DE69821242T2 - Optisches assay-verfahren mit nahezu senkrechtem lichteinfall und wellenlängen- und winkelempfindlichkeit - Google Patents
Optisches assay-verfahren mit nahezu senkrechtem lichteinfall und wellenlängen- und winkelempfindlichkeit Download PDFInfo
- Publication number
- DE69821242T2 DE69821242T2 DE69821242T DE69821242T DE69821242T2 DE 69821242 T2 DE69821242 T2 DE 69821242T2 DE 69821242 T DE69821242 T DE 69821242T DE 69821242 T DE69821242 T DE 69821242T DE 69821242 T2 DE69821242 T2 DE 69821242T2
- Authority
- DE
- Germany
- Prior art keywords
- angles
- sensor
- angle
- incidence
- anomaly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims description 18
- 230000003287 optical effect Effects 0.000 title claims description 11
- 230000035945 sensitivity Effects 0.000 title description 7
- 238000003556 assay Methods 0.000 title 1
- 239000000126 substance Substances 0.000 claims description 30
- 230000008859 change Effects 0.000 claims description 24
- 238000000926 separation method Methods 0.000 claims description 20
- 230000003993 interaction Effects 0.000 claims description 6
- 230000023077 detection of light stimulus Effects 0.000 claims 2
- 239000010410 layer Substances 0.000 description 43
- 238000001514 detection method Methods 0.000 description 30
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 29
- 239000013076 target substance Substances 0.000 description 18
- 229910052751 metal Inorganic materials 0.000 description 15
- 239000002184 metal Substances 0.000 description 15
- 238000002310 reflectometry Methods 0.000 description 15
- 230000010287 polarization Effects 0.000 description 11
- 239000000758 substrate Substances 0.000 description 9
- 206010070834 Sensitisation Diseases 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 230000008313 sensitization Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 230000008901 benefit Effects 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 239000004332 silver Substances 0.000 description 4
- 239000010409 thin film Substances 0.000 description 4
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 239000010408 film Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000004065 semiconductor Substances 0.000 description 3
- 230000001235 sensitizing effect Effects 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 description 1
- 102100023635 Alpha-fetoprotein Human genes 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 108010038061 Chymotrypsinogen Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- -1 Dinitrophenyl Chemical group 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 229910052581 Si3N4 Inorganic materials 0.000 description 1
- 102000004338 Transferrin Human genes 0.000 description 1
- 108090000901 Transferrin Proteins 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 1
- 230000003667 anti-reflective effect Effects 0.000 description 1
- 230000037007 arousal Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000003989 dielectric material Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- BCQZXOMGPXTTIC-UHFFFAOYSA-N halothane Chemical compound FC(F)(F)C(Cl)Br BCQZXOMGPXTTIC-UHFFFAOYSA-N 0.000 description 1
- 229960003132 halothane Drugs 0.000 description 1
- 108060003552 hemocyanin Proteins 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229920000323 polyazulene Polymers 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
- G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
- G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Engineering & Computer Science (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/915,057 US5955378A (en) | 1997-08-20 | 1997-08-20 | Near normal incidence optical assaying method and system having wavelength and angle sensitivity |
| US915057 | 1997-08-20 | ||
| PCT/US1998/017084 WO1999009392A2 (en) | 1997-08-20 | 1998-08-18 | Near normal incidence optical assaying method and system having wavelength and angle sensitivity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69821242D1 DE69821242D1 (de) | 2004-02-26 |
| DE69821242T2 true DE69821242T2 (de) | 2004-11-04 |
Family
ID=25435145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69821242T Expired - Fee Related DE69821242T2 (de) | 1997-08-20 | 1998-08-18 | Optisches assay-verfahren mit nahezu senkrechtem lichteinfall und wellenlängen- und winkelempfindlichkeit |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US5955378A (enExample) |
| EP (1) | EP1005634B1 (enExample) |
| JP (1) | JP2001516017A (enExample) |
| DE (1) | DE69821242T2 (enExample) |
| WO (1) | WO1999009392A2 (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994150A (en) | 1997-11-19 | 1999-11-30 | Imation Corp. | Optical assaying method and system having rotatable sensor disk with multiple sensing regions |
| US6235534B1 (en) * | 1998-04-27 | 2001-05-22 | Ronald Frederich Brookes | Incremental absorbance scanning of liquid in dispensing tips |
| US6320991B1 (en) | 1998-10-16 | 2001-11-20 | Imation Corp. | Optical sensor having dielectric film stack |
| US8111401B2 (en) | 1999-11-05 | 2012-02-07 | Robert Magnusson | Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats |
| US7167615B1 (en) | 1999-11-05 | 2007-01-23 | Board Of Regents, The University Of Texas System | Resonant waveguide-grating filters and sensors and methods for making and using same |
| US6466323B1 (en) | 1999-11-23 | 2002-10-15 | Westinghouse Savannah River Company, L.L.C. | Surface plasmon resonance spectroscopy sensor and methods for using same |
| US7101660B2 (en) | 2000-10-30 | 2006-09-05 | Sru Biosystems, Inc. | Method for producing a colorimetric resonant reflection biosensor on rigid surfaces |
| US6951715B2 (en) * | 2000-10-30 | 2005-10-04 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
| US7142296B2 (en) * | 2000-10-30 | 2006-11-28 | Sru Biosystems, Inc. | Method and apparatus for detecting biomolecular interactions |
| US7264973B2 (en) * | 2000-10-30 | 2007-09-04 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant optical biosensor |
| US20030092075A1 (en) * | 2000-10-30 | 2003-05-15 | Sru Biosystems, Llc | Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors |
| US7175980B2 (en) | 2000-10-30 | 2007-02-13 | Sru Biosystems, Inc. | Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities |
| US7202076B2 (en) | 2000-10-30 | 2007-04-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
| US7875434B2 (en) | 2000-10-30 | 2011-01-25 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
| US7023544B2 (en) * | 2000-10-30 | 2006-04-04 | Sru Biosystems, Inc. | Method and instrument for detecting biomolecular interactions |
| US7070987B2 (en) | 2000-10-30 | 2006-07-04 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
| US7300803B2 (en) * | 2000-10-30 | 2007-11-27 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
| US7153702B2 (en) * | 2000-10-30 | 2006-12-26 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
| US7217574B2 (en) * | 2000-10-30 | 2007-05-15 | Sru Biosystems, Inc. | Method and apparatus for biosensor spectral shift detection |
| US7615339B2 (en) | 2000-10-30 | 2009-11-10 | Sru Biosystems, Inc. | Method for producing a colorimetric resonant reflection biosensor on rigid surfaces |
| US7371562B2 (en) | 2000-10-30 | 2008-05-13 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
| US7306827B2 (en) * | 2000-10-30 | 2007-12-11 | Sru Biosystems, Inc. | Method and machine for replicating holographic gratings on a substrate |
| US7575939B2 (en) | 2000-10-30 | 2009-08-18 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
| US7094595B2 (en) * | 2000-10-30 | 2006-08-22 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
| US20030113766A1 (en) * | 2000-10-30 | 2003-06-19 | Sru Biosystems, Llc | Amine activated colorimetric resonant biosensor |
| US6576430B1 (en) * | 2000-11-20 | 2003-06-10 | Becton, Dickinson And Company | Detection of ligands by refractive surface methods |
| US20020135771A1 (en) * | 2001-01-19 | 2002-09-26 | Quantech Ltd | System and method of reducing particulate interference in fluid analyte detection |
| JP3793430B2 (ja) * | 2001-07-18 | 2006-07-05 | 株式会社日立製作所 | 近接場光を用いた光学装置 |
| TW593999B (en) * | 2001-12-21 | 2004-06-21 | Univ Nat Taiwan | Surface plasma seed resonance sensing system and method |
| US7429492B2 (en) | 2002-09-09 | 2008-09-30 | Sru Biosystems, Inc. | Multiwell plates with integrated biosensors and membranes |
| US7927822B2 (en) | 2002-09-09 | 2011-04-19 | Sru Biosystems, Inc. | Methods for screening cells and antibodies |
| US7309614B1 (en) | 2002-12-04 | 2007-12-18 | Sru Biosystems, Inc. | Self-referencing biodetection method and patterned bioassays |
| CA2423512A1 (en) * | 2003-03-26 | 2004-09-26 | Institut National D'optique | Optical sensor for volatile organic compounds |
| US7497992B2 (en) * | 2003-05-08 | 2009-03-03 | Sru Biosystems, Inc. | Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers |
| US7292333B2 (en) * | 2003-06-24 | 2007-11-06 | Corning Incorporated | Optical interrogation system and method for 2-D sensor arrays |
| US7057720B2 (en) * | 2003-06-24 | 2006-06-06 | Corning Incorporated | Optical interrogation system and method for using same |
| GB0318808D0 (en) * | 2003-08-11 | 2003-09-10 | Toshiba Res Europ Ltd | An encoded carrier |
| US8298780B2 (en) | 2003-09-22 | 2012-10-30 | X-Body, Inc. | Methods of detection of changes in cells |
| AU2004290375A1 (en) * | 2003-11-06 | 2005-05-26 | Sru Biosystems, Inc. | High-density amine-functionalized surface |
| JP2005189198A (ja) * | 2003-12-26 | 2005-07-14 | Fuji Photo Film Co Ltd | 光学デバイス |
| SE0500484L (sv) | 2004-10-28 | 2006-04-29 | All Set Marine Lashing Ab | Lastsäkringsanordning |
| CN104076162A (zh) | 2005-07-20 | 2014-10-01 | 康宁股份有限公司 | 无标记高通量生物分子筛选系统和方法 |
| US7483127B1 (en) * | 2005-08-08 | 2009-01-27 | Sru Biosystems, Inc. | Method and apparatus for generating an image of biomolecular sensor target area |
| KR101006793B1 (ko) * | 2005-08-11 | 2011-01-10 | 에스알유 바이오시스템즈, 인코포레이티드 | 라벨 없는 바인딩 검출 및 형광 증폭과 조합된 격자-기반센서 및 센서를 위한 판독 시스템 |
| US7790406B2 (en) * | 2005-08-11 | 2010-09-07 | Sru Biosystems, Inc | Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor |
| US20070279634A1 (en) * | 2006-05-31 | 2007-12-06 | Gruhlke Russell W | Label-free grating-based surface plasmon resonance sensor |
| EP2041583A1 (en) * | 2006-06-30 | 2009-04-01 | Corning Incorporated | Fluid handling system for flow-through assay |
| US7976217B2 (en) | 2006-09-15 | 2011-07-12 | Corning Incorporated | Screening system and method for analyzing a plurality of biosensors |
| US7737392B2 (en) * | 2006-11-09 | 2010-06-15 | The Board Of Trustees Of The University Of Illinois | Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis |
| PT103601B (pt) * | 2006-11-09 | 2008-10-14 | Biosurfit Sa | Dispositivo de detecção baseado no efeito de ressonância de plasmão de superfície |
| CA2683082A1 (en) * | 2007-04-19 | 2008-10-30 | Sru Biosystems, Inc. | Method for employing a biosensor to detect small molecules that bind directly to immobilized targets |
| CN100582745C (zh) * | 2007-05-23 | 2010-01-20 | 中国科学院光电技术研究所 | 单面刻槽表面等离子体生化传感器 |
| KR100865755B1 (ko) * | 2007-06-29 | 2008-10-28 | 삼성전기주식회사 | 표면 플라즈몬 공명을 이용한 다채널 바이오 센서 |
| US9134307B2 (en) | 2007-07-11 | 2015-09-15 | X-Body, Inc. | Method for determining ion channel modulating properties of a test reagent |
| CA2693700A1 (en) | 2007-07-11 | 2009-01-15 | Sru Biosystems, Inc. | Methods for identifying modulators of ion channels |
| EP2060904A1 (en) * | 2007-11-13 | 2009-05-20 | Koninklijke Philips Electronics N.V. | Plasmon grating biosensor |
| US8462355B2 (en) * | 2008-01-17 | 2013-06-11 | The Salk Institute For Biological Studies | 3D scanning acousto-optic microscope |
| US8257936B2 (en) | 2008-04-09 | 2012-09-04 | X-Body Inc. | High resolution label free analysis of cellular properties |
| US8094316B1 (en) * | 2008-05-12 | 2012-01-10 | Institute Of Photonics And Electronics As Cr, V.V.I. | Surface plasmon resonance coupler and disperser sensor |
| US20100015721A1 (en) * | 2008-06-04 | 2010-01-21 | Sru Biosystems, Inc. | Detection of Promiscuous Small Submicrometer Aggregates |
| GB2464721C (en) | 2008-10-23 | 2013-08-14 | Biosurfit Sa | Jet deflection device |
| GB2466644B (en) | 2008-12-30 | 2011-05-11 | Biosurfit Sa | Liquid handling |
| WO2011059999A1 (en) * | 2009-11-16 | 2011-05-19 | Corning Incorporated | Non-spectroscopic label-independent optical reader system and methods |
| GB2476474B (en) | 2009-12-22 | 2012-03-28 | Biosurfit Sa | Surface plasmon resonance detection system |
| GB2479139A (en) | 2010-03-29 | 2011-10-05 | Biosurfit Sa | A liquid distribution and metering device |
| JP6257521B2 (ja) | 2011-12-08 | 2018-01-10 | バイオサーフィット、 ソシエダッド アノニマ | 逐次分注および沈降速度の指標の決定 |
| GB201216645D0 (en) * | 2012-09-18 | 2012-10-31 | Univ Nottingham | Surface plasmon microscopy |
| US10481089B2 (en) * | 2013-03-12 | 2019-11-19 | Integrated Plasmonics Corporation | Optical detection system with tilted sensor |
| WO2022265497A1 (en) * | 2021-06-18 | 2022-12-22 | Technische Universiteit Eindhoven | A spectral sensing system |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1237645A (en) * | 1982-12-21 | 1988-06-07 | John H. Fisher | Assay technique |
| GB8423204D0 (en) * | 1984-09-14 | 1984-10-17 | Comtech Res Unit | Assay technique and equipment |
| US5118605A (en) * | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| GB8509492D0 (en) * | 1985-04-12 | 1985-05-15 | Plessey Co Plc | Optical assay |
| US4815843A (en) * | 1985-05-29 | 1989-03-28 | Oerlikon-Buhrle Holding Ag | Optical sensor for selective detection of substances and/or for the detection of refractive index changes in gaseous, liquid, solid and porous samples |
| GB8618133D0 (en) * | 1986-07-24 | 1986-09-03 | Pa Consulting Services | Biosensors |
| GB8618159D0 (en) * | 1986-07-25 | 1986-09-03 | Pa Consulting Services | Spectrometer based instruments |
| GB8705649D0 (en) * | 1987-03-10 | 1987-04-15 | Pa Consulting Services | Assay sensor |
| GB8714503D0 (en) * | 1987-06-20 | 1987-07-22 | Pa Consulting Services | Detector |
| CA1321488C (en) * | 1987-08-22 | 1993-08-24 | Martin Francis Finlan | Biological sensors |
| EP0341928A1 (en) * | 1988-05-10 | 1989-11-15 | AMERSHAM INTERNATIONAL plc | Improvements relating to surface plasmon resonance sensors |
| US5478755A (en) * | 1988-07-25 | 1995-12-26 | Ares Serono Research & Development Ltd. | Long range surface plasma resonance immunoassay |
| SE8804074D0 (sv) * | 1988-11-10 | 1988-11-10 | Pharmacia Ab | Sensorenhet och dess anvaendning i biosensorsystem |
| GB8916764D0 (en) * | 1989-07-21 | 1989-09-06 | Sambles John R | Surface plasmon optical sensor |
| FI85768C (fi) * | 1990-07-04 | 1992-05-25 | Valtion Teknillinen | Foerfarande foer utfoerning av ytplasmonresonansmaetning samt i foerfarandet anvaendbar givare. |
| US5583643A (en) * | 1991-04-12 | 1996-12-10 | British Technology Group Ltd. | Methods of and apparatus for measurement using acousto-optic devices |
| GB2256477B (en) * | 1991-06-07 | 1995-03-08 | Marconi Gec Ltd | An optical sensor |
| DE69110032T2 (de) * | 1991-06-08 | 1995-12-21 | Hewlett Packard Gmbh | Verfahren und Gerät zur Feststellung und/oder Konzentrationsbestimmung von Biomolekülen. |
| GB9120000D0 (en) * | 1991-09-19 | 1991-11-06 | British Gas Plc | Optical sensing |
| GB9200564D0 (en) * | 1992-01-11 | 1992-03-11 | Fisons Plc | Analytical device with variable angle of incidence |
| US5351127A (en) * | 1992-06-17 | 1994-09-27 | Hewlett-Packard Company | Surface plasmon resonance measuring instruments |
| GB9314991D0 (en) * | 1993-07-20 | 1993-09-01 | Sandoz Ltd | Mechanical device |
| US5636633A (en) * | 1995-08-09 | 1997-06-10 | Rio Grande Medical Technologies, Inc. | Diffuse reflectance monitoring apparatus |
| US5751482A (en) * | 1996-04-22 | 1998-05-12 | Imation Corp. | Achromatic polarization-rotating right-angle prism system |
| EP1650548A3 (en) * | 1996-04-30 | 2009-11-25 | FUJIFILM Corporation | Surface plasmon sensor |
| US5776785A (en) * | 1996-12-30 | 1998-07-07 | Diagnostic Products Corporation | Method and apparatus for immunoassay using fluorescent induced surface plasma emission |
-
1997
- 1997-08-20 US US08/915,057 patent/US5955378A/en not_active Expired - Lifetime
-
1998
- 1998-08-18 WO PCT/US1998/017084 patent/WO1999009392A2/en not_active Ceased
- 1998-08-18 JP JP2000510008A patent/JP2001516017A/ja active Pending
- 1998-08-18 EP EP98942094A patent/EP1005634B1/en not_active Expired - Lifetime
- 1998-08-18 DE DE69821242T patent/DE69821242T2/de not_active Expired - Fee Related
-
1999
- 1999-06-22 US US09/337,750 patent/US6100991A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69821242D1 (de) | 2004-02-26 |
| JP2001516017A (ja) | 2001-09-25 |
| EP1005634A2 (en) | 2000-06-07 |
| US6100991A (en) | 2000-08-08 |
| EP1005634B1 (en) | 2004-01-21 |
| WO1999009392A2 (en) | 1999-02-25 |
| US5955378A (en) | 1999-09-21 |
| WO1999009392A3 (en) | 1999-06-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69821242T2 (de) | Optisches assay-verfahren mit nahezu senkrechtem lichteinfall und wellenlängen- und winkelempfindlichkeit | |
| DE69922956T2 (de) | Optischer sensor mit optimiertem oberflächenprofil | |
| DE69915851T2 (de) | Optischer sensor mit gestapelten dielektrischen schichten | |
| DE69818092T2 (de) | Verfahren zur optischen prüfung und system mit einem bewegbaren sensor mit mehreren sensorbereichen | |
| DE69115493T2 (de) | Vorrichtung zur analyse | |
| DE69527390T2 (de) | Vorrichtung und Verfahren zur intrakavitären Messung der makroskopischen Eigenschaften von Chemikalien | |
| DE69115494T2 (de) | Vorrichtung zur oberflächenplasmonen-resonanz | |
| DE69119750T2 (de) | Messzelle für chemische oder biochemische proben | |
| EP0834066B1 (de) | Verfahren und einrichtung zum nachweis physikalischer, chemischer, biologischer oder biochemischer reaktionen und wechselwirkungen | |
| DE69531125T2 (de) | Nachweis einer Zielsubstanz in einer Probe | |
| DE68903688T2 (de) | Biosensoren. | |
| DE69711655T2 (de) | Optischer sensor zum nachweis von in wasser gelösten oder dispergierten chemischen substanzen | |
| DE69622176T2 (de) | Überwachung des refraktionsindex von optischen sensoren zur bestimmung von änderungen in der oberflächenstruktur | |
| DE69407161T2 (de) | Faseroptischer sensor und damit verbundene vorrichtung und methode | |
| DE69320623T2 (de) | Mikropolarimeter, Mikrosensorsystem und Methode zum charakterisieren Dünner Filme | |
| DE4024476C1 (enExample) | ||
| EP0617273A2 (de) | Optisches Verfahren und Vorrichtung zur Analyse von Substanzen an Sensoroberflächen | |
| DE10008006A1 (de) | SPR-Sensor und SPR-Sensoranordnung | |
| DE68922295T2 (de) | Verfahren und Vorrichtung zur infrarot-spektralphotometrischen Analyse. | |
| DE2616377A1 (de) | Verfahren zur kontinuierlichen erzeugung von wellen kohaerenter anti-stokes- schwingungsspektren | |
| DE4200088C2 (de) | Verfahren und Vorrichtung zum optischen Nachweis einer An- oder Einlagerung mindestens einer stofflichen Spezies in oder an mindestens einer dünnen Schicht | |
| DE102019114167A1 (de) | Optische Messvorrichtung und Verfahren | |
| DE3719524C2 (enExample) | ||
| DE102008048266A1 (de) | Verfahren zur schnellen Bestimmung der separaten Anteile von Volumen- und Oberflächenabsorption von optischen Materialien, eine Vorrichtung hierzu sowie deren Verwendung | |
| DE102021100321B4 (de) | SPR-Sensoreinheit und Verfahren zur Bestimmung des Brechungsindex eines Proben-mediums sowie Messeinrichtung zur Erfassung der Dichte eines Messmediums |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |