DE69715847T2 - Halogensubstituierte Carbamatderivate von 2-Phenyl-1,2-ethandiol - Google Patents

Halogensubstituierte Carbamatderivate von 2-Phenyl-1,2-ethandiol

Info

Publication number
DE69715847T2
DE69715847T2 DE69715847T DE69715847T DE69715847T2 DE 69715847 T2 DE69715847 T2 DE 69715847T2 DE 69715847 T DE69715847 T DE 69715847T DE 69715847 T DE69715847 T DE 69715847T DE 69715847 T2 DE69715847 T2 DE 69715847T2
Authority
DE
Germany
Prior art keywords
ethanediol
phenyl
halogen substituted
carbamate derivatives
substituted carbamate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69715847T
Other languages
English (en)
Other versions
DE69715847D1 (de
Inventor
Moon Choi
Woo Kim
Han Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SK Inc
Original Assignee
SK Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27079720&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69715847(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SK Corp filed Critical SK Corp
Application granted granted Critical
Publication of DE69715847D1 publication Critical patent/DE69715847D1/de
Publication of DE69715847T2 publication Critical patent/DE69715847T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69715847T 1996-01-16 1997-01-16 Halogensubstituierte Carbamatderivate von 2-Phenyl-1,2-ethandiol Expired - Lifetime DE69715847T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/586,497 US5698588A (en) 1996-01-16 1996-01-16 Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
US08/781,101 US5854283A (en) 1996-01-16 1997-01-09 Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
PCT/KR1997/000006 WO1997026241A1 (en) 1996-01-16 1997-01-16 Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol

Publications (2)

Publication Number Publication Date
DE69715847D1 DE69715847D1 (de) 2002-10-31
DE69715847T2 true DE69715847T2 (de) 2003-05-28

Family

ID=27079720

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69715847T Expired - Lifetime DE69715847T2 (de) 1996-01-16 1997-01-16 Halogensubstituierte Carbamatderivate von 2-Phenyl-1,2-ethandiol

Country Status (10)

Country Link
US (4) US5698588A (de)
EP (1) EP0907635B1 (de)
JP (4) JP4023825B2 (de)
KR (1) KR100467760B1 (de)
CN (1) CN1077567C (de)
AU (1) AU724812B2 (de)
CA (1) CA2242865C (de)
DE (1) DE69715847T2 (de)
ES (1) ES2184058T3 (de)
WO (1) WO1997026241A1 (de)

