DE69920476D1 - Liganden mit hoher affinität für den nociceptin-rezeptor orl-1 - Google Patents

Liganden mit hoher affinität für den nociceptin-rezeptor orl-1

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Publication number
DE69920476D1
DE69920476D1 DE69920476T DE69920476T DE69920476D1 DE 69920476 D1 DE69920476 D1 DE 69920476D1 DE 69920476 T DE69920476 T DE 69920476T DE 69920476 T DE69920476 T DE 69920476T DE 69920476 D1 DE69920476 D1 DE 69920476D1
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Germany
Prior art keywords
affinity ligands
nociceptin receptor
highly affinity
receptor orl
orl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69920476T
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English (en)
Other versions
DE69920476T2 (de
Inventor
Deen Tulshian
D Ho
S Silverman
J Matasi
L Mcleod
John A Hey
W Chapman
Ana Bercovici
M Cuss
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Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
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Publication of DE69920476D1 publication Critical patent/DE69920476D1/de
Publication of DE69920476T2 publication Critical patent/DE69920476T2/de
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    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D211/10Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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DE69920476T 1998-07-27 1999-07-26 Liganden mit hoher affinität für den nociceptin-rezeptor orl-1 Expired - Lifetime DE69920476T2 (de)

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AR068757A2 (es) 2009-12-02
CN1311777A (zh) 2001-09-05
NO20010467D0 (no) 2001-01-26
CO5080744A1 (es) 2001-09-25
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ATE277013T1 (de) 2004-10-15
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AU768607C (en) 2004-07-15
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DK1100781T3 (da) 2004-12-06
EP1258244A1 (de) 2002-11-20
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MY140505A (en) 2009-12-31
SI1100781T1 (en) 2005-02-28
KR100462074B1 (ko) 2004-12-16
DE69920476T2 (de) 2005-10-13
ID29137A (id) 2001-08-02
TW502021B (en) 2002-09-11
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BR9912495B1 (pt) 2013-10-22
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CA2338206A1 (en) 2000-02-10
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