DE69836346T2 - Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmer - Google Patents
Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmer Download PDFInfo
- Publication number
- DE69836346T2 DE69836346T2 DE69836346T DE69836346T DE69836346T2 DE 69836346 T2 DE69836346 T2 DE 69836346T2 DE 69836346 T DE69836346 T DE 69836346T DE 69836346 T DE69836346 T DE 69836346T DE 69836346 T2 DE69836346 T2 DE 69836346T2
- Authority
- DE
- Germany
- Prior art keywords
- methyl
- amino
- alkyl
- aminocarbonylmethyl
- pyridinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CCN(C)*(C)(C1)C1C(C)CCC(*)(C[C@@]1*CCC1)C(C)C Chemical compound CCN(C)*(C)(C1)C1C(C)CCC(*)(C[C@@]1*CCC1)C(C)C 0.000 description 8
- MUIXBWMLQDSNIW-UHFFFAOYSA-N CC(CCC1)CN1C(N)=N Chemical compound CC(CCC1)CN1C(N)=N MUIXBWMLQDSNIW-UHFFFAOYSA-N 0.000 description 1
- SABKLSWJFURHNL-UHFFFAOYSA-N CC(N(CC(NCCONC(N)=N)=O)C1=O)=CC=C1NS(C=O)(c1ccccn1)=O Chemical compound CC(N(CC(NCCONC(N)=N)=O)C1=O)=CC=C1NS(C=O)(c1ccccn1)=O SABKLSWJFURHNL-UHFFFAOYSA-N 0.000 description 1
- MOFYGKLKVPUKEM-UHFFFAOYSA-N CC(N(CC(NCCONC(N)=N)=O)C1=O)=CC=C1NS(Cc1cc(F)ccc1)(=O)=O Chemical compound CC(N(CC(NCCONC(N)=N)=O)C1=O)=CC=C1NS(Cc1cc(F)ccc1)(=O)=O MOFYGKLKVPUKEM-UHFFFAOYSA-N 0.000 description 1
- CSBIFMMBICHMPO-UHFFFAOYSA-N CC(N(CC(NCCONC(N)=N)=O)C1=O)=CC=C1NS(c1cccc(C(F)(F)F)c1)(P)=O Chemical compound CC(N(CC(NCCONC(N)=N)=O)C1=O)=CC=C1NS(c1cccc(C(F)(F)F)c1)(P)=O CSBIFMMBICHMPO-UHFFFAOYSA-N 0.000 description 1
- SXTGGCGPBZFLAS-UHFFFAOYSA-N CC(N(CC(NCCONC(N)=N)=O)C1=O)=CC=C1NS(c1ccccc1F)(P)=O Chemical compound CC(N(CC(NCCONC(N)=N)=O)C1=O)=CC=C1NS(c1ccccc1F)(P)=O SXTGGCGPBZFLAS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6647597P | 1997-11-26 | 1997-11-26 | |
US66475P | 1997-11-26 | ||
US6732497P | 1997-12-05 | 1997-12-05 | |
US67324P | 1997-12-05 | ||
US7910798P | 1998-03-23 | 1998-03-23 | |
US79107P | 1998-03-23 | ||
PCT/US1998/025185 WO1999026926A1 (en) | 1997-11-26 | 1998-11-25 | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69836346D1 DE69836346D1 (de) | 2006-12-14 |
DE69836346T2 true DE69836346T2 (de) | 2007-05-24 |
Family
ID=27370979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69836346T Expired - Fee Related DE69836346T2 (de) | 1997-11-26 | 1998-11-25 | Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmer |
Country Status (14)
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU751412B2 (en) * | 1997-11-26 | 2002-08-15 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors |
EP1073449A4 (en) * | 1998-04-24 | 2003-01-02 | Dimensional Pharm Inc | AMINO ACID AMIDINOHYDRAZONES, ALCOXYGUANIDINES AND AMINOGUANIDINES FOR USE AS ENZYME PROTEASE INHIBITORS |
DE69942159D1 (de) * | 1998-06-11 | 2010-04-29 | Ortho Mcneil Pharm Inc | Pyrazine Protease Inhibitore |
US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
AU771928B2 (en) * | 1999-05-19 | 2004-04-08 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
US6664255B1 (en) * | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
US6906068B1 (en) | 1999-05-19 | 2005-06-14 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants |
US6908919B2 (en) * | 1999-05-19 | 2005-06-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6653316B1 (en) * | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
MXPA01011956A (es) | 1999-05-27 | 2002-06-21 | Dimensional Pharm Inc | Oxazaheterociclos como inhibidores de proteasas. |
DE60005351D1 (de) | 1999-07-09 | 2003-10-23 | Dimensional Pharm Inc | Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittel |
DK1212300T3 (da) | 1999-09-13 | 2004-03-15 | Dimensional Pharm Inc | Azacyclololalkanonserinproteaseinhibitorer |
EP1127884A1 (en) * | 2000-02-26 | 2001-08-29 | Aventis Pharma Deutschland GmbH | Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them |
US6660885B2 (en) | 2000-03-13 | 2003-12-09 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
EP1268428A2 (en) | 2000-04-05 | 2003-01-02 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
ATE289299T1 (de) * | 2000-04-05 | 2005-03-15 | Pharmacia Corp | Polyzyclisch aryl und heteroaryl substituierte 4- pyronen verwendbar als selektive hemmung von dem koagulationsprozess |
US20040171616A9 (en) * | 2000-04-17 | 2004-09-02 | South Michael S. | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
WO2001087842A1 (en) * | 2000-05-18 | 2001-11-22 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
KR20030015393A (ko) | 2000-07-17 | 2003-02-20 | 3-디멘져널 파마슈티칼즈 인코오포레이티드 | 프로테아제 억제제 기능이 있는 시클릭 옥시구아니딘피라지논 |
AU2001277242A1 (en) | 2000-08-04 | 2002-02-18 | 3-Dimensional Pharmaceuticals, Inc. | Cyclic oxyguanidine protease inhibitors |
US6486174B2 (en) | 2000-08-07 | 2002-11-26 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
US20020037897A1 (en) * | 2000-08-07 | 2002-03-28 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
UA75093C2 (en) * | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
US6624180B2 (en) | 2000-11-20 | 2003-09-23 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
US20030236257A1 (en) * | 2001-04-04 | 2003-12-25 | South Michael S. | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the cogulation cascade |
DE10133786A1 (de) * | 2001-07-16 | 2003-02-06 | Boehringer Ingelheim Pharma | Verwendung von Thrombin-Inhibitoren zur Behandlung von Arthritis |
CA2462647A1 (en) * | 2001-10-03 | 2003-04-10 | Michael S. South | 6-membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade |
US20040082585A1 (en) * | 2001-10-03 | 2004-04-29 | Pharmacia Corporation | Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade |
BR0213092A (pt) * | 2001-10-03 | 2004-10-19 | Pharmacia Corp | Compostos heterocìclicos de 6 elementos úteis para a inibição seletiva da cascata de coagulação |
WO2003093242A2 (en) | 2001-10-03 | 2003-11-13 | Pharmacia Corporation | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade |
US7262211B2 (en) | 2001-12-04 | 2007-08-28 | Dendreon Corporation | Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation |
JP4744149B2 (ja) | 2002-12-03 | 2011-08-10 | ファーマサイクリックス インコーポレイテッド | 第viia因子阻害剤としての2−(2−ヒドロキシビフェニル−3−イル)−1h−ベンゾイミダゾール−5−カルボキサミジン誘導体 |
ATE432703T1 (de) * | 2003-04-10 | 2009-06-15 | Ortho Mcneil Pharm Inc | Substituierte phenylacetamide und ihre anwendung als protease inhibitoren |
WO2005110988A1 (en) * | 2004-05-07 | 2005-11-24 | Janssen Pharmaceutica, N.V. | Pyridone compounds as inhibitors of bacterial type iii protein secretion systems |
US7553810B2 (en) * | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
US20050281740A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue |
US20050281799A1 (en) | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting damaged lung tissue using compositions |
US20050281739A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue using compositions |
US7608579B2 (en) * | 2004-06-16 | 2009-10-27 | Pneumrx, Inc. | Lung volume reduction using glue compositions |
US7678767B2 (en) | 2004-06-16 | 2010-03-16 | Pneumrx, Inc. | Glue compositions for lung volume reduction |
US20050281798A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting sites of damaged lung tissue using composition |
US7766938B2 (en) | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
US20070255177A1 (en) * | 2006-04-27 | 2007-11-01 | Pronovost Allan D | Devices and methods for collecting oral samples of enriched serous fluid |
US7758001B2 (en) * | 2006-09-13 | 2010-07-20 | Premier Mounts | Mount with magnetic attachment and automatic safety latching |
US20100297218A1 (en) * | 2006-09-20 | 2010-11-25 | Pneumrx, Inc. | Tissue adhesive compositions and methods thereof |
NZ581606A (en) | 2007-05-03 | 2012-06-29 | Intermune Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
US8563732B2 (en) | 2007-05-31 | 2013-10-22 | Shionogi & Co., Ltd. | Oxyimino compounds and the use thereof |
ES2408159T3 (es) | 2008-06-11 | 2013-06-18 | Shionogi & Co., Ltd. | Compuestos de oxicarbamoilo y su utilización |
EP3018481B1 (en) | 2009-05-20 | 2018-02-21 | Sekisui Medical Co., Ltd. | Blood coagulation time prolonging agent |
US8318737B2 (en) | 2009-09-02 | 2012-11-27 | Canthera Therapeutics Inc. | Compounds and compositions for treating cancer |
US8349832B2 (en) * | 2009-09-02 | 2013-01-08 | Canthera Therapeutics | Compounds and compositions for treating cancer |
AU2011349022B2 (en) | 2010-12-21 | 2017-04-13 | The Medicines Company (Leipzig) Gmbh | Trypsin-like serine protease inhibitors, their preparation and use as selective inhibitors of the clotting factors IIa and Xa |
EP2658580A4 (en) | 2010-12-31 | 2014-07-23 | Corridor Pharmaceuticals Inc | ARGINE STARTER AND USE METHOD |
US9609861B2 (en) | 2011-05-17 | 2017-04-04 | Velico Medical Inc. | Platelet additive solution having a β-galactosidase inhibitor |
AU2012255137A1 (en) | 2011-05-17 | 2013-12-12 | The Brigham And Women's Hospital, Inc. | Improved platelet storage using a sialidase inhibitor |
US9788539B2 (en) | 2011-05-17 | 2017-10-17 | Velico Medical, Inc. | Platelet protection solution having beta-galactosidase and sialidase inhibitors |
WO2014120886A1 (en) | 2013-01-30 | 2014-08-07 | Velico Medical, Inc. | Platelet additive solution having a self-assembling hydrogel-forming peptide |
US20150365084A1 (en) * | 2014-06-13 | 2015-12-17 | Infineon Technologies Austria Ag | Circuits and methods for operating a circuit |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4097472A (en) | 1974-11-08 | 1978-06-27 | Mitsubishi Chemical Industries Limited | N2 -arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof |
SU328634A1 (ru) | 1971-01-05 | 1978-01-05 | Butyrin V G | Устройство дл забора проб крови у животных |
SU938739A3 (ru) | 1977-01-19 | 1982-06-23 | Мицубиси Кемикал Индастриз Лимитед(Фирма) | Способ получени N -арилсульфонил-L-аргининамидов или их солей |
US4418052A (en) * | 1980-08-12 | 1983-11-29 | Wong Dennis W | Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body |
US4980148A (en) * | 1985-02-06 | 1990-12-25 | Mallinckrodt, Inc. | Methods for enhancing magnetic resonance imaging |
US5011686A (en) * | 1987-09-21 | 1991-04-30 | Creative Biomolecules, Inc. | Thrombus specific conjugates |
ZA897515B (en) * | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
US5024829A (en) * | 1988-11-21 | 1991-06-18 | Centocor, Inc. | Method of imaging coronary thrombi |
US5656600A (en) * | 1993-03-25 | 1997-08-12 | Corvas International, Inc. | α-ketoamide derivatives as inhibitors of thrombosis |
US5658885A (en) * | 1993-04-27 | 1997-08-19 | The Dupont Merck Pharmaceutical Company | Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes |
GB9318637D0 (en) | 1993-09-08 | 1993-10-27 | Ferring Res Ltd | Enzyme inhibitors |
US5466811A (en) * | 1994-07-18 | 1995-11-14 | Merck & Co., Inc. | Dioxolenylmethyl carbamates pro moieties for amine drugs |
US5656645A (en) * | 1994-12-13 | 1997-08-12 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
NZ298699A (en) * | 1994-12-13 | 2001-03-30 | Corvas Int Inc | 3-amino-1,2-dihydropyrid-1-yl(and 5-amino-1,6-dihydro-6-oxo(and 5,6-dioxo)pyrimidin-1-yl)-acetyl-argininal derivatives, useful for the treatment of blood coagulation and thrombosis |
US5658930A (en) * | 1994-12-13 | 1997-08-19 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
JPH11508558A (ja) * | 1995-06-27 | 1999-07-27 | メルク エンド カンパニー インコーポレーテッド | ピリジノン トロンビン阻害剤 |
JP2000512616A (ja) * | 1996-02-22 | 2000-09-26 | メルク エンド カンパニー インコーポレーテッド | ピリジノントロンビンインヒビター |
US5891909A (en) | 1996-03-29 | 1999-04-06 | 3-Dimensional Pharmaceuticals, Inc. | Amidinohydrazones as protease inhibitors |
TW499412B (en) | 1996-11-26 | 2002-08-21 | Dimensional Pharm Inc | Aminoguanidines and alkoxyguanidines as protease inhibitors |
AU751412B2 (en) * | 1997-11-26 | 2002-08-15 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors |
DE69942159D1 (de) * | 1998-06-11 | 2010-04-29 | Ortho Mcneil Pharm Inc | Pyrazine Protease Inhibitore |
MXPA01011956A (es) | 1999-05-27 | 2002-06-21 | Dimensional Pharm Inc | Oxazaheterociclos como inhibidores de proteasas. |
DE60005351D1 (de) | 1999-07-09 | 2003-10-23 | Dimensional Pharm Inc | Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittel |
US6236492B1 (en) * | 1999-08-03 | 2001-05-22 | Crystal Corporation | Electrode with a balanced centroid, soft edges and an apodization ratio greater than one |
-
1998
- 1998-11-25 AU AU17991/99A patent/AU751412B2/en not_active Ceased
- 1998-11-25 CA CA002311969A patent/CA2311969A1/en not_active Abandoned
- 1998-11-25 BR BR9815325-0A patent/BR9815325A/pt not_active Application Discontinuation
- 1998-11-25 EP EP98962838A patent/EP1036063B1/en not_active Expired - Lifetime
- 1998-11-25 AT AT98962838T patent/ATE344246T1/de not_active IP Right Cessation
- 1998-11-25 ES ES98962838T patent/ES2274587T3/es not_active Expired - Lifetime
- 1998-11-25 WO PCT/US1998/025185 patent/WO1999026926A1/en active IP Right Grant
- 1998-11-25 PL PL98340560A patent/PL340560A1/xx not_active Application Discontinuation
- 1998-11-25 JP JP2000522084A patent/JP2001524467A/ja active Pending
- 1998-11-25 US US09/199,167 patent/US6037356A/en not_active Expired - Lifetime
- 1998-11-25 EA EA200000578A patent/EA004180B1/ru not_active IP Right Cessation
- 1998-11-25 DE DE69836346T patent/DE69836346T2/de not_active Expired - Fee Related
- 1998-11-25 TW TW087119488A patent/TWI222441B/zh not_active IP Right Cessation
- 1998-11-26 AR ARP980106006A patent/AR016702A1/es unknown
-
2000
- 2000-01-14 US US09/482,540 patent/US6245763B1/en not_active Expired - Lifetime
-
2001
- 2001-04-06 US US09/827,292 patent/US6350764B2/en not_active Expired - Lifetime
- 2001-12-12 US US10/012,445 patent/US6472399B2/en not_active Expired - Lifetime
-
2002
- 2002-09-12 US US10/241,513 patent/US6566379B1/en not_active Expired - Lifetime
-
2003
- 2003-03-27 US US10/400,073 patent/US6706021B2/en not_active Expired - Lifetime
- 2003-11-17 US US10/714,988 patent/US7029654B2/en not_active Expired - Lifetime
-
2005
- 2005-10-19 US US11/254,086 patent/US7402586B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AR016702A1 (es) | 2001-07-25 |
US6472399B2 (en) | 2002-10-29 |
US6350764B2 (en) | 2002-02-26 |
EA200000578A1 (ru) | 2001-02-26 |
JP2001524467A (ja) | 2001-12-04 |
US20030225115A1 (en) | 2003-12-04 |
DE69836346D1 (de) | 2006-12-14 |
US20030087921A1 (en) | 2003-05-08 |
BR9815325A (pt) | 2001-12-26 |
EA004180B1 (ru) | 2004-02-26 |
US20020007070A1 (en) | 2002-01-17 |
AU1799199A (en) | 1999-06-15 |
CA2311969A1 (en) | 1999-06-03 |
US20020086872A1 (en) | 2002-07-04 |
TWI222441B (en) | 2004-10-21 |
AU751412B2 (en) | 2002-08-15 |
US6245763B1 (en) | 2001-06-12 |
US6037356A (en) | 2000-03-14 |
WO1999026926A1 (en) | 1999-06-03 |
ATE344246T1 (de) | 2006-11-15 |
EP1036063B1 (en) | 2006-11-02 |
EP1036063A1 (en) | 2000-09-20 |
US20060211719A1 (en) | 2006-09-21 |
US7402586B2 (en) | 2008-07-22 |
US7029654B2 (en) | 2006-04-18 |
US6566379B1 (en) | 2003-05-20 |
US20040106633A1 (en) | 2004-06-03 |
ES2274587T3 (es) | 2007-05-16 |
US6706021B2 (en) | 2004-03-16 |
PL340560A1 (en) | 2001-02-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69836346T2 (de) | Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmer | |
DE60122546T2 (de) | Aminopyridinyl-, aminoguanidinyl- und alkoxyguanidinyl- substituierte phenylacetamide als protease inhibitoren | |
EP1086122B1 (en) | Pyrazinone protease inhibitors | |
DE69637307T2 (de) | Aus d-aminosäuren abgeleitete cystein-und serinproteasehemmer | |
DE69631692T2 (de) | Amidino proteaseinhibitoren | |
US6326492B1 (en) | Heterocyclic protease inhibitors | |
US6420397B1 (en) | Heteroaryl protease inhibitors and diagnostic imaging agents | |
DE60006407T2 (de) | Azazykloalkanone serin-protease-hemmer | |
JP2006522809A (ja) | 置換フェニルアセトアミおよびプロテアーゼインヒビターとしてのその使用 | |
MXPA00005055A (en) | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors | |
DE60204800T2 (de) | Bestimmte glycin-derivate als faktor xa inhibitoren zur verwendung in der behandlung von thrombose | |
MXPA00011612A (en) | Pyrazinone protease inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |