DE9190107U1 - Abgabe-Vorrichtung mit durch Grenzflächen-Polymerisation erhaltenen Membranen - Google Patents
Abgabe-Vorrichtung mit durch Grenzflächen-Polymerisation erhaltenen MembranenInfo
- Publication number
- DE9190107U1 DE9190107U1 DE9190107U DE9190107U DE9190107U1 DE 9190107 U1 DE9190107 U1 DE 9190107U1 DE 9190107 U DE9190107 U DE 9190107U DE 9190107 U DE9190107 U DE 9190107U DE 9190107 U1 DE9190107 U1 DE 9190107U1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- dispensing device
- interfacial polymerization
- membranes obtained
- date feb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Medicinal Preparation (AREA)
- Polyesters Or Polycarbonates (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Polyurethanes Or Polyureas (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56400890A | 1990-08-07 | 1990-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE9190107U1 true DE9190107U1 (de) | 1993-12-16 |
Family
ID=24252794
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE9190107U Expired - Lifetime DE9190107U1 (de) | 1990-08-07 | 1991-08-01 | Abgabe-Vorrichtung mit durch Grenzflächen-Polymerisation erhaltenen Membranen |
DE69107461T Expired - Fee Related DE69107461T2 (de) | 1990-08-07 | 1991-08-01 | Verwendung von interfacial polymerisierten membranen in abgabevorrichtungen. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69107461T Expired - Fee Related DE69107461T2 (de) | 1990-08-07 | 1991-08-01 | Verwendung von interfacial polymerisierten membranen in abgabevorrichtungen. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5876752A (de) |
EP (1) | EP0542926B1 (de) |
JP (1) | JPH0794379B2 (de) |
AT (1) | ATE118345T1 (de) |
CA (1) | CA2087435C (de) |
DE (2) | DE9190107U1 (de) |
DK (1) | DK0542926T3 (de) |
ES (1) | ES2067957T3 (de) |
FI (1) | FI108610B (de) |
GR (1) | GR3015731T3 (de) |
IE (1) | IE65403B1 (de) |
PT (1) | PT98571B (de) |
WO (1) | WO1992002212A2 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2267219B (en) * | 1992-05-28 | 1996-04-03 | Elan Corp Plc | Differential release tablet with multiple active agents |
WO1994012159A1 (en) * | 1992-11-30 | 1994-06-09 | Pfizer Inc. | Supported liquid membrane delivery devices |
ES2120354B1 (es) * | 1996-02-12 | 1999-07-01 | Univ Sevilla | Dispositivo terapeutico para direccionar farmacos hacia el tramo del tracto gastrointestinal deseado en funcion de las caracteristicas fisicoquimicas del mismo. |
EP0811374A1 (de) * | 1996-05-29 | 1997-12-10 | Pfizer Inc. | Formulierung für ein Kombinationspräparat mit Cetirizin und Pseudoephedrin |
WO1999001121A1 (en) | 1997-07-01 | 1999-01-14 | Pfizer Inc. | Sertraline salts and sustained-release dosage forms of sertraline |
US20030133974A1 (en) * | 1997-07-01 | 2003-07-17 | Curatolo William John | Encapsulated solution dosage forms of sertraline |
DK1035834T3 (da) * | 1997-12-05 | 2002-07-08 | Alza Corp | Osmotisk doseringsform omfattende en første og anden coating |
DE19814256A1 (de) * | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Feste, schnellzerfallende Cetirizin-Formulierungen |
ATE424810T1 (de) | 1998-12-11 | 2009-03-15 | Nostrum Pharmaceuticals Inc | Ein hydrokolloid und einen celluloseether enthaltende tablette mit verzögerter freisetzung |
GB9923045D0 (en) * | 1999-09-29 | 1999-12-01 | Novartis Ag | New oral formulations |
US6613357B2 (en) * | 2000-01-13 | 2003-09-02 | Osmotica Corp. | Osmotic device containing pseudoephedrine and an H1 antagonist |
