DE69814076T2 - 8-chlor-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2.b]pyridine polymorphe formen - Google Patents

8-chlor-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2.b]pyridine polymorphe formen Download PDF

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Publication number
DE69814076T2
DE69814076T2 DE69814076T DE69814076T DE69814076T2 DE 69814076 T2 DE69814076 T2 DE 69814076T2 DE 69814076 T DE69814076 T DE 69814076T DE 69814076 T DE69814076 T DE 69814076T DE 69814076 T2 DE69814076 T2 DE 69814076T2
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DE
Germany
Prior art keywords
polymorphic form
descarbonylethoxyloratadine
approximately
crystalline
characteristic peaks
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69814076T
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German (de)
English (en)
Other versions
DE69814076D1 (de
Inventor
P. Doris SCHUMACHER
Junning Lee
Lawrence R. Rogers
G. Charles ECKHART
S. Naneshwar SAWANT
B. Michael MITCHELL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
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Publication date
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Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69814076D1 publication Critical patent/DE69814076D1/de
Publication of DE69814076T2 publication Critical patent/DE69814076T2/de
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69814076T 1997-07-02 1998-07-01 8-chlor-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2.b]pyridine polymorphe formen Expired - Lifetime DE69814076T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88676697A 1997-07-02 1997-07-02
US886766 1997-07-02
PCT/US1998/013433 WO1999001450A1 (en) 1997-07-02 1998-07-01 POLYMORPHS OF 8-CHLORO-6, 11-DIHYDRO-11- (4-PIPERIDYLIDENE) -5H-BENZO[5,6] CYCLOHEPTA[1,2-b]PYRIDINE

Publications (2)

Publication Number Publication Date
DE69814076D1 DE69814076D1 (de) 2003-06-05
DE69814076T2 true DE69814076T2 (de) 2004-02-26

Family

ID=25389724

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69814076T Expired - Lifetime DE69814076T2 (de) 1997-07-02 1998-07-01 8-chlor-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2.b]pyridine polymorphe formen

Country Status (25)

Country Link
EP (1) EP0993455B1 (https=)
JP (2) JP2002507991A (https=)
KR (1) KR20010014316A (https=)
CN (1) CN1261886A (https=)
AR (1) AR013161A1 (https=)
AT (1) ATE239010T1 (https=)
AU (1) AU734487B2 (https=)
BR (1) BR9811658A (https=)
CA (1) CA2294352C (https=)
CO (1) CO4940423A1 (https=)
DE (1) DE69814076T2 (https=)
ES (1) ES2197480T3 (https=)
HU (1) HUP0004308A3 (https=)
IL (1) IL133387A (https=)
MY (1) MY132943A (https=)
NO (1) NO996547L (https=)
NZ (1) NZ501417A (https=)
PE (1) PE86399A1 (https=)
PL (1) PL337712A1 (https=)
RU (1) RU2197485C2 (https=)
SK (1) SK185299A3 (https=)
TR (1) TR199903308T2 (https=)
UA (1) UA62976C2 (https=)
WO (1) WO1999001450A1 (https=)
ZA (1) ZA985783B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
US7678908B2 (en) * 2002-04-15 2010-03-16 Sun Pharmaceutical Industries Limited Process of preparing desaloratadine
WO2004012738A1 (en) * 2002-08-05 2004-02-12 Sandoz Ag Novel salt and polymorphs of desloratadine hemifumarate
US20060135547A1 (en) * 2003-03-12 2006-06-22 Toth Zoltan G Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine
WO2004080461A2 (en) * 2003-03-12 2004-09-23 TEVA Gyógyszergyár Részvénytársaság Stable pharmaceutical compositions of desloratadine
SK50112007A3 (sk) * 2004-07-07 2007-07-06 Egis Gy�gyszergy�r Nyrt. Nový pseudopolymorf desloratadínu vytvorený s oxidom uhličitým
TW200735871A (en) * 2005-11-17 2007-10-01 Teva Pharma Desloratadine crystalline forms mixtures having a low level of residual solvents
HU230417B1 (hu) * 2006-10-26 2016-05-30 Egis Gyógyszergyár Zrt Eljárás desloratadine szén-dioxiddal képezett adduktjának előállítására
EP2164470A1 (en) * 2007-05-11 2010-03-24 ratiopharm GmbH Pharmaceutical composition comprising desloratadine
EP2269586B1 (en) 2009-07-01 2011-09-21 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical composition comprising desloratadine
PT2568970T (pt) 2010-05-10 2019-02-11 Lesvi Laboratorios Sl Formulações farmacêuticas estáveis contendo um anti-histamínico
EP2727592A1 (en) 2012-11-05 2014-05-07 Kücükgüzel, Sükriye Güniz A combination of desloratadine and paracetamol
CN103755682A (zh) * 2013-12-30 2014-04-30 山东达因海洋生物制药股份有限公司 一种地氯雷他定新晶型及制备方法
CN108358892A (zh) * 2018-04-11 2018-08-03 常州方圆制药有限公司 一种地氯雷他定粗品的提纯方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985003707A1 (en) * 1984-02-15 1985-08-29 Schering Corporation 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
EP0208855B1 (en) * 1985-05-13 1991-03-06 Schering Corporation process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions
IE68935B1 (en) * 1990-06-22 1996-07-24 Schering Corp Bis-benzo or benzopyrido cyclohepta piperidene piperidylidene and piperazine compounds compositions and methods of use

Also Published As

Publication number Publication date
HUP0004308A3 (en) 2004-07-28
EP0993455A1 (en) 2000-04-19
SK185299A3 (en) 2000-07-11
AR013161A1 (es) 2000-12-13
PL337712A1 (en) 2000-08-28
PE86399A1 (es) 1999-10-23
ES2197480T3 (es) 2004-01-01
ATE239010T1 (de) 2003-05-15
BR9811658A (pt) 2000-09-05
UA62976C2 (en) 2004-01-15
HUP0004308A2 (hu) 2001-10-28
CN1261886A (zh) 2000-08-02
MY132943A (en) 2007-10-31
JP2002507991A (ja) 2002-03-12
CO4940423A1 (es) 2000-07-24
NO996547L (no) 2000-03-01
ZA985783B (en) 1999-01-19
AU8271098A (en) 1999-01-25
NZ501417A (en) 2000-10-27
NO996547D0 (no) 1999-12-29
TR199903308T2 (xx) 2000-11-21
KR20010014316A (ko) 2001-02-26
WO1999001450A1 (en) 1999-01-14
IL133387A (en) 2004-02-08
DE69814076D1 (de) 2003-06-05
HK1024687A1 (en) 2000-10-20
AU734487B2 (en) 2001-06-14
JP2009242436A (ja) 2009-10-22
IL133387A0 (en) 2001-04-30
CA2294352A1 (en) 1999-01-14
CA2294352C (en) 2008-05-06
RU2197485C2 (ru) 2003-01-27
EP0993455B1 (en) 2003-05-02

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