DE69405396T2 - Verfahren zur synthese von nukleinsäuren auf einem festträger und verbindungen verwendbar als festträger in diesem verfahren - Google Patents

Verfahren zur synthese von nukleinsäuren auf einem festträger und verbindungen verwendbar als festträger in diesem verfahren

Info

Publication number
DE69405396T2
DE69405396T2 DE69405396T DE69405396T DE69405396T2 DE 69405396 T2 DE69405396 T2 DE 69405396T2 DE 69405396 T DE69405396 T DE 69405396T DE 69405396 T DE69405396 T DE 69405396T DE 69405396 T2 DE69405396 T2 DE 69405396T2
Authority
DE
Germany
Prior art keywords
solid support
nucleic acids
epoxy
glycol
compounds used
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69405396T
Other languages
English (en)
Other versions
DE69405396D1 (de
Inventor
Ludmilla Baranova
Francois Chatelain
Viktor Kumarev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Aldrich Co LLC
Original Assignee
Serono Genetics Institute SA
Genset SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Genetics Institute SA, Genset SA filed Critical Serono Genetics Institute SA
Publication of DE69405396D1 publication Critical patent/DE69405396D1/de
Application granted granted Critical
Publication of DE69405396T2 publication Critical patent/DE69405396T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Catalysts (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69405396T 1993-07-09 1994-07-07 Verfahren zur synthese von nukleinsäuren auf einem festträger und verbindungen verwendbar als festträger in diesem verfahren Expired - Lifetime DE69405396T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9308498A FR2707296B1 (fr) 1993-07-09 1993-07-09 Procédé de synthèse d'acides nucléiques sur support solide et composés utiles notamment comme support solide dans ledit procédé.
PCT/FR1994/000842 WO1995001987A1 (fr) 1993-07-09 1994-07-07 Procede de synthese d'acides nucleiques sur support solide et comoposes utiles notamment comme support solide dans ledit procede

Publications (2)

Publication Number Publication Date
DE69405396D1 DE69405396D1 (de) 1997-10-09
DE69405396T2 true DE69405396T2 (de) 1998-03-26

Family

ID=9449129

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69405396T Expired - Lifetime DE69405396T2 (de) 1993-07-09 1994-07-07 Verfahren zur synthese von nukleinsäuren auf einem festträger und verbindungen verwendbar als festträger in diesem verfahren

Country Status (14)

Country Link
EP (1) EP0707592B1 (de)
JP (1) JPH08512306A (de)
KR (1) KR960703937A (de)
AT (1) ATE157668T1 (de)
AU (1) AU696421B2 (de)
CA (1) CA2166765A1 (de)
DE (1) DE69405396T2 (de)
DK (1) DK0707592T3 (de)
ES (1) ES2109005T3 (de)
FR (1) FR2707296B1 (de)
GR (1) GR3025420T3 (de)
HK (1) HK1002731A1 (de)
TW (1) TW397839B (de)
WO (1) WO1995001987A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714061B1 (fr) 1993-12-16 1996-03-08 Genset Sa Procédé de préparation de polynucléotides sur support solide et appareil permettant sa mise en Óoeuvre.
US5869696A (en) * 1996-04-22 1999-02-09 Beckman Instruments, Inc. Universal solid supports and methods for their use
US6590092B1 (en) 1998-05-19 2003-07-08 Nam Q. Ngo Process for preparing a “universal support” and the reagents used for generating such support
EP1006121B1 (de) * 1998-12-02 2003-05-02 Council of Scientific and Industrial Research Universale Polymere Träger zur Synthese von Oligonukleotiden
AU779411B2 (en) 1999-02-12 2005-01-20 Serono Genetics Institute S.A. Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism
AU2942100A (en) * 1999-03-11 2000-09-28 Kuraray Co., Ltd. Vitamin d derivatives and process for the preparation thereof
DE60000014T2 (de) * 2000-05-16 2002-05-02 Biochip Technologies Gmbh Linker-System zum Aktivieren von Oberflächen für die Biokonjugation und Verfahren zu ihrer Verwendung
US7211654B2 (en) 2001-03-14 2007-05-01 Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
EP1925672A1 (de) 2001-06-22 2008-05-28 Syngeta Participations AG Auf abiotischen Stress ansprechende Polynukleotide und Polypeptide
US7858297B2 (en) 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
US7572886B2 (en) 2001-12-18 2009-08-11 Centre National De La Recherche Scientifique Death associated proteins, and THAP1 and PAR4 pathways in apoptosis control
EP1485408A2 (de) 2002-03-13 2004-12-15 Bayer CropScience S.A. Mutagenese des pilzes aspergillus und identifikation von genen essentiell für das wachstum
FR2900415B1 (fr) 2006-04-28 2010-08-13 Agronomique Inst Nat Rech Systeme genetique pour le controle du developpement du type floral d'une plante dicotyledone, et mise en oeuvre dans les procedes de detection et de selection
FR2954349A1 (fr) 2009-12-22 2011-06-24 Agronomique Inst Nat Rech Sulfatase modifiant selectivement les glycosaminoglycanes
US10865445B2 (en) 2010-08-18 2020-12-15 Fred Hutchinson Cancer Research Center Methods for alleviating facioscapulohumeral dystrophy (FSHD) by N siRNA molecule inhibiting the expression of DUX4-FL
WO2018013999A1 (en) 2016-07-15 2018-01-18 Am Chemicals Llc Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155950B1 (de) * 1983-09-02 1990-01-17 Molecular Biosystems, Inc. Oligonukleotid-polymer-tragsystem
US4739044A (en) * 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
WO1991000868A1 (en) * 1989-07-07 1991-01-24 National Research Development Corporation Immobilised polynucleotides
WO1991008307A1 (en) * 1989-12-04 1991-06-13 Microprobe Corporation Enhanced capture of target nucleic acid by the use of oligonucleotides covalently attached to polymers
IE913762A1 (en) * 1990-10-26 1992-05-22 Genta Inc Non-aromatic organic polymeric reagents for solid phase¹synthesis of oligomers
JPH06509542A (ja) * 1990-10-26 1994-10-27 ジンタ・インコーポレイテッド オリゴマーを合成するための改良法

Also Published As

Publication number Publication date
DE69405396D1 (de) 1997-10-09
WO1995001987A1 (fr) 1995-01-19
FR2707296B1 (fr) 1995-09-29
AU696421B2 (en) 1998-09-10
DK0707592T3 (da) 1998-03-30
ES2109005T3 (es) 1998-01-01
EP0707592B1 (de) 1997-09-03
HK1002731A1 (en) 1998-09-11
EP0707592A1 (de) 1996-04-24
JPH08512306A (ja) 1996-12-24
ATE157668T1 (de) 1997-09-15
TW397839B (en) 2000-07-11
CA2166765A1 (fr) 1995-01-19
FR2707296A1 (fr) 1995-01-13
GR3025420T3 (en) 1998-02-27
KR960703937A (ko) 1996-08-31
AU7230994A (en) 1995-02-06

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