DE69825051T2 - Schwefel-überführungs-reagenz für oligonukleotid-synthese - Google Patents

Schwefel-überführungs-reagenz für oligonukleotid-synthese Download PDF

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Publication number
DE69825051T2
DE69825051T2 DE69825051T DE69825051T DE69825051T2 DE 69825051 T2 DE69825051 T2 DE 69825051T2 DE 69825051 T DE69825051 T DE 69825051T DE 69825051 T DE69825051 T DE 69825051T DE 69825051 T2 DE69825051 T2 DE 69825051T2
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DE
Germany
Prior art keywords
amino
thione
dithiazole
organic group
sulfur transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69825051T
Other languages
German (de)
English (en)
Other versions
DE69825051D1 (de
Inventor
Han Yongxin
Jimmy Tang
Zhoada Zhang
Jin-Yan Tang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Avecia Inc
Original Assignee
Avecia Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Biotechnology Inc filed Critical Avecia Biotechnology Inc
Application granted granted Critical
Publication of DE69825051D1 publication Critical patent/DE69825051D1/de
Publication of DE69825051T2 publication Critical patent/DE69825051T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69825051T 1997-05-30 1998-05-26 Schwefel-überführungs-reagenz für oligonukleotid-synthese Expired - Lifetime DE69825051T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/865,666 US6096881A (en) 1997-05-30 1997-05-30 Sulfur transfer reagents for oligonucleotide synthesis
US865666 1997-05-30
PCT/US1998/010653 WO1998054198A1 (en) 1997-05-30 1998-05-26 Novel sulfur transfer reagents for oligonucleotide synthesis

Publications (2)

Publication Number Publication Date
DE69825051D1 DE69825051D1 (de) 2004-08-19
DE69825051T2 true DE69825051T2 (de) 2005-10-06

Family

ID=25345990

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69825051T Expired - Lifetime DE69825051T2 (de) 1997-05-30 1998-05-26 Schwefel-überführungs-reagenz für oligonukleotid-synthese

Country Status (9)

Country Link
US (1) US6096881A (https=)
EP (1) EP0986571B1 (https=)
JP (1) JP4393594B2 (https=)
AT (1) ATE271065T1 (https=)
AU (1) AU7597498A (https=)
CA (1) CA2291688C (https=)
DE (1) DE69825051T2 (https=)
ES (1) ES2226135T3 (https=)
WO (1) WO1998054198A1 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69910140T2 (de) * 1998-10-08 2004-06-03 Novartis Ag Verfahren zur Sulfurierung von Phosphor-enthaltenden Verbindungen
US7098325B2 (en) * 1998-10-08 2006-08-29 Pierre Martin Process for the sulfurization of a phosphorus-containing compound
GB0004889D0 (en) 2000-03-01 2000-04-19 Avecia Ltd Synthesis of oligonucleotides
CA2714353A1 (en) * 2000-12-05 2002-06-13 Avecia Biotechnology Inc Process for the preparation of phosphorothioate oligonucleotides
US6768005B2 (en) * 2000-12-20 2004-07-27 Avecia Limited Process
AR036122A1 (es) * 2001-07-03 2004-08-11 Avecia Biotechnology Inc Un complejo de sal que comprende un n-alquilimidazol y una 1,1-dioxo-1,2-dihidro-1l6-benzo [d]-isotiazol-3-ona y un metodo para sintetizar oligonucleotidos utilizando la quimica de fosforamidita
JP4825375B2 (ja) * 2001-08-28 2011-11-30 株式会社 資生堂 ジチアゾール化合物及びマトリックスメタロプロテアーゼ活性阻害剤、皮膚外用剤
GB0209539D0 (en) * 2002-04-26 2002-06-05 Avecia Ltd Monomer Polymer and process
JP2007531794A (ja) * 2004-04-05 2007-11-08 アルニラム ファーマスーティカルズ インコーポレイテッド オリゴヌクレオチドの合成および精製に使用する方法および反応試薬
CN104086516B (zh) * 2014-07-18 2016-01-06 成都樵枫科技发展有限公司 R-(+)-硫代四氢呋喃-2-甲酸的合成方法
EP3564373A4 (en) 2016-12-28 2020-12-16 Daiichi Sankyo Company, Limited THERAPEUTIC DRUG FOR ALPORT SYNDROME
WO2019111791A1 (ja) * 2017-12-07 2019-06-13 第一三共株式会社 ジストロフィン遺伝子のイントロンリテンションを解消するアンチセンスオリゴヌクレオチド
KR102398295B1 (ko) 2018-03-09 2022-05-17 다이이찌 산쿄 가부시키가이샤 당원병 Ia형 치료약
CN112218950A (zh) 2018-06-13 2021-01-12 第一三共株式会社 心肌损伤治疗药
EP3981436A4 (en) 2019-06-05 2024-06-19 Fukuoka University Stable target-editing guide rna having chemically modified nucleic acid introduced thereinto
JP7715345B2 (ja) 2019-06-26 2025-07-30 神戸天然物化学株式会社 ミオスタチン遺伝子のｍＲＮＡの産生を抑制する核酸医薬
US20220364086A1 (en) 2019-07-12 2022-11-17 Daiichi Sankyo Company, Limited ANTISENSE OLIGONUCLEOTIDE CAPABLE OF ALTERING SPLICING OF DUX4 pre-mRNA
IL291251B1 (en) 2019-09-10 2026-02-01 Daiichi Sankyo Co Ltd Oligonucleotide-galnac conjugate for targeted delivery to the liver and method for its production
IL292286A (en) 2019-10-18 2022-06-01 Daiichi Sankyo Co Ltd Production method for bicyclic phosphoramidite
CA3175125A1 (en) 2020-03-11 2021-09-16 Biocomber Co., Ltd. Single-stranded nucleic acid molecule for inducing -1 frameshift and composition
CN115916976A (zh) 2020-07-28 2023-04-04 神户天然物化学株式会社 诱导血管紧张素转换酶2基因外显子跳跃的反义核酸
MX2023006714A (es) 2020-12-08 2023-07-13 Univ Fukuoka Acido ribonucleico (arn) guia estable de edicion de objetivo al cual se introduce acido nucleico quimicamente modificado.
CA3211057A1 (en) 2021-02-26 2022-09-01 Knc Laboratories Co., Ltd. Nucleic acid medicine expressing splicing variant of myostatin
US20250188477A1 (en) 2022-03-16 2025-06-12 Daiichi Sankyo Company, Limited CHEMICALLY MODIFIED OLIGONUCLEOTIDE HAVING RNAi ACTIVITY
EP4495240A1 (en) 2022-03-16 2025-01-22 Daiichi Sankyo Company, Limited Sirna for suppressing expression of transferrin receptor-2
WO2025047679A1 (ja) 2023-08-25 2025-03-06 学校法人福岡大学 リン酸部修飾を導入した安定型標的編集ガイドｒｎａ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753908A (en) * 1971-08-30 1973-08-21 Chevron Res Oxidation inhibited lubricating oil compositions with extreme pressure properties
DE4320157A1 (de) * 1993-06-18 1994-12-22 Bayer Ag Verwendung von 1,2,4-Dithiazolium-Salzen als Chemotherapeutica

Also Published As

Publication number Publication date
CA2291688A1 (en) 1998-12-03
EP0986571A1 (en) 2000-03-22
WO1998054198A1 (en) 1998-12-03
US6096881A (en) 2000-08-01
JP2002501534A (ja) 2002-01-15
AU7597498A (en) 1998-12-30
CA2291688C (en) 2008-01-29
JP4393594B2 (ja) 2010-01-06
EP0986571B1 (en) 2004-07-14
WO1998054198A9 (en) 1999-04-01
ES2226135T3 (es) 2005-03-16
DE69825051D1 (de) 2004-08-19
ATE271065T1 (de) 2004-07-15

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