DE69940198D1 - Mikrovorrichtung zum screening von biomolekülen - Google Patents
Mikrovorrichtung zum screening von biomolekülenInfo
- Publication number
- DE69940198D1 DE69940198D1 DE69940198T DE69940198T DE69940198D1 DE 69940198 D1 DE69940198 D1 DE 69940198D1 DE 69940198 T DE69940198 T DE 69940198T DE 69940198 T DE69940198 T DE 69940198T DE 69940198 D1 DE69940198 D1 DE 69940198D1
- Authority
- DE
- Germany
- Prior art keywords
- devices
- screening
- micro
- biomolecules
- parallel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000012216 screening Methods 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000007877 drug screening Methods 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Materials Engineering (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Composite Materials (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/115,397 US6576478B1 (en) | 1998-07-14 | 1998-07-14 | Microdevices for high-throughput screening of biomolecules |
PCT/US1999/015969 WO2000004390A2 (en) | 1998-07-14 | 1999-07-14 | Microdevices for screening biomolecules |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69940198D1 true DE69940198D1 (de) | 2009-02-12 |
Family
ID=22361123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69940198T Expired - Lifetime DE69940198D1 (de) | 1998-07-14 | 1999-07-14 | Mikrovorrichtung zum screening von biomolekülen |
Country Status (8)
Country | Link |
---|---|
US (6) | US6576478B1 (de) |
EP (1) | EP1097379B1 (de) |
JP (1) | JP4489949B2 (de) |
AT (1) | ATE419527T1 (de) |
AU (1) | AU764027B2 (de) |
CA (1) | CA2337197C (de) |
DE (1) | DE69940198D1 (de) |
WO (1) | WO2000004390A2 (de) |
Families Citing this family (229)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU755913B2 (en) | 1997-06-18 | 2003-01-02 | Masad Damha | Nucleic acid biosensor diagnostics |
US6893877B2 (en) | 1998-01-12 | 2005-05-17 | Massachusetts Institute Of Technology | Methods for screening substances in a microwell array |
EP2189791A3 (de) | 1998-02-04 | 2011-03-09 | Life Technologies Corporation | Mikroarrays und Verwendungen dafür |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US6780582B1 (en) | 1998-07-14 | 2004-08-24 | Zyomyx, Inc. | Arrays of protein-capture agents and methods of use thereof |
US6794197B1 (en) | 1998-07-14 | 2004-09-21 | Zyomyx, Inc. | Microdevice and method for detecting a characteristic of a fluid |
US6576478B1 (en) * | 1998-07-14 | 2003-06-10 | Zyomyx, Inc. | Microdevices for high-throughput screening of biomolecules |
US6897073B2 (en) * | 1998-07-14 | 2005-05-24 | Zyomyx, Inc. | Non-specific binding resistant protein arrays and methods for making the same |
US20020119579A1 (en) * | 1998-07-14 | 2002-08-29 | Peter Wagner | Arrays devices and methods of use thereof |
DE19853640C2 (de) * | 1998-11-20 | 2002-01-31 | Molecular Machines & Ind Gmbh | Mehrgefäßanordnung mit verbesserter Empfindlichkeit für die optische Analytik, Verfahren zu ihrer Herstellung sowie ihre Verwendung in optischen Analyseverfahren |
US6827979B2 (en) | 1999-01-07 | 2004-12-07 | Northwestern University | Methods utilizing scanning probe microscope tips and products therefor or produced thereby |
US6635311B1 (en) | 1999-01-07 | 2003-10-21 | Northwestern University | Methods utilizing scanning probe microscope tips and products therefor or products thereby |
US6573369B2 (en) | 1999-05-21 | 2003-06-03 | Bioforce Nanosciences, Inc. | Method and apparatus for solid state molecular analysis |
US7195670B2 (en) | 2000-06-27 | 2007-03-27 | California Institute Of Technology | High throughput screening of crystallization of materials |
US7052545B2 (en) * | 2001-04-06 | 2006-05-30 | California Institute Of Technology | High throughput screening of crystallization of materials |
US8709153B2 (en) | 1999-06-28 | 2014-04-29 | California Institute Of Technology | Microfludic protein crystallography techniques |
US7179638B2 (en) * | 1999-07-30 | 2007-02-20 | Large Scale Biology Corporation | Microarrays and their manufacture by slicing |
US6969506B2 (en) * | 1999-08-17 | 2005-11-29 | Battelle Memorial Institute | Methods of conducting simultaneous exothermic and endothermic reactions |
US20020151040A1 (en) * | 2000-02-18 | 2002-10-17 | Matthew O' Keefe | Apparatus and methods for parallel processing of microvolume liquid reactions |
WO2001061054A2 (en) * | 2000-02-18 | 2001-08-23 | Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of micro-volume liquid reactions |
JP2003524193A (ja) | 2000-02-23 | 2003-08-12 | ザイオミックス インコーポレイテッド | 高い位置に配置されたサンプル表面を有するチップ |
US6686461B1 (en) | 2000-03-22 | 2004-02-03 | Solulink Bioscience, Inc. | Triphosphate oligonucleotide modification reagents and uses thereof |
US7102024B1 (en) | 2000-08-01 | 2006-09-05 | Schwartz David A | Functional biopolymer modification reagents and uses thereof |
US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
SE0001669D0 (sv) * | 2000-05-04 | 2000-05-04 | Forskarpatent I Syd Ab | Monitoring of analytes at submicromolar with extremely high sensitivity |
US8399383B2 (en) * | 2000-05-04 | 2013-03-19 | Yale University | Protein chips for high throughput screening of protein activity |
US7005078B2 (en) * | 2000-05-25 | 2006-02-28 | Debiotech Sa | Micromachined fluidic device and method for making same |
US20020049152A1 (en) * | 2000-06-19 | 2002-04-25 | Zyomyx, Inc. | Methods for immobilizing polypeptides |
AU2001278968A1 (en) * | 2000-07-19 | 2002-01-30 | Pointilliste, Inc. | Nested sorting and high throughput screening |
US7354721B2 (en) | 2000-09-22 | 2008-04-08 | Clontech Laboratories, Inc. | Highly sensitive proteomic analysis methods, and kits and systems for practicing the same |
CA2425476C (en) * | 2000-10-10 | 2011-02-01 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
US20100261159A1 (en) * | 2000-10-10 | 2010-10-14 | Robert Hess | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
WO2002045215A2 (en) | 2000-10-20 | 2002-06-06 | Northwestern University | Nanolithography methods and products therefor and produced thereby |
US7371563B2 (en) | 2000-11-08 | 2008-05-13 | Surface Logix, Inc. | Peelable and resealable devices for biochemical assays |
US7351575B2 (en) | 2000-11-08 | 2008-04-01 | Surface Logix, Inc. | Methods for processing biological materials using peelable and resealable devices |
US7439056B2 (en) | 2000-11-08 | 2008-10-21 | Surface Logix Inc. | Peelable and resealable devices for arraying materials |
