DE69736745D1 - Verfahren zur behandlung von prostaterkrankungen unter verwendung von vitamin-d-formulierungen mit verzögerter und/oder verlängerter wirkstofffreigabe - Google Patents
Verfahren zur behandlung von prostaterkrankungen unter verwendung von vitamin-d-formulierungen mit verzögerter und/oder verlängerter wirkstofffreigabeInfo
- Publication number
- DE69736745D1 DE69736745D1 DE69736745T DE69736745T DE69736745D1 DE 69736745 D1 DE69736745 D1 DE 69736745D1 DE 69736745 T DE69736745 T DE 69736745T DE 69736745 T DE69736745 T DE 69736745T DE 69736745 D1 DE69736745 D1 DE 69736745D1
- Authority
- DE
- Germany
- Prior art keywords
- vitamin
- delayed
- sustained release
- formulations
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/775,447 US5795882A (en) | 1992-06-22 | 1996-12-30 | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
PCT/US1997/022034 WO1998029105A2 (en) | 1996-12-30 | 1997-12-10 | Method of treating prostatic diseases using delayed and/or sustained release vitamin d formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69736745D1 true DE69736745D1 (de) | 2006-11-09 |
Family
ID=25104456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69736745T Expired - Lifetime DE69736745D1 (de) | 1996-12-30 | 1997-12-10 | Verfahren zur behandlung von prostaterkrankungen unter verwendung von vitamin-d-formulierungen mit verzögerter und/oder verlängerter wirkstofffreigabe |
Country Status (15)
Country | Link |
---|---|
US (1) | US5795882A (de) |
EP (1) | EP0951286B1 (de) |
JP (1) | JP2001512418A (de) |
KR (1) | KR20000062405A (de) |
CN (1) | CN100345547C (de) |
AT (1) | ATE340581T1 (de) |
AU (1) | AU724153B2 (de) |
BR (1) | BR9715022A (de) |
CA (1) | CA2276465A1 (de) |
DE (1) | DE69736745D1 (de) |
HU (1) | HUP0003526A2 (de) |
MX (1) | MXPA99006988A (de) |
NZ (1) | NZ336511A (de) |
PL (1) | PL334348A1 (de) |
WO (1) | WO1998029105A2 (de) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6538037B2 (en) * | 1991-01-08 | 2003-03-25 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2 |
US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US5547957A (en) | 1993-10-15 | 1996-08-20 | Merck & Co., Inc. | Method of treating androgenic alopecia with 5-α reductase inhibitors |
TW382595B (en) * | 1993-10-15 | 2000-02-21 | Merck & Co Inc | Pharmaceutical composition for use in arresting and reversing androgenic alopecia |
US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
FR2759293B1 (fr) * | 1997-02-11 | 1999-04-30 | Ethypharm Lab Prod Ethiques | Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie |
US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
PL336231A1 (en) * | 1997-02-13 | 2000-06-19 | Bone Care International | System for aimed therapeutic delivery of vitamin d compounds |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
US20020076442A1 (en) * | 1997-09-02 | 2002-06-20 | Martin Burke | Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders |
US6849616B1 (en) * | 1998-03-27 | 2005-02-01 | Pharmacia Italia S.P.A. | Methods to potentiate intravenous estramustine phosphate |
EP1064000B1 (de) | 1998-03-27 | 2011-07-06 | Oregon Health & Science University | Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungen |
US6479474B2 (en) * | 1999-07-08 | 2002-11-12 | Wisconsin Alumni Research Foundation | Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis |
WO2002006218A2 (en) * | 2000-07-18 | 2002-01-24 | Bone Care International, Inc. | STABILIZED 1α-HYDROXY VITAMIN D |
WO2002039996A2 (en) * | 2000-11-16 | 2002-05-23 | Pharmacia & Up John Company | Combined therapy against tumors comprising estramustine phosphate and lhrh agonists or antagonists |
US20040071789A1 (en) * | 2002-02-14 | 2004-04-15 | Baron John A | Calcium supplementation to reduce prostate cancer risk |
US7129230B2 (en) * | 2001-03-12 | 2006-10-31 | Nestec S.A. | Method and product for treating cancer in pets |
EA008072B1 (ru) * | 2001-12-03 | 2007-02-27 | Новацея, Инк. | Фармацевтические составы, содержащие соединения активного витамина d |
US20080260834A1 (en) * | 2002-08-20 | 2008-10-23 | Martin Burke | Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders |
WO2004024192A1 (en) * | 2002-09-12 | 2004-03-25 | University Of Chicago | Monitoring and diagnosis of gastric emptying and gastroparesis |
US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
AU2003295773A1 (en) * | 2002-11-21 | 2004-06-18 | Novacea, Inc. | Treatment of liver disease with active vitamin d compounds |
US20060189586A1 (en) * | 2003-06-11 | 2006-08-24 | Cleland Jeffrey L | Pharmaceutical compositions comprising active vitamin D compounds |
AU2004247109A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc | Treatment of cancer with active vitamin D compounds in combination with radiotherapeutic agents and treatments |
JP2007501864A (ja) * | 2003-06-11 | 2007-02-01 | ノバセア インコーポレイティッド | 活性ビタミンd化合物単独または他の治療薬との併用による、免疫介在疾患の治療法 |
WO2005011660A1 (en) * | 2003-07-29 | 2005-02-10 | Abbott Laboratories | Use of vitamin d to down regulate the renin-angiotensin-aldosterone system |
WO2005029078A1 (en) * | 2003-09-17 | 2005-03-31 | Guava Technologies, Inc. | Compositions and methods for analysis of target analytes |
US7332482B2 (en) * | 2003-09-24 | 2008-02-19 | Bioxell S.P.A. | Method for treating benign prostatic hyperplasia |
WO2005030223A1 (en) * | 2003-09-24 | 2005-04-07 | Bioxell, S.P.A. | Methods for treating bladder dysfunction |
WO2005117542A2 (en) * | 2004-05-10 | 2005-12-15 | Novacea, Inc. | Treatment of pancreatic cancer with active vitamin d compounds in combination with other treatments |
AU2005303773A1 (en) * | 2004-11-12 | 2006-05-18 | Bioxell Spa | Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer |
US20070122477A1 (en) * | 2005-10-12 | 2007-05-31 | Cytochroma, Inc. | Methods and articles for treating 25-hydroxyvitamin D insufficiency and deficiency |
WO2007070494A2 (en) * | 2005-12-12 | 2007-06-21 | Women & Infants Hospital Of Rhode Island | Heterocycles and derivatives thereof and methods of manufacture and therapeutic use |
PL1993559T3 (pl) | 2006-02-03 | 2017-01-31 | Opko Renal, Llc | Leczenie niedoboru i deficytu witaminy d z zastosowaniem 25-hydroksywitaminy d2 i 25-hydroksywitaminy d3 |
US20100009949A1 (en) * | 2006-03-24 | 2010-01-14 | Bioxell S.P.A. | Novel method |
LT2679228T (lt) | 2006-06-21 | 2018-05-10 | Opko Ireland Global Holdings, Ltd. | Terapija naudojant vitamino d atstatymo agentą ir vitamino d hormoninį pakaitinį agentą |
KR101495578B1 (ko) * | 2007-04-25 | 2015-02-25 | 사이토크로마 인코포레이티드 | 비타민 d 부족 및 결핍의 치료 방법 |
JP5647516B2 (ja) * | 2007-04-25 | 2014-12-24 | シトクロマ インコーポレイテッド | ビタミンd療法のための方法および化合物 |
WO2008134512A1 (en) | 2007-04-25 | 2008-11-06 | Cytochroma Inc. | Oral controlled release compositions comprising vitamin d compound and waxy carrier |
JP2010525080A (ja) | 2007-04-25 | 2010-07-22 | プロヴェンティヴ セラピュティックス リミテッド ライアビリティ カンパニー | 慢性腎臓病における続発性副甲状腺機能亢進症の安全かつ効果的な治療および予防方法 |
US8221803B1 (en) | 2007-06-25 | 2012-07-17 | OncoNatural Solutions, Inc. | Composition for prostate health |
ES2954932T3 (es) | 2008-04-02 | 2023-11-27 | Eirgen Pharma Ltd | Métodos, composiciones, usos y kits útiles para la deficiencia de vitamina D y trastornos relacionados |
WO2010075537A1 (en) * | 2008-12-23 | 2010-07-01 | Teva Pharmaceutical Industries Ltd. | Formulations comprising vitamin d or derivatives thereof |
WO2010099508A1 (en) | 2009-02-26 | 2010-09-02 | Theraquest Biosciences, Inc. | Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use |
KR102125424B1 (ko) | 2010-03-29 | 2020-06-22 | 사이토크로마 인코포레이티드 | 부갑상선 수준을 낮추기 위한 방법 및 조성물 |
US8999393B1 (en) * | 2013-01-09 | 2015-04-07 | Edgemont Pharmaceuticals Llc | Sustained release formulations of lorazepam |
KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 d 방출 제형 |
CN103142553B (zh) * | 2013-03-21 | 2014-10-01 | 青岛正大海尔制药有限公司 | 一种骨化三醇缓释胶囊及其制备方法 |
CN103142537B (zh) * | 2013-03-21 | 2014-11-12 | 青岛正大海尔制药有限公司 | 骨化三醇缓释剂片 |
CN103142554B (zh) * | 2013-03-21 | 2014-11-12 | 青岛正大海尔制药有限公司 | 骨化三醇控释胶囊及其制备方法 |
CN103142555B (zh) * | 2013-03-21 | 2014-10-01 | 青岛正大海尔制药有限公司 | 一种阿法骨化醇缓释胶囊及其制备方法 |
JP6282939B2 (ja) * | 2014-06-05 | 2018-02-21 | 株式会社ファンケル | 耐酸性錠剤 |
TW201618783A (zh) | 2014-08-07 | 2016-06-01 | 艾森塔製藥公司 | 以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法 |
CR20170085A (es) | 2014-08-07 | 2017-04-25 | Opko Ireland Global Holdings Ltd | Terapia adjuntiva con 25-hidroxi vitamina d |
JP7032322B2 (ja) | 2016-03-28 | 2022-03-08 | オプコ アイルランド グローバル ホールディングス リミテッド | ビタミンd治療法 |
KR102121400B1 (ko) * | 2018-07-31 | 2020-06-17 | (주)에이치케이바이오텍 | 신령버섯균사체 액체배양 추출물을 포함하는 전립선 비대증의 예방 또는 치료용 조성물 |
IT201900003843A1 (it) * | 2019-03-15 | 2020-09-15 | Lo Li Pharma Srl | Trattamento di fibromi con vitamina D e un agente come l'epigallocatechina gallato (EGCG) |
CN110917163A (zh) * | 2019-12-11 | 2020-03-27 | 正大制药(青岛)有限公司 | 一种帕立骨化醇固体口服制剂 |
CN110917169A (zh) * | 2019-12-11 | 2020-03-27 | 正大制药(青岛)有限公司 | 帕立骨化醇胶囊剂及其制备方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2216719A (en) * | 1935-07-06 | 1940-10-08 | Hartford Nat Bank & Trust Co | Vitamin |
US2434015A (en) * | 1942-11-21 | 1948-01-06 | Du Pont | Stable provitamin d composition |
US4335120A (en) * | 1979-03-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
US4230701A (en) * | 1979-03-21 | 1980-10-28 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
JPS57149224A (en) * | 1981-03-13 | 1982-09-14 | Chugai Pharmaceut Co Ltd | Tumor-suppressing agent |
EP0070588B1 (de) * | 1981-07-17 | 1986-05-07 | Duphar International Research B.V | Verfahren zur Herstellung von 1-alpha-hydroxy vitamin D oder 1-alpha hydroxy Previtamin D Derivaten und Previtamin D oder Tachysteroladdukten mit geeigneten Dienophilen |
JPS5910562A (ja) * | 1982-07-07 | 1984-01-20 | Teijin Ltd | プレ−1α−ヒドロキシコレカルシフエロ−ル類の製造法 |
DE3448360C2 (de) * | 1983-05-09 | 1991-10-02 | Wisconsin Alumni Res Found | |
US4505906A (en) * | 1984-01-30 | 1985-03-19 | Wisconsin Alumni Research Foundation | Hydroxyvitamin D2 isomers |
US4684524A (en) * | 1984-03-19 | 1987-08-04 | Alza Corporation | Rate controlled dispenser for administering beneficial agent |
US4728643A (en) * | 1984-11-02 | 1988-03-01 | The General Hospital Corporation | Method of treating psoriasis |
EP0215956A4 (de) * | 1985-03-14 | 1988-09-07 | Chugai Pharmaceutical Co Ltd | Mittel zur behandlung von hautkrankheiten. |
ZA886284B (en) * | 1987-08-31 | 1990-04-25 | Advanced Polymer Systems Inc | Controlled release formulations |
WO1990009179A1 (en) * | 1989-02-16 | 1990-08-23 | University Of Georgia Research Foundation, Inc. | Treatment of tibial dyschondroplasia |
US5372996A (en) * | 1989-03-10 | 1994-12-13 | Endorecherche, Inc. | Method of treatment of androgen-related diseases |
US5013728A (en) * | 1990-05-04 | 1991-05-07 | Colgate - Palmolive Company | Composition for treating osteoporosis and hormonal imbalance |
JPH04198129A (ja) * | 1990-11-28 | 1992-07-17 | Sumitomo Pharmaceut Co Ltd | 活性型ビタミンd↓3類含有組成物 |
IL110117A0 (en) * | 1994-06-24 | 1994-10-07 | Univ Ben Gurion | Pharmaceutical compositions comprising vitamin-d analogs |
JPH11507649A (ja) * | 1995-06-14 | 1999-07-06 | シエーリング アクチエンゲゼルシヤフト | 25位の炭素に置換基を有する新規なビタミンd誘導体、その製造方法、中間生成物及び薬剤の製造のためのその使用 |
-
1996
- 1996-12-30 US US08/775,447 patent/US5795882A/en not_active Expired - Lifetime
-
1997
- 1997-12-10 CA CA002276465A patent/CA2276465A1/en not_active Abandoned
- 1997-12-10 CN CNB971819750A patent/CN100345547C/zh not_active Expired - Fee Related
- 1997-12-10 PL PL97334348A patent/PL334348A1/xx unknown
- 1997-12-10 DE DE69736745T patent/DE69736745D1/de not_active Expired - Lifetime
- 1997-12-10 HU HU0003526A patent/HUP0003526A2/hu unknown
- 1997-12-10 WO PCT/US1997/022034 patent/WO1998029105A2/en active IP Right Grant
- 1997-12-10 AT AT97949716T patent/ATE340581T1/de not_active IP Right Cessation
- 1997-12-10 JP JP53001798A patent/JP2001512418A/ja not_active Ceased
- 1997-12-10 AU AU78883/98A patent/AU724153B2/en not_active Ceased
- 1997-12-10 KR KR1019997006004A patent/KR20000062405A/ko not_active Application Discontinuation
- 1997-12-10 NZ NZ336511A patent/NZ336511A/xx unknown
- 1997-12-10 EP EP97949716A patent/EP0951286B1/de not_active Expired - Lifetime
- 1997-12-10 MX MXPA99006988A patent/MXPA99006988A/es not_active IP Right Cessation
- 1997-12-10 BR BR9715022-3A patent/BR9715022A/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MXPA99006988A (es) | 2002-07-02 |
BR9715022A (pt) | 2001-09-18 |
EP0951286B1 (de) | 2006-09-27 |
NZ336511A (en) | 2001-08-31 |
CN100345547C (zh) | 2007-10-31 |
AU7888398A (en) | 1998-07-31 |
HUP0003526A2 (en) | 2001-03-28 |
ATE340581T1 (de) | 2006-10-15 |
WO1998029105A3 (en) | 1998-10-15 |
CA2276465A1 (en) | 1998-07-09 |
EP0951286A2 (de) | 1999-10-27 |
PL334348A1 (en) | 2000-02-28 |
CN1251527A (zh) | 2000-04-26 |
WO1998029105A2 (en) | 1998-07-09 |
KR20000062405A (ko) | 2000-10-25 |
JP2001512418A (ja) | 2001-08-21 |
US5795882A (en) | 1998-08-18 |
AU724153B2 (en) | 2000-09-14 |
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