EP2216323A3 - Verfahren zur Synthetisierung und Reinigung von Aminoalkyl-Tetracyclinverbindungen - Google Patents

Verfahren zur Synthetisierung und Reinigung von Aminoalkyl-Tetracyclinverbindungen Download PDF

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Publication number
EP2216323A3
EP2216323A3 EP10152022A EP10152022A EP2216323A3 EP 2216323 A3 EP2216323 A3 EP 2216323A3 EP 10152022 A EP10152022 A EP 10152022A EP 10152022 A EP10152022 A EP 10152022A EP 2216323 A3 EP2216323 A3 EP 2216323A3
Authority
EP
European Patent Office
Prior art keywords
methods
synthesizing
purifying
tetracycline compounds
aminoalkyl tetracycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10152022A
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English (en)
French (fr)
Other versions
EP2216323A2 (de
Inventor
Sean Johnston
Tedeusz Warchol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Paratek Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc filed Critical Paratek Pharmaceuticals Inc
Publication of EP2216323A2 publication Critical patent/EP2216323A2/de
Publication of EP2216323A3 publication Critical patent/EP2216323A3/de
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
EP10152022A 2007-04-27 2008-04-28 Verfahren zur Synthetisierung und Reinigung von Aminoalkyl-Tetracyclinverbindungen Withdrawn EP2216323A3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92646107P 2007-04-27 2007-04-27
EP08754132A EP2144870A2 (de) 2007-04-27 2008-04-28 Verfahren zur synthese und reinigung von aminoalkyl-tetracyclin-verbindungen

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP08754132.2 Division 2008-04-28

Publications (2)

Publication Number Publication Date
EP2216323A2 EP2216323A2 (de) 2010-08-11
EP2216323A3 true EP2216323A3 (de) 2010-12-29

Family

ID=39739603

Family Applications (3)

Application Number Title Priority Date Filing Date
EP10152023A Withdrawn EP2213655A1 (de) 2007-04-27 2008-04-28 Verfahren zur Reinigung von Aminoalkyl-Tetracyclinverbindungen
EP10152022A Withdrawn EP2216323A3 (de) 2007-04-27 2008-04-28 Verfahren zur Synthetisierung und Reinigung von Aminoalkyl-Tetracyclinverbindungen
EP08754132A Withdrawn EP2144870A2 (de) 2007-04-27 2008-04-28 Verfahren zur synthese und reinigung von aminoalkyl-tetracyclin-verbindungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP10152023A Withdrawn EP2213655A1 (de) 2007-04-27 2008-04-28 Verfahren zur Reinigung von Aminoalkyl-Tetracyclinverbindungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP08754132A Withdrawn EP2144870A2 (de) 2007-04-27 2008-04-28 Verfahren zur synthese und reinigung von aminoalkyl-tetracyclin-verbindungen

Country Status (6)

Country Link
US (4) US9434680B2 (de)
EP (3) EP2213655A1 (de)
JP (2) JP2010525069A (de)
AU (2) AU2008246119A1 (de)
CA (1) CA2688662A1 (de)
WO (1) WO2008134048A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
CN101786991A (zh) 2003-07-09 2010-07-28 帕拉特克药品公司 取代的四环素化合物
EP2284150A3 (de) * 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
US8088755B2 (en) 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
EP2026776A2 (de) * 2006-05-15 2009-02-25 Paratek Pharmaceuticals, Inc. Verfahren zur regelung der genexpression oder genprodukte mithilfe von substituierten tetracyclinverbindungen
PT2120963T (pt) 2006-12-21 2018-12-17 Paratek Pharm Innc Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele
ES2463457T3 (es) 2006-12-21 2014-05-28 Paratek Pharmaceuticals, Inc. Derivados de la tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias
EP2144614A1 (de) 2007-04-12 2010-01-20 Paratek Pharmaceuticals, Inc. Verfahren zur behandlung von spinaler muskelatrophie mittels tetracyclinverbindungen
CA2688662A1 (en) * 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
ES2386926T3 (es) 2007-07-06 2012-09-06 Paratek Pharmaceuticals, Inc. Métodos para sintetizar minociclina9-sustituida
WO2009111064A2 (en) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
US20100022483A1 (en) * 2008-04-14 2010-01-28 Paratek Pharmaceuticals, Inc. Substituted Tetracycline Compounds
AP2011005631A0 (en) * 2008-09-19 2011-04-30 Paratek Pharmaceuticals Ind Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment.
EP4268897A3 (de) 2015-03-24 2024-01-03 Paratek Pharmaceuticals, Inc. Minocyclinverbindungen zur bioabwehr
SG10201913599RA (en) 2016-11-01 2020-02-27 Paratek Pharm Innc 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
CN111484424B (zh) * 2020-04-14 2022-10-25 成都百特万合医药科技有限公司 一种合成奥马环素的方法
AU2021288202A1 (en) * 2020-06-11 2022-12-08 Paratek Pharmaceuticals Inc. Crystalline forms of omadacycline, methods of synthesis thereof and methods of use thereof
PT117254B (pt) 2021-05-26 2024-04-18 Hovione Farm S A Método de síntese de compostos 9-aminometil tetraciclinas
CN114591216A (zh) * 2022-02-17 2022-06-07 四川澄华生物科技有限公司 一种合成奥马环素中间体的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004406A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 9-substituted minocycline compounds
WO2004091513A2 (en) * 2003-04-10 2004-10-28 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
US20050026876A1 (en) * 2001-03-13 2005-02-03 Nelson Mark L. 9-aminomethyl substituted minocycline compounds

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US3304227A (en) 1965-07-15 1967-02-14 Loyal E Loveless Antibiotic-containing animal feed
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US20140031319A1 (en) 2014-01-30
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CA2688662A1 (en) 2008-11-06
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