DE69925145D1 - 2-aminothiazolederivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel - Google Patents
2-aminothiazolederivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittelInfo
- Publication number
- DE69925145D1 DE69925145D1 DE69925145T DE69925145T DE69925145D1 DE 69925145 D1 DE69925145 D1 DE 69925145D1 DE 69925145 T DE69925145 T DE 69925145T DE 69925145 T DE69925145 T DE 69925145T DE 69925145 D1 DE69925145 D1 DE 69925145D1
- Authority
- DE
- Germany
- Prior art keywords
- antitum
- preparation
- aminothiazole derivatives
- aminothiazole
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9823871.0A GB9823871D0 (en) | 1998-10-30 | 1998-10-30 | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
GB9823871 | 1998-10-30 | ||
PCT/EP1999/008306 WO2000026202A1 (en) | 1998-10-30 | 1999-10-27 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69925145D1 true DE69925145D1 (de) | 2005-06-09 |
DE69925145T2 DE69925145T2 (de) | 2006-02-16 |
Family
ID=10841638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69925145T Expired - Fee Related DE69925145T2 (de) | 1998-10-30 | 1999-10-27 | 2-aminothiazolederivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel |
Country Status (27)
Country | Link |
---|---|
US (1) | US7037929B1 (de) |
EP (1) | EP1124810B9 (de) |
JP (1) | JP2002528537A (de) |
KR (1) | KR20010085977A (de) |
CN (1) | CN1325389A (de) |
AR (1) | AR025276A1 (de) |
AT (1) | ATE294785T1 (de) |
AU (2) | AU766193B2 (de) |
CA (1) | CA2347188A1 (de) |
CZ (1) | CZ20011414A3 (de) |
DE (1) | DE69925145T2 (de) |
EA (1) | EA005575B1 (de) |
ES (1) | ES2241338T3 (de) |
GB (1) | GB9823871D0 (de) |
HK (1) | HK1041261A1 (de) |
HU (1) | HUP0104200A3 (de) |
ID (1) | ID28623A (de) |
IL (1) | IL142371A0 (de) |
MX (1) | MXPA01004278A (de) |
NO (1) | NO20012057L (de) |
NZ (1) | NZ510965A (de) |
PL (1) | PL347505A1 (de) |
PT (1) | PT1124810E (de) |
SK (1) | SK4732001A3 (de) |
TW (1) | TWI222447B (de) |
WO (1) | WO2000026202A1 (de) |
ZA (1) | ZA200102870B (de) |
Families Citing this family (136)
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EP1087951B9 (de) * | 1998-06-18 | 2006-09-13 | Bristol-Myers Squibb Company | Durch kohlenstoff substituierte aminothiazole als inhibitoren von zyclin-abhägigen kinasen |
US6414156B2 (en) | 1998-10-21 | 2002-07-02 | Bristol-Myers Squibb Company | Process for preparing azacycloalkanoylaminothiazoles |
US6214852B1 (en) | 1998-10-21 | 2001-04-10 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
US6610846B1 (en) | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
US6320050B1 (en) | 1999-03-29 | 2001-11-20 | Hoffmann-La Roche Inc. | Heteroaromatic glucokinase activators |
PL215901B1 (pl) | 1999-04-15 | 2014-02-28 | Bristol Myers Squibb Co | Cykliczny inhibitor bialkowych kinaz tyrozynowych, jego zastosowanie oraz kompozycja farmaceutyczna zawierajaca taki zwiazek |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
AR030154A1 (es) * | 1999-07-05 | 2003-08-13 | Nihon Nohyaku Co Ltd | Derivado de ftalamida, derivado de amina heterociclico util como intermediario para la produccion del mismo, insecticida agrohorticola y metodo para utilizar dicho insecticida |
US6114365A (en) * | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
US6515004B1 (en) | 1999-12-15 | 2003-02-04 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
US6392053B2 (en) | 1999-12-15 | 2002-05-21 | Bristol-Myers Squibb Company | Process for preparing arylacetylaminothiazoles |
IT1317826B1 (it) | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
DE10037310A1 (de) * | 2000-07-28 | 2002-02-07 | Asta Medica Ag | Neue Indolderivate und deren Verwendung als Arzneimittel |
DE60127420T2 (de) | 2000-08-17 | 2007-11-29 | Lumera Corp., Bothell | Design und synthese von nlo-materialien für electro-optische anwendungen, die von thiophen abgeleitet sind |
MXPA03004644A (es) * | 2000-11-27 | 2003-09-05 | Pharmacia Italia Spa | Derivados de fenilacetamdia-pirazol y su uso como agentes antitumorales. |
DK1347971T3 (da) | 2000-12-21 | 2006-05-15 | Bristol Myers Squibb Co | Thiazolylinhibitorer af tyrosinkinaser fra Tec-familien |
US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
DE60208630T2 (de) * | 2001-05-11 | 2006-08-17 | Pfizer Products Inc., Groton | Thiazolderivate und ihre Verwendung als cdk-Inhibitoren |
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
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WO2003008365A2 (en) * | 2001-07-19 | 2003-01-30 | Pharmacia Italia S.P.A. | Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents |
EP1724270A3 (de) | 2001-07-19 | 2007-01-03 | Pfizer Italia S.r.l. | Phenylacetamido-thiazole Verbindungen, Verfahren zu ihren Herstellung und ihre Anwendung als antitumor Mittel |
EP2335700A1 (de) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur |
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-
1998
- 1998-10-30 GB GBGB9823871.0A patent/GB9823871D0/en not_active Ceased
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1999
- 1999-10-27 EP EP99955931A patent/EP1124810B9/de not_active Expired - Lifetime
- 1999-10-27 IL IL14237199A patent/IL142371A0/xx unknown
- 1999-10-27 AT AT99955931T patent/ATE294785T1/de not_active IP Right Cessation
- 1999-10-27 AU AU12679/00A patent/AU766193B2/en not_active Ceased
- 1999-10-27 EA EA200100487A patent/EA005575B1/ru not_active IP Right Cessation
- 1999-10-27 HU HU0104200A patent/HUP0104200A3/hu unknown
- 1999-10-27 US US09/807,962 patent/US7037929B1/en not_active Expired - Fee Related
- 1999-10-27 ID IDW00200101146A patent/ID28623A/id unknown
- 1999-10-27 ES ES99955931T patent/ES2241338T3/es not_active Expired - Lifetime
- 1999-10-27 MX MXPA01004278A patent/MXPA01004278A/es unknown
- 1999-10-27 JP JP2000579591A patent/JP2002528537A/ja active Pending
- 1999-10-27 TW TW088118558A patent/TWI222447B/zh active
- 1999-10-27 CN CN99812926A patent/CN1325389A/zh active Pending
- 1999-10-27 CZ CZ20011414A patent/CZ20011414A3/cs unknown
- 1999-10-27 SK SK473-2001A patent/SK4732001A3/sk unknown
- 1999-10-27 CA CA002347188A patent/CA2347188A1/en not_active Abandoned
- 1999-10-27 PL PL99347505A patent/PL347505A1/xx not_active Application Discontinuation
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- 1999-10-27 DE DE69925145T patent/DE69925145T2/de not_active Expired - Fee Related
- 1999-10-27 PT PT99955931T patent/PT1124810E/pt unknown
- 1999-10-27 KR KR1020017005374A patent/KR20010085977A/ko not_active Application Discontinuation
- 1999-10-27 WO PCT/EP1999/008306 patent/WO2000026202A1/en not_active Application Discontinuation
- 1999-10-29 AR ARP990105474A patent/AR025276A1/es unknown
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JP2002528537A (ja) | 2002-09-03 |
CN1325389A (zh) | 2001-12-05 |
EA005575B1 (ru) | 2005-04-28 |
EP1124810B9 (de) | 2005-12-28 |
AU1267900A (en) | 2000-05-22 |
EP1124810B1 (de) | 2005-05-04 |
HUP0104200A3 (en) | 2003-12-29 |
PT1124810E (pt) | 2005-09-30 |
GB9823871D0 (en) | 1998-12-23 |
PL347505A1 (en) | 2002-04-08 |
NO20012057L (no) | 2001-06-28 |
IL142371A0 (en) | 2002-03-10 |
KR20010085977A (ko) | 2001-09-07 |
HK1041261A1 (zh) | 2002-07-05 |
EP1124810A1 (de) | 2001-08-22 |
ID28623A (id) | 2001-06-21 |
CZ20011414A3 (cs) | 2001-09-12 |
DE69925145T2 (de) | 2006-02-16 |
ZA200102870B (en) | 2001-10-10 |
NO20012057D0 (no) | 2001-04-26 |
TWI222447B (en) | 2004-10-21 |
US7037929B1 (en) | 2006-05-02 |
CA2347188A1 (en) | 2000-05-11 |
AU766193B2 (en) | 2003-10-09 |
HUP0104200A2 (hu) | 2002-03-28 |
ATE294785T1 (de) | 2005-05-15 |
MXPA01004278A (es) | 2002-06-21 |
AU2004200096A1 (en) | 2004-02-05 |
SK4732001A3 (en) | 2001-12-03 |
ES2241338T3 (es) | 2005-10-16 |
AR025276A1 (es) | 2002-11-20 |
NZ510965A (en) | 2003-10-31 |
EA200100487A1 (ru) | 2001-10-22 |
WO2000026202A1 (en) | 2000-05-11 |
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