DE69930660T2 - Zellen, kulturverfahren, und ihre verwendung in autologer transplantationstherapie - Google Patents

Zellen, kulturverfahren, und ihre verwendung in autologer transplantationstherapie Download PDF

Info

Publication number
DE69930660T2
DE69930660T2 DE69930660T DE69930660T DE69930660T2 DE 69930660 T2 DE69930660 T2 DE 69930660T2 DE 69930660 T DE69930660 T DE 69930660T DE 69930660 T DE69930660 T DE 69930660T DE 69930660 T2 DE69930660 T2 DE 69930660T2
Authority
DE
Germany
Prior art keywords
cells
disease
use according
host
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69930660T
Other languages
German (de)
English (en)
Other versions
DE69930660D1 (de
Inventor
Alison Bridgend DAVIES
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HEBE Ltd
Original Assignee
HEBE Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10842531&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69930660(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by HEBE Ltd filed Critical HEBE Ltd
Publication of DE69930660D1 publication Critical patent/DE69930660D1/de
Application granted granted Critical
Publication of DE69930660T2 publication Critical patent/DE69930660T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/414—Nervous system antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/10—Mineral substrates
    • C12N2533/18—Calcium salts, e.g. apatite, Mineral components from bones, teeth, shells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
DE69930660T 1998-11-16 1999-11-16 Zellen, kulturverfahren, und ihre verwendung in autologer transplantationstherapie Expired - Lifetime DE69930660T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9825096 1998-11-16
GB9825096A GB2343679A (en) 1998-11-16 1998-11-16 Autologous transplantation and method for making cells dormant
PCT/GB1999/003813 WO2000029551A2 (en) 1998-11-16 1999-11-16 Cells, culture methods, and their use in autologous transplantation therapy

Publications (2)

Publication Number Publication Date
DE69930660D1 DE69930660D1 (de) 2006-05-18
DE69930660T2 true DE69930660T2 (de) 2007-04-05

Family

ID=10842531

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69930660T Expired - Lifetime DE69930660T2 (de) 1998-11-16 1999-11-16 Zellen, kulturverfahren, und ihre verwendung in autologer transplantationstherapie

Country Status (12)

Country Link
US (1) US20060246042A1 (OSRAM)
EP (1) EP1131408B1 (OSRAM)
JP (1) JP2002530293A (OSRAM)
AT (1) ATE321843T1 (OSRAM)
AU (1) AU775597B2 (OSRAM)
CY (1) CY1105439T1 (OSRAM)
DE (1) DE69930660T2 (OSRAM)
DK (1) DK1131408T3 (OSRAM)
ES (1) ES2262346T3 (OSRAM)
GB (1) GB2343679A (OSRAM)
PT (1) PT1131408E (OSRAM)
WO (1) WO2000029551A2 (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0322806D0 (en) 2003-09-30 2003-10-29 Lifeforce Group Plc Cell bank for contingent autologous leukocyte transplantation
EP1711214A1 (en) 2004-02-02 2006-10-18 Interface Multigrad Technology (IMT) Ltd. Device for directional cooling of biological matter
JP4777908B2 (ja) 2004-02-02 2011-09-21 コア・ダイナミクス・リミテッド 生物学的材料ならびに生物学的材料の保存のための方法および溶液
ATE460947T1 (de) 2004-06-07 2010-04-15 Core Dynamics Ltd Verfahren zur sterilisation von biologischen präparaten
US8037696B2 (en) 2004-08-12 2011-10-18 Core Dynamics Limited Method and apparatus for freezing or thawing of a biological material
US8198085B2 (en) 2005-08-03 2012-06-12 Core Dynamics Limited Somatic cells for use in cell therapy
DE102007004855B4 (de) * 2007-01-31 2014-03-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zur Deposition von biologischem Material in einem Zielsubstrat
US20120070450A1 (en) * 2009-03-24 2012-03-22 Riken Leukemia stem cell markers
EP2943206A4 (en) * 2013-01-12 2017-01-04 Cesca Therapeutics Inc. Rapid infusion of autologous bone marrow derived stem cells
ES2729640T3 (es) * 2013-10-24 2019-11-05 Neuroplast Beheer B V Procedimiento de reducción de la actividad inflamatoria de un trasplante de células madre y usos del mismo
CN105219709A (zh) * 2015-09-23 2016-01-06 上海吉泉生物技术有限公司 单采法建立免疫细胞库及应用
CL2016000753A1 (es) * 2016-03-31 2017-11-10 Fund Ciencia Para La Vida Atenuación de la neurodegeneración asociada a la enfermedad de parkison mediante la inhibición del receptor de dopamina d3 en células t cd4+.
JP6401818B2 (ja) * 2016-04-27 2018-10-10 株式会社金太郎CellsPower 活性化幹細胞製造方法
DE102021116694B4 (de) * 2021-06-29 2023-03-09 Promocell Gmbh Wässrige Lösung zur Zellkonservierung
CN114984048A (zh) * 2022-06-16 2022-09-02 浙江百越生物技术有限公司 一种预防与治疗老年人行动迟缓的细胞疗法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004681B1 (en) * 1987-11-12 2000-04-11 Biocyte Corp Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
JPH04282301A (ja) * 1991-03-08 1992-10-07 Kachiku Jiyuseiran Ishiyoku Gijutsu Kenkyu Kumiai 生物試料の急速凍結方法
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
AU6167394A (en) * 1993-01-27 1994-08-15 Hemosol Inc. Selective cell proliferation
AU8078894A (en) * 1993-10-08 1995-05-04 Cellpro Ii Methods for collection and cryopreservation of human granulocytes
US5866332A (en) * 1994-02-02 1999-02-02 Incyte Pharmaceuticals, Inc. Human myeloid terminal differentiation response gene
EP0668013B1 (en) * 1994-02-22 2005-04-20 Nippon Telegraph And Telephone Corporation Freeze-dried blood cells, stem cells and platelets and manufacturing method for the same
US5704889A (en) * 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus
US5865784A (en) * 1995-06-07 1999-02-02 Alliance Pharmaceutical Corp. Method of hemodilution facilitated by monitoring oxygenation status
US5922597A (en) * 1995-11-14 1999-07-13 Regents Of The University Of Minnesota Ex vivo culture of stem cells
JP2002515756A (ja) * 1997-01-31 2002-05-28 ヘモソル インク. 選択されたリンパ球の生産方法
AU6346898A (en) * 1997-03-06 1998-09-22 University Of Massachusetts Gene therapy using bone marrow transplants transfected with therapeutic genes under the control of tissue-specific promoters

Also Published As

Publication number Publication date
GB2343679A (en) 2000-05-17
CY1105439T1 (el) 2010-04-28
DE69930660D1 (de) 2006-05-18
EP1131408A2 (en) 2001-09-12
PT1131408E (pt) 2006-08-31
ATE321843T1 (de) 2006-04-15
AU775597B2 (en) 2004-08-05
US20060246042A1 (en) 2006-11-02
AU1068000A (en) 2000-06-05
WO2000029551B1 (en) 2001-01-11
DK1131408T3 (da) 2006-08-07
EP1131408B1 (en) 2006-03-29
WO2000029551A2 (en) 2000-05-25
JP2002530293A (ja) 2002-09-17
GB9825096D0 (en) 1999-01-13
WO2000029551A3 (en) 2000-10-19
ES2262346T3 (es) 2006-11-16

Similar Documents

Publication Publication Date Title
DE69231063T2 (de) Lysate von keratinozyten zur verwendung als heilmittel für wunden.
Peake et al. Busulfan as a myelosuppressive agent for generating stable high-level bone marrow chimerism in mice
Porter et al. Transformation of adult allogeneic small lymphocytes after transfusion into newborn rats
DE19833476A1 (de) Genetisch modifizierte CD34-Negative, adhärent wachsende Stammzellen und deren Verwendung in der Gentherapie
EP1131408B1 (en) Cells, culture methods, and their use in autologous transplantation therapy
Fox Cytological estimation of proliferating donor cells during graft-versus-host disease in F1 hybrid mice injected with parental spleen cells
DE2645993A1 (de) Mittel gegen myeloische leukaemie und sein herstellungsverfahren
DE69626853T2 (de) Nicht-immunogene Blutplättchen und rote Blutzellen enthaltende Zubereitungen
DE69922090T2 (de) Austausch von T-Lymphozyten
DE3650139T2 (de) Verfahren zum reduzieren der immunogenizität und zum induzieren immunologischer toleranz.
DE69819749T2 (de) Behandlung von stress und vorbehandlung gegen stress
HAYS The effects of allografts of thymic epithelial reticular cells on the lymphoid tissues of neonatally thymectomized mice
CH650154A5 (de) Wasserloesliche, biologisch aktive fraktion aus dem interzellularen medium des knochenmarks, verfahren zu deren gewinnung und diese enthaltende pharmazeutische zubereitung.
DE2016269A1 (de) Verfahren zur Abtrennung von Leukocyten vom Gesamtblut und Verfahren zur Verlängerung der Lebensfähigkeit der abgetrennten Lymphocyten
Laflamme et al. Bone marrow chimeras to study neuroinflammation
EP1341915A1 (de) Verwendung von aus embryonalen stammzellen hergeleiteten zellen zur erhöhung der transplantationstoleranz und zur wiederherstellung zerstörten gewebes
WO2001088099A1 (en) Cells, culture methods and their uses
DE3524794A1 (de) Pharmazeutisches praeparat enthaltend lebende vermehrungsfaehige embryonalzellen, verfahren zu dessen herstellung und testverfahren zur bestimmung der pharmazeutischen wirksamkeit
DE2016274A1 (OSRAM)
Stehle Jr et al. Impact of sex, MHC, and age of recipients on the therapeutic effect of transferred leukocytes from cancer-resistant SR/CR mice
WO2012110639A1 (de) Verfahren zur herstellung eines dc-vakzins gegen krebs
Uri Differential requirement for CD28 co-stimulation on donor T cell subsets in mouse models of acute graft versus host disease and graft versus tumour effect
Ayala et al. Flow Cytometry Analysis of Graft Conditioning on the T-Cell Response in Graft-Versus-Host Disease Following Murine Allogeneic Transplantation
EP0815253B1 (de) Multifaktorielles abwehr-modulatorengemisch, verfahren zu seiner herstellung und diese modulatoren enthaltende arzneimittel
Ali Hassan Role of Green Tea or Bone Marrow Mesenchymal Stem Cells against Skin Damage Induced in Male Albino Rats Exposed to Gamma Radiation

Legal Events

Date Code Title Description
8363 Opposition against the patent