DE69834024D1 - Tetracycline verbindungen zur behandlung von spezifischen krebsarten - Google Patents

Tetracycline verbindungen zur behandlung von spezifischen krebsarten

Info

Publication number
DE69834024D1
DE69834024D1 DE69834024T DE69834024T DE69834024D1 DE 69834024 D1 DE69834024 D1 DE 69834024D1 DE 69834024 T DE69834024 T DE 69834024T DE 69834024 T DE69834024 T DE 69834024T DE 69834024 D1 DE69834024 D1 DE 69834024D1
Authority
DE
Germany
Prior art keywords
cells
cancer
growth
tetracycline compounds
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69834024T
Other languages
English (en)
Other versions
DE69834024T2 (de
Inventor
M Golub
F Mcnamara
S Ramamurthy
Hsi-Ming Lee
Sanford Simon
L Lokeshwar
G Selzer
L Block
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of State University of New York
University of Miami
Original Assignee
Research Foundation of State University of New York
University of Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of State University of New York, University of Miami filed Critical Research Foundation of State University of New York
Publication of DE69834024D1 publication Critical patent/DE69834024D1/de
Application granted granted Critical
Publication of DE69834024T2 publication Critical patent/DE69834024T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69834024T 1997-01-15 1998-01-15 Tetracycline verbindungen zur behandlung von spezifischen krebsarten Expired - Lifetime DE69834024T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/783,655 US5837696A (en) 1997-01-15 1997-01-15 Method of inhibiting cancer growth
PCT/US1998/000332 WO1998031224A1 (en) 1997-01-15 1998-01-15 Method of inhibiting cancer growth
US783655 2001-02-14

Publications (2)

Publication Number Publication Date
DE69834024D1 true DE69834024D1 (de) 2006-05-18
DE69834024T2 DE69834024T2 (de) 2006-12-07

Family

ID=25130005

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69834024T Expired - Lifetime DE69834024T2 (de) 1997-01-15 1998-01-15 Tetracycline verbindungen zur behandlung von spezifischen krebsarten

Country Status (11)

Country Link
US (2) US5837696A (de)
EP (1) EP0971585B1 (de)
JP (1) JP4428727B2 (de)
KR (1) KR20000070212A (de)
AT (1) ATE321452T1 (de)
AU (1) AU729886B2 (de)
CA (1) CA2277865C (de)
DE (1) DE69834024T2 (de)
ES (1) ES2262221T3 (de)
PT (1) PT971585E (de)
WO (1) WO1998031224A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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US5837696A (en) * 1997-01-15 1998-11-17 The Research Foundation Of State University Of New York Method of inhibiting cancer growth
US6429204B1 (en) 1997-01-15 2002-08-06 University Of Miami Method of inhibiting cancer growth
WO1999030720A1 (en) * 1997-12-19 1999-06-24 New York University Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha
US6277061B1 (en) 1998-03-31 2001-08-21 The Research Foundation Of State University Of New York Method of inhibiting membrane-type matrix metalloproteinase
US6015804A (en) * 1998-09-11 2000-01-18 The Research Foundation Of State University Of New York Method of using tetracycline compounds to enhance interleukin-10 production
US5977091A (en) * 1998-09-21 1999-11-02 The Research Foundation Of State University Of New York Method of preventing acute lung injury
PL349216A1 (en) * 1998-12-23 2002-07-01 Searle & Co Method of using a cyclooxygenase-2 inhibitor and a matrix metalloproteinase inhibitor as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6984619B1 (en) * 1999-03-19 2006-01-10 Arch Development Corporation Method for protection against tumor metastasis formation
DE10032256C2 (de) * 2000-07-03 2003-06-05 Infineon Technologies Ag Chip-ID-Register-Anordnung
US20040115261A1 (en) * 2001-04-05 2004-06-17 Ashley Robert A. Controlled delivery of tetracycline compounds and tetracycline derivatives
EP2332549A1 (de) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Neue Tetracyclinverbindungen und deren medizinischen Anwendung
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
MY133403A (en) * 2001-10-05 2007-11-30 Tetragenex Pharmaceuticals Inc Tetracycline derivatives and methods of use thereof
PE20030701A1 (es) * 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
WO2003057169A2 (en) 2002-01-08 2003-07-17 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
CN102531948A (zh) 2002-03-08 2012-07-04 帕拉特克药品公司 氨基-甲基取代的四环素类化合物
AU2003218243B2 (en) 2002-03-21 2010-04-01 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
KR20050005466A (ko) * 2002-05-06 2005-01-13 콜라제넥스 파마슈티칼스, 인크 점막염 및 진균 감염을 동시에 치료하는 방법
WO2003099270A1 (en) * 2002-05-20 2003-12-04 Collagenex Pharmaceuticals, Inc. Methods of treating allergic reactions
KR101148415B1 (ko) 2002-07-12 2012-05-21 파라테크 파마슈티컬스, 인크. 3, 10, 및 12ａ 치환된 테트라시클린 화합물
JP4686189B2 (ja) 2002-10-24 2011-05-18 パラテック ファーマシューティカルズ インコーポレイテッド Ｒｎａを調節するための置換テトラサイクリン化合物の使用方法
EP1615622B1 (de) 2003-04-07 2012-07-11 Supernus Pharmaceuticals, Inc. Doxycyclin-zubereitungen zur einmal täglichen anwendung
JP4738333B2 (ja) 2003-07-09 2011-08-03 パラテック ファーマシューティカルズ インコーポレイテッド ９−アミノメチルテトラサイクリン化合物のプロドラッグ
EP2298322A3 (de) 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
CA2553510C (en) * 2004-01-15 2012-09-25 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
EP2284156A3 (de) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
CA2585418A1 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
ES2701725T3 (es) * 2006-12-21 2019-02-25 Paratek Pharm Innc Compuestos de tetraciclina sustituida para el tratamiento de trastornos inflamatorios de la piel
CA2925939C (en) 2006-12-21 2019-10-01 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2216323A3 (de) 2007-04-27 2010-12-29 Paratek Pharmaceuticals, Inc. Verfahren zur Synthetisierung und Reinigung von Aminoalkyl-Tetracyclinverbindungen
BRPI0823405A2 (pt) * 2007-07-06 2012-12-25 Paratek Pharm Innc mÉtodos para sintetizar compostos de tetraciclina substituÍda
TW202332671A (zh) 2008-05-23 2023-08-16 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
AR072990A1 (es) 2008-08-08 2010-10-06 Tetraphase Pharmaceuticals Inc Compuestos de tetraciclina sustituidos con fluor en c7
CN107021887A (zh) 2009-05-08 2017-08-08 四相制药公司 四环素类化合物
WO2011025982A2 (en) 2009-08-28 2011-03-03 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
JP2013521314A (ja) * 2010-03-10 2013-06-10 ユニバーシティー ヘルス ネットワーク 癌の処置のためのチゲサイクリンの使用
EP2552890B1 (de) 2010-03-31 2017-01-04 Tetraphase Pharmaceuticals, Inc. Polycyclische tetracyclinverbindungen
NZ740051A (en) 2012-08-31 2019-09-27 Tetraphase Pharmaceuticals Inc Tetracycline compounds
WO2014108571A2 (en) * 2013-01-14 2014-07-17 Biocopea Limited Cancer drug and uses
SG11201903327PA (en) 2016-10-19 2019-05-30 Tetraphase Pharmaceuticals Inc Crystalline forms of eravacycline
EP3612187B1 (de) 2017-04-21 2022-04-13 Lunella Biotech, Inc. Vitamin c und doxycyclin: eine synthetische letale kombinationstherapie zur eradikation von krebsstammzellen (cscs)
US11229657B2 (en) 2017-04-21 2022-01-25 Lunella Biotech, Inc. Targeting hypoxic cancer stem cells (CSCs) with doxycycline: implications for improving anti-angiogenic therapy
US12006553B2 (en) 2017-05-19 2024-06-11 Lunella Biotech, Inc. Companion diagnostics for mitochondrial inhibitors
WO2018213751A1 (en) 2017-05-19 2018-11-22 Lunella Biotech, Inc. Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
US20210395198A1 (en) 2018-11-09 2021-12-23 Tetraphase Pharmaceuticals, Inc. Polymorphic forms of a compound and uses thereof
CN115006411A (zh) * 2022-07-26 2022-09-06 中南大学湘雅医院 依拉环素类化合物的应用、药物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3016587B2 (ja) * 1989-12-04 2000-03-06 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク 非ステロイド抗炎症剤及びテトラサイクリンの配合
US5308839A (en) * 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
AU1411992A (en) * 1991-01-15 1992-08-27 Robert A Bok A composition containing a tetracycline and use for inhibiting angiogenesis
US5668122A (en) * 1993-07-28 1997-09-16 Fife; Rose S. Method to treat cancer with tetracyclines
US5574026A (en) * 1994-12-13 1996-11-12 American Cyanamid Company Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth
US5567693A (en) * 1994-12-13 1996-10-22 American Cyanamid Company Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5563130A (en) * 1994-12-13 1996-10-08 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5837696A (en) * 1997-01-15 1998-11-17 The Research Foundation Of State University Of New York Method of inhibiting cancer growth

Also Published As

Publication number Publication date
US6100248A (en) 2000-08-08
EP0971585A4 (de) 2001-01-24
ES2262221T3 (es) 2006-11-16
AU5910498A (en) 1998-08-07
ATE321452T1 (de) 2006-04-15
WO1998031224A1 (en) 1998-07-23
EP0971585B1 (de) 2006-03-29
US5837696A (en) 1998-11-17
CA2277865A1 (en) 1998-07-23
EP0971585A1 (de) 2000-01-19
JP4428727B2 (ja) 2010-03-10
KR20000070212A (ko) 2000-11-25
JP2001508794A (ja) 2001-07-03
PT971585E (pt) 2006-08-31
DE69834024T2 (de) 2006-12-07
AU729886B2 (en) 2001-02-15
CA2277865C (en) 2009-06-02

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