ATE236918T1 - Aromatische amide, ihrer verfahren zur herstellung ung verwendung als arzneimitteln - Google Patents

Aromatische amide, ihrer verfahren zur herstellung ung verwendung als arzneimitteln

Info

Publication number
ATE236918T1
ATE236918T1 AT99900500T AT99900500T ATE236918T1 AT E236918 T1 ATE236918 T1 AT E236918T1 AT 99900500 T AT99900500 T AT 99900500T AT 99900500 T AT99900500 T AT 99900500T AT E236918 T1 ATE236918 T1 AT E236918T1
Authority
AT
Austria
Prior art keywords
production
medicinal products
aromatic amides
amides
aromatic
Prior art date
Application number
AT99900500T
Other languages
English (en)
Inventor
Jean-Luc Haesslein
Michel Klich
Patrick Laurin
Branislav Musicki
Anne-Marie Periers
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9800116A external-priority patent/FR2773369B1/fr
Priority claimed from FR9812936A external-priority patent/FR2784681B1/fr
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE236918T1 publication Critical patent/ATE236918T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06Benzopyran radicals
    • C07H17/065Benzo[b]pyrans
    • C07H17/075Benzo[b]pyran-2-ones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT99900500T 1998-01-08 1999-01-07 Aromatische amide, ihrer verfahren zur herstellung ung verwendung als arzneimitteln ATE236918T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9800116A FR2773369B1 (fr) 1998-01-08 1998-01-08 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments
FR9812936A FR2784681B1 (fr) 1998-10-15 1998-10-15 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments
PCT/FR1999/000014 WO1999035155A1 (fr) 1998-01-08 1999-01-07 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
ATE236918T1 true ATE236918T1 (de) 2003-04-15

Family

ID=26234055

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99900500T ATE236918T1 (de) 1998-01-08 1999-01-07 Aromatische amide, ihrer verfahren zur herstellung ung verwendung als arzneimitteln

Country Status (36)

Country Link
US (2) US6420538B1 (de)
EP (1) EP1045856B1 (de)
JP (1) JP2002500229A (de)
KR (1) KR100604290B1 (de)
CN (2) CN1257164C (de)
AP (1) AP2000001857A0 (de)
AR (1) AR015211A1 (de)
AT (1) ATE236918T1 (de)
AU (1) AU750742B2 (de)
BR (1) BR9906819A (de)
CA (1) CA2317951A1 (de)
CO (1) CO4810298A1 (de)
CZ (1) CZ299840B6 (de)
DE (1) DE69906684T2 (de)
DK (1) DK1045856T3 (de)
DZ (1) DZ2702A1 (de)
EA (1) EA003275B1 (de)
ES (1) ES2192031T3 (de)
HU (1) HUP0100847A3 (de)
ID (1) ID27558A (de)
IL (1) IL137201A0 (de)
MA (1) MA26593A1 (de)
NO (1) NO20003496L (de)
NZ (1) NZ505523A (de)
PA (1) PA8466601A1 (de)
PE (1) PE20000175A1 (de)
PL (1) PL193130B1 (de)
PT (1) PT1045856E (de)
RS (1) RS50047B (de)
SA (1) SA99191247B1 (de)
SI (1) SI1045856T1 (de)
SK (1) SK284734B6 (de)
TN (1) TNSN99003A1 (de)
TR (1) TR200002009T2 (de)
TW (1) TW538046B (de)
WO (1) WO1999035155A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2749585B1 (fr) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
TW538046B (en) * 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof
US6916846B2 (en) 2000-05-12 2005-07-12 Merck & Co. Inc. Coumermycin analogs as chemical dimerizers of chimeric proteins
ES2331250T3 (es) 2000-12-15 2009-12-28 Vertex Pharmaceuticals Incorporated Inhibidores de la girasa bacteriana y usos de los mismos.
FR2844273B1 (fr) * 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US8404852B2 (en) 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7582641B2 (en) 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8193352B2 (en) 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7569591B2 (en) 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7618974B2 (en) 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (es) 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
TW201026694A (en) 2008-12-12 2010-07-16 Astrazeneca Ab Compound 468
TW201026695A (en) 2008-12-12 2010-07-16 Astrazeneca Ab Piperidine compounds and uses thereof-596
TW201102065A (en) 2009-05-29 2011-01-16 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
WO2011024004A1 (en) 2009-08-26 2011-03-03 Astrazeneca Ab Heterocyclic urea derivatives useful for treatment of bacterial infection
WO2011026107A1 (en) 2009-08-31 2011-03-03 University Of Notre Dame Du Lac Phthalanilate compounds and methods of use
SG191924A1 (en) 2011-01-14 2013-08-30 Vertex Pharma Solid forms of gyrase inhibitor (r)-1-ethyl-3-[5-[2-{1-hydroxy-1-methyl-ethyl}pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl}-1h-benzimidazol-2-yl]urea
ES2526902T3 (es) 2011-01-14 2015-01-16 Vertex Pharmaceuticals Incorporated Procesos de producción de inhibidores de la girasa y topoisomerasa IV
CA2824403C (en) 2011-01-14 2019-09-24 Vertex Pharmaceuticals Incorporated Solid forms of gyrase inhibitor (r)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1h-benzimidazol-2-yl]urea
WO2012097269A1 (en) 2011-01-14 2012-07-19 Vertex Pharmaceuticals Incorporated Pyrimidine gyrase and topoisomerase iv inhibitors
JP5977344B2 (ja) 2011-06-20 2016-08-24 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated ジャイレースおよびトポイソメラーゼ阻害剤のリン酸エステル
WO2014014845A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases
AR093226A1 (es) 2012-07-18 2015-05-27 Vertex Pharma Formas solidas de dihidrogeno fosfato de (r)-2-(5-(2-(3-etilureido)-6-fluoro-7-(tetrahidrofuran-2-il)-1h-benzo[d]imidazol-5-il)pirimidin-2-il)propan-2-ilo y sus sales
EP3847172A1 (de) 2018-09-03 2021-07-14 Univerza v Ljubljani Neue klasse von dna-gyrase- und/oder topoisomerase-iv-inhibitoren mit aktivität gegen grampositive und gramnegative bakterien
EP4263503A1 (de) 2020-12-17 2023-10-25 Univerza V Ljubljani Neue n-phenylpyrrolamid-inhibitoren der dna-gyrase und topoisomerase iv mit antibakterieller wirkung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226978A (en) * 1978-03-13 1980-10-07 Miles Laboratories, Inc. β-Galactosyl-umbelliferone-labeled aminoglycoside antibiotics and intermediates in their preparation
SK282894B6 (sk) 1996-03-20 2003-01-09 Hoechst Marion Roussel Tricyklické zlúčeniny, spôsob ich prípravy a medziprodukty tohto spôsobu, ich použitie ako liečiv a farmaceutické zmesi, ktoré ich obsahujú
FR2749585B1 (fr) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
TW538046B (en) * 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof

Also Published As

Publication number Publication date
CN1257164C (zh) 2006-05-24
SI1045856T1 (en) 2003-08-31
AP2000001857A0 (en) 2000-09-30
US20030060609A1 (en) 2003-03-27
MA26593A1 (fr) 2004-12-20
NO20003496D0 (no) 2000-07-07
US6583119B2 (en) 2003-06-24
US6420538B1 (en) 2002-07-16
CZ299840B6 (cs) 2008-12-10
SK284734B6 (sk) 2005-10-06
YU42700A (sh) 2002-12-10
RS50047B (sr) 2008-11-28
EA200000749A1 (ru) 2000-12-25
KR20010033939A (ko) 2001-04-25
KR100604290B1 (ko) 2006-07-28
BR9906819A (pt) 2000-10-17
ES2192031T3 (es) 2003-09-16
CA2317951A1 (fr) 1999-07-15
SK10152000A3 (sk) 2001-07-10
TR200002009T2 (tr) 2001-05-21
CO4810298A1 (es) 1999-06-30
AU1973699A (en) 1999-07-26
DE69906684D1 (de) 2003-05-15
WO1999035155A1 (fr) 1999-07-15
HUP0100847A1 (hu) 2001-07-30
EP1045856A1 (de) 2000-10-25
DK1045856T3 (da) 2003-07-21
PE20000175A1 (es) 2000-03-09
SA99191247B1 (ar) 2006-09-20
AU750742B2 (en) 2002-07-25
NZ505523A (en) 2003-01-31
TNSN99003A1 (fr) 2005-11-10
AR015211A1 (es) 2001-04-18
DZ2702A1 (fr) 2003-09-01
NO20003496L (no) 2000-09-08
ID27558A (id) 2001-04-12
PT1045856E (pt) 2003-08-29
CZ20002523A3 (cs) 2000-11-15
CN1291988A (zh) 2001-04-18
HUP0100847A3 (en) 2003-07-28
CN1502617A (zh) 2004-06-09
TW538046B (en) 2003-06-21
IL137201A0 (en) 2001-07-24
EA003275B1 (ru) 2003-04-24
DE69906684T2 (de) 2003-11-06
CN1269833C (zh) 2006-08-16
PL193130B1 (pl) 2007-01-31
PA8466601A1 (es) 2000-05-24
PL341590A1 (en) 2001-04-23
EP1045856B1 (de) 2003-04-09
JP2002500229A (ja) 2002-01-08

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