DE69739394D1 - Enteral-formulierungen von proanthocyanidzusammensetzungen gegen diarrhöe - Google Patents

Enteral-formulierungen von proanthocyanidzusammensetzungen gegen diarrhöe

Info

Publication number
DE69739394D1
DE69739394D1 DE69739394T DE69739394T DE69739394D1 DE 69739394 D1 DE69739394 D1 DE 69739394D1 DE 69739394 T DE69739394 T DE 69739394T DE 69739394 T DE69739394 T DE 69739394T DE 69739394 D1 DE69739394 D1 DE 69739394D1
Authority
DE
Germany
Prior art keywords
polymer composition
proanthocyanidin polymer
formulations
stomach acid
proanthocyanide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69739394T
Other languages
German (de)
English (en)
Inventor
Edward J Rozhon
Atul S Khandwala
Akram Sabouni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Napo Pharmaceuticals Inc
Original Assignee
Napo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Napo Pharmaceuticals Inc filed Critical Napo Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69739394D1 publication Critical patent/DE69739394D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE69739394T 1996-10-16 1997-10-14 Enteral-formulierungen von proanthocyanidzusammensetzungen gegen diarrhöe Expired - Lifetime DE69739394D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73077296A 1996-10-16 1996-10-16
PCT/US1997/018845 WO1998016111A1 (en) 1996-10-16 1997-10-14 Enteric formulations of proanthocyanidin polymer antidiarrheal compositions

Publications (1)

Publication Number Publication Date
DE69739394D1 true DE69739394D1 (de) 2009-06-18

Family

ID=24936755

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69739394T Expired - Lifetime DE69739394D1 (de) 1996-10-16 1997-10-14 Enteral-formulierungen von proanthocyanidzusammensetzungen gegen diarrhöe

Country Status (14)

