DE69400807T2 - Bausteine mit carbamate luternukleosidverbindungen und oligonukleotide abgeleitet davon - Google Patents
Bausteine mit carbamate luternukleosidverbindungen und oligonukleotide abgeleitet davonInfo
- Publication number
- DE69400807T2 DE69400807T2 DE69400807T DE69400807T DE69400807T2 DE 69400807 T2 DE69400807 T2 DE 69400807T2 DE 69400807 T DE69400807 T DE 69400807T DE 69400807 T DE69400807 T DE 69400807T DE 69400807 T2 DE69400807 T2 DE 69400807T2
- Authority
- DE
- Germany
- Prior art keywords
- carbamate
- oligonucleotids
- derived
- air
- building blocks
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title abstract 4
- -1 NUCLEOSIDE COMPOUNDS Chemical class 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/098,945 US6605708B1 (en) | 1993-07-28 | 1993-07-28 | Building blocks with carbamate internucleoside linkages and oligonucleotides derived therefrom |
| PCT/US1994/008655 WO1995004066A1 (en) | 1993-07-28 | 1994-07-27 | Building blocks with carbamate internucleoside linkages and novel oligonucleotides derived therefrom |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69400807D1 DE69400807D1 (de) | 1996-11-28 |
| DE69400807T2 true DE69400807T2 (de) | 1997-04-03 |
Family
ID=22271676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69400807T Expired - Fee Related DE69400807T2 (de) | 1993-07-28 | 1994-07-27 | Bausteine mit carbamate luternukleosidverbindungen und oligonukleotide abgeleitet davon |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6605708B1 (de) |
| EP (1) | EP0711302B1 (de) |
| JP (1) | JPH09503494A (de) |
| KR (1) | KR960703938A (de) |
| CN (1) | CN1131951A (de) |
| AT (1) | ATE144525T1 (de) |
| AU (1) | AU682533B2 (de) |
| CA (1) | CA2167679A1 (de) |
| DE (1) | DE69400807T2 (de) |
| DK (1) | DK0711302T3 (de) |
| ES (1) | ES2096484T3 (de) |
| FI (1) | FI960375A (de) |
| GR (1) | GR3021955T3 (de) |
| NO (1) | NO960304L (de) |
| WO (1) | WO1995004066A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| AR040996A1 (es) * | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| CA2502015A1 (en) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | 5' cpg nucleic acids and methods of use |
| JP4989225B2 (ja) | 2003-09-25 | 2012-08-01 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 核酸親油性接合体 |
| WO2006080946A2 (en) * | 2004-06-08 | 2006-08-03 | Coley Pharmaceutical Gmbh | Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist |
| WO2006025154A1 (ja) * | 2004-08-30 | 2006-03-09 | Gifu University | 修飾オリゴヌクレオチド |
| MY159370A (en) | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
| US7232923B2 (en) * | 2005-02-15 | 2007-06-19 | Imperial Innovations Limited | Method of hydroaminating N-alkenoylcarbamates with primary aromatic amines |
| KR101251707B1 (ko) | 2006-09-27 | 2013-04-11 | 콜리 파마슈티칼 게엠베하 | 면역 자극 활성이 증강된 소수성 Ｔ 유사체를 함유하는 ＣｐＧ 올리고뉴클레오티드 유사체 |
| WO2011005861A1 (en) * | 2009-07-07 | 2011-01-13 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide end caps |
| JP5544833B2 (ja) * | 2009-11-17 | 2014-07-09 | 富士通株式会社 | インドール基用保護基 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2071483C (en) * | 1989-10-24 | 2001-04-17 | Mark Matteucci | Oligonucleotide analogs with novel linkages |
| US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
| EP0464638B1 (de) | 1990-07-02 | 1997-04-02 | Hoechst Aktiengesellschaft | Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-Internucleotidverknüpfungen |
| US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
-
1993
- 1993-07-28 US US08/098,945 patent/US6605708B1/en not_active Expired - Lifetime
-
1994
- 1994-07-27 AU AU75528/94A patent/AU682533B2/en not_active Expired - Fee Related
- 1994-07-27 ES ES94925713T patent/ES2096484T3/es not_active Expired - Lifetime
- 1994-07-27 WO PCT/US1994/008655 patent/WO1995004066A1/en active IP Right Grant
- 1994-07-27 KR KR1019960700396A patent/KR960703938A/ko not_active Application Discontinuation
- 1994-07-27 EP EP94925713A patent/EP0711302B1/de not_active Expired - Lifetime
- 1994-07-27 AT AT94925713T patent/ATE144525T1/de not_active IP Right Cessation
- 1994-07-27 DE DE69400807T patent/DE69400807T2/de not_active Expired - Fee Related
- 1994-07-27 CA CA002167679A patent/CA2167679A1/en not_active Abandoned
- 1994-07-27 JP JP7506036A patent/JPH09503494A/ja active Pending
- 1994-07-27 DK DK94925713.3T patent/DK0711302T3/da active
- 1994-07-27 CN CN94193565A patent/CN1131951A/zh active Pending
-
1996
- 1996-01-25 NO NO960304A patent/NO960304L/no unknown
- 1996-01-26 FI FI960375A patent/FI960375A/fi not_active Application Discontinuation
- 1996-12-10 GR GR960403375T patent/GR3021955T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69400807D1 (de) | 1996-11-28 |
| ATE144525T1 (de) | 1996-11-15 |
| EP0711302B1 (de) | 1996-10-23 |
| JPH09503494A (ja) | 1997-04-08 |
| GR3021955T3 (en) | 1997-03-31 |
| DK0711302T3 (da) | 1997-03-17 |
| NO960304L (no) | 1996-03-04 |
| CN1131951A (zh) | 1996-09-25 |
| US6605708B1 (en) | 2003-08-12 |
| CA2167679A1 (en) | 1995-02-09 |
| AU682533B2 (en) | 1997-10-09 |
| FI960375A0 (fi) | 1996-01-26 |
| AU7552894A (en) | 1995-02-28 |
| NO960304D0 (no) | 1996-01-25 |
| KR960703938A (ko) | 1996-08-31 |
| EP0711302A1 (de) | 1996-05-15 |
| WO1995004066A1 (en) | 1995-02-09 |
| FI960375A (fi) | 1996-03-25 |
| ES2096484T3 (es) | 1997-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |