AU6346898A - Gene therapy using bone marrow transplants transfected with therapeutic genes under the control of tissue-specific promoters - Google Patents

Gene therapy using bone marrow transplants transfected with therapeutic genes under the control of tissue-specific promoters

Info

Publication number
AU6346898A
AU6346898A AU63468/98A AU6346898A AU6346898A AU 6346898 A AU6346898 A AU 6346898A AU 63468/98 A AU63468/98 A AU 63468/98A AU 6346898 A AU6346898 A AU 6346898A AU 6346898 A AU6346898 A AU 6346898A
Authority
AU
Australia
Prior art keywords
transfected
tissue
bone marrow
control
gene therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU63468/98A
Inventor
Baruch Frenkel
Zhen Hou
Jane B. Lian
Susie Nilsson
Stefan Peters
Peter Quesenberry
Gary S. Stein
Janet L. Stein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Massachusetts UMass
Original Assignee
University of Massachusetts UMass
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Massachusetts UMass filed Critical University of Massachusetts UMass
Publication of AU6346898A publication Critical patent/AU6346898A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU63468/98A 1997-03-06 1998-03-06 Gene therapy using bone marrow transplants transfected with therapeutic genes under the control of tissue-specific promoters Abandoned AU6346898A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3983997P 1997-03-06 1997-03-06
US60039839 1997-03-06
PCT/US1998/004421 WO1998039427A2 (en) 1997-03-06 1998-03-06 Gene therapy using bone marrow transplants transfected with therapeutic genes under the control of tissue-specific promoters

Publications (1)

Publication Number Publication Date
AU6346898A true AU6346898A (en) 1998-09-22

Family

ID=21907604

Family Applications (1)

Application Number Title Priority Date Filing Date
AU63468/98A Abandoned AU6346898A (en) 1997-03-06 1998-03-06 Gene therapy using bone marrow transplants transfected with therapeutic genes under the control of tissue-specific promoters

Country Status (2)

Country Link
AU (1) AU6346898A (en)
WO (1) WO1998039427A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69927812D1 (en) * 1998-06-08 2005-11-24 Acgt Medico Inc DETECTION OF DNA, RNA AND PROTEINS
DE19850986A1 (en) * 1998-11-05 2000-05-25 Aventis Pharma Gmbh The genetic engineering of cells and their use for the prophylaxis and therapy of diseases
GB2343679A (en) * 1998-11-16 2000-05-17 Alison Miriam Davies Autologous transplantation and method for making cells dormant
WO2001088099A1 (en) * 2000-05-16 2001-11-22 Alison Davies Cells, culture methods and their uses
US6576464B2 (en) 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
US6921665B2 (en) 2000-11-27 2005-07-26 Roslin Institute (Edinburgh) Selective antibody targeting of undifferentiated stem cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08511935A (en) * 1993-01-27 1996-12-17 ヘモソル インコーポレーテッド Selective cell growth
JPH07289116A (en) * 1994-04-27 1995-11-07 Hoechst Japan Ltd Transgenic animal of metabolic bone disease model
AUPM746694A0 (en) * 1994-08-15 1994-09-08 Garvan Institute Of Medical Research Expression vector

Also Published As

Publication number Publication date
WO1998039427A3 (en) 1998-12-03
WO1998039427A2 (en) 1998-09-11

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