RS50047B - Novi aromatični amidi, njihov postupak dobijanja i primena kao lekova - Google Patents

Novi aromatični amidi, njihov postupak dobijanja i primena kao lekova

Info

Publication number
RS50047B
RS50047B YUP-427/00A YU42700A RS50047B RS 50047 B RS50047 B RS 50047B YU 42700 A YU42700 A YU 42700A RS 50047 B RS50047 B RS 50047B
Authority
RS
Serbia
Prior art keywords
radical
carbon atoms
alkyl
atom
hydrogen atom
Prior art date
Application number
YUP-427/00A
Other languages
English (en)
Inventor
Michel Klich
Branislav Musicki
Jean-Luc Haesslein
Patrick Lavrin
Anne-Marie Periers
Original Assignee
Novexel,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9800116A external-priority patent/FR2773369B1/fr
Priority claimed from FR9812936A external-priority patent/FR2784681B1/fr
Application filed by Novexel, filed Critical Novexel,
Publication of YU42700A publication Critical patent/YU42700A/sh
Publication of RS50047B publication Critical patent/RS50047B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
YUP-427/00A 1998-01-08 1999-01-07 Novi aromatični amidi, njihov postupak dobijanja i primena kao lekova RS50047B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9800116A FR2773369B1 (fr) 1998-01-08 1998-01-08 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments
FR9812936A FR2784681B1 (fr) 1998-10-15 1998-10-15 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
YU42700A YU42700A (sh) 2002-12-10
RS50047B true RS50047B (sr) 2008-11-28

Family

ID=26234055

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-427/00A RS50047B (sr) 1998-01-08 1999-01-07 Novi aromatični amidi, njihov postupak dobijanja i primena kao lekova

Country Status (36)

Country Link
US (2) US6420538B1 (sr)
EP (1) EP1045856B1 (sr)
JP (1) JP2002500229A (sr)
KR (1) KR100604290B1 (sr)
CN (2) CN1269833C (sr)
AP (1) AP2000001857A0 (sr)
AR (1) AR015211A1 (sr)
AT (1) ATE236918T1 (sr)
AU (1) AU750742B2 (sr)
BR (1) BR9906819A (sr)
CA (1) CA2317951A1 (sr)
CO (1) CO4810298A1 (sr)
CZ (1) CZ299840B6 (sr)
DE (1) DE69906684T2 (sr)
DK (1) DK1045856T3 (sr)
DZ (1) DZ2702A1 (sr)
EA (1) EA003275B1 (sr)
ES (1) ES2192031T3 (sr)
HU (1) HUP0100847A3 (sr)
ID (1) ID27558A (sr)
IL (1) IL137201A0 (sr)
MA (1) MA26593A1 (sr)
NO (1) NO20003496L (sr)
NZ (1) NZ505523A (sr)
PA (1) PA8466601A1 (sr)
PE (1) PE20000175A1 (sr)
PL (1) PL193130B1 (sr)
PT (1) PT1045856E (sr)
RS (1) RS50047B (sr)
SA (1) SA99191247B1 (sr)
SI (1) SI1045856T1 (sr)
SK (1) SK284734B6 (sr)
TN (1) TNSN99003A1 (sr)
TR (1) TR200002009T2 (sr)
TW (1) TW538046B (sr)
WO (1) WO1999035155A1 (sr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2749585B1 (fr) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
TW538046B (en) * 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof
US6916846B2 (en) 2000-05-12 2005-07-12 Merck & Co. Inc. Coumermycin analogs as chemical dimerizers of chimeric proteins
SI1341769T1 (sl) * 2000-12-15 2008-02-29 Vertex Pharma Inhibitorji bakterijske giraze in njihove uporabe
FR2844273B1 (fr) * 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
AR042956A1 (es) 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
US8404852B2 (en) 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7582641B2 (en) 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8193352B2 (en) 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7569591B2 (en) 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7618974B2 (en) 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
TW201026694A (en) 2008-12-12 2010-07-16 Astrazeneca Ab Compound 468
TW201026695A (en) 2008-12-12 2010-07-16 Astrazeneca Ab Piperidine compounds and uses thereof-596
TW201102065A (en) 2009-05-29 2011-01-16 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
TW201111380A (en) 2009-08-26 2011-04-01 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
WO2011026107A1 (en) 2009-08-31 2011-03-03 University Of Notre Dame Du Lac Phthalanilate compounds and methods of use
CA2824403C (en) 2011-01-14 2019-09-24 Vertex Pharmaceuticals Incorporated Solid forms of gyrase inhibitor (r)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1h-benzimidazol-2-yl]urea
WO2012097270A1 (en) 2011-01-14 2012-07-19 Vertex Pharmaceuticals Incorporated Solid forms of gyrase inhibitor (r)-1-ethyl-3-[5-[2-{1-hydroxy-1-methyl-ethyl}pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl}-1h-benzimidazol-2-yl]urea
AU2012205415B2 (en) 2011-01-14 2017-02-02 Spero Therapeutics, Inc. Pyrimidine gyrase and topoisomerase IV inhibitors
SG191945A1 (en) 2011-01-14 2013-08-30 Vertex Pharma Process of making gyrase and topoisomerase iv inhibitors
ES2576298T3 (es) 2011-06-20 2016-07-06 Vertex Pharmaceuticals Incorporated Ésteres de fosfato de inhibidores de girasa y topoisomerasa
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
WO2014015105A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Solid forms of (r)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1h-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
EP3847172A1 (en) 2018-09-03 2021-07-14 Univerza v Ljubljani New class of dna gyrase and/or topoisomerase iv inhibitors with activity against gram-positive and gram-negative bacteria
EP4263503A1 (en) 2020-12-17 2023-10-25 Univerza V Ljubljani New n-phenylpyrrolamide inhibitors of dna gyrase and topoisomerase iv with antibacterial activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226978A (en) 1978-03-13 1980-10-07 Miles Laboratories, Inc. β-Galactosyl-umbelliferone-labeled aminoglycoside antibiotics and intermediates in their preparation
DK0888292T3 (da) 1996-03-20 2002-02-18 Genentech Inc Tricykliske forbindelser med virkning over for integriner, især alphavbeta3 integriner, fremgangsmåde til deres fremstilling, mellemprodukter deraf, deres anvendelse som lægemidler og farmaceutiske præparater med indhold deraf
FR2749585B1 (fr) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
TW538046B (en) * 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof

Also Published As

Publication number Publication date
DE69906684T2 (de) 2003-11-06
US20030060609A1 (en) 2003-03-27
AP2000001857A0 (en) 2000-09-30
PT1045856E (pt) 2003-08-29
HUP0100847A3 (en) 2003-07-28
IL137201A0 (en) 2001-07-24
SI1045856T1 (en) 2003-08-31
AU750742B2 (en) 2002-07-25
AU1973699A (en) 1999-07-26
SK10152000A3 (sk) 2001-07-10
WO1999035155A1 (fr) 1999-07-15
PA8466601A1 (es) 2000-05-24
SA99191247B1 (ar) 2006-09-20
YU42700A (sh) 2002-12-10
US6420538B1 (en) 2002-07-16
TR200002009T2 (tr) 2001-05-21
ID27558A (id) 2001-04-12
KR20010033939A (ko) 2001-04-25
CN1291988A (zh) 2001-04-18
US6583119B2 (en) 2003-06-24
CA2317951A1 (fr) 1999-07-15
HUP0100847A1 (hu) 2001-07-30
CN1502617A (zh) 2004-06-09
CO4810298A1 (es) 1999-06-30
EA200000749A1 (ru) 2000-12-25
PL341590A1 (en) 2001-04-23
ATE236918T1 (de) 2003-04-15
NZ505523A (en) 2003-01-31
PL193130B1 (pl) 2007-01-31
BR9906819A (pt) 2000-10-17
CN1269833C (zh) 2006-08-16
CZ20002523A3 (cs) 2000-11-15
DK1045856T3 (da) 2003-07-21
PE20000175A1 (es) 2000-03-09
TNSN99003A1 (fr) 2005-11-10
JP2002500229A (ja) 2002-01-08
KR100604290B1 (ko) 2006-07-28
DZ2702A1 (fr) 2003-09-01
DE69906684D1 (de) 2003-05-15
AR015211A1 (es) 2001-04-18
EP1045856B1 (fr) 2003-04-09
ES2192031T3 (es) 2003-09-16
EA003275B1 (ru) 2003-04-24
EP1045856A1 (fr) 2000-10-25
CN1257164C (zh) 2006-05-24
CZ299840B6 (cs) 2008-12-10
SK284734B6 (sk) 2005-10-06
TW538046B (en) 2003-06-21
NO20003496L (no) 2000-09-08
NO20003496D0 (no) 2000-07-07
MA26593A1 (fr) 2004-12-20

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