DEU0001761MA - - Google Patents

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Publication number

DEU0001761MA

DEU0001761MA DEU0001761MA DE U0001761M A DEU0001761M A DE U0001761MA DE U0001761M A DEU0001761M A DE U0001761MA

Authority

DE

Germany

Prior art keywords

acetone

ethylene dichloride

dione

vol

rhizopus

Prior art date

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• HBGALFVDRUBTCE-UHFFFAOYSA-N 1,2-dichloroethane;propan-2-one Chemical compound CC(C)=O.ClCCCl HBGALFVDRUBTCE-UHFFFAOYSA-N 0.000 claims description 22
• 150000003431 steroids Chemical class 0.000 claims description 13
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
• 238000000034 method Methods 0.000 claims description 12
• 241000233866 Fungi Species 0.000 claims description 10
• 230000001590 oxidative effect Effects 0.000 claims description 5
• 102000004190 Enzymes Human genes 0.000 claims description 3
• 108090000790 Enzymes Proteins 0.000 claims description 3
• 241000235527 Rhizopus Species 0.000 claims description 3
• 241000235546 Rhizopus stolonifer Species 0.000 claims description 3
• 238000004519 manufacturing process Methods 0.000 claims description 3
• 241000894007 species Species 0.000 claims description 3
• 235000001674 Agaricus brunnescens Nutrition 0.000 claims description 2
• 241000235388 Mucorales Species 0.000 claims description 2
• 240000005384 Rhizopus oryzae Species 0.000 claims description 2
• 235000013752 Rhizopus oryzae Nutrition 0.000 claims description 2
• 238000000605 extraction Methods 0.000 claims description 2
• HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 claims description 2
• 229910052919 magnesium silicate Inorganic materials 0.000 claims description 2
• 235000019792 magnesium silicate Nutrition 0.000 claims description 2
• 239000000391 magnesium silicate Substances 0.000 claims description 2
• 239000002156 adsorbate Substances 0.000 claims 1
• 239000007795 chemical reaction product Substances 0.000 claims 1
• 238000000926 separation method Methods 0.000 claims 1
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 18
• 239000002904 solvent Substances 0.000 description 4
• 239000003795 chemical substances by application Substances 0.000 description 3
• 235000015097 nutrients Nutrition 0.000 description 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
• WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 2
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
• 239000000284 extract Substances 0.000 description 2
• 239000011521 glass Substances 0.000 description 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
• VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
• 239000007787 solid Substances 0.000 description 2
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 240000008042 Zea mays Species 0.000 description 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
• 238000010521 absorption reaction Methods 0.000 description 1
• 210000004404 adrenal cortex Anatomy 0.000 description 1
• 210000004100 adrenal gland Anatomy 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 239000003638 chemical reducing agent Substances 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1
• 235000005822 corn Nutrition 0.000 description 1
• 239000008121 dextrose Substances 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 230000002255 enzymatic effect Effects 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• 238000000855 fermentation Methods 0.000 description 1
• 230000004151 fermentation Effects 0.000 description 1
• 239000000706 filtrate Substances 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 238000005984 hydrogenation reaction Methods 0.000 description 1
• 238000011534 incubation Methods 0.000 description 1
• 238000002329 infrared spectrum Methods 0.000 description 1
• 125000000468 ketone group Chemical group 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 1
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
• 239000002480 mineral oil Substances 0.000 description 1
• 235000010446 mineral oil Nutrition 0.000 description 1
• 239000000203 mixture Substances 0.000 description 1
• 230000003647 oxidation Effects 0.000 description 1
• 238000007254 oxidation reaction Methods 0.000 description 1
• 230000010412 perfusion Effects 0.000 description 1
• 239000000047 product Substances 0.000 description 1
• 239000005297 pyrex Substances 0.000 description 1
• 239000002994 raw material Substances 0.000 description 1
• 239000011541 reaction mixture Substances 0.000 description 1
• 238000006722 reduction reaction Methods 0.000 description 1
• 239000010822 slaughterhouse waste Substances 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
• 235000017557 sodium bicarbonate Nutrition 0.000 description 1
• 235000010344 sodium nitrate Nutrition 0.000 description 1
• 239000004317 sodium nitrate Substances 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• -1 steroids Steroids Chemical class 0.000 description 1
• 238000003786 synthesis reaction Methods 0.000 description 1
• FKHIFSZMMVMEQY-UHFFFAOYSA-N talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 238000005303 weighing Methods 0.000 description 1