PT971585E - Compostos tetraciclina no tratamento de certos tipos de cancros - Google Patents

Compostos tetraciclina no tratamento de certos tipos de cancros

Info

Publication number
PT971585E
PT971585E PT98902437T PT98902437T PT971585E PT 971585 E PT971585 E PT 971585E PT 98902437 T PT98902437 T PT 98902437T PT 98902437 T PT98902437 T PT 98902437T PT 971585 E PT971585 E PT 971585E
Authority
PT
Portugal
Prior art keywords
cancer
cells
growth
tetracycline compounds
treatment
Prior art date
Application number
PT98902437T
Other languages
English (en)
Inventor
Lorne M Golub
Thomas F Mcnamara
Nungavaram S Ramamurthy
Hsi-Ming Lee
Sanford Simon
Balakrishna L Lokeshwar
Marie G Selzer
Normal L Block
Original Assignee
Univ Miami
Res Foundation Of State Univ O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Miami, Res Foundation Of State Univ O filed Critical Univ Miami
Publication of PT971585E publication Critical patent/PT971585E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
PT98902437T 1997-01-15 1998-01-15 Compostos tetraciclina no tratamento de certos tipos de cancros PT971585E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/783,655 US5837696A (en) 1997-01-15 1997-01-15 Method of inhibiting cancer growth

Publications (1)

Publication Number Publication Date
PT971585E true PT971585E (pt) 2006-08-31

Family

ID=25130005

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98902437T PT971585E (pt) 1997-01-15 1998-01-15 Compostos tetraciclina no tratamento de certos tipos de cancros

Country Status (11)

Country Link
US (2) US5837696A (pt)
EP (1) EP0971585B1 (pt)
JP (1) JP4428727B2 (pt)
KR (1) KR20000070212A (pt)
AT (1) ATE321452T1 (pt)
AU (1) AU729886B2 (pt)
CA (1) CA2277865C (pt)
DE (1) DE69834024T2 (pt)
ES (1) ES2262221T3 (pt)
PT (1) PT971585E (pt)
WO (1) WO1998031224A1 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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US6429204B1 (en) 1997-01-15 2002-08-06 University Of Miami Method of inhibiting cancer growth
US5837696A (en) * 1997-01-15 1998-11-17 The Research Foundation Of State University Of New York Method of inhibiting cancer growth
PT1041991E (pt) * 1997-12-19 2008-10-03 Univ New York Tetraciclinas não antibacterianas para o tratamento de esclerose múltipla
US6277061B1 (en) * 1998-03-31 2001-08-21 The Research Foundation Of State University Of New York Method of inhibiting membrane-type matrix metalloproteinase
US6015804A (en) * 1998-09-11 2000-01-18 The Research Foundation Of State University Of New York Method of using tetracycline compounds to enhance interleukin-10 production
US5977091A (en) * 1998-09-21 1999-11-02 The Research Foundation Of State University Of New York Method of preventing acute lung injury
EP1140179A2 (en) * 1998-12-23 2001-10-10 G.D. SEARLE & CO. Use of a cyclooxygenase 2 inhibitor and an integrin antagonist as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6984619B1 (en) * 1999-03-19 2006-01-10 Arch Development Corporation Method for protection against tumor metastasis formation
DE10032256C2 (de) * 2000-07-03 2003-06-05 Infineon Technologies Ag Chip-ID-Register-Anordnung
CA2447008A1 (en) * 2001-04-05 2002-10-24 Collagenex Pharmaceuticals, Inc. Controlled delivery of tetracycline compounds and tetracycline derivatives
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2332547A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of inflammatory bowel disease
WO2003030819A2 (en) * 2001-10-05 2003-04-17 Tetragenex Pharmaceuticals, Inc. Tetracycline derivatives and methods of use thereof
PE20030701A1 (es) * 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
US7056902B2 (en) 2002-01-08 2006-06-06 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
CN102531948A (zh) 2002-03-08 2012-07-04 帕拉特克药品公司 氨基-甲基取代的四环素类化合物
EP1503981A4 (en) 2002-03-21 2007-08-15 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS
CA2500134A1 (en) * 2002-05-06 2003-11-13 Collagenex Pharmaceuticals, Inc. Methods of simultaneously treating mucositis and fungal infection
KR20050007553A (ko) * 2002-05-20 2005-01-19 콜라제넥스 파마슈티칼스, 인크 알레르기 반응을 치료하는 방법
WO2004006850A2 (en) 2002-07-12 2004-01-22 Paratek Pharmaceuticals, Inc 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS
JP4686189B2 (ja) 2002-10-24 2011-05-18 パラテック ファーマシューティカルズ インコーポレイテッド Ｒｎａを調節するための置換テトラサイクリン化合物の使用方法
ES2534827T3 (es) 2003-04-07 2015-04-29 Supernus Pharmaceuticals, Inc. Formulaciones de tetraciclinas en dosis única diaria
CA2531732C (en) 2003-07-09 2012-04-10 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2295404A3 (en) 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP1716101A1 (en) * 2004-01-15 2006-11-02 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
EP2284153A3 (en) 2004-10-25 2012-03-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2301916A3 (en) 2004-10-25 2011-09-28 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
CA2616224A1 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
TR201818983T4 (tr) 2006-12-21 2019-01-21 Paratek Pharm Innc İnflamatuvar Cilt Bozukluklarının Tedavisine Yönelik Olarak Sübstitüe Edilmiş Tetrasiklin Bileşikleri
BRPI0720569B8 (pt) * 2006-12-21 2021-05-25 Paratek Pharm Innc compostos de tetraciclina substituída e uso dos ditos compostos para o tratamento de uma infecção bacteriana, viral ou parasitária
WO2008134048A2 (en) 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
BRPI0813990A2 (pt) * 2007-07-06 2011-09-13 Paratek Pharm Innc métodos para sintetizar compostos de minociclina substituìda
TW202216656A (zh) 2008-05-23 2022-05-01 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
AR072990A1 (es) 2008-08-08 2010-10-06 Tetraphase Pharmaceuticals Inc Compuestos de tetraciclina sustituidos con fluor en c7
EP2427425B1 (en) 2009-05-08 2017-03-08 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
CA2772386C (en) 2009-08-28 2017-09-19 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
EP2544692A4 (en) * 2010-03-10 2013-08-07 Univ Health Network USE OF TIGECYCLINE FOR THE TREATMENT OF CANCER
BR112012025045A2 (pt) 2010-03-31 2016-06-21 Tetraphase Pharmaceuticals Inc compostos de tetraciclina policíclica
CN108329312B (zh) 2012-08-31 2021-12-31 四相制药公司 四环素化合物
US9622982B2 (en) 2013-01-14 2017-04-18 Health Clinics Limited Cancer drug and uses
MA46567A (fr) 2016-10-19 2019-08-28 Tetraphase Pharmaceuticals Inc Formes cristallines de l'éravacycline
US11197872B2 (en) 2017-04-21 2021-12-14 Lunella Biotech, Inc. Vitamin C and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (CSCs)
US11229657B2 (en) 2017-04-21 2022-01-25 Lunella Biotech, Inc. Targeting hypoxic cancer stem cells (CSCs) with doxycycline: implications for improving anti-angiogenic therapy
CR20190524A (es) 2017-05-19 2020-01-10 Lunella Biotech Inc Antimitoscinas: inhibidores específicos de la biogénesis mitocondrial para erradicar células madre cancerosas
WO2020097450A1 (en) 2018-11-09 2020-05-14 Tetraphase Pharmaceuticals, Inc. Polymorphic forms of a compound and uses thereof
CN115006411A (zh) * 2022-07-26 2022-09-06 中南大学湘雅医院 依拉环素类化合物的应用、药物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3016587B2 (ja) * 1989-12-04 2000-03-06 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク 非ステロイド抗炎症剤及びテトラサイクリンの配合
US5308839A (en) * 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
US5668122A (en) * 1993-07-28 1997-09-16 Fife; Rose S. Method to treat cancer with tetracyclines
US5567693A (en) * 1994-12-13 1996-10-22 American Cyanamid Company Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5574026A (en) * 1994-12-13 1996-11-12 American Cyanamid Company Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth
US5563130A (en) * 1994-12-13 1996-10-08 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5837696A (en) * 1997-01-15 1998-11-17 The Research Foundation Of State University Of New York Method of inhibiting cancer growth

Also Published As

Publication number Publication date
KR20000070212A (ko) 2000-11-25
ATE321452T1 (de) 2006-04-15
DE69834024T2 (de) 2006-12-07
DE69834024D1 (de) 2006-05-18
JP2001508794A (ja) 2001-07-03
US6100248A (en) 2000-08-08
EP0971585B1 (en) 2006-03-29
WO1998031224A1 (en) 1998-07-23
EP0971585A1 (en) 2000-01-19
AU5910498A (en) 1998-08-07
EP0971585A4 (en) 2001-01-24
AU729886B2 (en) 2001-02-15
ES2262221T3 (es) 2006-11-16
JP4428727B2 (ja) 2010-03-10
CA2277865C (en) 2009-06-02
CA2277865A1 (en) 1998-07-23
US5837696A (en) 1998-11-17

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