DE69834024T2 - Tetracycline verbindungen zur behandlung von spezifischen krebsarten - Google Patents

Tetracycline verbindungen zur behandlung von spezifischen krebsarten Download PDF

Info

Publication number
DE69834024T2
DE69834024T2 DE69834024T DE69834024T DE69834024T2 DE 69834024 T2 DE69834024 T2 DE 69834024T2 DE 69834024 T DE69834024 T DE 69834024T DE 69834024 T DE69834024 T DE 69834024T DE 69834024 T2 DE69834024 T2 DE 69834024T2
Authority
DE
Germany
Prior art keywords
cmt
dimethylamino
tetracycline
cancer
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69834024T
Other languages
German (de)
English (en)
Other versions
DE69834024D1 (de
Inventor
M. Lorne Smithtown GOLUB
F. Thomas Port Jefferson McNAMARA
S. Nungavaram Smithtown RAMAMURTHY
Hsi-Ming Setauket LEE
Sanford Stony Brook SIMON
L. Balakrishna Miami LOKESHWAR
G. Marie Fort Lauderdale SELZER
L. Normal Miami BLOCK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miami
Research Foundation of the State University of New York
Original Assignee
University of Miami
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Miami, Research Foundation of the State University of New York filed Critical University of Miami
Application granted granted Critical
Publication of DE69834024D1 publication Critical patent/DE69834024D1/de
Publication of DE69834024T2 publication Critical patent/DE69834024T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69834024T 1997-01-15 1998-01-15 Tetracycline verbindungen zur behandlung von spezifischen krebsarten Expired - Lifetime DE69834024T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/783,655 US5837696A (en) 1997-01-15 1997-01-15 Method of inhibiting cancer growth
PCT/US1998/000332 WO1998031224A1 (en) 1997-01-15 1998-01-15 Method of inhibiting cancer growth
US783655 2001-02-14

Publications (2)

Publication Number Publication Date
DE69834024D1 DE69834024D1 (de) 2006-05-18
DE69834024T2 true DE69834024T2 (de) 2006-12-07

Family

ID=25130005

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69834024T Expired - Lifetime DE69834024T2 (de) 1997-01-15 1998-01-15 Tetracycline verbindungen zur behandlung von spezifischen krebsarten

Country Status (11)

Country Link
US (2) US5837696A (https=)
EP (1) EP0971585B1 (https=)
JP (1) JP4428727B2 (https=)
KR (1) KR20000070212A (https=)
AT (1) ATE321452T1 (https=)
AU (1) AU729886B2 (https=)
CA (1) CA2277865C (https=)
DE (1) DE69834024T2 (https=)
ES (1) ES2262221T3 (https=)
PT (1) PT971585E (https=)
WO (1) WO1998031224A1 (https=)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837696A (en) * 1997-01-15 1998-11-17 The Research Foundation Of State University Of New York Method of inhibiting cancer growth
US6429204B1 (en) 1997-01-15 2002-08-06 University Of Miami Method of inhibiting cancer growth
AU2001599A (en) * 1997-12-19 1999-07-05 New York University Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha
US6277061B1 (en) 1998-03-31 2001-08-21 The Research Foundation Of State University Of New York Method of inhibiting membrane-type matrix metalloproteinase
US6015804A (en) * 1998-09-11 2000-01-18 The Research Foundation Of State University Of New York Method of using tetracycline compounds to enhance interleukin-10 production
US5977091A (en) * 1998-09-21 1999-11-02 The Research Foundation Of State University Of New York Method of preventing acute lung injury
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
BR9916536A (pt) * 1998-12-23 2002-01-02 Searle & Co Método para o tratamento ou prevenção de um distúrbio de neoplasia em um mamìfero em necessidade deste tratamento ou prevenção, e, combinação
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6984619B1 (en) * 1999-03-19 2006-01-10 Arch Development Corporation Method for protection against tumor metastasis formation
DE10032256C2 (de) * 2000-07-03 2003-06-05 Infineon Technologies Ag Chip-ID-Register-Anordnung
EP2311440A1 (en) * 2001-04-05 2011-04-20 Collagenex Pharmaceuticals, Inc. Controlled delivery of tetracycline compounds and tetracycline derivatives
EP2327409A1 (en) 2001-07-13 2011-06-01 Paratek Pharmaceuticals, Inc. Tetracycline compound having target therapeutic activities
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
RU2300380C2 (ru) * 2001-10-05 2007-06-10 Тетрадженекс Фармасьютикалс, Инк. Производные тетрациклина и способы их применения
PE20030701A1 (es) * 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
ES2551708T3 (es) 2002-01-08 2015-11-23 Paratek Pharmaceuticals, Inc. Compuestos de 4-desdimetilamino tetraciclina
EP2311451A1 (en) 2002-03-08 2011-04-20 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
EP1503981A4 (en) 2002-03-21 2007-08-15 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS
JP2005526114A (ja) * 2002-05-06 2005-09-02 コッラジェネックス ファーマシューチカルス インコーポレイテッド 粘膜炎及び真菌感染症の同時治療方法
JP2005533766A (ja) * 2002-05-20 2005-11-10 コッラジェネックス ファーマシューチカルス インコーポレイテッド アレルギー反応の治療方法
AU2003261161B2 (en) 2002-07-12 2009-09-10 Paratek Pharmaceuticals, Inc 3, 10, and 12a substituted tetracycline compounds
CA2503446C (en) 2002-10-24 2012-12-18 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate rna
WO2004091483A2 (en) 2003-04-07 2004-10-28 Shire Laboratories, Inc. Once daily formulations of tetracyclines
US20050143352A1 (en) 2003-07-09 2005-06-30 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2004259661B2 (en) 2003-07-09 2011-11-10 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
JP5010284B2 (ja) * 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族a環誘導体
EP2033950A1 (en) 2004-10-25 2009-03-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP1805134B1 (en) 2004-10-25 2012-06-20 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
WO2008079339A2 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
CA2892739A1 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
EP2216323A3 (en) * 2007-04-27 2010-12-29 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
EP2176216B1 (en) * 2007-07-06 2012-04-25 Paratek Pharmaceuticals, Inc. Methods for synthesizing 9-substituted minocycline
TWI680117B (zh) 2008-05-19 2019-12-21 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
KR101746795B1 (ko) 2008-08-08 2017-06-13 테트라페이즈 파마슈티컬스, 인코포레이티드 C7-플루오로 치환된 테트라시클린 화합물
WO2010129057A2 (en) 2009-05-08 2010-11-11 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
NO2470500T3 (https=) 2009-08-28 2018-03-03
WO2011109899A1 (en) * 2010-03-10 2011-09-15 University Health Network Use of tigecycline for treatment of cancer
DK2552890T3 (en) 2010-03-31 2017-04-03 Tetraphase Pharmaceuticals Inc POLYCYCLIC TETRACYCLINE COMPOUNDS
CA2883238C (en) 2012-08-31 2021-11-23 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
CN105142631A (zh) * 2013-01-14 2015-12-09 健康诊所有限公司 抗癌药物和用途
HUE066360T2 (hu) 2016-10-19 2024-07-28 Tetraphase Pharmaceuticals Inc Eravaciklin kristályformái
US11197872B2 (en) 2017-04-21 2021-12-14 Lunella Biotech, Inc. Vitamin C and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (CSCs)
CA3060509A1 (en) 2017-04-21 2018-10-25 Federica Sotgia Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy
US12006553B2 (en) 2017-05-19 2024-06-11 Lunella Biotech, Inc. Companion diagnostics for mitochondrial inhibitors
KR20200010343A (ko) 2017-05-19 2020-01-30 루넬라 바이오테크 인코포레이티드 안티미토신: 암 줄기 세포를 근절하기 위한 미토콘드리아 생물발생의 표적화 억제제
US12570604B2 (en) 2018-11-09 2026-03-10 Tetraphase Pharmaceuticals, Inc. Polymorphic forms of a tetracycline compound and uses thereof
CN115006411A (zh) * 2022-07-26 2022-09-06 中南大学湘雅医院 依拉环素类化合物的应用、药物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308839A (en) * 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
JP3016587B2 (ja) * 1989-12-04 2000-03-06 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク 非ステロイド抗炎症剤及びテトラサイクリンの配合
AU1411992A (en) * 1991-01-15 1992-08-27 Robert A Bok A composition containing a tetracycline and use for inhibiting angiogenesis
US5668122A (en) * 1993-07-28 1997-09-16 Fife; Rose S. Method to treat cancer with tetracyclines
US5574026A (en) * 1994-12-13 1996-11-12 American Cyanamid Company Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth
US5567693A (en) * 1994-12-13 1996-10-22 American Cyanamid Company Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5563130A (en) * 1994-12-13 1996-10-08 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5837696A (en) * 1997-01-15 1998-11-17 The Research Foundation Of State University Of New York Method of inhibiting cancer growth

Also Published As

Publication number Publication date
JP4428727B2 (ja) 2010-03-10
WO1998031224A1 (en) 1998-07-23
EP0971585A4 (en) 2001-01-24
EP0971585A1 (en) 2000-01-19
JP2001508794A (ja) 2001-07-03
KR20000070212A (ko) 2000-11-25
ATE321452T1 (de) 2006-04-15
PT971585E (pt) 2006-08-31
US6100248A (en) 2000-08-08
US5837696A (en) 1998-11-17
CA2277865A1 (en) 1998-07-23
DE69834024D1 (de) 2006-05-18
ES2262221T3 (es) 2006-11-16
CA2277865C (en) 2009-06-02
EP0971585B1 (en) 2006-03-29
AU5910498A (en) 1998-08-07
AU729886B2 (en) 2001-02-15

Similar Documents

Publication Publication Date Title
DE69834024T2 (de) Tetracycline verbindungen zur behandlung von spezifischen krebsarten
DE69829748T2 (de) Hemmung der serine proteinase mittels hydrophoben tetracyclins
DE69929810T2 (de) Verwendung von tetracyclinderivaten zur steigerung der interleukin-10 produktion
DE69924268T2 (de) Kombination von bisphosphonat und tetracyclin
DE69734661T2 (de) Foerderung der wundheilung durch chemisch modifizierte tetracycline
DE60117615T2 (de) Arzneimittelkombinationen (z.b. chlorpromazin und pentamidin) zur therapie von neoplastischen erkrankungen
DE3686956T2 (de) Nichtantibakterielle tetracyclinzusammensetzungen mit anticollagenolytischen eigenschaften.
DE69001429T2 (de) Zusammensetzung mit gehalt an einem nichtsteroiden entzuendungshemmenden mittel und einem nichtbakterizidwirksamen tetracyclin.
DE69930252T2 (de) Verwendung von tetracyclinen zur behandlung von störungen der meibomschen drüsen
DE69327788T2 (de) Pharmazeutische zusammenstezungen zur hemmung von tumoren in verbindung mit prostaten adenokarzinom magenkrebs und brustkrebs
DE69014141T2 (de) Verwendung von Benzimidazol-Derivaten als antibakterielle Mittel.
DE60218443T2 (de) Jasmonate enthaltende therapeutische zusammensetzungen für die behandlung von krebs
DE69026620T2 (de) Anti-tumor-zubereitung enthaltend interleukin-2 und histamin, analoge dazu oder h2-rezeptor-agonisten
US6429204B1 (en) Method of inhibiting cancer growth
DE69615984T2 (de) Verwendung von Ursolsäure zur Herstellung eines Arzneimittels zur Unterdrückung von Metastasen
EP0864579B1 (de) Wismutsalze von Antibiotika der Moenomycin-Gruppe, Verfahren zu ihrer Herstellung, ihre Verwendung und solche Salze enthaltende Arzneimittel
DE69809928T2 (de) Tizoxanide und nitazoxanide enthaltende pharmazeutische zusammensetzungen
EP0655249B1 (de) Moenomycin als Arzneimittel zur Behandlung von Magengeschwüren
DE10008159B4 (de) Verwendung von 2-Methyl-thiazolidin-2,4-dicarbonsäure und/oder ihrer physiologisch verträglichen Salze als Antikrebsmittel
DE69713570T2 (de) Verfahren zum abtöten neoplastischer zellen mittels piperazin-oxiran derivaten
EP0817623B1 (de) Arzneistoffe zur selektiven bekämpfung von tumorgewebe
DE2824610C2 (de) Arzneimittelgemisch aus einer Penicillansäure und aus einem Penicillin oder Cephalosporin
DE3785953T2 (de) Bakterientötende Gemische.
DE69132145T2 (de) Peritoneal wirksame medikamente
MXPA99006554A (en) Method of inhibiting cancer growth

Legal Events

Date Code Title Description
8364 No opposition during term of opposition