DE69936052T2 - N1 modifizierte glycopeptide - Google Patents
N1 modifizierte glycopeptide Download PDFInfo
- Publication number
- DE69936052T2 DE69936052T2 DE69936052T DE69936052T DE69936052T2 DE 69936052 T2 DE69936052 T2 DE 69936052T2 DE 69936052 T DE69936052 T DE 69936052T DE 69936052 T DE69936052 T DE 69936052T DE 69936052 T2 DE69936052 T2 DE 69936052T2
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- Prior art keywords
- compound according
- phenyl
- alkyl
- amino acid
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical class NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title claims description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 39
- -1 p-biphenylyl Chemical group 0.000 claims description 21
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8387998P | 1998-05-01 | 1998-05-01 | |
| US83879P | 1998-05-01 | ||
| PCT/US1999/004306 WO1999056760A1 (en) | 1998-05-01 | 1999-02-26 | N1-modified glycopeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69936052D1 DE69936052D1 (de) | 2007-06-21 |
| DE69936052T2 true DE69936052T2 (de) | 2008-01-17 |
Family
ID=22181253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69936052T Expired - Fee Related DE69936052T2 (de) | 1998-05-01 | 1999-02-26 | N1 modifizierte glycopeptide |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6670446B1 (https=) |
| EP (1) | EP1073447B1 (https=) |
| JP (1) | JP4307723B2 (https=) |
| AT (1) | ATE361931T1 (https=) |
| AU (1) | AU2881399A (https=) |
| CA (1) | CA2330619A1 (https=) |
| DE (1) | DE69936052T2 (https=) |
| DK (1) | DK1073447T3 (https=) |
| ES (1) | ES2283107T3 (https=) |
| WO (1) | WO1999056760A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999056760A1 (en) * | 1998-05-01 | 1999-11-11 | Eli Lilly And Company | N1-modified glycopeptides |
| DE69908819T2 (de) | 1998-12-23 | 2004-05-06 | Theravance, Inc., South San Francisco | Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten |
| US6699836B2 (en) | 1999-04-02 | 2004-03-02 | The Trustees Of Princeton University | Vancomycin analogs |
| AU4054900A (en) | 1999-04-02 | 2000-10-23 | Advanced Medicine East, Inc. | Desleucyl glycopeptide antibiotics and methods of making same |
| MXPA02007739A (es) * | 2000-02-11 | 2002-10-11 | Lilly Co Eli | N-acilacion selectiva de analogos del glicopeptido a82846. |
| AR053347A1 (es) | 2005-04-06 | 2007-05-02 | Astrazeneca Ab | Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos |
| UA90707C2 (en) | 2005-04-06 | 2010-05-25 | Астразенека Аб | Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives |
| JP5192384B2 (ja) | 2005-09-22 | 2013-05-08 | メディバス エルエルシー | ビス−（α−アミノ）−ジオール−ジエステル含有ポリ（エステルアミド）およびポリ（エステルウレタン）組成物および使用の方法 |
| CA2623239C (en) | 2005-09-22 | 2016-07-12 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
| EP2260060A4 (en) | 2008-04-01 | 2013-01-16 | Univ Cornell | ORGANIC SOLUBLE CHITOSA SALT AND CHITOSAN DERIVED BIOMATERIALS MANUFACTURED THEREFROM |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4698327A (en) | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
| US4643987A (en) | 1985-08-14 | 1987-02-17 | Eli Lilly And Company | Modified glycopeptides |
| US4639433A (en) | 1985-08-14 | 1987-01-27 | Eli Lilly And Company | Glycopeptide derivatives |
| EG18377A (en) * | 1986-09-19 | 1993-04-30 | Lilly Co Eli | Process for preparing glycopeptide antibiotics |
| US5534420A (en) | 1988-07-28 | 1996-07-09 | Eli Lilly And Company | Biotransformation of glycopeptide antibiotics |
| CA2031803C (en) * | 1989-12-13 | 2001-05-29 | Ramakrishnan Nagarajan | Improvements in or relating to glycopeptide deriveratives |
| MY128335A (en) | 1994-01-28 | 2007-01-31 | Lilly Co Eli | Glycopeptide antibiotic derivatives |
| US5952310A (en) * | 1997-05-20 | 1999-09-14 | Eli Lilly And Company | Glycopeptide hexapeptides |
| WO1999056760A1 (en) | 1998-05-01 | 1999-11-11 | Eli Lilly And Company | N1-modified glycopeptides |
-
1999
- 1999-02-26 WO PCT/US1999/004306 patent/WO1999056760A1/en not_active Ceased
- 1999-02-26 AT AT99909654T patent/ATE361931T1/de not_active IP Right Cessation
- 1999-02-26 EP EP99909654A patent/EP1073447B1/en not_active Expired - Lifetime
- 1999-02-26 ES ES99909654T patent/ES2283107T3/es not_active Expired - Lifetime
- 1999-02-26 DK DK99909654T patent/DK1073447T3/da active
- 1999-02-26 DE DE69936052T patent/DE69936052T2/de not_active Expired - Fee Related
- 1999-02-26 US US09/647,113 patent/US6670446B1/en not_active Expired - Fee Related
- 1999-02-26 JP JP2000546785A patent/JP4307723B2/ja not_active Expired - Fee Related
- 1999-02-26 AU AU28813/99A patent/AU2881399A/en not_active Abandoned
- 1999-02-26 CA CA002330619A patent/CA2330619A1/en not_active Abandoned
-
2003
- 2003-11-18 US US10/717,163 patent/US6939947B2/en not_active Expired - Fee Related
-
2005
- 2005-09-02 US US11/219,523 patent/US20060128609A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002513764A (ja) | 2002-05-14 |
| EP1073447A4 (en) | 2001-10-04 |
| US20050037950A1 (en) | 2005-02-17 |
| WO1999056760A1 (en) | 1999-11-11 |
| CA2330619A1 (en) | 1999-11-11 |
| JP4307723B2 (ja) | 2009-08-05 |
| DK1073447T3 (da) | 2007-09-03 |
| ES2283107T3 (es) | 2007-10-16 |
| ATE361931T1 (de) | 2007-06-15 |
| DE69936052D1 (de) | 2007-06-21 |
| EP1073447A1 (en) | 2001-02-07 |
| US20060128609A1 (en) | 2006-06-15 |
| AU2881399A (en) | 1999-11-23 |
| US6670446B1 (en) | 2003-12-30 |
| US6939947B2 (en) | 2005-09-06 |
| EP1073447B1 (en) | 2007-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |