DE69837675D1 - Pyrazolderivate - Google Patents
PyrazolderivateInfo
- Publication number
- DE69837675D1 DE69837675D1 DE69837675T DE69837675T DE69837675D1 DE 69837675 D1 DE69837675 D1 DE 69837675D1 DE 69837675 T DE69837675 T DE 69837675T DE 69837675 T DE69837675 T DE 69837675T DE 69837675 D1 DE69837675 D1 DE 69837675D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrazolderivate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP27909397 | 1997-10-13 | ||
JP27909397 | 1997-10-13 | ||
PCT/JP1998/004583 WO1999019303A1 (fr) | 1997-10-13 | 1998-10-12 | Derives de pyrazole |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69837675D1 true DE69837675D1 (en) | 2007-06-06 |
DE69837675T2 DE69837675T2 (de) | 2008-01-10 |
Family
ID=17606326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69837675T Expired - Fee Related DE69837675T2 (de) | 1997-10-13 | 1998-10-12 | Pyrazolderivate |
Country Status (18)
Country | Link |
---|---|
US (4) | US6348480B1 (de) |
EP (1) | EP1024138B1 (de) |
KR (1) | KR100589868B1 (de) |
CN (1) | CN1107671C (de) |
AR (1) | AR016957A1 (de) |
AT (1) | ATE360618T1 (de) |
AU (2) | AU751139B2 (de) |
BR (1) | BR9803883A (de) |
CA (1) | CA2304979A1 (de) |
DE (1) | DE69837675T2 (de) |
ES (1) | ES2285784T3 (de) |
HU (1) | HUP9802310A1 (de) |
NO (1) | NO317417B1 (de) |
PL (1) | PL192411B1 (de) |
PT (1) | PT1024138E (de) |
RU (1) | RU2185381C2 (de) |
TW (1) | TW495498B (de) |
WO (1) | WO1999019303A1 (de) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU751139B2 (en) * | 1997-10-13 | 2002-08-08 | Astellas Pharma Inc. | Amide derivative |
AU3387999A (en) * | 1998-04-08 | 1999-10-25 | Abbott Laboratories | Pyrazole inhibitors of cytokine production |
CA2332957A1 (en) * | 1998-06-05 | 1999-12-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents |
EP1100495A4 (de) * | 1998-07-28 | 2002-09-25 | Smithkline Beecham Corp | Propenamide als ccr5 modulatoren |
EP1101759A4 (de) * | 1998-07-31 | 2001-12-12 | Nippon Soda Co | Phenylazol-derivate, verfahren zu ihrer herstellung und medikamente für hyperlipemie |
JP2001031509A (ja) * | 1999-07-15 | 2001-02-06 | Nippon Bayer Agrochem Co Ltd | チエニル−ピラゾール類の有害生物防除剤としての利用 |
EP1257536A1 (de) * | 2000-01-27 | 2002-11-20 | Cytovia, Inc. | Substituierte nicotinamiden und analoge als caspaseaktivatoren und apoptose-induzierende mittel und ihre verwendung |
US6451820B1 (en) * | 2000-03-23 | 2002-09-17 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenly)triazoles and their use as anti-inflammatory agents |
US6353007B1 (en) * | 2000-07-13 | 2002-03-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents |
EP1184457A1 (de) * | 2000-09-05 | 2002-03-06 | Warner-Lambert Company | Identifizierung eines kapazitiven Calcium Kanals in Antigen-präsentierenden Zellen und dessen Verwendung |
EP1186661A1 (de) * | 2000-09-05 | 2002-03-13 | Warner-Lambert Company | Identifizierung eines kapazitativen Calcium Kanals in Antigen-präsentierenden Zellen und dessen Verwendung |
CA2432713C (en) * | 2000-12-22 | 2009-10-27 | Ishihara Sangyo Kaisha, Ltd. | Aniline derivatives or salts thereof and cytokine production inhibitors containing the same |
MXPA03011002A (es) * | 2001-06-06 | 2004-10-28 | Agouron Pharma | Agentes gnrh no peptidicos, composiciones farmaceuticas y procedimientos para su uso y procesos para prepararlos a ellos y a sus intermedios. |
DE60222264T2 (de) * | 2001-06-29 | 2008-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Phenylpyrazolderivate als seh-inhibitoren |
GB0209715D0 (en) * | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
CA2495437A1 (en) * | 2002-08-27 | 2004-03-11 | Yamanouchi Pharmaceutical Co., Ltd. | Novel crystal |
US20040077650A1 (en) * | 2002-10-18 | 2004-04-22 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
US7790724B2 (en) * | 2003-04-25 | 2010-09-07 | Janssen Pharmaceutica N.V. | c-fms kinase inhibitors |
KR20060058092A (ko) * | 2003-07-23 | 2006-05-29 | 신타 파마슈티칼스 코프. | 염증 및 면역에 이용되는 화합물 |
CA2548374C (en) | 2003-12-23 | 2014-05-27 | Astex Therapeutics Limited | Pyrazole derivatives as protein kinase modulators |
ATE432273T1 (de) | 2004-03-09 | 2009-06-15 | Boehringer Ingelheim Pharma | 3-ä4-heterocyclyl-1,2,3-triazol-1-ylü-n- arylbenzamide als inhibitoren der cytokinenproduktion für die behandlung von chronischen entzündlichen erkrankungen |
EP1732900A4 (de) * | 2004-03-25 | 2007-12-12 | Synta Pharmaceuticals Corp | Acrylnitrilderivate für entzündungs- und immunspezifische verwendungen |
TW200633990A (en) * | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
CA2606239A1 (en) * | 2005-04-22 | 2006-11-02 | Astellas Pharma Inc. | Preventive or remedy for bowel disease |
GB2427406A (en) * | 2005-06-21 | 2006-12-27 | Astex Technology Ltd | Silicon-containing PKB/PKA kinase inhibitors |
EP1902032A1 (de) | 2005-06-22 | 2008-03-26 | Astex Therapeutics Limited | Pharmazeutische verbindungen |
US8541461B2 (en) | 2005-06-23 | 2013-09-24 | Astex Therapeutics Limited | Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators |
US7816535B2 (en) | 2006-01-25 | 2010-10-19 | Synta Pharmaceuticals Corp. | Vinyl-phenyl derivatives for inflammation and immune-related uses |
AU2013200480B2 (en) * | 2006-02-28 | 2016-06-09 | Dart Neuroscience (Cayman) Ltd. | Therapeutic compounds |
SG171617A1 (en) * | 2006-02-28 | 2011-06-29 | Helicon Therapeutics Inc | Therapeutic compounds |
CN101490017B (zh) | 2006-02-28 | 2013-01-23 | 海利空医疗公司 | 作为pde4抑制剂的用于治疗的哌嗪类 |
US7803799B2 (en) * | 2006-07-07 | 2010-09-28 | National Health Research Institutes | Selenophene compounds |
EP2058309A4 (de) * | 2006-08-04 | 2010-12-22 | Takeda Pharmaceutical | Kondensierte heterocyclische verbindung |
AU2007288245A1 (en) * | 2006-08-24 | 2008-02-28 | Novartis Ag | 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyrazol-3-yl) -thiazole derivatives as well as related compounds as stearoyl-CoA desaturase (SCD) inhibitors for the treatment of metabolic, cardiovascular and other disorders |
CA2662074A1 (en) | 2006-08-30 | 2008-03-06 | Cellzome Limited | Triazole derivatives as kinase inhibitors |
TWI408136B (zh) * | 2006-10-02 | 2013-09-11 | Nat Health Research Institutes | 噻吩化合物及其醫藥組成物 |
TWI339205B (en) * | 2006-10-02 | 2011-03-21 | Nat Health Research Institutes | Pyrazole compounds and pharmaceutical composition |
UY30892A1 (es) * | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
EP2136820A4 (de) * | 2007-03-05 | 2010-09-15 | Univ Queensland | Target für die brustkrebstherapie und/oder diagnose |
GB0704932D0 (en) | 2007-03-14 | 2007-04-25 | Astex Therapeutics Ltd | Pharmaceutical compounds |
JP5718053B2 (ja) | 2007-08-27 | 2015-05-13 | ヘリコン・セラピューティクス・インコーポレーテッド | 治療用イソオキサゾール化合物 |
GB0801888D0 (en) * | 2008-02-01 | 2008-03-12 | Isis Innovation | Treatment of mast cell related disorders |
DE102008014523A1 (de) * | 2008-03-15 | 2009-09-17 | Robert Bosch Gmbh | Heizgerät |
EP2565191B1 (de) * | 2008-05-14 | 2014-10-08 | Astellas Pharma Inc. | 4-(Indol-7-ylcarbonylaminomethyl)cyclohexancarbonsäure-Derivate als EP4-Rezeptor Antagonisten verwendbar für die Behandlung von chronischem Nierenversagen oder diabetischer Nephropathie |
JP2010030970A (ja) * | 2008-07-31 | 2010-02-12 | Bayer Cropscience Ag | 殺虫性ベンゼンジカルボキサミド誘導体 |
TWI434686B (zh) * | 2008-11-03 | 2014-04-21 | Nat Health Research Institutes | 咪唑-4-酮及咪唑-4-硫酮化合物 |
JP2012516344A (ja) * | 2009-01-30 | 2012-07-19 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩 |
TW201103892A (en) * | 2009-04-24 | 2011-02-01 | Glaxo Group Ltd | Compounds |
EP2421834A1 (de) | 2009-04-24 | 2012-02-29 | Glaxo Group Limited | Pyrazol- und triazolcarbonsäureamide als inhibitoren des crac-kanals |
WO2010126002A1 (ja) * | 2009-04-28 | 2010-11-04 | 塩野義製薬株式会社 | ヘテロ環スルホンアミド化合物を含有する医薬 |
EP2440553B1 (de) * | 2009-06-12 | 2017-08-23 | Merck Sharp & Dohme Corp. | Thiophene als glucagonrezeptorantagonisten, zusammensetzungen und verfahren zu ihrer verwendung |
US8377970B2 (en) | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
US8993612B2 (en) * | 2009-10-08 | 2015-03-31 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer |
WO2011139489A2 (en) | 2010-04-27 | 2011-11-10 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
AU2011248579A1 (en) | 2010-04-27 | 2012-11-29 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US10703722B2 (en) | 2010-04-27 | 2020-07-07 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US9079891B2 (en) | 2010-08-27 | 2015-07-14 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
ES2532213T3 (es) | 2010-10-21 | 2015-03-25 | Glaxo Group Limited | Compuestos de pirazol que actúan contra afecciones alérgicas, inmunitarias e inflamatorias |
WO2012052459A1 (en) | 2010-10-21 | 2012-04-26 | Glaxo Group Limited | Pyrazole compounds acting against allergic, inflammatory and immune disorders |
US9604978B2 (en) | 2011-05-03 | 2017-03-28 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
WO2012170931A2 (en) | 2011-06-10 | 2012-12-13 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
WO2013059677A1 (en) | 2011-10-19 | 2013-04-25 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
AU2012325901A1 (en) * | 2011-10-19 | 2014-05-15 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
CA2871222A1 (en) | 2012-05-02 | 2013-11-07 | Lupin Limited | Substituted pyrazole compounds as crac modulators |
US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
EA201500736A1 (ru) | 2013-01-10 | 2016-04-29 | Грюненталь Гмбх | Пиразолилкарбоксамиды i в качестве ингибиторов crac каналов |
EP2943197A1 (de) | 2013-01-10 | 2015-11-18 | Grünenthal GmbH | Pyrazolylbasierte carboxamide ii als crac-kanal-hemmer |
CA2919828C (en) | 2013-07-30 | 2022-07-19 | Phaserx, Inc. | Block copolymers and their conjugates or complexes with oligonucleotides |
ES2660760T3 (es) * | 2013-12-19 | 2018-03-26 | Grünenthal GmbH | Pirrolocarboxamidas fluorometil-sustituidas como bloqueantes del canal de Ca CaV2.2 |
AU2014365740A1 (en) * | 2013-12-19 | 2016-05-26 | Grünenthal GmbH | Fluoromethyl-substituted pyrrole carboxamides iv |
CN104926801B (zh) * | 2014-03-22 | 2019-06-04 | 浙江大学 | 取代氮杂环类衍生物、含其的药物组合物及其在抗肿瘤中的应用 |
WO2015197187A1 (en) | 2014-06-24 | 2015-12-30 | Grünenthal GmbH | Pyrazolyl-based carboxamides v |
CN114642735A (zh) | 2015-01-21 | 2022-06-21 | 菲泽尔克斯公司 | 用于将治疗剂和诊断剂递送到细胞中的方法、组合物和系统 |
DK3778595T3 (da) | 2015-02-27 | 2021-10-18 | Calcimedica Inc | Pancreatitisbehandling |
EP3331525B1 (de) | 2015-08-07 | 2020-10-07 | Calcimedica, Inc. | Verwendung von crac-kanal-inhibitoren zur behandlung von schlaganfällen und traumatischen gehirnschäden |
CN105503832B (zh) * | 2015-12-18 | 2018-03-27 | 浙江大学 | 取代吡唑环类衍生物及其用途 |
EP3562510A4 (de) | 2016-12-30 | 2021-01-06 | Genevant Sciences GmbH | Verzweigte peg-moleküle sowie zugehörige zusammensetzungen und verfahren |
KR20210062023A (ko) | 2018-09-14 | 2021-05-28 | 리젠 파마슈티컬스 아게 | Crac 억제제 및 코르티코스테로이드를 포함하는 조성물 및 그의 사용 방법 |
CN111187204B (zh) * | 2020-01-13 | 2022-11-08 | 海利尔药业集团股份有限公司 | 一种啶虫脒共晶及其制备方法、用途 |
AU2021228770A1 (en) * | 2020-02-28 | 2022-09-29 | Remix Therapeutics Inc. | Thiophenyl derivatives useful for modulating nucleic acid splicing |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3401911A1 (de) * | 1984-01-20 | 1985-08-01 | A. Nattermann & Cie GmbH, 5000 Köln | Substituierte 4,5-dihydro-6-vinyl-3(2h)-pyridazinone und 6-vinyl-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung |
GB8409986D0 (en) * | 1984-04-17 | 1984-05-31 | Beecham Group Plc | Beta-lactam antibacterial agents |
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-
1998
- 1998-09-29 AU AU87139/98A patent/AU751139B2/en not_active Ceased
- 1998-10-06 BR BR9803883-4A patent/BR9803883A/pt not_active IP Right Cessation
- 1998-10-09 RU RU98118557/04A patent/RU2185381C2/ru not_active IP Right Cessation
- 1998-10-12 HU HU9802310A patent/HUP9802310A1/hu unknown
- 1998-10-12 ES ES98947818T patent/ES2285784T3/es not_active Expired - Lifetime
- 1998-10-12 PT PT98947818T patent/PT1024138E/pt unknown
- 1998-10-12 AT AT98947818T patent/ATE360618T1/de not_active IP Right Cessation
- 1998-10-12 TW TW087116918A patent/TW495498B/zh not_active IP Right Cessation
- 1998-10-12 KR KR1019980042475A patent/KR100589868B1/ko not_active IP Right Cessation
- 1998-10-12 EP EP98947818A patent/EP1024138B1/de not_active Expired - Lifetime
- 1998-10-12 WO PCT/JP1998/004583 patent/WO1999019303A1/ja active IP Right Grant
- 1998-10-12 AU AU94593/98A patent/AU9459398A/en not_active Abandoned
- 1998-10-12 DE DE69837675T patent/DE69837675T2/de not_active Expired - Fee Related
- 1998-10-12 PL PL329150A patent/PL192411B1/pl not_active IP Right Cessation
- 1998-10-12 CA CA002304979A patent/CA2304979A1/en not_active Abandoned
- 1998-10-12 US US09/529,131 patent/US6348480B1/en not_active Expired - Fee Related
- 1998-10-13 CN CN98121354A patent/CN1107671C/zh not_active Expired - Fee Related
- 1998-10-13 AR ARP980105064A patent/AR016957A1/es unknown
-
2000
- 2000-04-12 NO NO20001907A patent/NO317417B1/no not_active IP Right Cessation
-
2001
- 2001-02-02 US US09/773,736 patent/US6958339B2/en not_active Expired - Fee Related
-
2005
- 2005-06-17 US US11/154,591 patent/US7247635B2/en not_active Expired - Fee Related
-
2006
- 2006-04-07 US US11/399,379 patent/US7285554B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6958339B2 (en) | 2005-10-25 |
NO20001907L (no) | 2000-06-09 |
TW495498B (en) | 2002-07-21 |
US20060264430A1 (en) | 2006-11-23 |
CN1107671C (zh) | 2003-05-07 |
EP1024138A4 (de) | 2002-02-06 |
AU8713998A (en) | 1999-04-29 |
NO20001907D0 (no) | 2000-04-12 |
PT1024138E (pt) | 2007-08-01 |
US6348480B1 (en) | 2002-02-19 |
AU9459398A (en) | 1999-05-03 |
PL192411B1 (pl) | 2006-10-31 |
US7247635B2 (en) | 2007-07-24 |
US20050234055A1 (en) | 2005-10-20 |
CN1218046A (zh) | 1999-06-02 |
RU2185381C2 (ru) | 2002-07-20 |
BR9803883A (pt) | 2000-05-16 |
ES2285784T3 (es) | 2007-11-16 |
US7285554B2 (en) | 2007-10-23 |
PL329150A1 (en) | 1999-04-26 |
DE69837675T2 (de) | 2008-01-10 |
AU751139B2 (en) | 2002-08-08 |
HUP9802310A1 (hu) | 2000-03-28 |
HU9802310D0 (en) | 1998-12-28 |
US20010011090A1 (en) | 2001-08-02 |
KR19990037018A (ko) | 1999-05-25 |
ATE360618T1 (de) | 2007-05-15 |
NO317417B1 (no) | 2004-10-25 |
KR100589868B1 (ko) | 2006-10-24 |
EP1024138A1 (de) | 2000-08-02 |
EP1024138B1 (de) | 2007-04-25 |
WO1999019303A1 (fr) | 1999-04-22 |
AR016957A1 (es) | 2001-08-01 |
CA2304979A1 (en) | 1999-04-22 |
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