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US5763708A (en) * 1995-09-20 1998-06-09 Allied Signal Inc. Process for the production of difluoromethane
US5698588A (en) * 1996-01-16 1997-12-16 Yukong Limited Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
SK1962003A3 (en) 2000-07-21 2004-08-03 Ortho Mcneil Pharm Inc Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
KR100725087B1 (ko) * 2000-09-14 2007-06-04 삼성전자주식회사 동작 스피드를 개선한 신호라인 배치구조를 가지는 반도체장치
MXPA03007722A (es) * 2001-02-27 2004-11-12 Johnson & Johnson Compuestos de carbamato para usar en la prevencion o tratamiento de trastornos sicoticos.
WO2002067924A1 (en) * 2001-02-27 2002-09-06 Ortho-Mcneil Pharmaceutical, Inc. Carbamate compounds for use in preventing or treating bipolar disorder
CN1235579C (zh) * 2001-02-27 2006-01-11 奥索-麦克尼尔药品公司 用于预防或治疗神经变性疾病的氨基甲酸酯化合物
DK1408953T3 (da) * 2001-02-27 2006-08-21 Ortho Mcneil Pharm Inc Carbamatforbindelser til anvendelse til forebyggelse eller behandling af bipolær sygdom
RU2283106C2 (ru) * 2001-02-27 2006-09-10 Орто-Макнейл Фармасьютикал, Инк. Производные карбаматов для использования для лечения боли
RS50505B (sr) * 2001-02-27 2010-03-02 Ortho-Mcneil Pharmaceutical Inc. Karbamatna jedinjenja za upotrebu u sprečavanju ili lečenju anksioznih poremećaja
CZ20032299A3 (cs) 2001-02-27 2004-08-18 Ortho@Mcneilápharmaceuticalźáinc Léčivo pro prevenci nebo léčbu motorických poruch
ATE373475T1 (de) * 2001-06-25 2007-10-15 Sk Corp Carbamate von 2-heterozyklischen 1,2-ethandiolen
CA2454049A1 (en) * 2001-07-16 2003-01-30 Ortho-Mcneil Pharmaceutical, Inc. Carbamate compounds for use in preventing or treating neuropathic pain
RU2299729C2 (ru) * 2001-07-16 2007-05-27 Орто-Макнейл Фармасьютикал, Инк. Карбаматные соединения для применения для предотвращения или лечения невропатической боли и боли, связанной с кластерной и мигреневой головной болью
EP2248799B1 (de) * 2001-12-21 2015-05-20 SK Biopharmaceuticals Co., LTD Verfahren zur herstellung von 2-(substituierte phenyl)-2-hydroxy-ethyl-carbamate
KR100945720B1 (ko) * 2001-12-21 2010-03-05 오르토-맥네일 파마슈티칼, 인코퍼레이티드 2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법
JP2008513466A (ja) * 2004-09-16 2008-05-01 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 癲癇発生および癲癇を処置するための２−フェニル−１，２−エタンジオール（ｄｉ）カルバメートの使用
EA200700871A1 (ru) * 2004-10-15 2007-10-26 Янссен Фармацевтика Н. В. Способы нейропротекции
CA2595599A1 (en) * 2005-01-20 2006-07-27 Janssen Pharmaceutica N.V. Methods for qt interval control
CN101163699A (zh) * 2005-04-21 2008-04-16 美邦特保健有限公司 二氨甲酸酯化合物的合成方法及形成其的中间体
PE20070325A1 (es) * 2005-06-29 2007-05-12 Alza Corp Formas de dosificacion oral que comprenden compuestos derivados de carbamato
US20070021501A1 (en) * 2005-07-12 2007-01-25 Twyman Roy E Methods of treating epileptogenesis
US20070021500A1 (en) * 2005-07-12 2007-01-25 Twyman Roy E Methods for neuroprotection
CN101657195A (zh) * 2006-10-06 2010-02-24 詹森药业有限公司 氨基甲酸(s)-(+)-2-(2-氯代苯基)-2-羟基乙酯的新型晶体
KR20090082209A (ko) * 2006-10-10 2009-07-29 얀센 파마슈티카 엔.브이. 신규 (ｓ)-(＋)-2-(2-클로로페닐)-2-하이드록시-에틸 카바메이트 결정
US20080090903A1 (en) * 2006-10-13 2008-04-17 Pandey Ramendra N Phenylalkyl carbamate compositions
CA2667510A1 (en) * 2006-10-27 2008-06-12 Janssen Pharmaceutica N.V. Methods for treating disruptive behavior disorders
AU2007319578A1 (en) * 2006-10-27 2008-05-22 Janssen Pharmaceuticals, N.V. Methods for treatment of cochlear and vestibular disorders
JP2010508355A (ja) * 2006-10-30 2010-03-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 鬱病を処置する方法
US20090105498A1 (en) * 2007-10-18 2009-04-23 Porstmann Frank Improved process for preparing 2-(substituted phenyol)-2-hydroxy-ethyl-carbamates
US8263652B2 (en) 2007-10-31 2012-09-11 Sk Biopharmaceuticals Co., Ltd. Stabilized pediatric suspension of carisbamate
CA2803825C (en) * 2010-07-02 2015-12-29 Bio-Pharm Solutions Co., Ltd. Phenylcarbamate compound and muscle relaxant containing the same
US9018253B2 (en) 2010-07-02 2015-04-28 Bio-Pharm Solutions Co., Ltd. Phenylcarbamate compound and muscle relaxant containing the same
US8609849B1 (en) 2010-11-30 2013-12-17 Fox Chase Chemical Diversity Center, Inc. Hydroxylated sulfamides exhibiting neuroprotective action and their method of use
JP5838226B2 (ja) * 2011-01-13 2016-01-06 バイオ−ファーム ソリューションズ カンパニー リミテッド フェニルカルバメート誘導体の製造方法
JP2015504054A (ja) 2011-12-27 2015-02-05 バイオ−ファーム ソリューションズ カンパニー リミテッド 多発性硬化症の治療または予防に使用されるフェニルカルバメート化合物
CN109939092B (zh) * 2013-03-12 2022-03-22 比皮艾思药物研发有限公司 用于预防或治疗小儿癫痫和癫痫相关综合征的苯基氨基甲酸酯化合物
KR102014615B1 (ko) * 2013-03-12 2019-08-27 (주)바이오팜솔루션즈 페닐카바메이트 화합물 및 이를 포함하는 신경보호용 조성물
US10777330B2 (en) 2014-12-26 2020-09-15 Techno Eye Corporation MgF2 system fluoride sintered body for radiation moderator and method for producing the same

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2884444A (en) * 1956-01-13 1959-04-28 Carter Prod Inc 2-phenyl-1,3 propane diol dicarbamate
US2937119A (en) * 1959-06-11 1960-05-17 Carter Prod Inc Nu-monosubstituted-2, 2-dialkyl-1, 3-propanediol dicarbamates
US3313692A (en) * 1958-04-21 1967-04-11 Armour Pharma Method of inducing calming and muscle relaxation with carbamates
US3313696A (en) * 1962-06-26 1967-04-11 Armour Pharmacentical Company Carbamate sedative compositions and method of use
US3313699A (en) * 1962-06-26 1967-04-11 Armour Pharma Compositions for and method of treating the central nervous system
US3313697A (en) * 1962-06-26 1967-04-11 Armour Pharma Carbamate compositions for and methods of treating the central nervous system
US3248418A (en) * 1962-06-26 1966-04-26 Charles D Bossinger 2-hydroxy-2-phenyl alkyl carbamates
US3265727A (en) * 1962-06-26 1966-08-09 Armour Pharma Phenyl alkyl-1, 2 dicarbamates
US3144389A (en) * 1962-06-26 1964-08-11 Armour Pharma 2-hydroxy-2-phenyl-ethyl carbamate for muscle relaxation
US3313700A (en) * 1962-07-18 1967-04-11 Armour Pharmacentical Company Method of treating the central nervous system with substituted phenethyl carbamates and compositions therefor
US3265728A (en) * 1962-07-18 1966-08-09 Armour Pharma Substituted phenethyl carbamates
FR5671M (de) * 1965-04-23 1968-01-02
KR100197901B1 (ko) * 1994-02-21 1999-06-15 남창우 페닐-1,2-에탄디올 광학이성체의 단일 카바메이트
US5698588A (en) * 1996-01-16 1997-12-16 Yukong Limited Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol

Also Published As

Publication number Publication date
JP2007314563A (ja) 2007-12-06
US6103759A (en) 2000-08-15
JP2002515029A (ja) 2002-05-21
JP4023825B2 (ja) 2007-12-19
US5698588A (en) 1997-12-16
AU1320597A (en) 1997-08-11
EP0907635A1 (de) 1999-04-14
CN1208402A (zh) 1999-02-17
US6127412A (en) 2000-10-03
JP4740202B2 (ja) 2011-08-03
AU724812B2 (en) 2000-09-28
KR970059163A (ko) 1997-08-12
JP2011037897A (ja) 2011-02-24
DE69715847D1 (de) 2002-10-31
JP5831835B2 (ja) 2015-12-09
EP0907635B1 (de) 2002-09-25
CA2242865C (en) 2006-03-28
KR100467760B1 (ko) 2005-04-19
CA2242865A1 (en) 1997-07-24
JP2014193899A (ja) 2014-10-09
US5854283A (en) 1998-12-29
ES2184058T3 (es) 2003-04-01
WO1997026241A1 (en) 1997-07-24
CN1077567C (zh) 2002-01-09

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Owner name: SK HOLDINGS CO., LTD., SEOUL, KR

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