US6803205B2 (en) | 2000-11-08 | 2004-10-12 | Surface Logix, Inc. | Methods of measuring enzyme activity using peelable and resealable devices |
US7001740B2 (en) | 2000-11-08 | 2006-02-21 | Surface Logix, Inc. | Methods of arraying biological materials using peelable and resealable devices |
US6967074B2 (en) | 2000-11-08 | 2005-11-22 | Surface Logix, Inc. | Methods of detecting immobilized biomolecules |
US6653121B2 (en) * | 2000-11-10 | 2003-11-25 | Tactical Fabs, Inc. | Roughened and oxidized well chips and method of making same |
US6905816B2 (en) | 2000-11-27 | 2005-06-14 | Intelligent Medical Devices, Inc. | Clinically intelligent diagnostic devices and methods |
EP2202520A1 (de) | 2000-11-27 | 2010-06-30 | Intelligent Medical Devices LLC | Klinische intelligente diagnostische Vorrichtungen und Verfahren |
US7776571B2 (en) | 2000-12-12 | 2010-08-17 | Autogenomics, Inc. | Multi-substrate biochip unit |
US6582987B2 (en) * | 2000-12-30 | 2003-06-24 | Electronics And Telecommunications Research Institute | Method of fabricating microchannel array structure embedded in silicon substrate |
US7332286B2 (en) | 2001-02-02 | 2008-02-19 | University Of Pennsylvania | Peptide or protein microassay method and apparatus |
US6913697B2 (en) * | 2001-02-14 | 2005-07-05 | Science & Technology Corporation @ Unm | Nanostructured separation and analysis devices for biological membranes |
US20020164816A1 (en) * | 2001-04-06 | 2002-11-07 | California Institute Of Technology | Microfluidic sample separation device |
US6752922B2 (en) * | 2001-04-06 | 2004-06-22 | Fluidigm Corporation | Microfluidic chromatography |
AU2002307152A1 (en) | 2001-04-06 | 2002-10-21 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
US7183050B2 (en) | 2001-04-18 | 2007-02-27 | Krull Ulrich J | Gradient resolved information platform |
AU2002338428A1 (en) * | 2001-04-20 | 2002-11-05 | Carnegie Mellon University | Methods and systems for identifying proteins |
US7723123B1 (en) * | 2001-06-05 | 2010-05-25 | Caliper Life Sciences, Inc. | Western blot by incorporating an affinity purification zone |
AU2002327220A1 (en) * | 2001-07-10 | 2003-01-29 | Wisconsin Alumni Research Foundation | Surface plasmon resonance imaging of micro-arrays |
EP1410029B1 (de) | 2001-07-16 | 2007-09-12 | Protein Forest, Inc. | Puffer-arrays zum nachweis von biomolekülen anhand ihres isoelektrischen punktes |
US6976527B2 (en) * | 2001-07-17 | 2005-12-20 | The Regents Of The University Of California | MEMS microcapillary pumped loop for chip-level temperature control |
US7128876B2 (en) * | 2001-07-17 | 2006-10-31 | Agilent Technologies, Inc. | Microdevice and method for component separation in a fluid |
US20030143612A1 (en) * | 2001-07-18 | 2003-07-31 | Pointilliste, Inc. | Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening |
US6977138B2 (en) | 2001-07-24 | 2005-12-20 | Massachusetts Institute Of Technology | Reactive polymer coatings |
US7666661B2 (en) | 2001-08-27 | 2010-02-23 | Platypus Technologies, Llc | Substrates, devices, and methods for quantitative liquid crystal assays |
AT500669B1 (de) * | 2001-09-24 | 2007-02-15 | Oesterr Forsch Seibersdorf | Fester träger zur immobilisierung von biomolekülen |
TWI272386B (en) * | 2001-10-02 | 2007-02-01 | Univ Northwestern | Protein and peptide nanoarrays |
US8440093B1 (en) | 2001-10-26 | 2013-05-14 | Fuidigm Corporation | Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels |
EP1451357A4 (de) * | 2001-11-01 | 2005-10-26 | Univ California | Biokatalytische sol-gel-mikroarrays |
US7691333B2 (en) | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
ES2403560T3 (es) | 2001-11-30 | 2013-05-20 | Fluidigm Corporation | Dispositivo microfluídico y procedimientos de utilización del mismo |
US7361310B1 (en) | 2001-11-30 | 2008-04-22 | Northwestern University | Direct write nanolithographic deposition of nucleic acids from nanoscopic tips |
GB2384239A (en) | 2001-12-05 | 2003-07-23 | Sense Proteomic Ltd | Arrays of protein variants |
EP1770429A3 (de) * | 2001-12-11 | 2007-04-11 | Autogenomics, Inc. | Mehrfachsubstrat-biochip-einheit |
US20050221283A1 (en) * | 2001-12-11 | 2005-10-06 | Mahant Vijay K | Biochip |
EP1474504A2 (de) * | 2002-01-24 | 2004-11-10 | Pointilliste, Inc. | Verwendung von sammlungen von bindungsstellen für die probenprofilierung und andere anwendungen |
JP3740528B2 (ja) * | 2002-02-05 | 2006-02-01 | 独立行政法人産業技術総合研究所 | 微細粒子製造方法 |
US6703216B2 (en) | 2002-03-14 | 2004-03-09 | The Regents Of The University Of California | Methods, compositions and apparatuses for detection of gamma-hydroxybutyric acid (GHB) |
AU2003224817B2 (en) | 2002-04-01 | 2008-11-06 | Fluidigm Corporation | Microfluidic particle-analysis systems |
GB0208766D0 (en) * | 2002-04-02 | 2002-05-29 | Univ Surrey | Liquid-liquid separation |
US7112444B2 (en) * | 2002-04-24 | 2006-09-26 | Wisconsin Alumni Research Foundation | Method of performing gradient-based assays in a microfluidic device |
SE0201257D0 (sv) * | 2002-04-25 | 2002-04-25 | Medical Invest In Sweden Ab | Improved Separation |
JP4895504B2 (ja) * | 2002-04-30 | 2012-03-14 | ユィロス・パテント・アクチボラグ | 集中マイクロ流体デバイス(ea) |
WO2003093802A1 (en) * | 2002-04-30 | 2003-11-13 | Gyros Ab | Integrated microfluidic device (ea) |
JP4030796B2 (ja) * | 2002-05-13 | 2008-01-09 | 富士フイルム株式会社 | 測定チップ |
AU2003300257A1 (en) | 2002-05-21 | 2004-05-04 | Northwestern University | Peptide and protein arrays and direct-write lithographic printing of peptides and proteins |
EP1549953A4 (de) * | 2002-05-22 | 2006-12-06 | Platypus Technologies Inc | Substrate, vorrichtungen und verfahren für zelltests |
US8268614B2 (en) | 2002-05-22 | 2012-09-18 | Platypus Technologies, Llc | Method for assaying cell movement |
AU2003248273A1 (en) * | 2002-07-12 | 2004-02-02 | Mitsubishi Chemical Corporation | Analytical chip, analytical chip unit, analyzing apparatus, method of analysis using the apparatus, and method of producing the analytical chip |
US20050008828A1 (en) * | 2002-07-25 | 2005-01-13 | Trustees Of Stevens Institute Of Technology | Patterned polymer microgel and method of forming same |
US8277753B2 (en) | 2002-08-23 | 2012-10-02 | Life Technologies Corporation | Microfluidic transfer pin |
EP2213615A3 (de) | 2002-09-25 | 2012-02-29 | California Institute of Technology | Mikrofluidische Großintegration |
US20040226620A1 (en) * | 2002-09-26 | 2004-11-18 | Daniel Therriault | Microcapillary networks |
