DE69715847T2 - Halogensubstituierte Carbamatderivate von 2-Phenyl-1,2-ethandiol - Google Patents
Halogensubstituierte Carbamatderivate von 2-Phenyl-1,2-ethandiolInfo
- Publication number
- DE69715847T2 DE69715847T2 DE69715847T DE69715847T DE69715847T2 DE 69715847 T2 DE69715847 T2 DE 69715847T2 DE 69715847 T DE69715847 T DE 69715847T DE 69715847 T DE69715847 T DE 69715847T DE 69715847 T2 DE69715847 T2 DE 69715847T2
- Authority
- DE
- Germany
- Prior art keywords
- ethanediol
- phenyl
- halogen substituted
- carbamate derivatives
- substituted carbamate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/586,497 US5698588A (en) | 1996-01-16 | 1996-01-16 | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
US08/781,101 US5854283A (en) | 1996-01-16 | 1997-01-09 | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
PCT/KR1997/000006 WO1997026241A1 (en) | 1996-01-16 | 1997-01-16 | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69715847D1 DE69715847D1 (de) | 2002-10-31 |
DE69715847T2 true DE69715847T2 (de) | 2003-05-28 |
Family
ID=27079720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69715847T Expired - Lifetime DE69715847T2 (de) | 1996-01-16 | 1997-01-16 | Halogensubstituierte Carbamatderivate von 2-Phenyl-1,2-ethandiol |
Country Status (10)
Country | Link |
---|---|
US (4) | US5698588A (de) |
EP (1) | EP0907635B1 (de) |
JP (4) | JP4023825B2 (de) |
KR (1) | KR100467760B1 (de) |
CN (1) | CN1077567C (de) |
AU (1) | AU724812B2 (de) |
CA (1) | CA2242865C (de) |
DE (1) | DE69715847T2 (de) |
ES (1) | ES2184058T3 (de) |
WO (1) | WO1997026241A1 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5763708A (en) * | 1995-09-20 | 1998-06-09 | Allied Signal Inc. | Process for the production of difluoromethane |
US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
US20020107283A1 (en) * | 2000-07-21 | 2002-08-08 | Codd Ellen E. | Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain |
KR100725087B1 (ko) * | 2000-09-14 | 2007-06-04 | 삼성전자주식회사 | 동작 스피드를 개선한 신호라인 배치구조를 가지는 반도체장치 |
NZ527990A (en) * | 2001-02-27 | 2006-01-27 | Ortho Mcneil Pharm Inc | Carbamate compounds for use in preventing or treating neurodegenerative disorders |
ES2262801T3 (es) * | 2001-02-27 | 2006-12-01 | Ortho-Mcneil Pharmaceutical, Inc. | Uso de un compuesto de carbamato para la prevencion o el tratamiento de trastorno bipolar. |
BR0207829A (pt) * | 2001-02-27 | 2004-06-22 | Ortho Mcneil Pharm Inc | Composto de carbamato para uso na prevenção ou tratamento de distúrbios psicóticos |
KR20030074849A (ko) * | 2001-02-27 | 2003-09-19 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 양극성 장애의 예방 또는 치료에 사용하기 위한카바메이트 화합물 |
ATE493125T1 (de) | 2001-02-27 | 2011-01-15 | Ortho Mcneil Pharm Inc | Carbamatverbindungen zur behandlung von schmerz |
ATE369130T1 (de) | 2001-02-27 | 2007-08-15 | Ortho Mcneil Pharm Inc | Carbamatverbindungen zur vorbeugung und behandlung von bewegungsstörungen |
RS50505B (sr) * | 2001-02-27 | 2010-03-02 | Ortho-Mcneil Pharmaceutical Inc. | Karbamatna jedinjenja za upotrebu u sprečavanju ili lečenju anksioznih poremećaja |
ES2294140T3 (es) * | 2001-06-25 | 2008-04-01 | Sk Holdings Co Ltd. | Carbamatos de 2-heterociclico-1,2-etanodioles. |
MXPA04000555A (es) * | 2001-07-16 | 2005-06-20 | Johnson & Johnson | Compuestos de carbamato para utilizarse en la prevencion o tratamiento del dolor neuropatico y el dolor asociado con la cefalea acuminada y migranosa. |
CN1259911C (zh) * | 2001-07-16 | 2006-06-21 | 奥索-麦克尼尔药品公司 | 用于预防或治疗神经性疼痛和丛集性头痛及偏头痛性疼痛的氨基甲酸酯化合物 |
AU2002358806B2 (en) * | 2001-12-21 | 2009-09-10 | Sk Biopharmaceuticals Co., Ltd. | Process for preparing 2-(substituted phenyl)-2-hydroxy-ethyl carbamates |
KR100945720B1 (ko) * | 2001-12-21 | 2010-03-05 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법 |
RS51269B (sr) * | 2004-09-16 | 2010-12-31 | Janssen Pharmaceutica N.V. | Upotreba 2-fenil-1,2-etandiol-(di)karbamata za tretiranje epileptogeneze |
EP1802294A1 (de) * | 2004-10-15 | 2007-07-04 | Janssen Pharmaceutica N.V. | Carbamatverbindungen zur verwendung bei der behandlung neurodegenerativer erkrankungen |
AU2006206778A1 (en) * | 2005-01-20 | 2006-07-27 | Schuchean Chien | Methods for QT interval control |
WO2006116007A2 (en) * | 2005-04-21 | 2006-11-02 | Medpointe Healthcare Inc. | Methods for synthesis of dicarbamate compounds and intermediates in the formation thereof |
PE20070325A1 (es) * | 2005-06-29 | 2007-05-12 | Alza Corp | Formas de dosificacion oral que comprenden compuestos derivados de carbamato |
US20070021500A1 (en) * | 2005-07-12 | 2007-01-25 | Twyman Roy E | Methods for neuroprotection |
US20070021501A1 (en) * | 2005-07-12 | 2007-01-25 | Twyman Roy E | Methods of treating epileptogenesis |
CA2665573A1 (en) * | 2006-10-06 | 2008-04-17 | Janssen Pharmaceutica N.V. | Novel crystal of (s)-(+)-2-(2-chlorophenyl)-2-hydroxy-ethyl carbamate |
EA200970368A1 (ru) * | 2006-10-10 | 2009-10-30 | Янссен Фармацевтика Нв | Новый кристалл (s)-(+)-2-(2-хлорфенил)-2-гидроксиэтилкарбамата |
EA200970378A1 (ru) * | 2006-10-13 | 2009-10-30 | Янссен Фармацевтика, Н. В. | Композиции фенилалкилкарбамата |
KR20090085071A (ko) * | 2006-10-27 | 2009-08-06 | 얀센 파마슈티카 엔.브이. | 달팽이관 및 전정기관 장애의 치료 방법 |
EP2089015B1 (de) * | 2006-10-27 | 2010-11-24 | Janssen Pharmaceutica, N.V. | Verfahren zur behandlung disruptiver verhaltensstörungen |
US20080317883A1 (en) * | 2006-10-30 | 2008-12-25 | Yong Moon Choi | Methods for treating depression |
US20090105498A1 (en) * | 2007-10-18 | 2009-04-23 | Porstmann Frank | Improved process for preparing 2-(substituted phenyol)-2-hydroxy-ethyl-carbamates |
US8263652B2 (en) | 2007-10-31 | 2012-09-11 | Sk Biopharmaceuticals Co., Ltd. | Stabilized pediatric suspension of carisbamate |
BR112013000050B1 (pt) * | 2010-07-02 | 2021-10-19 | Bio-Pharm Solutions Co., Ltd | Compostos de carbamato de fenila e composição farmacêutica |
US9018253B2 (en) | 2010-07-02 | 2015-04-28 | Bio-Pharm Solutions Co., Ltd. | Phenylcarbamate compound and muscle relaxant containing the same |
US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
WO2012096458A2 (en) * | 2011-01-13 | 2012-07-19 | Bio-Pharm Solutions Co., Ltd. | Process for preparation of phenyl carbamate derivatives |
CN104870421A (zh) * | 2011-12-27 | 2015-08-26 | 比皮艾思药物研发有限公司 | 用于预防或治疗als的苯基氨基甲酸酯化合物 |
KR101717872B1 (ko) * | 2013-03-12 | 2017-03-17 | (주)바이오팜솔루션즈 | 소아 간질 및 간질-관련 증후군의 예방 또는 치료용 페닐카바메이트 화합물 |
CN105209430B (zh) * | 2013-03-12 | 2019-09-13 | 比皮艾思药物研发有限公司 | 苯基氨基甲酸酯化合物及包含其的神经保护组合物 |
WO2016104354A1 (ja) | 2014-12-26 | 2016-06-30 | 国立大学法人筑波大学 | 放射線減速材用MgF2系フッ化物焼結体及びその製造方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2884444A (en) * | 1956-01-13 | 1959-04-28 | Carter Prod Inc | 2-phenyl-1,3 propane diol dicarbamate |
US2937119A (en) * | 1959-06-11 | 1960-05-17 | Carter Prod Inc | Nu-monosubstituted-2, 2-dialkyl-1, 3-propanediol dicarbamates |
US3313692A (en) * | 1958-04-21 | 1967-04-11 | Armour Pharma | Method of inducing calming and muscle relaxation with carbamates |
US3248418A (en) * | 1962-06-26 | 1966-04-26 | Charles D Bossinger | 2-hydroxy-2-phenyl alkyl carbamates |
US3265727A (en) * | 1962-06-26 | 1966-08-09 | Armour Pharma | Phenyl alkyl-1, 2 dicarbamates |
US3313699A (en) * | 1962-06-26 | 1967-04-11 | Armour Pharma | Compositions for and method of treating the central nervous system |
US3313696A (en) * | 1962-06-26 | 1967-04-11 | Armour Pharmacentical Company | Carbamate sedative compositions and method of use |
US3144389A (en) * | 1962-06-26 | 1964-08-11 | Armour Pharma | 2-hydroxy-2-phenyl-ethyl carbamate for muscle relaxation |
US3313697A (en) * | 1962-06-26 | 1967-04-11 | Armour Pharma | Carbamate compositions for and methods of treating the central nervous system |
US3313700A (en) * | 1962-07-18 | 1967-04-11 | Armour Pharmacentical Company | Method of treating the central nervous system with substituted phenethyl carbamates and compositions therefor |
US3265728A (en) * | 1962-07-18 | 1966-08-09 | Armour Pharma | Substituted phenethyl carbamates |
FR5671M (de) * | 1965-04-23 | 1968-01-02 | ||
KR100197901B1 (ko) * | 1994-02-21 | 1999-06-15 | 남창우 | 페닐-1,2-에탄디올 광학이성체의 단일 카바메이트 |
US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
-
1996
- 1996-01-16 US US08/586,497 patent/US5698588A/en not_active Expired - Lifetime
-
1997
- 1997-01-09 US US08/781,101 patent/US5854283A/en not_active Expired - Lifetime
- 1997-01-16 CN CN97191722A patent/CN1077567C/zh not_active Expired - Lifetime
- 1997-01-16 WO PCT/KR1997/000006 patent/WO1997026241A1/en active IP Right Grant
- 1997-01-16 AU AU13205/97A patent/AU724812B2/en not_active Expired
- 1997-01-16 EP EP97900794A patent/EP0907635B1/de not_active Expired - Lifetime
- 1997-01-16 ES ES97900794T patent/ES2184058T3/es not_active Expired - Lifetime
- 1997-01-16 DE DE69715847T patent/DE69715847T2/de not_active Expired - Lifetime
- 1997-01-16 KR KR1019970001536A patent/KR100467760B1/ko not_active IP Right Cessation
- 1997-01-16 JP JP52587897A patent/JP4023825B2/ja not_active Expired - Fee Related
- 1997-01-16 CA CA002242865A patent/CA2242865C/en not_active Expired - Lifetime
-
1999
- 1999-07-08 US US09/349,850 patent/US6103759A/en not_active Expired - Lifetime
- 1999-07-08 US US09/349,852 patent/US6127412A/en not_active Expired - Lifetime
-
2007
- 2007-07-25 JP JP2007193230A patent/JP4740202B2/ja not_active Expired - Fee Related
-
2010
- 2010-11-10 JP JP2010251660A patent/JP2011037897A/ja active Pending
-
2014
- 2014-05-26 JP JP2014107729A patent/JP5831835B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR970059163A (ko) | 1997-08-12 |
AU724812B2 (en) | 2000-09-28 |
JP2007314563A (ja) | 2007-12-06 |
ES2184058T3 (es) | 2003-04-01 |
EP0907635A1 (de) | 1999-04-14 |
JP2014193899A (ja) | 2014-10-09 |
CN1077567C (zh) | 2002-01-09 |
JP5831835B2 (ja) | 2015-12-09 |
WO1997026241A1 (en) | 1997-07-24 |
JP2002515029A (ja) | 2002-05-21 |
EP0907635B1 (de) | 2002-09-25 |
CN1208402A (zh) | 1999-02-17 |
CA2242865C (en) | 2006-03-28 |
JP2011037897A (ja) | 2011-02-24 |
DE69715847D1 (de) | 2002-10-31 |
US6127412A (en) | 2000-10-03 |
US5698588A (en) | 1997-12-16 |
KR100467760B1 (ko) | 2005-04-19 |
US6103759A (en) | 2000-08-15 |
JP4023825B2 (ja) | 2007-12-19 |
CA2242865A1 (en) | 1997-07-24 |
AU1320597A (en) | 1997-08-11 |
US5854283A (en) | 1998-12-29 |
JP4740202B2 (ja) | 2011-08-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: SK HOLDINGS CO., LTD., SEOUL, KR |
|
R082 | Change of representative |
Ref document number: 907635 Country of ref document: EP Representative=s name: BEETZ & PARTNER PATENT- UND RECHTSANWAELTE, 80538 |