DE69906684T2 - Aromatische amide, ihrer verfahren zur herstellung ung verwendung als arzneimitteln - Google Patents

Aromatische amide, ihrer verfahren zur herstellung ung verwendung als arzneimitteln

Info

Publication number
DE69906684T2
DE69906684T2 DE69906684T DE69906684T DE69906684T2 DE 69906684 T2 DE69906684 T2 DE 69906684T2 DE 69906684 T DE69906684 T DE 69906684T DE 69906684 T DE69906684 T DE 69906684T DE 69906684 T2 DE69906684 T2 DE 69906684T2
Authority
DE
Germany
Prior art keywords
drugs
preparing
aromatic amides
amides
aromatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69906684T
Other languages
English (en)
Other versions
DE69906684D1 (de
Inventor
Jean-Luc Haesslein
Michel Klich
Patrick Laurin
Branislav Musicki
Anne-Marie Periers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novexel SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9800116A external-priority patent/FR2773369B1/fr
Priority claimed from FR9812936A external-priority patent/FR2784681B1/fr
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of DE69906684D1 publication Critical patent/DE69906684D1/de
Publication of DE69906684T2 publication Critical patent/DE69906684T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06Benzopyran radicals
    • C07H17/065Benzo[b]pyrans
    • C07H17/075Benzo[b]pyran-2-ones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE69906684T 1998-01-08 1999-01-07 Aromatische amide, ihrer verfahren zur herstellung ung verwendung als arzneimitteln Expired - Fee Related DE69906684T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9800116A FR2773369B1 (fr) 1998-01-08 1998-01-08 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments
FR9812936A FR2784681B1 (fr) 1998-10-15 1998-10-15 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments
PCT/FR1999/000014 WO1999035155A1 (fr) 1998-01-08 1999-01-07 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
DE69906684D1 DE69906684D1 (de) 2003-05-15
DE69906684T2 true DE69906684T2 (de) 2003-11-06

Family

ID=26234055

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69906684T Expired - Fee Related DE69906684T2 (de) 1998-01-08 1999-01-07 Aromatische amide, ihrer verfahren zur herstellung ung verwendung als arzneimitteln

Country Status (36)

Country Link
US (2) US6420538B1 (de)
EP (1) EP1045856B1 (de)
JP (1) JP2002500229A (de)
KR (1) KR100604290B1 (de)
CN (2) CN1269833C (de)
AP (1) AP2000001857A0 (de)
AR (1) AR015211A1 (de)
AT (1) ATE236918T1 (de)
AU (1) AU750742B2 (de)
BR (1) BR9906819A (de)
CA (1) CA2317951A1 (de)
CO (1) CO4810298A1 (de)
CZ (1) CZ299840B6 (de)
DE (1) DE69906684T2 (de)
DK (1) DK1045856T3 (de)
DZ (1) DZ2702A1 (de)
EA (1) EA003275B1 (de)
ES (1) ES2192031T3 (de)
HU (1) HUP0100847A3 (de)
ID (1) ID27558A (de)
IL (1) IL137201A0 (de)
MA (1) MA26593A1 (de)
NO (1) NO20003496L (de)
NZ (1) NZ505523A (de)
PA (1) PA8466601A1 (de)
PE (1) PE20000175A1 (de)
PL (1) PL193130B1 (de)
PT (1) PT1045856E (de)
RS (1) RS50047B (de)
SA (1) SA99191247B1 (de)
SI (1) SI1045856T1 (de)
SK (1) SK284734B6 (de)
TN (1) TNSN99003A1 (de)
TR (1) TR200002009T2 (de)
TW (1) TW538046B (de)
WO (1) WO1999035155A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2749585B1 (fr) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
TW538046B (en) * 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof
US6916846B2 (en) 2000-05-12 2005-07-12 Merck & Co. Inc. Coumermycin analogs as chemical dimerizers of chimeric proteins
ATE375983T1 (de) 2000-12-15 2007-11-15 Vertex Pharma Bakterielle gyrase-hemmer und deren verwendung
FR2844273B1 (fr) * 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US8404852B2 (en) 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7618974B2 (en) 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7569591B2 (en) 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7582641B2 (en) 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8193352B2 (en) 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (es) 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
US8071605B2 (en) 2008-12-12 2011-12-06 Astrazeneca Ab Piperidine compounds for use in the treatment of bacterial infections
TW201026694A (en) 2008-12-12 2010-07-16 Astrazeneca Ab Compound 468
TW201102065A (en) 2009-05-29 2011-01-16 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
WO2011024004A1 (en) 2009-08-26 2011-03-03 Astrazeneca Ab Heterocyclic urea derivatives useful for treatment of bacterial infection
WO2011026107A1 (en) 2009-08-31 2011-03-03 University Of Notre Dame Du Lac Phthalanilate compounds and methods of use
CN103443096B (zh) 2011-01-14 2016-06-29 沃泰克斯药物股份有限公司 促旋酶和拓扑异构酶iv抑制剂
SG191945A1 (en) 2011-01-14 2013-08-30 Vertex Pharma Process of making gyrase and topoisomerase iv inhibitors
MX341342B (es) 2011-01-14 2016-08-17 Vertex Pharma Formas solidas del inhibidor de girasa (r)-1-etil-3-[6-fluoro-5-[2 -(1-hidroxi-1-metil-etil) pirimidin-5-il]-7-(tetrahidrofuran-2-il) -1h-benzimidazol-2-il]urea.
EP2663558A1 (de) 2011-01-14 2013-11-20 Vertex Pharmaceuticals Incorporated Feste formen von gyrasehemmer-(r)-1-ethyl-3-[5-[2-{1-hydroxy-1-methyl-ethyl-}pyrimidin-5-yl-]7-(tetrahydrofuran-2-yl-)-1h-benzimidazol-2-yl-]harnstoff
ES2576298T3 (es) 2011-06-20 2016-07-06 Vertex Pharmaceuticals Incorporated Ésteres de fosfato de inhibidores de girasa y topoisomerasa
WO2014014845A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases
US9018216B2 (en) 2012-07-18 2015-04-28 Vertex Pharmaceuticals Incorporated Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
EP3847172A1 (de) 2018-09-03 2021-07-14 Univerza v Ljubljani Neue klasse von dna-gyrase- und/oder topoisomerase-iv-inhibitoren mit aktivität gegen grampositive und gramnegative bakterien
EP4263503A1 (de) 2020-12-17 2023-10-25 Univerza V Ljubljani Neue n-phenylpyrrolamid-inhibitoren der dna-gyrase und topoisomerase iv mit antibakterieller wirkung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226978A (en) 1978-03-13 1980-10-07 Miles Laboratories, Inc. β-Galactosyl-umbelliferone-labeled aminoglycoside antibiotics and intermediates in their preparation
NZ331778A (en) 1996-03-20 2000-02-28 Inc Genentech Tricyclic compounds having activity specific for integrins, particularly avb3 integrins, method for preparing same, intermediates therefore, use of said compounds as drugs, and pharmaceutical compositions containing same
FR2749585B1 (fr) 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
TW538046B (en) * 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof

Also Published As

Publication number Publication date
CA2317951A1 (fr) 1999-07-15
NO20003496L (no) 2000-09-08
CN1502617A (zh) 2004-06-09
CO4810298A1 (es) 1999-06-30
ATE236918T1 (de) 2003-04-15
EA200000749A1 (ru) 2000-12-25
AP2000001857A0 (en) 2000-09-30
AU750742B2 (en) 2002-07-25
SI1045856T1 (en) 2003-08-31
NO20003496D0 (no) 2000-07-07
AR015211A1 (es) 2001-04-18
KR20010033939A (ko) 2001-04-25
DE69906684D1 (de) 2003-05-15
PL341590A1 (en) 2001-04-23
PE20000175A1 (es) 2000-03-09
CZ299840B6 (cs) 2008-12-10
TNSN99003A1 (fr) 2005-11-10
JP2002500229A (ja) 2002-01-08
PL193130B1 (pl) 2007-01-31
ES2192031T3 (es) 2003-09-16
AU1973699A (en) 1999-07-26
PT1045856E (pt) 2003-08-29
NZ505523A (en) 2003-01-31
WO1999035155A1 (fr) 1999-07-15
EP1045856B1 (de) 2003-04-09
SA99191247B1 (ar) 2006-09-20
EA003275B1 (ru) 2003-04-24
ID27558A (id) 2001-04-12
US20030060609A1 (en) 2003-03-27
HUP0100847A1 (hu) 2001-07-30
IL137201A0 (en) 2001-07-24
MA26593A1 (fr) 2004-12-20
US6583119B2 (en) 2003-06-24
TW538046B (en) 2003-06-21
EP1045856A1 (de) 2000-10-25
TR200002009T2 (tr) 2001-05-21
CN1269833C (zh) 2006-08-16
BR9906819A (pt) 2000-10-17
YU42700A (sh) 2002-12-10
KR100604290B1 (ko) 2006-07-28
CN1257164C (zh) 2006-05-24
SK284734B6 (sk) 2005-10-06
SK10152000A3 (sk) 2001-07-10
DK1045856T3 (da) 2003-07-21
RS50047B (sr) 2008-11-28
CZ20002523A3 (cs) 2000-11-15
PA8466601A1 (es) 2000-05-24
CN1291988A (zh) 2001-04-18
HUP0100847A3 (en) 2003-07-28
DZ2702A1 (fr) 2003-09-01
US6420538B1 (en) 2002-07-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: NOVEXEL, ROMAINVILLE, FR

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

8339 Ceased/non-payment of the annual fee