12-24 2005-08-11 Siddiqui Mohammed Jaweed Mukarram An efficient process for the manufacture of (e)-entacapone polymorphic form a
WO2005066117A1 (en) * 2003-12-29 2005-07-21 Wockhardt Limited Stable polymorphs of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
AU2003287844A1 (en) * 2003-12-31 2005-07-21 Cilag Ag Novel crystalline forms of entacapone, and production thereof
US20080076825A1 (en) * 2003-12-31 2008-03-27 Thomas Bader Novel Crystalline Forms of Entacapone and Production Thereof
EP1577289A1 (de) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Nicht-glykosylierte/-glykosidische/-peptidische keine Moleküle als Selektininhibitoren für die Behandlung entzündlicher Erkrankungen.
AU2005257982B8 (en) * 2004-06-16 2011-03-10 Jack Arbiser Carbazole formulations for the treatment of psoriasis and angiogenesis
EP1812070B1 (de) 2004-11-10 2013-10-02 Orion Corporation Behandlung des syndroms der ruhelosen beine
EA013161B1 (ru) 2005-06-08 2010-02-26 Орион Корпорейшн Дозированная форма для перорального применения
AU2006261893A1 (en) * 2005-06-23 2007-01-04 Combinatorx, Incorporated Improved dosage forms for movement disorder treatment
EP1764093A1 (de) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue aromatische Verbindungen und deren medizinische Verwendung
EP1764095A1 (de) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue Nitrocatecholderivate mit Selectin-Ligand-Activität
EP1764096A1 (de) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue Phloroglucinolderivate mit Selectin-Ligand-Aktivität
EP1945607B1 (de) * 2005-11-09 2009-10-14 USV Limited Verfahren zur herstellung von hochreinem (e)-n,n-diethyl-2-cyano-3-(3,4-dihydro-5-nitrophenyl)acrylamid (entacapon)
US20080300420A1 (en) * 2006-01-02 2008-12-04 Sanmar Speciality Chemicals Ltd. Process for the Preparation of Entacapone Form-A
US7932415B2 (en) * 2006-02-06 2011-04-26 Orion Corporation Process for manufacturing entacapone
WO2007094007A1 (en) * 2006-02-13 2007-08-23 Suven Life Sciences Ltd., An improved process for the preparation of entacapone
WO2007113845A1 (en) * 2006-04-03 2007-10-11 Alembic Limited A process for the preparation of (e)-2-cyano-3-(3, 4-dihydroxy-5-nitrophenyl)-n, n-diethyl-2-propenamide (entacapone)
GB0610207D0 (en) * 2006-05-23 2006-07-05 Pliva Istrazivanje I Razvoj D New forms of active pharmaceutical ingredient
US20080131492A1 (en) * 2006-06-23 2008-06-05 Spherics, Inc. Dosage forms for movement disorder treatment
US20080004343A1 (en) * 2006-06-29 2008-01-03 Wockhardt Limited Stable polymorphs of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
GB0613826D0 (en) * 2006-07-12 2006-08-23 Pliva Istrazivanje I Razvoj D Process and product
ES2306587B1 (es) * 2006-11-15 2009-08-07 Quimica Sintetica, S.A. Nueva forma cristalina de entacapona y procedimiento para su obtencion.
ITMI20062450A1 (it) * 2006-12-19 2008-06-20 Dipharma Spa Procedimento per la preparazione di entacapone
EP2063867A2 (de) * 2006-12-22 2009-06-03 Combinatorx, Incorporated Pharmazeutische zusammensetzungen zur behandlung von morbus parkinson und damit verbundenen leiden
ES2319024B1 (es) * 2007-02-13 2009-12-11 Quimica Sintetica, S.A. Procedimiento para la obtencion de entacapona sustancialmente libre de isomero z, sus intermedios de sintesis y nueva forma cristalina.
WO2009084031A2 (en) * 2007-12-03 2009-07-09 Neuland Laboratories Ltd An improved process for preparation of (2e)-2-cyano-3-(3,4- dihydroxy-5-nitrophenyl)n,n-diethyl-2-propenamide polymorphic form a
EP2251323B1 (de) 2009-05-14 2014-04-23 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Verfahren zur Reinigung von Entacapon
EA026419B1 (ru) 2010-03-04 2017-04-28 Орион Корпорейшн Применение леводопы, карбидопы и энтакапона для лечения болезни паркинсона
CN103845317B (zh) 2012-11-28 2018-05-08 北京生命科学研究所 恩他卡朋在预防或治疗肥胖等代谢综合征中的应用
US10987313B2 (en) 2013-10-07 2021-04-27 Impax Laboratories, Llc Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
CA2926082C (en) 2013-10-07 2022-06-14 Impax Laboratories, Inc. Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
CN104402764A (zh) * 2014-11-26 2015-03-11 千辉药业（安徽）有限责任公司 一种恩他卡朋的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU213587A (en) * 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives
EP0304493B1 (de) * 1987-03-11 1992-09-02 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Hydroxystyren-derivate
AU618595B2 (en) * 1988-04-28 1992-01-02 Suntory Limited Derivative of caffeic acid and pharmaceutical composition containing the same
JP2535058B2 (ja) * 1988-07-29 1996-09-18 富士通株式会社 半導体装置の製造方法

Also Published As

Publication number Publication date
BR1100289A (pt) 1999-10-05
US5135950A (en) 1992-08-04
JP2823680B2 (ja) 1998-11-11
DE69022166D1 (de) 1995-10-12
FI107149B (fi) 2001-06-15
GB8924838D0 (en) 1989-12-20
DK0426468T3 (da) 1995-10-23
ES2075885T3 (es) 1995-10-16
GB2238047A (en) 1991-05-22
JPH03169844A (ja) 1991-07-23
FI905198A0 (fi) 1990-10-23
DE69022166T2 (de) 1996-02-15
LU91071I2 (fr) 2005-06-21
DE122004000014I1 (de) 2004-08-12
GR3017526T3 (en) 1995-12-31
GB2238047B (en) 1993-02-10
NL300147I1 (nl) 2004-07-01
EP0426468B1 (de) 1995-09-06
EP0426468A3 (en) 1992-05-06
EP0426468A2 (de) 1991-05-08

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