MXPA02007254A (es) | 2000-02-04 | 2002-12-09 | Depomed Inc | Forma de dosis de cubierta-y-nucleo que se aproxima a liberacion de droga de orden cero. |
US6616652B1 (en) | 2000-02-15 | 2003-09-09 | Microsolutions, Inc. | Osmotic pump delivery system with pre-hydrated membrane(s) and/or primable catheter |
US6464688B1 (en) | 2000-02-15 | 2002-10-15 | Microsolutions, Inc. | Osmotic pump delivery system with flexible drug compartment |
WO2002036077A2 (en) * | 2000-11-06 | 2002-05-10 | Andrx Pharmaceuticals, Inc. | Once a day antihistamine and decongestant formulation |
US6632217B2 (en) | 2001-04-19 | 2003-10-14 | Microsolutions, Inc. | Implantable osmotic pump |
KR20090029314A (ko) * | 2001-06-28 | 2009-03-20 | 유씨비 파쉼 소시에떼아노님 | 세티리진 및 슈도에페드린을 포함하는 정제 |
CN100335041C (zh) | 2002-04-04 | 2007-09-05 | 辉瑞产品公司 | 美味咀嚼片剂 |
US8092831B2 (en) * | 2002-11-08 | 2012-01-10 | Andrx Pharmaceuticals, Llc | Antihistamine and decongestant system |
US20040131672A1 (en) * | 2003-01-07 | 2004-07-08 | Nilobon Podhipleux | Direct compression pharmaceutical composition containing a pharmaceutically active ingredient with poor flowing properties |
PL196544B1 (pl) * | 2003-08-08 | 2008-01-31 | Biovail Lab Int Srl | Tabletka o zmodyfikowanym uwalnianiu |
US20060200250A1 (en) * | 2005-03-04 | 2006-09-07 | Ku David N | Biocompatible implant device |
US20070036859A1 (en) * | 2005-08-11 | 2007-02-15 | Perry Ronald L | Sustained release antihistamine and decongestant composition |
NZ573174A (en) * | 2006-06-01 | 2012-01-12 | Msd Consumer Care Inc | Sustained release pharmaceutical dosage form containing phenylephrine |
PL2034970T3 (pl) * | 2006-06-01 | 2012-12-31 | Msd Consumer Care Inc | Preparat farmaceutyczny o przedłużonym uwalnianiu zawierający fenylefrynę |
TWI405567B (zh) * | 2006-06-01 | 2013-08-21 | Merck Sharp & Dohme | 持續釋放脫羥腎上腺素之醫藥組合物 |
CN101472561A (zh) * | 2006-06-01 | 2009-07-01 | 先灵公司 | 去氧肾上腺素脉冲释放制剂和药物组合物 |
US20080299186A1 (en) * | 2007-06-01 | 2008-12-04 | Schering-Plough Healthcare Products, Inc. | Coatings for applying substances onto substrate carrier |
PE20091084A1 (es) * | 2007-12-07 | 2009-07-23 | Schering Plough Healthcare | Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal |
US8857629B2 (en) | 2010-07-15 | 2014-10-14 | International Business Machines Corporation | Composite membrane with multi-layered active layer |
US9022227B2 (en) | 2011-03-21 | 2015-05-05 | International Business Machines Corporation | Composite membranes and methods of preparation thereof |
US9561474B2 (en) | 2012-06-07 | 2017-02-07 | International Business Machines Corporation | Composite membrane with multi-layered active layer |
JP6532010B2 (ja) * | 2015-03-25 | 2019-06-19 | トッパン・フォームズ株式会社 | マイクロカプセル、シート、樹脂組成物及び液状組成物 |
CA3169982A1 (en) | 2020-02-03 | 2021-08-12 | Johnson & Johnson Consumer Inc. | A single layer chewable tablet comprising cetirizine |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL271831A (de) * | 1960-11-29 | |||
US3270100A (en) * | 1962-08-01 | 1966-08-30 | Delvan Mfg Company | Method for making capsules by interfacial polymerization |
US3577515A (en) * | 1963-12-13 | 1971-05-04 | Pennwalt Corp | Encapsulation by interfacial polycondensation |
US3615536A (en) * | 1968-01-02 | 1971-10-26 | Eastman Kodak Co | Photographic element and process having a light-sensitive metal complex |
US3538214A (en) * | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
US3995631A (en) * | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
US3875074A (en) * | 1972-03-06 | 1975-04-01 | Champion Int Corp | Formation of microcapsules by interfacial cross-linking of emulsifier, and microcapsules produced thereby |
US3884801A (en) * | 1972-05-02 | 1975-05-20 | Us Interior | Preparation of reverse osmosis membranes by complete evaporation of the solvent system |
US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3952741A (en) * | 1975-01-09 | 1976-04-27 | Bend Research Inc. | Controlled release delivery system by an osmotic bursting mechanism |
US4056610A (en) * | 1975-04-09 | 1977-11-01 | Minnesota Mining And Manufacturing Company | Microcapsule insecticide composition |
US3977404A (en) * | 1975-09-08 | 1976-08-31 | Alza Corporation | Osmotic device having microporous reservoir |
US4077407A (en) * | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
US4016880A (en) * | 1976-03-04 | 1977-04-12 | Alza Corporation | Osmotically driven active agent dispenser |
HU174057B (hu) * | 1976-09-17 | 1979-10-28 | Richter Gedeon Vegyeszet | Sostav dlja pokrytij obespechivajuhhij uregulirovannuju otdachy aktivnogo vehhestva biologicheski aktivnykh preparatov i sposob poluchenija takikh preparatov s uregulirovannoj otdachej aktivnogo vehhestva |
US4203439A (en) * | 1976-11-22 | 1980-05-20 | Alza Corporation | Osmotic system with volume amplifier for increasing amount of agent delivered therefrom |
NZ185772A (en) * | 1976-11-26 | 1978-12-18 | Pennwalt Corp | A pharmaceutical composition comprising a complex of a drug absorbed on an ion exchange resin the complex being treated with a solvating agent and then coated |
US4160452A (en) * | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
US4251387A (en) * | 1979-04-17 | 1981-02-17 | Damon Corporation | Process for preparing semipermeable microcapsules |
IL59063A (en) * | 1979-01-11 | 1983-12-30 | Key Pharma | Polymeric diffusion matrix for release of pharmaceutical dosage |
US4235236A (en) * | 1979-02-12 | 1980-11-25 | Alza Corporation | Device for dispensing drug by combined diffusional and osmotic operations |
US4423009A (en) * | 1980-04-02 | 1983-12-27 | Aluminium Pechiney | Carbonate, sulphate and hydroxide or hydrogen carbonate |
DE3020781C2 (de) * | 1980-05-31 | 1982-11-18 | Hoechst Ag, 6000 Frankfurt | Druckbeständige Mikrokapseln mit einer Polyamid-Außenhülle und einer durch Polyurethan-Polyharnstoff oder Polyharnstoff strukturierten Innenmasse und Verfahren zu ihrer Herstellung |
US4333972A (en) * | 1980-06-25 | 1982-06-08 | Puropore, Inc. | Highly anisotropic membranes |
DE3167521D1 (en) * | 1981-01-22 | 1985-01-17 | Capsugel Ag | A process for producing a pharmaceutical capsule having enteric properties |
DE3264867D1 (en) * | 1981-04-27 | 1985-08-29 | Haessle Ab | New pharmaceutical preparation |
ZA822995B (en) * | 1981-05-21 | 1983-12-28 | Wyeth John & Brother Ltd | Slow release pharmaceutical composition |
FR2514261B1 (fr) * | 1981-10-08 | 1986-08-22 | Aec Chim Organ Biolog | Nouvelle composition pour l'enrobage des aliments et des medicaments et granules ainsi enrobes |
JPS58134019A (ja) * | 1982-02-05 | 1983-08-10 | Ono Pharmaceut Co Ltd | プロスタグランジン含有持続放出型三層状フイルム製剤及びその製造方法 |
US4439196A (en) * | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
US4455143A (en) * | 1982-03-22 | 1984-06-19 | Alza Corporation | Osmotic device for dispensing two different medications |
US4443428A (en) * | 1982-06-21 | 1984-04-17 | Euroceltique, S.A. | Extended action controlled release compositions |
US4557925A (en) * | 1982-07-08 | 1985-12-10 | Ab Ferrosan | Membrane-coated sustained-release tablets and method |
DK152744C (da) * | 1982-08-13 | 1988-10-31 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat |
US4673405A (en) * | 1983-03-04 | 1987-06-16 | Alza Corporation | Osmotic system with instant drug availability |
US4576604A (en) * | 1983-03-04 | 1986-03-18 | Alza Corporation | Osmotic system with instant drug availability |
NZ206600A (en) * | 1983-05-11 | 1987-01-23 | Alza Corp | Osmotic drug delivery device |
GB8322007D0 (en) * | 1983-08-16 | 1983-09-21 | Wellcome Found | Pharmaceutical delivery system |
US4680323A (en) * | 1983-12-01 | 1987-07-14 | Hans Lowey | Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration |
US4563212A (en) * | 1983-12-27 | 1986-01-07 | Monsanto Company | High concentration encapsulation by interfacial polycondensation |
US4643764A (en) * | 1984-01-09 | 1987-02-17 | Stauffer Chemical Company | Multiple types of microcapsules and their production |
DE3404310A1 (de) * | 1984-02-08 | 1985-08-08 | Henkel KGaA, 4000 Düsseldorf | Verwendung von salicylsaeureestern als riechstoffe und diese enthaltende riechstoffkompositionen |
US4684524A (en) * | 1984-03-19 | 1987-08-04 | Alza Corporation | Rate controlled dispenser for administering beneficial agent |
NL8401912A (nl) * | 1984-06-15 | 1986-01-02 | Tno | Met aktieve stof beladen biodegradeerbare polymeersubstraten, geschikt voor het gecontroleerd afgeven van de aktieve stof door middel van een membraan. |
DE3486409T2 (de) * | 1984-08-17 | 1996-04-25 | Wellcome Found | Zusammensetzung zur kontrollierten Abgabe eines Wirkstoffs. |
US4629619A (en) * | 1984-09-05 | 1986-12-16 | Ab Ferrosan | Membrane-coated sustained-release tablets and method |
US4629620A (en) * | 1984-09-05 | 1986-12-16 | Ab Ferrosan | Membrane-coated sustained-release tablets and method |
SE8404467D0 (sv) * | 1984-09-06 | 1984-09-06 | Ferrosan Ab | Controlled-release medical preparations |
BR8506634A (pt) * | 1984-12-20 | 1986-09-09 | Rhone Poulenc Sante | Composicoes para o revestimento de aditivos alimentares destinados aos ruminantes e granulados sob forma de microcapsulas assim revestidos |
FR2577227B1 (fr) * | 1985-02-11 | 1987-05-15 | Inst Nat Rech Chimique | Membranes asymetriques ou composites a base de polyquinoxalines, leur application possible en permeation gazeuse et plus particulierement pour le fractionnement des melanges gazeux, et notamment la deshydratation et la desacidification des gaz, specialement les hydrocarbures gazeux |
ES8801121A1 (es) * | 1985-02-19 | 1988-01-01 | Key Pharma | Procedimiento de fabricacion de una unidad de dosificacion para la administracion oral de cloruro potasico. |
US4609374A (en) * | 1985-04-22 | 1986-09-02 | Alza Corporation | Osmotic device comprising means for governing initial time of agent release therefrom |
GB8521494D0 (en) * | 1985-08-29 | 1985-10-02 | Zyma Sa | Controlled release tablet |
US4693896A (en) * | 1985-10-07 | 1987-09-15 | Fmc Corporation | Ethylcellulose-coated, gastric-disintegrable aspirin tablet |
SE455836B (sv) * | 1985-10-11 | 1988-08-15 | Haessle Ab | Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning |
SE450087B (sv) * | 1985-10-11 | 1987-06-09 | Haessle Ab | Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial |
US4892742A (en) * | 1985-11-18 | 1990-01-09 | Hoffmann-La Roche Inc. | Controlled release compositions with zero order release |
JPS62163702A (ja) * | 1986-01-14 | 1987-07-20 | Nok Corp | 界面重合逆浸透膜 |
JPS62197183A (ja) * | 1986-02-24 | 1987-08-31 | Nisshinbo Ind Inc | 表面多孔性プラスチツクシ−トの製造方法 |
ATE59550T1 (de) * | 1986-04-17 | 1991-01-15 | Alza Corp | Chlorpheniramine therapie. |
US4816264A (en) * | 1986-06-06 | 1989-03-28 | Warner-Lambert Company | Sustained release formulations |
US4786500A (en) * | 1986-06-26 | 1988-11-22 | Alza Corporation | Programmable agent delivery system |
US4803076A (en) * | 1986-09-04 | 1989-02-07 | Pfizer Inc. | Controlled release device for an active substance |
US4767789A (en) * | 1986-10-21 | 1988-08-30 | American Home Products Corporation (Del.) | Spray dried acetaminophen |
US4828705A (en) * | 1986-10-31 | 1989-05-09 | Kingston Technologies, Inc. | Pressure-dependent anisotropic-transport membrane system |
US4954381A (en) * | 1986-12-30 | 1990-09-04 | The Research Foundation Of The State University Of New York | Preparation of porous substrates having well defined morphology |
US4837111A (en) * | 1988-03-21 | 1989-06-06 | Alza Corporation | Dosage form for dispensing drug for human therapy |
IL91398A (en) * | 1988-08-30 | 1994-05-30 | Pfizer | A device for the controlled release of pneumatic substances, including the active substance, surrounded by an asymmetric membrane |
-
1991
- 1991-08-01 CA CA002087435A patent/CA2087435C/en not_active Expired - Fee Related
- 1991-08-01 DE DE9190107U patent/DE9190107U1/de not_active Expired - Lifetime
- 1991-08-01 AT AT91919243T patent/ATE118345T1/de not_active IP Right Cessation
- 1991-08-01 JP JP3516602A patent/JPH0794379B2/ja not_active Expired - Fee Related
- 1991-08-01 ES ES91919243T patent/ES2067957T3/es not_active Expired - Lifetime
- 1991-08-01 DE DE69107461T patent/DE69107461T2/de not_active Expired - Fee Related
- 1991-08-01 EP EP91919243A patent/EP0542926B1/de not_active Expired - Lifetime
- 1991-08-01 WO PCT/US1991/005337 patent/WO1992002212A2/en active IP Right Grant
- 1991-08-01 US US07/969,844 patent/US5876752A/en not_active Expired - Fee Related
- 1991-08-01 DK DK91919243.5T patent/DK0542926T3/da active
- 1991-08-05 PT PT98571A patent/PT98571B/pt not_active IP Right Cessation
- 1991-08-06 IE IE278191A patent/IE65403B1/en not_active IP Right Cessation
-
1993
- 1993-02-05 FI FI930509A patent/FI108610B/fi not_active IP Right Cessation
-
1995
- 1995-04-10 GR GR950400864T patent/GR3015731T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IE912781A1 (en) | 1992-02-12 |
FI108610B (fi) | 2002-02-28 |
WO1992002212A3 (en) | 1992-04-02 |
WO1992002212A2 (en) | 1992-02-20 |
PT98571A (pt) | 1993-09-30 |
EP0542926A1 (de) | 1993-05-26 |
DK0542926T3 (da) | 1995-05-15 |
US5876752A (en) | 1999-03-02 |
FI930509A0 (fi) | 1993-02-05 |
IE65403B1 (en) | 1995-10-18 |
ES2067957T3 (es) | 1995-04-01 |
DE69107461D1 (de) | 1995-03-23 |
DE69107461T2 (de) | 1995-06-22 |
CA2087435C (en) | 1998-05-05 |
FI930509A (fi) | 1993-02-05 |
CA2087435A1 (en) | 1992-02-08 |
EP0542926B1 (de) | 1995-02-15 |
JPH05509107A (ja) | 1993-12-16 |
GR3015731T3 (en) | 1995-07-31 |
ATE118345T1 (de) | 1995-03-15 |
JPH0794379B2 (ja) | 1995-10-11 |
PT98571B (pt) | 1999-03-31 |
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