ATE485271T1 - Antihistaminische piperidinderivate und zwischenprodukte zu ihrer herstellung - Google Patents

Antihistaminische piperidinderivate und zwischenprodukte zu ihrer herstellung

Info

Publication number
ATE485271T1
ATE485271T1 AT99928753T AT99928753T ATE485271T1 AT E485271 T1 ATE485271 T1 AT E485271T1 AT 99928753 T AT99928753 T AT 99928753T AT 99928753 T AT99928753 T AT 99928753T AT E485271 T1 ATE485271 T1 AT E485271T1
Authority
AT
Austria
Prior art keywords
piperided
anthistaminic
derivatives
production
intermediate products
Prior art date
Application number
AT99928753T
Other languages
English (en)
Inventor
Timothy Ayers
Paul Brown
Original Assignee
Aventisub Ii Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22328222&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE485271(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventisub Ii Inc filed Critical Aventisub Ii Inc
Application granted granted Critical
Publication of ATE485271T1 publication Critical patent/ATE485271T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/90—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated
    • C07C233/91—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated with carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99928753T 1998-07-02 1999-06-17 Antihistaminische piperidinderivate und zwischenprodukte zu ihrer herstellung ATE485271T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10954298A 1998-07-02 1998-07-02
PCT/US1999/013693 WO2000001671A2 (en) 1998-07-02 1999-06-17 Antihistaminic piperidine derivatives and intermediates for the preparation thereof

Publications (1)

Publication Number Publication Date
ATE485271T1 true ATE485271T1 (de) 2010-11-15

Family

ID=22328222

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99928753T ATE485271T1 (de) 1998-07-02 1999-06-17 Antihistaminische piperidinderivate und zwischenprodukte zu ihrer herstellung

Country Status (20)

Country Link
EP (1) EP1091938B1 (de)
JP (1) JP2002519411A (de)
KR (2) KR100707904B1 (de)
CN (3) CN1246312C (de)
AR (1) AR019197A1 (de)
AT (1) ATE485271T1 (de)
AU (1) AU769284B2 (de)
BR (1) BR9911794A (de)
CA (1) CA2336380C (de)
DE (1) DE69942876D1 (de)
DK (1) DK1091938T3 (de)
ES (1) ES2354968T3 (de)
HU (1) HUP0104159A3 (de)
IL (6) IL140649A0 (de)
NO (1) NO319534B1 (de)
NZ (2) NZ528839A (de)
PT (1) PT1091938E (de)
TW (1) TW533197B (de)
WO (1) WO2000001671A2 (de)
ZA (1) ZA200007034B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003104197A1 (en) 2002-06-10 2003-12-18 Teva Pharmaceutical Industries Ltd. Polymorphic form xvi of fexofenadine hydrochloride
CN101585768B (zh) * 2009-06-06 2012-01-04 浙江大学宁波理工学院 合成2-[4-(4-氯丁酰基)苯基]-2-甲基丙酸酯的方法
CN101585767B (zh) * 2009-06-06 2012-02-15 浙江大学宁波理工学院 一种合成2—[4—(4—氯丁酰基)苯基]—2—甲基丙酸酯的方法
CN101585763B (zh) * 2009-06-06 2012-01-04 浙江大学宁波理工学院 一种合成2-[4-(4-氯丁酰基)苯基]-2-甲基丙酸的方法
CN101585764B (zh) * 2009-06-06 2012-02-15 浙江大学宁波理工学院 合成2—［4—(4—氯丁酰基)苯基］—2—甲基丙酸的方法
EP2289867A3 (de) * 2009-08-19 2012-04-25 Jubilant Organosys Limited Verfahren zur Herstellung von 4-(4-Halogen-1-oxybutyl)-alpha,alpha-dimethylbenzolessigsäure oder Alkylestern davon
JP6192554B2 (ja) * 2014-02-03 2017-09-06 三菱電機株式会社 真空断熱材の製造方法
CN112661693A (zh) * 2021-01-27 2021-04-16 西北农林科技大学 一种非索非那定的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3839431A (en) * 1970-07-13 1974-10-01 Squibb & Sons Inc Cyclopropylmethylphenylacetic acids and derivatives
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
JP3686950B2 (ja) * 1992-04-10 2005-08-24 メレル ファーマスーティカルズ インコーポレイテッド ピペリジン誘導体類の新規な方法
US5654433A (en) * 1993-01-26 1997-08-05 Merrell Pharmaceuticals Inc. Process for piperidine derivatives
DK1026147T3 (da) * 1993-06-24 2004-03-22 Albany Molecular Res Inc Forbindelser, der er anvendelige som mellemprodukter i fremstillingen af piperidinderivater
CA2362337C (en) * 1993-06-25 2005-08-02 Merrell Pharmaceuticals Inc. Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives
WO1996035667A1 (en) * 1995-05-08 1996-11-14 Hoescht Marion Roussel, Inc. Alpha-(substituted alkylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidine butanol derivatives, their preparation and their use as anti-histamines, anti-allergy agents and bronchodilators

Also Published As

Publication number Publication date
HUP0104159A3 (en) 2002-04-29
CN101311165A (zh) 2008-11-26
NZ508477A (en) 2003-12-19
DK1091938T3 (da) 2011-02-07
NO319534B1 (no) 2005-08-29
AU4574699A (en) 2000-01-24
IL171061A (en) 2007-09-20
CN100522921C (zh) 2009-08-05
KR20060035816A (ko) 2006-04-26
HK1125382A1 (en) 2009-08-07
IL171479A (en) 2007-10-31
NO20006694L (no) 2001-03-01
IL171062A (en) 2007-09-20
CN1807394A (zh) 2006-07-26
IL171063A (en) 2007-09-20
CN1308611A (zh) 2001-08-15
TW533197B (en) 2003-05-21
ES2354968T3 (es) 2011-03-21
DE69942876D1 (de) 2010-12-02
PT1091938E (pt) 2010-12-20
AU769284B2 (en) 2004-01-22
CA2336380A1 (en) 2000-01-13
CN1246312C (zh) 2006-03-22
NO20006694D0 (no) 2000-12-29
BR9911794A (pt) 2001-03-27
HK1091806A1 (zh) 2007-01-26
HUP0104159A2 (hu) 2002-03-28
WO2000001671A2 (en) 2000-01-13
KR100682447B1 (ko) 2007-02-16
WO2000001671A3 (en) 2000-04-06
AR019197A1 (es) 2001-12-26
EP1091938B1 (de) 2010-10-20
HK1034065A1 (en) 2001-10-12
IL140649A0 (en) 2002-02-10
KR100707904B1 (ko) 2007-04-16
CA2336380C (en) 2007-04-10
NZ528839A (en) 2005-03-24
ZA200007034B (en) 2002-04-08
CN101311165B (zh) 2011-05-18
EP1091938A2 (de) 2001-04-18
KR20010053324A (ko) 2001-06-25
JP2002519411A (ja) 2002-07-02
IL140649A (en) 2006-08-01

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