Country Link
US (5) US7341744B1 (https=)
EP (3) EP0935417B1 (https=)
JP (1) JP4195728B2 (https=)
KR (1) KR100467532B1 (https=)
AT (1) ATE430477T1 (https=)
AU (1) AU4988197A (https=)
CA (1) CA2269078C (https=)
DE (1) DE69739394D1 (https=)
DK (1) DK0935417T3 (https=)
ES (1) ES2326933T3 (https=)
NZ (1) NZ335317A (https=)
PT (1) PT935417E (https=)
TW (1) TW537898B (https=)
WO (1) WO1998016111A1 (https=)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0935417B1 (en) * 1996-10-16 2009-05-06 Napo Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions
WO2000047062A2 (en) * 1999-02-01 2000-08-17 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same
NZ513603A (en) * 1999-02-15 2002-12-20 Nikka Whisky Distilling Compan ADP-ribosylation inhibitors and remedies for endotoxic bacterial enteric infection containing proanthocyanidin as the active ingredient
BR0010649A (pt) * 1999-05-17 2002-02-19 D B F Grãnulos que contêm pelo menos uma substância vegetal e processo de preparação dos mesmos
US20040220117A1 (en) * 2001-03-28 2004-11-04 Motoyuki Tagashira Proteotoxin neutralizer
CO5400144A1 (es) * 2002-03-11 2004-05-31 Novartis Ag Compuestos organicos
GB0321996D0 (en) * 2003-09-19 2003-10-22 Novartis Nutrition Ag Organic compounds
KR101148734B1 (ko) 2003-10-10 2012-07-05 에띠빠흠 징코 빌로바 추출물을 포함하는 서방형 미세과립 및 이것을 제조하는 방법
KR100720817B1 (ko) * 2003-12-26 2007-05-21 (주)아모레퍼시픽 식물 추출물을 함유하는 제제 및 그 제조방법
JP2006232752A (ja) * 2005-02-25 2006-09-07 Tokyo Univ Of Marine Science & Technology コレステロール及び中性脂肪吸収抑制剤及びこれを含む食品
PT1698630E (pt) 2005-03-03 2014-09-15 Alfa Wassermann Spa Novas formas polimorfas de rifaximina, processos para a sua produção e a sua utilização nas preparações medicinais
ITBO20050123A1 (it) 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
US20090076132A1 (en) * 2005-03-11 2009-03-19 Gary Pekoe Antiviral compositions and methods of treatment
JP5167461B2 (ja) * 2005-09-16 2013-03-21 国立医薬品食品衛生研究所長 炎症性腸疾患予防剤
US7351853B2 (en) * 2006-01-23 2008-04-01 Albion Advanced Nutrition Method of manufacturing a granular mineral composition
CA2657803C (en) 2006-05-01 2019-01-08 Napo Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer
SG195538A1 (en) * 2006-05-01 2013-12-30 Napo Pharmaceuticals Inc Method for treatment of constipation-predominant irritable bowel syndrome
US20070254050A1 (en) * 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
US8048413B2 (en) * 2006-05-17 2011-11-01 Helene Huguet Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
WO2008083513A1 (en) * 2006-12-13 2008-07-17 Beijing Gingko-Group Biological Technology Co., Ltd. Black soybean hull extract and process for preparation and use thereof
WO2008115605A1 (en) * 2007-03-22 2008-09-25 Ibix Clear bismuth treatments and methods for making
WO2009020481A2 (en) * 2007-05-08 2009-02-12 Rq Bioscience, Inc. Therapeutic compositions and methods for treating gram-negative bacterial infections
US8734867B2 (en) * 2007-12-28 2014-05-27 Liveleaf, Inc. Antibacterial having an extract of pomegranate combined with hydrogen peroxide
WO2009094169A1 (en) * 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8236838B2 (en) * 2008-04-21 2012-08-07 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
US8207205B2 (en) * 2008-04-21 2012-06-26 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
WO2009131947A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising pyridazine derivatives
US20090264433A1 (en) * 2008-04-21 2009-10-22 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Triazine Derivatives
US20100034968A1 (en) * 2008-08-07 2010-02-11 Vector Corporation Polymer coating process using dry glidant in a rotor processor
US20100034967A1 (en) * 2008-08-07 2010-02-11 Vector Corporation Dry polymer layering using a rotor processor
US8807070B2 (en) * 2008-08-07 2014-08-19 Vector Corporation Rotor processor for dry powders
US20110237528A1 (en) * 2008-09-19 2011-09-29 Institute For Oneworld Health Compositions and methods comprising imidazole and triazole derivatives
FR2938430B1 (fr) * 2008-11-14 2011-05-20 Debregeas Et Associes Pharma Granules a base de plantes
MX344857B (es) * 2009-03-04 2017-01-10 Metaactiv Inc Metodo y material para el acomplejamiento activado en el sitio de moleculas biologicas.
US8511216B2 (en) * 2009-03-30 2013-08-20 Kanzaki Kokyukoki Mfg. Co., Ltd. Hydraulic actuator unit
US8343976B2 (en) * 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
PH12012500557A1 (en) * 2009-08-26 2012-10-22 Glenmark Pharmaceuticals Ltd Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations
US8652534B2 (en) 2009-10-14 2014-02-18 Berry Pharmaceuticals, LLC Compositions and methods for treatment of mammalian skin
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
EP2632550B1 (en) * 2010-10-31 2017-05-03 Napo Pharmaceuticals, Inc. Methods and compositions for treating hiv-associated diarrhea
WO2012101008A1 (en) 2011-01-27 2012-08-02 Glenmark Pharmaceuticals Limited Process for the production of proanthocyanidin polymeric composition
WO2012135702A1 (en) * 2011-04-01 2012-10-04 Ocean Spray Cranberries, Inc. Inflammation and immunity treatments
US9192635B2 (en) 2011-06-24 2015-11-24 Liveleaf, Inc. Method of treating damaged mucosal or gastrointestinal tissue by administering a composition comprising a mixture of pomegranate and green tea extracts and releasably bound hydrogen peroxide
US8722040B2 (en) 2011-06-24 2014-05-13 Liveleaf, Inc. Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
MX2014010926A (es) * 2012-03-13 2015-04-10 Piramal Entpr Ltd Composicion herbaria para el tratamiento de transtornos metabolicos.
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
US8716351B1 (en) 2012-12-23 2014-05-06 Liveleaf, Inc. Methods of treating gastrointestinal spasms
ITMI20130476A1 (it) * 2013-03-28 2014-09-29 Novintethical Pharma Sagl Composizioni per il trattamento di disturbi gastro-intestinali a base di complessi di tannini con proteine
CN103536583B (zh) * 2013-11-01 2015-02-25 潍坊医学院 一种原花青素缓释纳米微球及制备方法和应用
NZ723571A (en) 2014-05-12 2020-02-28 Alfasigma Spa New solvated crystal form of rifaximin, production, compositions and uses thereof
US20170119834A1 (en) * 2014-05-29 2017-05-04 Jaguar Animal Health, Inc. Methods of Treating Diarrhea in Adult Non-Human Animals
WO2015184101A1 (en) * 2014-05-29 2015-12-03 Jaguar Animal Health, Inc. Methods of treating diarrhea in neonatal and young non-human animals
US20170095442A1 (en) * 2014-05-29 2017-04-06 Jaguar Animal Health, Inc. Methods of Treating Salmonella-Induced Diarrhea in Non-Human Animals
US20180264061A1 (en) * 2015-01-09 2018-09-20 Jaguar Animal Health Methods of Treating Diarrhea in Companion Animals
WO2016138118A1 (en) * 2015-02-26 2016-09-01 Jaguar Animal Health, Inc. Use of croton- or calophyllum-derived proanthocyanidin polymers or botanical extracts in combination with rifaximin for the treatment of diarrhea in non-human animals
AU2016222791A1 (en) * 2015-02-26 2017-09-07 Jaguar Health, Inc. Methods of treating diarrhea and promoting intestinal health in non-human animals
WO2018022475A1 (en) * 2016-07-25 2018-02-01 Jaguar Health, Inc Methods of treating porcine epidemic diarrheal virus in piglets
IT201600122310A1 (it) 2016-12-01 2018-06-01 Sofar Spa Composizione per uso nella terapia di alterazioni dell'intestino
US20180168196A1 (en) 2016-12-15 2018-06-21 Nestec Sa Compositions and methods that modulate bacteria in a companion animal
JOP20190275B1 (ar) * 2017-05-31 2024-12-22 Napo Pharmaceuticals Inc طرق وتركيبات لعلاج اضطراب إسهال خِلقي
JOP20190276B1 (ar) * 2017-05-31 2024-04-18 Napo Pharmaceuticals Inc طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة
US20210361698A1 (en) * 2017-12-27 2021-11-25 Suntory Holdings Limited Composition for improving intestinal barrier function
KR20200008826A (ko) 2018-07-17 2020-01-29 성균관대학교산학협력단 대장균을 이용한 단백질가수분해효소 k의 생산 방법
CN109464491B (zh) * 2018-12-03 2022-02-01 四川省畜牧科学研究院 诃子组合物及其在制备预防和/或治疗腹泻和/或乳房炎的产品中的应用
WO2022115481A1 (en) * 2020-11-24 2022-06-02 Napo Pharmaceuticals, Inc. Methods and compositions for treating post-acute infection gastrointestinal disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377201A1 (fr) * 1977-01-18 1978-08-11 Fabre Sa Pierre Composition pharmaceutique a activite anti-inflammatoire et vasculotrope
SE446940B (sv) * 1983-02-16 1986-10-20 Carl Axel Virdalm Medel for bekempande av sjukdomstillstand i matsmeltningsapparaten innehallande skal eller ytterdelar av ber eller frukter
US4698360B1 (en) * 1985-04-09 1997-11-04 D Investigations Pharmacologiq Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
EP0214317B1 (fr) * 1985-08-30 1988-08-17 Societe Des Produits Nestle S.A. Produit diététique à activité dépurative et anti-diarrhéique et son procédé de préparation
US5141735A (en) * 1990-06-18 1992-08-25 Hoffman-La Roche, Inc. Substituted amino-benzodiazepines having anitviral activity
US5211944A (en) * 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
SI9011933A (sl) 1990-10-15 1998-06-30 TANIN SEVNICA Kemična industrija p.o. Kostanjev taninski ekstrakt, postopek za njegovo pridobivanje in njegova uporaba
US5234922A (en) 1992-09-28 1993-08-10 University Of Iowa Research Foundation Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea
US5750496A (en) * 1996-08-12 1998-05-12 Utah State University Method of controlling cryptosporidium infectons using protease inhibitors
EP0935417B1 (en) 1996-10-16 2009-05-06 Napo Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions

Also Published As

Publication number Publication date
EP0935417B1 (en) 2009-05-06
US8574634B2 (en) 2013-11-05
US20090148397A1 (en) 2009-06-11
KR100467532B1 (ko) 2005-01-24
JP4195728B2 (ja) 2008-12-10
US20050019389A1 (en) 2005-01-27
NZ335317A (en) 2001-02-23
CA2269078C (en) 2012-01-24
EP2060183A3 (en) 2009-06-03
TW537898B (en) 2003-06-21
US7323195B2 (en) 2008-01-29
DK0935417T3 (da) 2009-08-10
KR20000049206A (ko) 2000-07-25
US20140329896A1 (en) 2014-11-06
EP0935417A1 (en) 1999-08-18
ATE430477T1 (de) 2009-05-15
ES2326933T3 (es) 2009-10-21
EP0935417A4 (en) 2006-08-30
EP2060183A2 (en) 2009-05-20
JP2001524938A (ja) 2001-12-04
EP2255661A3 (en) 2010-12-22
EP2255661A2 (en) 2010-12-01
US20140011869A1 (en) 2014-01-09
CA2269078A1 (en) 1998-04-23
WO1998016111A1 (en) 1998-04-23
US7341744B1 (en) 2008-03-11
PT935417E (pt) 2009-07-17
AU4988197A (en) 1998-05-11

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