ATE271065T1 - Schwefel-überführungs-reagenz für oligonukleotid- synthese - Google Patents
Schwefel-überführungs-reagenz für oligonukleotid- syntheseInfo
- Publication number
- ATE271065T1 ATE271065T1 AT98923757T AT98923757T ATE271065T1 AT E271065 T1 ATE271065 T1 AT E271065T1 AT 98923757 T AT98923757 T AT 98923757T AT 98923757 T AT98923757 T AT 98923757T AT E271065 T1 ATE271065 T1 AT E271065T1
- Authority
- AT
- Austria
- Prior art keywords
- sulfur
- compounds
- reagents
- transfer
- transfer reagents
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052717 sulfur Inorganic materials 0.000 title abstract 2
- 239000011593 sulfur Substances 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 title 1
- 238000002515 oligonucleotide synthesis Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- YWZHEXZIISFIDA-UHFFFAOYSA-N 5-amino-1,2,4-dithiazole-3-thione Chemical compound NC1=NC(=S)SS1 YWZHEXZIISFIDA-UHFFFAOYSA-N 0.000 abstract 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- JUDOLRSMWHVKGX-UHFFFAOYSA-N 1,1-dioxo-1$l^{6},2-benzodithiol-3-one Chemical compound C1=CC=C2C(=O)SS(=O)(=O)C2=C1 JUDOLRSMWHVKGX-UHFFFAOYSA-N 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 abstract 2
- 238000005457 optimization Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/865,666 US6096881A (en) | 1997-05-30 | 1997-05-30 | Sulfur transfer reagents for oligonucleotide synthesis |
| PCT/US1998/010653 WO1998054198A1 (en) | 1997-05-30 | 1998-05-26 | Novel sulfur transfer reagents for oligonucleotide synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE271065T1 true ATE271065T1 (de) | 2004-07-15 |
Family
ID=25345990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98923757T ATE271065T1 (de) | 1997-05-30 | 1998-05-26 | Schwefel-überführungs-reagenz für oligonukleotid- synthese |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6096881A (https=) |
| EP (1) | EP0986571B1 (https=) |
| JP (1) | JP4393594B2 (https=) |
| AT (1) | ATE271065T1 (https=) |
| AU (1) | AU7597498A (https=) |
| CA (1) | CA2291688C (https=) |
| DE (1) | DE69825051T2 (https=) |
| ES (1) | ES2226135T3 (https=) |
| WO (1) | WO1998054198A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0992506B1 (en) * | 1998-10-08 | 2003-08-06 | Novartis AG | Process for the sulfurisation of phosphorus-containing compounds |
| US7098325B2 (en) * | 1998-10-08 | 2006-08-29 | Pierre Martin | Process for the sulfurization of a phosphorus-containing compound |
| GB0004889D0 (en) | 2000-03-01 | 2000-04-19 | Avecia Ltd | Synthesis of oligonucleotides |
| US6768005B2 (en) * | 2000-12-20 | 2004-07-27 | Avecia Limited | Process |
| WO2002046205A2 (en) * | 2000-12-05 | 2002-06-13 | Avecia Limited | Process for the preparation of phosphorothionate oligonucleotides |
| AR036122A1 (es) * | 2001-07-03 | 2004-08-11 | Avecia Biotechnology Inc | Un complejo de sal que comprende un n-alquilimidazol y una 1,1-dioxo-1,2-dihidro-1l6-benzo [d]-isotiazol-3-ona y un metodo para sintetizar oligonucleotidos utilizando la quimica de fosforamidita |
| JP4825375B2 (ja) * | 2001-08-28 | 2011-11-30 | 株式会社 資生堂 | ジチアゾール化合物及びマトリックスメタロプロテアーゼ活性阻害剤、皮膚外用剤 |
| GB0209539D0 (en) * | 2002-04-26 | 2002-06-05 | Avecia Ltd | Monomer Polymer and process |
| WO2005097817A2 (en) * | 2004-04-05 | 2005-10-20 | Alnylam Pharmaceuticals, Inc. | Process and reagents for oligonucleotide synthesis and purification |
| CN104086516B (zh) * | 2014-07-18 | 2016-01-06 | 成都樵枫科技发展有限公司 | R-(+)-硫代四氢呋喃-2-甲酸的合成方法 |
| CN110199023A (zh) | 2016-12-28 | 2019-09-03 | 第一三共株式会社 | 阿尔波特氏综合症治疗药 |
| WO2019111791A1 (ja) * | 2017-12-07 | 2019-06-13 | 第一三共株式会社 | ジストロフィン遺伝子のイントロンリテンションを解消するアンチセンスオリゴヌクレオチド |
| CN111511915A (zh) | 2018-03-09 | 2020-08-07 | 第一三共株式会社 | 糖原病Ia型治疗药 |
| US20210207136A1 (en) | 2018-06-13 | 2021-07-08 | Daiichi Sankyo Company, Limited | Myocardial dysfunction therapeutic agent |
| CA3140438A1 (en) | 2019-06-05 | 2020-12-10 | Masatora Fukuda | Stable target-editing guide rna having chemically modified nucleic acid introduced thereinto |
| EP3995153A4 (en) | 2019-06-26 | 2023-11-22 | KNC Laboratories Co., Ltd. | Nucleic acid drug suppressing production of myostatin gene mrna |
| BR112021024764A2 (pt) | 2019-07-12 | 2022-04-19 | Daiichi Sankyo Co Ltd | Oligonucleotídeo antissenso capaz de alterar o splicing de pré-mrna de dux4 |
| WO2021049504A1 (ja) | 2019-09-10 | 2021-03-18 | 第一三共株式会社 | 肝臓送達用ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲートおよび製造方法 |
| IL292286A (en) | 2019-10-18 | 2022-06-01 | Daiichi Sankyo Co Ltd | Production method for bicyclic phosphoramidite |
| EP4119167A4 (en) | 2020-03-11 | 2025-08-06 | Biocomber Co Ltd | SINGLE-STRANDED NUCLEIC ACID MOLECULE FOR INDUCING FRAME SHIFT-1 AND COMPOSITION |
| JP7722666B2 (ja) | 2020-07-28 | 2025-08-13 | 神戸天然物化学株式会社 | アンギオテンシン変換酵素２遺伝子のエクソンのスキッピングを誘導するアンチセンス核酸 |
| EP4261284A4 (en) | 2020-12-08 | 2025-07-16 | Univ Fukuoka | STABLE TARGET EDITING GUIDE RNA INTO WHICH A CHEMICALLY MODIFIED NUCLEIC ACID HAS BEEN INTRODUCED |
| US20240229036A9 (en) | 2021-02-26 | 2024-07-11 | Knc Laboratories Co., Ltd. | Nucleic acid medicine expressing splicing variant of myostatin |
| JPWO2023176863A1 (https=) | 2022-03-16 | 2023-09-21 | ||
| KR20240161967A (ko) | 2022-03-16 | 2024-11-13 | 다이이찌 산쿄 가부시키가이샤 | 트랜스페린 수용체 2 의 발현을 억제하는 siRNA |
| TW202523839A (zh) | 2023-08-25 | 2025-06-16 | 學校法人福岡大學 | 導入有磷酸部修飾之穩定型標靶編輯引導ｒｎａ |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753908A (en) * | 1971-08-30 | 1973-08-21 | Chevron Res | Oxidation inhibited lubricating oil compositions with extreme pressure properties |
| DE4320157A1 (de) * | 1993-06-18 | 1994-12-22 | Bayer Ag | Verwendung von 1,2,4-Dithiazolium-Salzen als Chemotherapeutica |
-
1997
- 1997-05-30 US US08/865,666 patent/US6096881A/en not_active Expired - Lifetime
-
1998
- 1998-05-26 CA CA002291688A patent/CA2291688C/en not_active Expired - Lifetime
- 1998-05-26 AU AU75974/98A patent/AU7597498A/en not_active Abandoned
- 1998-05-26 JP JP50080299A patent/JP4393594B2/ja not_active Expired - Lifetime
- 1998-05-26 EP EP98923757A patent/EP0986571B1/en not_active Expired - Lifetime
- 1998-05-26 DE DE69825051T patent/DE69825051T2/de not_active Expired - Lifetime
- 1998-05-26 ES ES98923757T patent/ES2226135T3/es not_active Expired - Lifetime
- 1998-05-26 AT AT98923757T patent/ATE271065T1/de not_active IP Right Cessation
- 1998-05-26 WO PCT/US1998/010653 patent/WO1998054198A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2291688A1 (en) | 1998-12-03 |
| CA2291688C (en) | 2008-01-29 |
| JP2002501534A (ja) | 2002-01-15 |
| DE69825051T2 (de) | 2005-10-06 |
| EP0986571A1 (en) | 2000-03-22 |
| DE69825051D1 (de) | 2004-08-19 |
| AU7597498A (en) | 1998-12-30 |
| ES2226135T3 (es) | 2005-03-16 |
| WO1998054198A1 (en) | 1998-12-03 |
| US6096881A (en) | 2000-08-01 |
| JP4393594B2 (ja) | 2010-01-06 |
| WO1998054198A9 (en) | 1999-04-01 |
| EP0986571B1 (en) | 2004-07-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0986571 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |