WO2000054046A3 - Universal protein array system - Google Patents

Universal protein array system Download PDF

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Publication number
WO2000054046A3
WO2000054046A3 PCT/US2000/006244 US0006244W WO0054046A3 WO 2000054046 A3 WO2000054046 A3 WO 2000054046A3 US 0006244 W US0006244 W US 0006244W WO 0054046 A3 WO0054046 A3 WO 0054046A3
Authority
WO
WIPO (PCT)
Prior art keywords
arrays
array system
universal protein
protein array
universal
Prior art date
Application number
PCT/US2000/006244
Other languages
French (fr)
Other versions
WO2000054046A2 (en
Inventor
Hui Ge
Original Assignee
Us Health
Hui Ge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Hui Ge filed Critical Us Health
Priority to EP00921374A priority Critical patent/EP1159615A2/en
Priority to CA002365431A priority patent/CA2365431A1/en
Priority to AU41705/00A priority patent/AU773291B2/en
Publication of WO2000054046A2 publication Critical patent/WO2000054046A2/en
Publication of WO2000054046A3 publication Critical patent/WO2000054046A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

This invention relates to ordered arrays of molecules, for instance polypeptides or proteins. Such arrays, referred to as universal protein arrays, are described in both macro- and microarray formats. Methods of production and use of such arrays are also described. Also disclosed are kits for the use of such arrays and the preparation of probes for use with them.
PCT/US2000/006244 1999-03-10 2000-03-10 Universal protein array system WO2000054046A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00921374A EP1159615A2 (en) 1999-03-10 2000-03-10 Universal protein array system
CA002365431A CA2365431A1 (en) 1999-03-10 2000-03-10 Universal protein array system
AU41705/00A AU773291B2 (en) 1999-03-10 2000-03-10 UPA, a universal protein array system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12358699P 1999-03-10 1999-03-10
US60/123,586 1999-03-10

Publications (2)

Publication Number Publication Date
WO2000054046A2 WO2000054046A2 (en) 2000-09-14
WO2000054046A3 true WO2000054046A3 (en) 2000-12-21

Family

ID=22409568

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006244 WO2000054046A2 (en) 1999-03-10 2000-03-10 Universal protein array system

Country Status (4)

Country Link
EP (1) EP1159615A2 (en)
AU (1) AU773291B2 (en)
CA (1) CA2365431A1 (en)
WO (1) WO2000054046A2 (en)

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US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6682942B1 (en) 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
US20020048823A1 (en) * 2000-08-11 2002-04-25 Qianjin Hu Methods and universal monoclonal antibody array
AUPR005600A0 (en) * 2000-09-12 2000-10-05 University Of Sydney, The Diagnostic assay
GB0022978D0 (en) * 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
WO2002025288A2 (en) 2000-09-22 2002-03-28 Clontech Laboratories Inc. Highly sensitive proteomic analysis methods and kits and systems for practicing the same
DE10054055A1 (en) 2000-10-31 2002-05-23 Nmi Univ Tuebingen Methods for analyzing proteins
DE60141171D1 (en) 2000-11-27 2010-03-11 Intelligent Medical Devices Ll CLINICAL INTELLIGENT DIAGNOSTIC DEVICES AND METHOD
JP4880188B2 (en) 2001-01-23 2012-02-22 プレジデント アンド フェロウズ オブ ハーバード カレッジ Nucleic acid programmed protein array
US7332286B2 (en) 2001-02-02 2008-02-19 University Of Pennsylvania Peptide or protein microassay method and apparatus
DE10118774A1 (en) * 2001-04-17 2002-10-31 Jerini Ag Method for determining the substrate specificity of an enzymatic activity and device therefor
US8148141B2 (en) 2001-05-07 2012-04-03 Hipep Laboratories Peptide-immobilized substrate and method for measuring target protein
US7981842B2 (en) * 2001-06-08 2011-07-19 Panomics, Inc. Method for detecting transcription factor-protein interactions
EP1279963A1 (en) * 2001-07-27 2003-01-29 Université de Nantes Protein-target screening method using near-infrared fluorescent dyes
JP4768224B2 (en) 2001-09-10 2011-09-07 メソ スケイル テクノロジーズ，エルエルシー Method and apparatus for performing multiple measurements on one sample
AU2002348289A1 (en) * 2001-11-19 2003-06-10 Protometrix, Inc. Method of using a non-antibody protein to detect and measure an analyte
GB0200617D0 (en) * 2002-01-11 2002-02-27 Oxford Glycosciences Uk Ltd Characterisation of analytes
GB0205910D0 (en) * 2002-03-13 2002-04-24 Sense Proteomic Ltd Arrays and methods
US7460960B2 (en) 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
US7618788B2 (en) 2002-05-10 2009-11-17 Millipore Corporation Proteome epitope tags and methods of use thereof in protein modification analysis
GB2402131A (en) * 2003-03-13 2004-12-01 Sense Proteomic Ltd Early entry
US20040209262A1 (en) * 2003-04-21 2004-10-21 Bass Jay K. Biopolymeric arrays comprising test probes for two or more different species and methods for using the same
EP1711819A4 (en) 2003-12-15 2008-04-16 Univ Pennsylvania Ct For Techn Method and devices for running reactions on a target plate for maldi mass spectrometry
KR100690948B1 (en) 2004-06-17 2007-03-09 한국과학기술원 Method for Cell Surface Display of Target Proteins Using FadL of E. coli
CN1312293C (en) * 2004-11-08 2007-04-25 博奥生物有限公司 High flux biochip and application thereof
KR100784261B1 (en) 2006-01-02 2007-12-11 한국과학기술원 Method for Cell Surface Displaying of Target Proteins Using Bacillus anthracis Exosporium
US7855057B2 (en) 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
JP2009543862A (en) 2006-07-14 2009-12-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Cancer biomarkers and methods of use thereof
DK3255146T3 (en) 2009-03-16 2019-08-19 Pangu Biopharma Ltd Compositions and Methods comprising Histidyl-tRNA Synthetase Splicing Variants with Non-Canonical Biological Activities
US20100310576A1 (en) 2009-03-31 2010-12-09 Adams Ryan A COMPOSITIONS AND METHODS COMPRISING ASPARTYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
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CN103096911B (en) 2010-04-27 2018-05-29 Atyr 医药公司 Treatment relevant with the protein fragments of Isoleucyl-tRNA synthetase, diagnosis and the innovation of antibody compositions are found
AU2011248489B2 (en) 2010-04-28 2016-10-06 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl tRNA synthetases
EP2563383B1 (en) 2010-04-29 2017-03-01 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
CN103097523B (en) 2010-04-29 2016-09-28 Atyr医药公司 The innovation for the treatment of, diagnosis and the antibody compositions relevant to the protein fragments of Asparaginyl-tRNA synthetase finds
WO2011150279A2 (en) 2010-05-27 2011-12-01 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
CA2800557A1 (en) 2010-04-29 2011-11-03 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy
EP2566496B1 (en) 2010-05-03 2018-02-28 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
CA2797277C (en) 2010-05-03 2021-02-23 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
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Title
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Also Published As

Publication number Publication date
CA2365431A1 (en) 2000-09-14
EP1159615A2 (en) 2001-12-05
AU773291B2 (en) 2004-05-20
AU4170500A (en) 2000-09-28
WO2000054046A2 (en) 2000-09-14

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