DE69722202D1 - Dihydrobenzopyran und ähnliche verbindungen verwendbar als antientzündungsmittel - Google Patents

Dihydrobenzopyran und ähnliche verbindungen verwendbar als antientzündungsmittel

Info

Publication number
DE69722202D1
DE69722202D1 DE69722202T DE69722202T DE69722202D1 DE 69722202 D1 DE69722202 D1 DE 69722202D1 DE 69722202 T DE69722202 T DE 69722202T DE 69722202 T DE69722202 T DE 69722202T DE 69722202 D1 DE69722202 D1 DE 69722202D1
Authority
DE
Germany
Prior art keywords
pct
branched
hydrogen
ignitant
dihydrobenzopyrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69722202T
Other languages
English (en)
Other versions
DE69722202T2 (de
Inventor
Michael Janusz
Randolph Johnson
Bandara Senanayake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Publication of DE69722202D1 publication Critical patent/DE69722202D1/de
Application granted granted Critical
Publication of DE69722202T2 publication Critical patent/DE69722202T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Luminescent Compositions (AREA)
  • Pyrane Compounds (AREA)
DE69722202T 1996-06-07 1997-06-06 Dihydrobenzopyran und ähnliche verbindungen verwendbar als antientzündungsmittel Expired - Fee Related DE69722202T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1941496P 1996-06-07 1996-06-07
US19414P 1996-06-07
PCT/US1997/009945 WO1997046548A1 (en) 1996-06-07 1997-06-06 Dihydrobenzopyran and related compounds useful as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
DE69722202D1 true DE69722202D1 (de) 2003-06-26
DE69722202T2 DE69722202T2 (de) 2004-04-01

Family

ID=21793077

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69722202T Expired - Fee Related DE69722202T2 (de) 1996-06-07 1997-06-06 Dihydrobenzopyran und ähnliche verbindungen verwendbar als antientzündungsmittel

Country Status (21)

Country Link
US (1) US6110960A (de)
EP (1) EP0907646B1 (de)
JP (1) JP3454832B2 (de)
KR (1) KR100314986B1 (de)
CN (1) CN1106394C (de)
AT (1) ATE240950T1 (de)
AU (1) AU733669B2 (de)
BR (1) BR9709556A (de)
CA (1) CA2256718C (de)
CZ (1) CZ398598A3 (de)
DE (1) DE69722202T2 (de)
DK (1) DK0907646T3 (de)
ES (1) ES2199362T3 (de)
HU (1) HUP0101131A3 (de)
IL (1) IL127379A0 (de)
NO (1) NO985679L (de)
PL (1) PL330408A1 (de)
RU (1) RU2156762C1 (de)
SK (1) SK167798A3 (de)
TR (1) TR199802538T2 (de)
WO (1) WO1997046548A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9709556A (pt) * 1996-06-07 1999-08-10 Procter & Gamble Dihidrobenzopirano e compostos a ele relacionados úteis como agentes antiflamatórios
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6586460B1 (en) 2001-04-02 2003-07-01 The Board Of Regents For Oklahoma State University Heteroarotinoids containing urea or thiourea linker
US20050101563A1 (en) * 2001-08-14 2005-05-12 Pharmacia Corporation Method and compositions for the treatment and prevention of pain and inflammation
US20030114416A1 (en) * 2001-08-14 2003-06-19 Pharmacia Corporation Method and compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate
US20030220374A1 (en) * 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
US20030212138A1 (en) * 2002-01-14 2003-11-13 Pharmacia Corporation Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor
US20040034083A1 (en) * 2002-04-18 2004-02-19 Stephenson Diane T. Combination therapy for the treatment of Parkinson's disease with cyclooxygenase-2 (COX2) inhibitor(s)
JP2005532293A (ja) * 2002-04-18 2005-10-27 ファルマシア・コーポレーション シクロオキシゲナーゼ−２（ｃｏｘ２）阻害剤を用いたパーキンソン病の治療のための単剤療法
US20040147581A1 (en) * 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
US20040204411A1 (en) * 2002-12-17 2004-10-14 Pharmacia Corporation Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof
US20040235925A1 (en) * 2002-12-17 2004-11-25 Pharmacia Corporation Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof
ES2335849B1 (es) * 2008-10-03 2011-03-22 Consejo Superior De Investigaciones Cientificas (Csic) Derivados de cromano y sus usos como inhibidores de la actividad de las proteinas desacoplantes.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026593A1 (de) * 1979-09-15 1981-04-08 Pfizer Limited Bicyclische Keto- und Aminosäuren, Ester und Amide und deren pharmazeutische Zusammensetzungen
JPS5829782A (ja) * 1981-08-12 1983-02-22 Nippon Zoki Pharmaceut Co Ltd 新規複素環化合物、その製法及び該化合物を含有する医薬組成物
US4680404A (en) * 1983-01-13 1987-07-14 Pfizer Inc. Benzopyrans
LU86351A1 (fr) * 1986-03-12 1987-11-11 Oreal Composes benzopyrannyl et benzothiopyrannyl benzoiques,leur procede de preparation et leur utilisation en cosmetique et en medecine humaine et veterinaire
WO1994004524A1 (en) * 1992-08-18 1994-03-03 Idemitsu Kosan Co., Ltd. Cyclohexanedione derivative
US5466861A (en) * 1992-11-25 1995-11-14 Sri International Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors
GB9316111D0 (en) * 1993-08-04 1993-09-22 Pfizer Ltd Benzopyrans
US5675024A (en) * 1995-11-22 1997-10-07 Allergan Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
BR9709556A (pt) * 1996-06-07 1999-08-10 Procter & Gamble Dihidrobenzopirano e compostos a ele relacionados úteis como agentes antiflamatórios
US5919817A (en) * 1996-10-28 1999-07-06 Novo Nordisk A/S Cis-3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes

Also Published As

Publication number Publication date
ES2199362T3 (es) 2004-02-16
IL127379A0 (en) 1999-10-28
BR9709556A (pt) 1999-08-10
US6110960A (en) 2000-08-29
ATE240950T1 (de) 2003-06-15
CA2256718C (en) 2004-09-21
DK0907646T3 (da) 2003-09-15
KR20000016427A (ko) 2000-03-25
AU733669B2 (en) 2001-05-24
EP0907646A1 (de) 1999-04-14
RU2156762C1 (ru) 2000-09-27
NO985679L (no) 1999-02-05
WO1997046548A1 (en) 1997-12-11
CA2256718A1 (en) 1997-12-11
NO985679D0 (no) 1998-12-04
KR100314986B1 (ko) 2002-01-12
HUP0101131A2 (hu) 2001-12-28
SK167798A3 (en) 2000-02-14
TR199802538T2 (xx) 2001-01-22
CN1106394C (zh) 2003-04-23
JP2000501417A (ja) 2000-02-08
PL330408A1 (en) 1999-05-10
DE69722202T2 (de) 2004-04-01
HUP0101131A3 (en) 2002-04-29
JP3454832B2 (ja) 2003-10-06
CZ398598A3 (cs) 1999-07-14
AU3382697A (en) 1998-01-05
CN1230955A (zh) 1999-10-06
EP0907646B1 (de) 2003-05-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee