HK1002731A1 - Process for solid support nucleic acid synthesis and compounds useful as solid supports in said process - Google Patents

Process for solid support nucleic acid synthesis and compounds useful as solid supports in said process

Info

Publication number
HK1002731A1
HK1002731A1 HK98101580A HK98101580A HK1002731A1 HK 1002731 A1 HK1002731 A1 HK 1002731A1 HK 98101580 A HK98101580 A HK 98101580A HK 98101580 A HK98101580 A HK 98101580A HK 1002731 A1 HK1002731 A1 HK 1002731A1
Authority
HK
Hong Kong
Prior art keywords
solid support
nucleic acid
acid synthesis
solid
compounds useful
Prior art date
Application number
HK98101580A
Inventor
Viktor Kumarev
Ludmilla Baranova
Francois Chatelain
Original Assignee
Genset Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genset Sa filed Critical Genset Sa
Publication of HK1002731A1 publication Critical patent/HK1002731A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Catalysts (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

The object of the present invention is a process for synthesizing solid phase nucleic acids, characterized in that a mineral or organic polymer, bound by a bivalent hydrocarbon radical to an epoxy or glycol-type group, is used as a solid support, said epoxy or glycol-type group comprising two adjacent saturated carbon atoms on which an OH and a nucleophilic group are substituted. The present invention also pertains to compounds containing an epoxy or glycol-type group as defined above, useful for example as a solid support in a process for solid support nucleic acid synthesis.
HK98101580A 1993-07-09 1998-02-27 Process for solid support nucleic acid synthesis and compounds useful as solid supports in said process HK1002731A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9308498A FR2707296B1 (en) 1993-07-09 1993-07-09 Process for the synthesis of nucleic acids on a solid support and compounds useful in particular as a solid support in said process.
PCT/FR1994/000842 WO1995001987A1 (en) 1993-07-09 1994-07-07 Process for solid support nucleic acid synthesis and compounds useful as solid supports in said process

Publications (1)

Publication Number Publication Date
HK1002731A1 true HK1002731A1 (en) 1998-09-11

Family

ID=9449129

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98101580A HK1002731A1 (en) 1993-07-09 1998-02-27 Process for solid support nucleic acid synthesis and compounds useful as solid supports in said process

Country Status (14)

Country Link
EP (1) EP0707592B1 (en)
JP (1) JPH08512306A (en)
KR (1) KR960703937A (en)
AT (1) ATE157668T1 (en)
AU (1) AU696421B2 (en)
CA (1) CA2166765A1 (en)
DE (1) DE69405396T2 (en)
DK (1) DK0707592T3 (en)
ES (1) ES2109005T3 (en)
FR (1) FR2707296B1 (en)
GR (1) GR3025420T3 (en)
HK (1) HK1002731A1 (en)
TW (1) TW397839B (en)
WO (1) WO1995001987A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714061B1 (en) 1993-12-16 1996-03-08 Genset Sa Process for the preparation of polynucleotides on solid support and apparatus allowing its implementation.
US5869696A (en) * 1996-04-22 1999-02-09 Beckman Instruments, Inc. Universal solid supports and methods for their use
US6590092B1 (en) 1998-05-19 2003-07-08 Nam Q. Ngo Process for preparing a “universal support” and the reagents used for generating such support
DE69814097T2 (en) * 1998-12-02 2004-04-08 Council Of Scientific And Industrial Research Universal polymer carrier for the synthesis of oligonucleotides
CA2362586A1 (en) 1999-02-12 2000-08-17 Genset S.A. Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism
AU2942100A (en) * 1999-03-11 2000-09-28 Kuraray Co., Ltd. Vitamin d derivatives and process for the preparation thereof
DK1132739T3 (en) * 2000-05-16 2002-01-28 Biochip Technologies Gmbh Linker system for activating surfaces for bioconjugation and methods for using them
US7211654B2 (en) 2001-03-14 2007-05-01 Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
EP1925672A1 (en) 2001-06-22 2008-05-28 Syngeta Participations AG Abiotic stress responsive polynucleotides and polypeptides
DE60234713D1 (en) 2001-12-18 2010-01-21 Endocube Sas NEW PROTEINS ASSOCIATED WITH CELL-DATE FROM THE THAP FAMILY AND PAR4 RELATED SIGNALING PATHS INVOLVED IN THE CONTROL OF APOPTOSIS
US7858297B2 (en) 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
EP1485408A2 (en) 2002-03-13 2004-12-15 Bayer CropScience S.A. Mutagenesis of aspergillus fungi and genes essential for growth
FR2900415B1 (en) 2006-04-28 2010-08-13 Agronomique Inst Nat Rech GENETIC SYSTEM FOR CONTROLLING THE DEVELOPMENT OF THE FLORAL TYPE OF A DICOTYLEDONE PLANT, AND IMPLEMENTATION IN DETECTION AND SELECTION PROCESSES
FR2954349A1 (en) 2009-12-22 2011-06-24 Agronomique Inst Nat Rech SULFATASE SELECTIVELY MODIFYING GLYCOSAMINOGLYCANS
US10865445B2 (en) 2010-08-18 2020-12-15 Fred Hutchinson Cancer Research Center Methods for alleviating facioscapulohumeral dystrophy (FSHD) by N siRNA molecule inhibiting the expression of DUX4-FL
IL291323B2 (en) 2016-07-15 2023-09-01 Am Chemicals Llc Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU575586B2 (en) * 1983-09-02 1988-08-04 Syngene, Inc. Oligonucleotide synthesis employing primer with oxidzable substituents in system
US4739044A (en) * 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
WO1991000868A1 (en) * 1989-07-07 1991-01-24 National Research Development Corporation Immobilised polynucleotides
WO1991008307A1 (en) * 1989-12-04 1991-06-13 Microprobe Corporation Enhanced capture of target nucleic acid by the use of oligonucleotides covalently attached to polymers
AU668855B2 (en) * 1990-10-26 1996-05-23 Genta Incorporated Non-aromatic organic polymeric reagents for solid phase synthesis of oligomers
ES2124231T3 (en) * 1990-10-26 1999-02-01 Genta Inc IMPROVED PROCEDURE FOR SYNTHESIS OF OLIGOMERS.

Also Published As

Publication number Publication date
EP0707592B1 (en) 1997-09-03
DE69405396D1 (en) 1997-10-09
KR960703937A (en) 1996-08-31
EP0707592A1 (en) 1996-04-24
DK0707592T3 (en) 1998-03-30
GR3025420T3 (en) 1998-02-27
JPH08512306A (en) 1996-12-24
ES2109005T3 (en) 1998-01-01
AU696421B2 (en) 1998-09-10
TW397839B (en) 2000-07-11
ATE157668T1 (en) 1997-09-15
FR2707296A1 (en) 1995-01-13
FR2707296B1 (en) 1995-09-29
AU7230994A (en) 1995-02-06
CA2166765A1 (en) 1995-01-19
DE69405396T2 (en) 1998-03-26
WO1995001987A1 (en) 1995-01-19

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20040707