AU2003277153A1 (en) | 2002-09-27 | 2004-04-19 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
WO2004040001A2 (en) | 2002-10-02 | 2004-05-13 | California Institute Of Technology | Microfluidic nucleic acid analysis |
EP1576126A3 (de) * | 2002-10-30 | 2005-10-26 | Pointilliste, Inc. | Systeme zum einfangen und zur analyse biologischer partikel und verfahren unter verwendung dieser systeme |
EP1562742A4 (de) * | 2002-10-31 | 2008-08-06 | Georgia Tech Res Inst | Mikrostrukturen und herstellungsverfahren dafür |
US7682565B2 (en) | 2002-12-20 | 2010-03-23 | Biotrove, Inc. | Assay apparatus and method using microfluidic arrays |
US20060094108A1 (en) * | 2002-12-20 | 2006-05-04 | Karl Yoder | Thermal cycler for microfluidic array assays |
US7172682B2 (en) * | 2003-01-24 | 2007-02-06 | Rensselaer Polytechnic Institute | Enzyme immobilization for electroosmotic flow |
EP1594798B1 (de) | 2003-01-30 | 2018-12-19 | Gyros Patent Ab | Innenwände mikrofluidischer vorrichtungen |
EP1597577A4 (de) * | 2003-02-10 | 2007-02-21 | Pointilliste Inc | Selbstanordnende arrays und ihre anwendung |
DE10312628A1 (de) * | 2003-03-21 | 2004-10-07 | Friz Biochem Gmbh | Verfahren und Vorrichtung zum Benetzen eines Substrats mit einer Flüssigkeit |
US7416708B2 (en) * | 2003-04-01 | 2008-08-26 | Nihon University | Method of measuring protein solubility, process for producing crystal and apparatus therefor |
US20050145496A1 (en) | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
US7666361B2 (en) | 2003-04-03 | 2010-02-23 | Fluidigm Corporation | Microfluidic devices and methods of using same |
US8828663B2 (en) | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US7604965B2 (en) | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US7476363B2 (en) * | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
US20040209383A1 (en) * | 2003-04-17 | 2004-10-21 | Industrial Technology Research Institute | Lift-off process for protein chip |
EP1616180A4 (de) * | 2003-04-22 | 2006-07-19 | Ciphergen Biosystems Inc | Analyseverfahren für wirtszellproteine |
US7316543B2 (en) * | 2003-05-30 | 2008-01-08 | The Board Of Trustees Of The Leland Stanford Junior University | Electroosmotic micropump with planar features |
US20040253642A1 (en) * | 2003-06-06 | 2004-12-16 | Grant Zimmermann | System and method for multidimensional evaluation of combinations of compositions |
US20040248323A1 (en) * | 2003-06-09 | 2004-12-09 | Protometrix, Inc. | Methods for conducting assays for enzyme activity on protein microarrays |
US7141617B2 (en) * | 2003-06-17 | 2006-11-28 | The Board Of Trustees Of The University Of Illinois | Directed assembly of three-dimensional structures with micron-scale features |
EP1649056A1 (de) * | 2003-07-02 | 2006-04-26 | Caliper Life Sciences, Inc. | Verfahren zur amplifikation und zum nachweis von nukleinsäuren in mikrofluidvorrichtungen unter bedingungen mit kontinuierlichem und nicht kontinuierlichem fluss |
US20060014003A1 (en) * | 2003-07-24 | 2006-01-19 | Libera Matthew R | Functional nano-scale gels |
AU2004262301A1 (en) | 2003-07-25 | 2005-02-10 | Platypus Technologies, Llc | Liquid crystal based analyte detection |
US7413712B2 (en) | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
WO2005022156A1 (ja) * | 2003-08-29 | 2005-03-10 | Reverse Proteomics Research Institute Co., Ltd. | タンパク質の固定化方法 |
WO2005024378A2 (en) | 2003-09-03 | 2005-03-17 | Zyomix, Inc. | Ion detection using a pillar chip |
US20050059139A1 (en) * | 2003-09-11 | 2005-03-17 | Norihisa Mino | Device substrate, method of manufacturing the same, and microchip |
EP1516665A1 (de) | 2003-09-18 | 2005-03-23 | Sony International (Europe) GmbH | Verfahren zu der Immobilisierung und dem Spannen einer Nukleinsäure auf ein Substrat |
US7166212B2 (en) * | 2003-09-30 | 2007-01-23 | Chromba, Inc. | Multicapillary column for chromatography and sample preparation |
US20070017870A1 (en) | 2003-09-30 | 2007-01-25 | Belov Yuri P | Multicapillary device for sample preparation |
US20060046305A1 (en) * | 2003-10-15 | 2006-03-02 | National University Of Singapore | Method and apparatus for detecting analyte with filter |
US20050095648A1 (en) * | 2003-10-30 | 2005-05-05 | Mario Geysen | Method for designing linear epitopes and algorithm therefor and polypeptide epitopes |
US20060057597A1 (en) * | 2003-11-12 | 2006-03-16 | California Institute Of Technology | Method and system for processing nanoparticles using a self assembly mechanism to form combined species |
JP4372521B2 (ja) * | 2003-11-27 | 2009-11-25 | 日立ソフトウエアエンジニアリング株式会社 | 生体分子の回収方法 |
WO2005059552A1 (en) | 2003-12-15 | 2005-06-30 | University Of Pennsylvania | Method and devices for running reactions on a target plate for maldi mass spectrometry |
US20060018911A1 (en) * | 2004-01-12 | 2006-01-26 | Dana Ault-Riche | Design of therapeutics and therapeutics |
US7407799B2 (en) | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
AU2005208879B2 (en) * | 2004-01-25 | 2010-06-03 | Fluidigm Corporation | Crystal forming devices and systems and methods for making and using the same |
US20060065528A1 (en) * | 2004-02-03 | 2006-03-30 | Gabriel Lopez | Nanostructured devices for separation and analysis |
US20050260522A1 (en) * | 2004-02-13 | 2005-11-24 | William Weber | Permanent resist composition, cured product thereof, and use thereof |
EP1735097B1 (de) | 2004-03-12 | 2016-11-30 | Life Technologies Corporation | Ladung eines nanoliter-arrays |
US7723126B2 (en) * | 2004-03-24 | 2010-05-25 | Wisconsin Alumni Research Foundation | Plasma-enhanced functionalization of inorganic oxide surfaces |
US8916348B2 (en) * | 2004-05-06 | 2014-12-23 | Clondiag Gmbh | Method and device for the detection of molecular interactions |
US7449280B2 (en) * | 2004-05-26 | 2008-11-11 | Microchem Corp. | Photoimageable coating composition and composite article thereof |
US12070731B2 (en) | 2004-08-04 | 2024-08-27 | Life Technologies Corporation | Methods and systems for aligning dispensing arrays with microfluidic sample arrays |
US20060105453A1 (en) * | 2004-09-09 | 2006-05-18 | Brenan Colin J | Coating process for microfluidic sample arrays |
CA2577140A1 (en) * | 2004-08-04 | 2006-02-09 | Axela Biosensors Inc. | Patterned surfaces with chemical crosslinkers for use in diffraction-based sensing |
US20060068424A1 (en) * | 2004-08-13 | 2006-03-30 | Fuji Photo Film Co., Ltd. | Biosensor |
US20080050659A1 (en) * | 2004-09-30 | 2008-02-28 | Japan Science And Technology Agency | Method of Patterning Self-Organizing Material, Patterned Substrate of Self-Organizing Material and Method of Producing the Same, and Photomask Using Patterned Substrate of Self-Organizing Material |
KR100489853B1 (ko) * | 2004-11-24 | 2005-05-17 | 주식회사 아이엠티 | 충격파를 이용한 건식 표면 클리닝 장치 |
SE0403139D0 (sv) * | 2004-12-23 | 2004-12-23 | Nanoxis Ab | Device and use thereof |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
EP1874920A4 (de) * | 2005-04-05 | 2009-11-04 | Cellpoint Diagnostics | Vorrichtungen und verfahren zur anreicherung und veränderung zirkulierender tumorzellen und anderer partikel |
US7648844B2 (en) * | 2005-05-02 | 2010-01-19 | Bioscale, Inc. | Method and apparatus for detection of analyte using an acoustic device |
US7749445B2 (en) * | 2005-05-02 | 2010-07-06 | Bioscale, Inc. | Method and apparatus for analyzing bioprocess fluids |
US7300631B2 (en) * | 2005-05-02 | 2007-11-27 | Bioscale, Inc. | Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles |
US7611908B2 (en) * | 2005-05-02 | 2009-11-03 | Bioscale, Inc. | Method and apparatus for therapeutic drug monitoring using an acoustic device |
CA2610875A1 (en) * | 2005-06-06 | 2006-12-14 | Decision Biomarkers, Inc. | Assays based on liquid flow over arrays |
JP2007010341A (ja) * | 2005-06-28 | 2007-01-18 | Sumitomo Bakelite Co Ltd | 免疫分析方法 |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
EP1920045A4 (de) * | 2005-08-11 | 2011-07-06 | Life Technologies Corp | Vorrichtung für test, synthese und lagerung sowie verfahren zur herstellung, verwendung und manipulation davon |
US7662572B2 (en) | 2005-08-25 | 2010-02-16 | Platypus Technologies, Llc. | Compositions and liquid crystals |
JP2007057458A (ja) * | 2005-08-26 | 2007-03-08 | Fujifilm Corp | バイオセンサー |
US20070059716A1 (en) * | 2005-09-15 | 2007-03-15 | Ulysses Balis | Methods for detecting fetal abnormality |
FR2897858B1 (fr) * | 2006-02-27 | 2008-06-20 | Commissariat Energie Atomique | Procede de fabrication d'un reseau de capillaires d'une puce |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US7909928B2 (en) | 2006-03-24 | 2011-03-22 | The Regents Of The University Of Michigan | Reactive coatings for regioselective surface modification |
EP2351610A3 (de) | 2006-03-28 | 2011-10-12 | Inanovate, Inc. | Biochipsubstrat mit Nanopartikel |
JP4984648B2 (ja) * | 2006-05-26 | 2012-07-25 | 富士通株式会社 | 検出素子、その製造方法、および標的検出装置 |
US7947148B2 (en) | 2006-06-01 | 2011-05-24 | The Regents Of The University Of Michigan | Dry adhesion bonding |
US20080070792A1 (en) | 2006-06-14 | 2008-03-20 | Roland Stoughton | Use of highly parallel snp genotyping for fetal diagnosis |
US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
US20080007838A1 (en) * | 2006-07-07 | 2008-01-10 | Omnitech Partners, Inc. | Field-of-view indicator, and optical system and associated method employing the same |
AU2007273055B2 (en) | 2006-07-14 | 2014-05-01 | The Regents Of The University Of California | Cancer biomarkers and methods of use thereof |
JP4292279B2 (ja) * | 2006-07-18 | 2009-07-08 | ファルマ・アクセス株式会社 | 結晶作製器具 |
US7842499B2 (en) * | 2006-08-07 | 2010-11-30 | Platypus Technologies, Llc | Substrates, devices, and methods for cellular assays |
WO2008024483A2 (en) * | 2006-08-25 | 2008-02-28 | U.S. Genomics, Inc. | Array-based analyte detection |
KR100851980B1 (ko) * | 2006-09-05 | 2008-08-12 | 삼성전자주식회사 | 열 활성 유닛을 구비한 원심력 기반의 미세유동 장치, 이를포함하는 미세유동 시스템 및 상기 미세유동 시스템의구동방법 |
US20090087925A1 (en) * | 2007-10-01 | 2009-04-02 | Zyomyx, Inc. | Devices and methods for analysis of samples with depletion of analyte content |
GB0622956D0 (en) * | 2006-11-17 | 2006-12-27 | Univ Birmingham | Molecular detection system |
US8029902B2 (en) * | 2006-12-11 | 2011-10-04 | Wisconsin Alumni Research Foundation | Plasma-enhanced functionalization of substrate surfaces with quaternary ammonium and quaternary phosphonium groups |
US8399047B2 (en) | 2007-03-22 | 2013-03-19 | The Regents Of The Univeristy Of Michigan | Multifunctional CVD coatings |
US7956102B2 (en) * | 2007-04-09 | 2011-06-07 | The Board Of Trustees Of The University Of Illinois | Sol-gel inks |
US8093039B2 (en) * | 2007-04-10 | 2012-01-10 | The Trustees Of The Stevens Institute Of Technology | Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells |
EP1990638A1 (de) * | 2007-05-11 | 2008-11-12 | Koninklijke Philips Electronics N.V. | Durchflussbiosensor |
EP2183408A2 (de) * | 2007-08-07 | 2010-05-12 | President And Fellows Of Harvard College | Metalloxidbeschichtung auf oberflächen |
WO2009026359A2 (en) | 2007-08-20 | 2009-02-26 | Platypus Technologies, Llc | Improved devices for cell assays |
US8354280B2 (en) * | 2007-09-06 | 2013-01-15 | Bioscale, Inc. | Reusable detection surfaces and methods of using same |
JP2009069051A (ja) * | 2007-09-14 | 2009-04-02 | Canon Inc | マイクロ流体デバイスの製造方法 |
EP2011573B1 (de) * | 2007-11-05 | 2010-07-21 | Agilent Technologies, Inc. | Einfrierung eines mikrofluidischen Chips |
US8580344B2 (en) * | 2008-03-17 | 2013-11-12 | Intermolecular, Inc. | Stamp usage to enhance surface layer functionalization and selectivity |
WO2009121034A2 (en) * | 2008-03-28 | 2009-10-01 | Pelican Group Holdings, Inc. | Multicapillary sample preparation devices and methods for processing analytes |
US8802027B2 (en) * | 2008-03-28 | 2014-08-12 | President And Fellows Of Harvard College | Surfaces, including microfluidic channels, with controlled wetting properties |
CN101550441B (zh) * | 2008-04-01 | 2011-11-23 | 博尔诚(北京)科技有限公司 | 含有生物标志物样本的高通量分析方法和样本库制备 |
WO2009145925A1 (en) * | 2008-05-30 | 2009-12-03 | Massachusetts Institute Of Technology | Compositions and methods for spatial separation and screening of cells |
US9182406B2 (en) * | 2008-08-04 | 2015-11-10 | Biodesy, Inc. | Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability |
US8178355B2 (en) * | 2008-09-15 | 2012-05-15 | Platypus Technologies, Llc. | Detection of vapor phase compounds by changes in physical properties of a liquid crystal |
EP2952589B1 (de) | 2008-09-20 | 2018-02-14 | The Board of Trustees of The Leland Stanford Junior University | Nicht invasive diagnose von fötaler aneuploidie durch sequenzierung |
US7922939B2 (en) * | 2008-10-03 | 2011-04-12 | The Board Of Trustees Of The University Of Illinois | Metal nanoparticle inks |
US8187500B2 (en) * | 2008-10-17 | 2012-05-29 | The Board Of Trustees Of The University Of Illinois | Biphasic inks |
EP2384367A4 (de) | 2008-12-30 | 2013-07-10 | Janssen Biotech Inc | Serummarker zur vorhersage der klinischen reaktion auf anti-tnf-antikörper bei patienten mit morbus bechterew |
WO2010085548A2 (en) * | 2009-01-22 | 2010-07-29 | Li-Cor, Inc. | Single molecule proteomics with dynamic probes |
US8331751B2 (en) | 2009-03-02 | 2012-12-11 | mBio Diagnositcs, Inc. | Planar optical waveguide with core of low-index-of-refraction interrogation medium |
US9212995B2 (en) | 2009-03-02 | 2015-12-15 | Mbio Diagnostics, Inc. | System and method for detecting multiple molecules in one assay |
US9658222B2 (en) | 2009-03-02 | 2017-05-23 | Mbio Diagnostics, Inc. | Planar waveguide based cartridges and associated methods for detecting target analyte |
US8300993B2 (en) * | 2009-03-02 | 2012-10-30 | Mbio Diagnostics, Inc. | Waveguide with integrated lens |
JP4922341B2 (ja) * | 2009-05-14 | 2012-04-25 | シャープ株式会社 | 標的認識分子および標的認識分子を固定化する方法 |
JP5412207B2 (ja) * | 2009-08-04 | 2014-02-12 | 株式会社日立ハイテクノロジーズ | 生体分子固定基板及びその製造方法 |
US9855735B2 (en) | 2009-11-23 | 2018-01-02 | Cyvek, Inc. | Portable microfluidic assay devices and methods of manufacture and use |
EP2504701B1 (de) | 2009-11-23 | 2017-09-13 | Cyvek, Inc. | Verfahren und vorrichtung zur durchführung von assays |
US10065403B2 (en) | 2009-11-23 | 2018-09-04 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
KR101105328B1 (ko) * | 2009-11-23 | 2012-01-16 | 한국표준과학연구원 | 분자 흡착 및 해리 동특성 측정장치 및 측정방법 |
US9759718B2 (en) | 2009-11-23 | 2017-09-12 | Cyvek, Inc. | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use |
US9500645B2 (en) | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
US10022696B2 (en) | 2009-11-23 | 2018-07-17 | Cyvek, Inc. | Microfluidic assay systems employing micro-particles and methods of manufacture |
JP2011137651A (ja) * | 2009-12-25 | 2011-07-14 | Sharp Corp | 標的認識分子および標的認識分子を固定化する方法 |
WO2011089903A1 (en) | 2010-01-25 | 2011-07-28 | Panasonic Corporation | A method for immobilizing protein a on a self-assembled monolayer |
JP5485772B2 (ja) * | 2010-03-31 | 2014-05-07 | 株式会社エンプラス | マイクロ流路チップ及びマイクロ分析システム |
EP3508854A1 (de) | 2010-04-27 | 2019-07-10 | The Regents of The University of California | Krebsbiomarker und verfahren zur verwendung davon |
KR20120006591A (ko) * | 2010-07-13 | 2012-01-19 | 삼성전자주식회사 | 기포의 발생이 방지된 유체용 센서 |
WO2012029202A1 (en) | 2010-08-30 | 2012-03-08 | Panasonic Corporation | A method for immobilizing streptavidin on a self-assembled monolayer |
WO2012037369A1 (en) | 2010-09-15 | 2012-03-22 | Mbio Diagnostics, Inc. | System and method for detecting multiple molecules in one assay |
JP5108166B2 (ja) | 2010-10-19 | 2012-12-26 | パナソニック株式会社 | グルコースオキシダーゼを自己組織化膜上に固定する方法 |
US8729502B1 (en) | 2010-10-28 | 2014-05-20 | The Research Foundation For The State University Of New York | Simultaneous, single-detector fluorescence detection of multiple analytes with frequency-specific lock-in detection |
WO2012129347A1 (en) | 2011-03-21 | 2012-09-27 | Biodesy, Llc | Classification of kinase inhibitors using nonlinear optical techniques |
CN106552682B (zh) * | 2011-03-22 | 2020-06-19 | 西维克公司 | 微流体装置以及制造方法和用途 |
JP5921083B2 (ja) * | 2011-05-10 | 2016-05-24 | キヤノン株式会社 | 流路デバイス、およびこれを用いた検査システム |
CN103492879B (zh) * | 2011-06-10 | 2015-04-01 | 松下健康医疗控股株式会社 | 将抗体固定到自组装膜上的方法 |
CN103946704B (zh) | 2011-08-26 | 2017-11-24 | 艾维亚纳分子技术有限公司 | 用于现场护理诊断使用的生物涂覆型压电生物传感器平台 |
JP5615306B2 (ja) * | 2012-02-03 | 2014-10-29 | シャープ株式会社 | 標的認識分子および標的認識分子を固定化する方法 |
KR102070469B1 (ko) | 2012-03-08 | 2020-01-28 | 싸이벡, 아이엔씨 | 미세유체 분석 어셈블리 및 제조방법 |
WO2016090323A1 (en) | 2014-12-05 | 2016-06-09 | Prelude, Inc. | Dcis recurrence and invasive breast cancer |
EP3237906B8 (de) | 2014-12-23 | 2020-10-28 | Bluelight Therapeutics, Inc. | Befestigung von proteinen an schnittstellen zur verwendung in nicht-linearer optischer detektion |
US10228367B2 (en) | 2015-12-01 | 2019-03-12 | ProteinSimple | Segmented multi-use automated assay cartridge |
CN107976411B (zh) * | 2016-10-25 | 2020-10-23 | 中国科学院微生物研究所 | 包含别构转录因子调控系统的生物传感器、试剂盒及其在小分子检测中的用途 |
EP3756010A4 (de) | 2018-02-20 | 2021-11-03 | Pavonis Diagnostics Inc. | Aluminiumoxidoberflächen und grenzflächenmoleküle |
EP3850368A4 (de) | 2018-09-14 | 2022-11-23 | Prelude Corporation | Verfahren zur auswahl zur behandlung von subjekten mit risiko auf invasiven brustkrebs |
Family Cites Families (182)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2348886A (en) * | 1942-10-19 | 1944-05-16 | David E Dodgson | Black-out port ventilator |
US2376252A (en) * | 1943-01-09 | 1945-05-15 | American Cyanamid Co | Oxide catalysts in dehydrogenation of cymene |
US4071409A (en) | 1976-05-20 | 1978-01-31 | Corning Glass Works | Immobilization of proteins on inorganic support materials |
US4281061A (en) * | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
US4722896A (en) | 1981-01-26 | 1988-02-02 | The Beth Israel Hospital Association | Method for affinity purification of hybridoma antibodies |
US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
US4690715A (en) | 1982-06-18 | 1987-09-01 | American Telephone And Telegraph Company, At&T Bell Laboratories | Modification of the properties of metals |
US4514508A (en) * | 1982-07-06 | 1985-04-30 | Biond Inc. | Assaying for a multiplicity of antigens or antibodies with a detection compound |
US4973493A (en) | 1982-09-29 | 1990-11-27 | Bio-Metric Systems, Inc. | Method of improving the biocompatibility of solid surfaces |
US4994373A (en) * | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
US4591570A (en) * | 1983-02-02 | 1986-05-27 | Centocor, Inc. | Matrix of antibody-coated spots for determination of antigens |
GB8314523D0 (en) | 1983-05-25 | 1983-06-29 | Lowe C R | Diagnostic device |
JPS6041183A (ja) | 1983-08-16 | 1985-03-04 | 三菱電機株式会社 | 入場管理装置 |
AU600885B2 (en) * | 1984-05-25 | 1990-08-30 | Zymogenetics Inc. | Stable DNA constructs |
US5096807A (en) | 1985-03-06 | 1992-03-17 | Murex Corporation | Imaging immunoassay detection system with background compensation and its use |
US5523215A (en) * | 1985-03-28 | 1996-06-04 | Chiron Corporation | Enhanced purification and expression of insoluble recombinant proteins |
US5866363A (en) * | 1985-08-28 | 1999-02-02 | Pieczenik; George | Method and means for sorting and identifying biological information |
US4894146A (en) * | 1986-01-27 | 1990-01-16 | University Of Utah | Thin channel split flow process and apparatus for particle fractionation |
US4802951A (en) * | 1986-03-07 | 1989-02-07 | Trustees Of Boston University | Method for parallel fabrication of nanometer scale multi-device structures |
US4728591A (en) * | 1986-03-07 | 1988-03-01 | Trustees Of Boston University | Self-assembled nanometer lithographic masks and templates and method for parallel fabrication of nanometer scale multi-device structures |
US5643948A (en) * | 1986-06-11 | 1997-07-01 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators. K. |
US4859538A (en) | 1986-11-20 | 1989-08-22 | Ribi Hans O | Novel lipid-protein compositions and articles and methods for their preparation |
US5079600A (en) | 1987-03-06 | 1992-01-07 | Schnur Joel M | High resolution patterning on solid substrates |
US5154808A (en) | 1987-06-26 | 1992-10-13 | Fuji Photo Film Co., Ltd. | Functional organic thin film and process for producing the same |
US4987032A (en) | 1987-06-26 | 1991-01-22 | Fuji Photo Film Co., Ltd. | Functional organic thin film and method of manufacture thereof |
GB8803000D0 (en) * | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
US5300425A (en) * | 1987-10-13 | 1994-04-05 | Terrapin Technologies, Inc. | Method to produce immunodiagnostic reagents |
US6692751B1 (en) * | 1988-05-06 | 2004-02-17 | New York Blood Center | Methods and systems for producing recombinant viral antigens |
US4908112A (en) | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
US5281540A (en) * | 1988-08-02 | 1994-01-25 | Abbott Laboratories | Test array for performing assays |
US5720928A (en) * | 1988-09-15 | 1998-02-24 | New York University | Image processing and analysis of individual nucleic acid molecules |
SE462454B (sv) | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
JPH02272081A (ja) | 1989-04-14 | 1990-11-06 | Fuji Photo Film Co Ltd | 機能性有機薄膜 |
IT1229691B (it) | 1989-04-21 | 1991-09-06 | Eniricerche Spa | Sensore con antigene legato chimicamente a un dispositivo semiconduttore. |
US6346413B1 (en) * | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
US6919211B1 (en) * | 1989-06-07 | 2005-07-19 | Affymetrix, Inc. | Polypeptide arrays |
US5424186A (en) * | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US6416952B1 (en) * | 1989-06-07 | 2002-07-09 | Affymetrix, Inc. | Photolithographic and other means for manufacturing arrays |
US5252743A (en) * | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
DE3939973A1 (de) | 1989-12-02 | 1991-06-06 | Basf Ag | Zweidimensional kristallisierte makromolekuelschichten |
US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
US5858188A (en) * | 1990-02-28 | 1999-01-12 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
WO1991016425A1 (de) | 1990-04-12 | 1991-10-31 | Hans Sigrist | Verfahren zur lichtinduzierten immobilisierung von biomolekülen an chemisch 'inerten' oberflächen |
US5861254A (en) * | 1997-01-31 | 1999-01-19 | Nexstar Pharmaceuticals, Inc. | Flow cell SELEX |
US5665582A (en) * | 1990-10-29 | 1997-09-09 | Dekalb Genetics Corp. | Isolation of biological materials |
US5639620A (en) * | 1990-10-31 | 1997-06-17 | Coulter Corporation | Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same |
US5294369A (en) | 1990-12-05 | 1994-03-15 | Akzo N.V. | Ligand gold bonding |
DE69132843T2 (de) * | 1990-12-06 | 2002-09-12 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Identifizierung von Nukleinsäuren in Proben |
US5763170A (en) * | 1991-04-16 | 1998-06-09 | Amersham International Plc | Method for forming an array of biological particles |
ES2112916T3 (es) * | 1991-10-15 | 1998-04-16 | Multilyte Ltd | Ensayo de union que utiliza un reactivo marcado. |
US6051380A (en) * | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
US5677195A (en) * | 1991-11-22 | 1997-10-14 | Affymax Technologies N.V. | Combinatorial strategies for polymer synthesis |
US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
ATE408012T1 (de) * | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
DE59108591D1 (de) * | 1991-12-06 | 1997-04-10 | Ciba Geigy Ag | Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren |
US5296144A (en) * | 1992-01-02 | 1994-03-22 | World Trade Corporation | Composite membrane of a hydrophilic asymmetric membrane coated with an organosiloxane block copolymer |
CA2064683A1 (en) | 1992-03-26 | 1993-09-27 | Krishna Mohan Rao Kallury | Formation of thermostable enzymes with extra-ordinary heat tolerance by immobilization on phospholipid matrices |
DE69305160T2 (de) | 1992-04-22 | 1997-04-30 | Ecole Polytech | Lipidmembranen fur biosensoranwendungen |
US5726026A (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
US5637469A (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
US5304487A (en) * | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
DE4237113B4 (de) * | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
CA2108705A1 (en) | 1992-11-06 | 1994-05-07 | Richard Barner | Biologically recognizing layers on new ti02 waveguide for biosensors |
US5472881A (en) | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
US5532142A (en) * | 1993-02-12 | 1996-07-02 | Board Of Regents, The University Of Texas System | Method of isolation and purification of fusion polypeptides |
IT1270866B (it) * | 1993-03-10 | 1997-05-13 | Eniricerche Spa | Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis |
US5512492A (en) | 1993-05-18 | 1996-04-30 | University Of Utah Research Foundation | Waveguide immunosensor with coating chemistry providing enhanced sensitivity |
US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
EP1347493A3 (de) | 1993-05-28 | 2005-11-23 | Baylor College Of Medicine | Verfahren und Gerät zur Desorption und Ionisierung von Analyte |
US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
US5861242A (en) | 1993-06-25 | 1999-01-19 | Affymetrix, Inc. | Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same |
US5441876A (en) * | 1993-07-30 | 1995-08-15 | The United States Of America As Represented By The Secretary Of The Navy | Process for the preparation of headgroup-modified phospholipids using phosphatidylhydroxyalkanols as intermediates |
RU2041262C1 (ru) * | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель |
JPH0784372A (ja) | 1993-09-17 | 1995-03-31 | Res Dev Corp Of Japan | 有機シラン修飾酸化物と修飾表面 光パターニング酸化物 |
DE4332003C2 (de) | 1993-09-21 | 1996-02-22 | Seeger Stefan | Verfahren zur Beschichtung von Oberflächen mit Biomolekülen und anderen Rezeptormolekülen |
US5776748A (en) * | 1993-10-04 | 1998-07-07 | President And Fellows Of Harvard College | Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor |
US5512131A (en) | 1993-10-04 | 1996-04-30 | President And Fellows Of Harvard College | Formation of microstamped patterns on surfaces and derivative articles |
JP3488465B2 (ja) | 1993-10-28 | 2004-01-19 | ヒューストン・アドバンスド・リサーチ・センター | 結合反応を別々に検出する微細加工フロースルー多孔性装置 |
US5429807A (en) * | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
US5429708A (en) | 1993-12-22 | 1995-07-04 | The Board Of Trustees Of The Leland Stanford Junior University | Molecular layers covalently bonded to silicon surfaces |
DE4435728A1 (de) * | 1994-01-19 | 1995-07-20 | Boehringer Mannheim Gmbh | Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix |
CA2179309A1 (en) | 1994-02-09 | 1995-08-17 | Ted J. Hanagan | Diagnostic flow cell device |
US6017693A (en) * | 1994-03-14 | 2000-01-25 | University Of Washington | Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry |
US5514501A (en) | 1994-06-07 | 1996-05-07 | The United States Of America As Represented By The Secretary Of Commerce | Process for UV-photopatterning of thiolate monolayers self-assembled on gold, silver and other substrates |
US6287850B1 (en) * | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US5653864A (en) * | 1994-06-30 | 1997-08-05 | Nok Corporation | Protein biosensor and method for protein measurement with the same |
WO1996002830A1 (en) | 1994-07-14 | 1996-02-01 | Technobiochip | Biosensor and method and instrument for deposition of alternating monomolecular layers |
US5498545A (en) * | 1994-07-21 | 1996-03-12 | Vestal; Marvin L. | Mass spectrometer system and method for matrix-assisted laser desorption measurements |
DE4427785A1 (de) * | 1994-08-08 | 1996-02-15 | Behringwerke Ag | Verfahren zum Nachweis von Störungen des Protein C/Protein S-Systems |
SE9403245D0 (sv) * | 1994-09-26 | 1994-09-26 | Pharmacia Biosensor Ab | Improvements relating to bilayer lipid membranes |
US5620850A (en) * | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
US5571410A (en) | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
US5603351A (en) | 1995-06-07 | 1997-02-18 | David Sarnoff Research Center, Inc. | Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device |
US5688642A (en) | 1994-12-01 | 1997-11-18 | The United States Of America As Represented By The Secretary Of The Navy | Selective attachment of nucleic acid molecules to patterned self-assembled surfaces |
US5622826A (en) | 1994-12-22 | 1997-04-22 | Houston Advanced Research Center | Method for immobilization of molecules on platinum solid support surfaces |
US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
EP0812434B1 (de) | 1995-03-01 | 2013-09-18 | President and Fellows of Harvard College | Oberflächenstrukturierung mittels mikrokontaktdruckverfahren, sowie damit erzeugte artikel |
US5629213A (en) | 1995-03-03 | 1997-05-13 | Kornguth; Steven E. | Analytical biosensor |
WO1996027614A1 (en) * | 1995-03-08 | 1996-09-12 | Elias Klein | Surface modified affinity separation membrane |
NZ306051A (en) * | 1995-03-10 | 1999-11-29 | Meso Scale Technologies Llc | Testing using electrochemiluminescence |
US6140045A (en) * | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
US5624711A (en) * | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
US5625184A (en) * | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
WO1996038726A1 (en) | 1995-05-30 | 1996-12-05 | Ecole Polytechnique Federale De Lausanne (Epfl) | Covalently immobilized phospholipid bilayers on solid surfaces |
US5776674A (en) | 1995-06-05 | 1998-07-07 | Seq, Ltd | Chemical biochemical and biological processing in thin films |
US5545531A (en) * | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
WO1996039937A1 (en) | 1995-06-07 | 1996-12-19 | The Regents Of The University Of California | Microfabricated devices for diagnostic applications |
US6720149B1 (en) * | 1995-06-07 | 2004-04-13 | Affymetrix, Inc. | Methods for concurrently processing multiple biological chip assays |
US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US5872010A (en) * | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
WO1997007429A1 (en) | 1995-08-18 | 1997-02-27 | President And Fellows Of Harvard College | Self-assembled monolayer directed patterning of surfaces |
US5849208A (en) | 1995-09-07 | 1998-12-15 | Microfab Technoologies, Inc. | Making apparatus for conducting biochemical analyses |
CA2187969C (en) * | 1995-10-17 | 2006-05-30 | Dale L. Boger | A template for solution phase synthesis of combinatorial libraries |
US5716825A (en) * | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
DE19543232A1 (de) | 1995-11-07 | 1997-05-15 | Knoell Hans Forschung Ev | Herstellung einer Matrix-gebundenen miniaturisierten kombinatorischen Poly- und Oligomerbibliothek |
US5763263A (en) * | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
US6440662B1 (en) | 1995-12-01 | 2002-08-27 | Innogenetics N.V. | Impedimetric detection system and method of production thereof |
DE19548152A1 (de) | 1995-12-22 | 1997-06-26 | Boehringer Mannheim Gmbh | Verfahren zur Bedeckung einer Oberfläche mit einem Film eines Oligoethylenglykolderivates |
AU725192B2 (en) | 1996-02-16 | 2000-10-05 | Brigham And Women's Hospital | Compositions and methods for the treatment and diagnosis of cardiovascular disease |
CA2248576C (en) | 1996-03-15 | 2006-01-24 | President And Fellows Of Harvard College | Method of forming articles and patterning surfaces via capillary micromolding |
JP4912517B2 (ja) | 1996-04-03 | 2012-04-11 | アプライド バイオシステムズ リミテッド ライアビリティー カンパニー | 複数の分析物の検出のためのデバイスおよび方法 |
US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
JP2000510233A (ja) | 1996-04-25 | 2000-08-08 | ペンス,インコーポレイテッド | バイオセンサ装置および方法 |
US5925552A (en) | 1996-04-25 | 1999-07-20 | Medtronic, Inc. | Method for attachment of biomolecules to medical devices surfaces |
US6165335A (en) | 1996-04-25 | 2000-12-26 | Pence And Mcgill University | Biosensor device and method |
US5731152A (en) | 1996-05-13 | 1998-03-24 | Motorola, Inc. | Methods and systems for biological reagent placement |
US6075875A (en) * | 1996-09-30 | 2000-06-13 | Microsoft Corporation | Segmentation of image features using hierarchical analysis of multi-valued image data and weighted averaging of segmentation results |
US20030017149A1 (en) * | 1996-10-10 | 2003-01-23 | Hoeffler James P. | Single chain monoclonal antibody fusion reagents that regulate transcription in vivo |
EP0941474B1 (de) | 1996-11-29 | 2006-03-29 | The Board Of Trustees Of The Leland Stanford Junior University | Anordnungen von unabhängig voneinander ansteuerbaren, gestützten flüssigbilayer-membranen und ihre anwendungsverfahren |
GB9624927D0 (en) * | 1996-11-29 | 1997-01-15 | Oxford Glycosciences Uk Ltd | Gels and their use |
US5905024A (en) * | 1996-12-17 | 1999-05-18 | University Of Chicago | Method for performing site-specific affinity fractionation for use in DNA sequencing |
EP0990142A4 (de) * | 1996-12-31 | 2000-09-27 | Genometrix Genomics Inc | Molekulares multiplexanalyse verfahren und vorrichtung dazu |
US5837860A (en) | 1997-03-05 | 1998-11-17 | Molecular Tool, Inc. | Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds |
US6180288B1 (en) * | 1997-03-21 | 2001-01-30 | Kimberly-Clark Worldwide, Inc. | Gel sensors and method of use thereof |
WO1998049548A1 (en) * | 1997-04-25 | 1998-11-05 | Caliper Technologies Corporation | Microfluidic devices incorporating improved channel geometries |
WO1998050773A2 (en) | 1997-05-08 | 1998-11-12 | University Of Minnesota | Microcantilever biosensor |
US5869004A (en) * | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
NZ516848A (en) * | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
US6368871B1 (en) * | 1997-08-13 | 2002-04-09 | Cepheid | Non-planar microstructures for manipulation of fluid samples |
US5922617A (en) * | 1997-11-12 | 1999-07-13 | Functional Genetics, Inc. | Rapid screening assay methods and devices |
US6061476A (en) * | 1997-11-24 | 2000-05-09 | Cognex Corporation | Method and apparatus using image subtraction and dynamic thresholding |
US6232066B1 (en) * | 1997-12-19 | 2001-05-15 | Neogen, Inc. | High throughput assay system |
ATE400358T1 (de) * | 1997-12-24 | 2008-07-15 | Cepheid | Vorrichtung und verfahren zur lyse |
US6087102A (en) * | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
EP2189791A3 (de) | 1998-02-04 | 2011-03-09 | Life Technologies Corporation | Mikroarrays und Verwendungen dafür |
US6087103A (en) * | 1998-03-04 | 2000-07-11 | Lifespan Biosciences, Inc. | Tagged ligand arrays for identifying target-ligand interactions |
JP4163383B2 (ja) * | 1998-04-14 | 2008-10-08 | カリフォルニア・インスティテュート・オブ・テクノロジー | 検体活性を判定するための方法とシステム |
US20030138973A1 (en) * | 1998-07-14 | 2003-07-24 | Peter Wagner | Microdevices for screening biomolecules |
US6897073B2 (en) * | 1998-07-14 | 2005-05-24 | Zyomyx, Inc. | Non-specific binding resistant protein arrays and methods for making the same |
US6576478B1 (en) * | 1998-07-14 | 2003-06-10 | Zyomyx, Inc. | Microdevices for high-throughput screening of biomolecules |
US20020119579A1 (en) * | 1998-07-14 | 2002-08-29 | Peter Wagner | Arrays devices and methods of use thereof |
US6682942B1 (en) * | 1998-07-14 | 2004-01-27 | Zyomyx, Inc. | Microdevices for screening biomolecules |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US6197599B1 (en) * | 1998-07-30 | 2001-03-06 | Guorong Chin | Method to detect proteins |
US6190908B1 (en) * | 1998-08-12 | 2001-02-20 | The Scripps Research Institute | Modulation of polypeptide display on modified filamentous phage |
US6635311B1 (en) * | 1999-01-07 | 2003-10-21 | Northwestern University | Methods utilizing scanning probe microscope tips and products therefor or products thereby |
WO2000052209A1 (en) | 1999-03-02 | 2000-09-08 | Chiron Corporation | Microarrays for identifying pathway activation or induction |
US6171850B1 (en) * | 1999-03-08 | 2001-01-09 | Caliper Technologies Corp. | Integrated devices and systems for performing temperature controlled reactions and analyses |
EP1159615A2 (de) | 1999-03-10 | 2001-12-05 | National Institutes of Health, as represented by the Secretary, Department of Health and Human Services of the Government | Universales eiweiseinreihungssystem |
AU3883300A (en) | 1999-03-11 | 2000-09-28 | Combimatrix Corporation | Microarrays of peptide affinity probes for analyzing gene products and methods for analyzing gene products |
US6573369B2 (en) * | 1999-05-21 | 2003-06-03 | Bioforce Nanosciences, Inc. | Method and apparatus for solid state molecular analysis |
US6899137B2 (en) * | 1999-06-28 | 2005-05-31 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
KR100379411B1 (ko) * | 1999-06-28 | 2003-04-10 | 엘지전자 주식회사 | 바이오칩 및 그의 생체 물질 패터닝 및 측정 방법 |
US6406840B1 (en) * | 1999-12-17 | 2002-06-18 | Biomosaic Systems, Inc. | Cell arrays and the uses thereof |
JP2003524193A (ja) * | 2000-02-23 | 2003-08-12 | ザイオミックス インコーポレイテッド | 高い位置に配置されたサンプル表面を有するチップ |
US7132251B1 (en) * | 2000-05-04 | 2006-11-07 | Procognia Ltd | Method and composition for analyzing a carbohydrate polymer |
US6531283B1 (en) * | 2000-06-20 | 2003-03-11 | Molecular Staging, Inc. | Protein expression profiling |
US7094568B2 (en) * | 2000-08-17 | 2006-08-22 | Sense Proteomic Ltd. | Method for producing proteins tagged at the N- or C-terminus |
US6699665B1 (en) * | 2000-11-08 | 2004-03-02 | Surface Logix, Inc. | Multiple array system for integrating bioarrays |
US20050095646A1 (en) * | 2001-11-19 | 2005-05-05 | Sherman Michael I. | Method of using a non-antibody protein to detect and measure an analyte |
US20040248323A1 (en) * | 2003-06-09 | 2004-12-09 | Protometrix, Inc. | Methods for conducting assays for enzyme activity on protein microarrays |
US20050026215A1 (en) * | 2003-07-17 | 2005-02-03 | Predki Paul F. | Method for the prediction of an epitope |
WO2006020126A2 (en) * | 2004-07-14 | 2006-02-23 | Protometrix, Inc. | Method for providing protein microarrays |
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- 1998-07-14 US US09/115,397 patent/US6576478B1/en not_active Expired - Fee Related
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US6576478B1 (en) | 2003-06-10 |
US20090047695A1 (en) | 2009-02-19 |
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WO2000004390A2 (en) | 2000-01-27 |
US20020110932A1 (en) | 2002-08-15 |
US6596545B1 (en) | 2003-07-22 |
JP4489949B2 (ja) | 2010-06-23 |
CA2337197A1 (en) | 2000-01-27 |
AU5102499A (en) | 2000-02-07 |
EP1097379B1 (de) | 2008-12-31 |
WO2000004390A3 (en) | 2000-05-04 |
US6582969B1 (en) | 2003-06-24 |
JP2002520621A (ja) | 2002-07-09 |
AU764027B2 (en) | 2003-08-07 |
CA2337197C (en) | 2007-09-18 |
ATE419527T1 (de) | 2009-01-15 |
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