ES2184058T3 - Compuestos de carbamato, sustituido con halogeno, de 2-fenil-1,2-etanodiol. - Google Patents
Compuestos de carbamato, sustituido con halogeno, de 2-fenil-1,2-etanodiol.Info
- Publication number
- ES2184058T3 ES2184058T3 ES97900794T ES97900794T ES2184058T3 ES 2184058 T3 ES2184058 T3 ES 2184058T3 ES 97900794 T ES97900794 T ES 97900794T ES 97900794 T ES97900794 T ES 97900794T ES 2184058 T3 ES2184058 T3 ES 2184058T3
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- ethanodiol
- halogen
- replaced
- carbamate compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE HA COMPROBADO QUE LAS FORMAS OPTICAMENTE PURAS DE MONOCARBAMATOS DE 2 - FENIL -1,2 - ETANDIOL HALOGENADO Y DE DICARBAMATO DE 2 - FENIL - 1,2 -ETANDIOL HALOGENADO SON EFECTIVAS EN EL TRATAMIENTO DE TRASTORNOSDEL SISTEMA NERVIOSO CENTRAL, ESPECIALMENTE COMO AGENTESANTICONVULSIVOS O ANTIEPILEPTICOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/586,497 US5698588A (en) | 1996-01-16 | 1996-01-16 | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
US08/781,101 US5854283A (en) | 1996-01-16 | 1997-01-09 | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2184058T3 true ES2184058T3 (es) | 2003-04-01 |
Family
ID=27079720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97900794T Expired - Lifetime ES2184058T3 (es) | 1996-01-16 | 1997-01-16 | Compuestos de carbamato, sustituido con halogeno, de 2-fenil-1,2-etanodiol. |
Country Status (10)
Country | Link |
---|---|
US (4) | US5698588A (es) |
EP (1) | EP0907635B1 (es) |
JP (4) | JP4023825B2 (es) |
KR (1) | KR100467760B1 (es) |
CN (1) | CN1077567C (es) |
AU (1) | AU724812B2 (es) |
CA (1) | CA2242865C (es) |
DE (1) | DE69715847T2 (es) |
ES (1) | ES2184058T3 (es) |
WO (1) | WO1997026241A1 (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5763708A (en) * | 1995-09-20 | 1998-06-09 | Allied Signal Inc. | Process for the production of difluoromethane |
US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
SK1962003A3 (en) | 2000-07-21 | 2004-08-03 | Ortho Mcneil Pharm Inc | Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain |
KR100725087B1 (ko) * | 2000-09-14 | 2007-06-04 | 삼성전자주식회사 | 동작 스피드를 개선한 신호라인 배치구조를 가지는 반도체장치 |
MXPA03007722A (es) * | 2001-02-27 | 2004-11-12 | Johnson & Johnson | Compuestos de carbamato para usar en la prevencion o tratamiento de trastornos sicoticos. |
WO2002067924A1 (en) * | 2001-02-27 | 2002-09-06 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamate compounds for use in preventing or treating bipolar disorder |
CN1235579C (zh) * | 2001-02-27 | 2006-01-11 | 奥索-麦克尼尔药品公司 | 用于预防或治疗神经变性疾病的氨基甲酸酯化合物 |
DK1408953T3 (da) * | 2001-02-27 | 2006-08-21 | Ortho Mcneil Pharm Inc | Carbamatforbindelser til anvendelse til forebyggelse eller behandling af bipolær sygdom |
RU2283106C2 (ru) * | 2001-02-27 | 2006-09-10 | Орто-Макнейл Фармасьютикал, Инк. | Производные карбаматов для использования для лечения боли |
RS50505B (sr) * | 2001-02-27 | 2010-03-02 | Ortho-Mcneil Pharmaceutical Inc. | Karbamatna jedinjenja za upotrebu u sprečavanju ili lečenju anksioznih poremećaja |
CZ20032299A3 (cs) | 2001-02-27 | 2004-08-18 | Ortho@Mcneilápharmaceuticalźáinc | Léčivo pro prevenci nebo léčbu motorických poruch |
ATE373475T1 (de) * | 2001-06-25 | 2007-10-15 | Sk Corp | Carbamate von 2-heterozyklischen 1,2-ethandiolen |
CA2454049A1 (en) * | 2001-07-16 | 2003-01-30 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamate compounds for use in preventing or treating neuropathic pain |
RU2299729C2 (ru) * | 2001-07-16 | 2007-05-27 | Орто-Макнейл Фармасьютикал, Инк. | Карбаматные соединения для применения для предотвращения или лечения невропатической боли и боли, связанной с кластерной и мигреневой головной болью |
EP2248799B1 (en) * | 2001-12-21 | 2015-05-20 | SK Biopharmaceuticals Co., LTD | Process for preparing 2-(substituted phenyl)-2-hydroxy-ethyl carbamates |
KR100945720B1 (ko) * | 2001-12-21 | 2010-03-05 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법 |
JP2008513466A (ja) * | 2004-09-16 | 2008-05-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 癲癇発生および癲癇を処置するための2−フェニル−1,2−エタンジオール(di)カルバメートの使用 |
EA200700871A1 (ru) * | 2004-10-15 | 2007-10-26 | Янссен Фармацевтика Н. В. | Способы нейропротекции |
CA2595599A1 (en) * | 2005-01-20 | 2006-07-27 | Janssen Pharmaceutica N.V. | Methods for qt interval control |
CN101163699A (zh) * | 2005-04-21 | 2008-04-16 | 美邦特保健有限公司 | 二氨甲酸酯化合物的合成方法及形成其的中间体 |
PE20070325A1 (es) * | 2005-06-29 | 2007-05-12 | Alza Corp | Formas de dosificacion oral que comprenden compuestos derivados de carbamato |
US20070021501A1 (en) * | 2005-07-12 | 2007-01-25 | Twyman Roy E | Methods of treating epileptogenesis |
US20070021500A1 (en) * | 2005-07-12 | 2007-01-25 | Twyman Roy E | Methods for neuroprotection |
CN101657195A (zh) * | 2006-10-06 | 2010-02-24 | 詹森药业有限公司 | 氨基甲酸(s)-(+)-2-(2-氯代苯基)-2-羟基乙酯的新型晶体 |
KR20090082209A (ko) * | 2006-10-10 | 2009-07-29 | 얀센 파마슈티카 엔.브이. | 신규 (s)-(+)-2-(2-클로로페닐)-2-하이드록시-에틸 카바메이트 결정 |
US20080090903A1 (en) * | 2006-10-13 | 2008-04-17 | Pandey Ramendra N | Phenylalkyl carbamate compositions |
CA2667510A1 (en) * | 2006-10-27 | 2008-06-12 | Janssen Pharmaceutica N.V. | Methods for treating disruptive behavior disorders |
AU2007319578A1 (en) * | 2006-10-27 | 2008-05-22 | Janssen Pharmaceuticals, N.V. | Methods for treatment of cochlear and vestibular disorders |
JP2010508355A (ja) * | 2006-10-30 | 2010-03-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 鬱病を処置する方法 |
US20090105498A1 (en) * | 2007-10-18 | 2009-04-23 | Porstmann Frank | Improved process for preparing 2-(substituted phenyol)-2-hydroxy-ethyl-carbamates |
US8263652B2 (en) | 2007-10-31 | 2012-09-11 | Sk Biopharmaceuticals Co., Ltd. | Stabilized pediatric suspension of carisbamate |
CA2803825C (en) * | 2010-07-02 | 2015-12-29 | Bio-Pharm Solutions Co., Ltd. | Phenylcarbamate compound and muscle relaxant containing the same |
US9018253B2 (en) | 2010-07-02 | 2015-04-28 | Bio-Pharm Solutions Co., Ltd. | Phenylcarbamate compound and muscle relaxant containing the same |
US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
JP5838226B2 (ja) * | 2011-01-13 | 2016-01-06 | バイオ−ファーム ソリューションズ カンパニー リミテッド | フェニルカルバメート誘導体の製造方法 |
JP2015504054A (ja) | 2011-12-27 | 2015-02-05 | バイオ−ファーム ソリューションズ カンパニー リミテッド | 多発性硬化症の治療または予防に使用されるフェニルカルバメート化合物 |
CN109939092B (zh) * | 2013-03-12 | 2022-03-22 | 比皮艾思药物研发有限公司 | 用于预防或治疗小儿癫痫和癫痫相关综合征的苯基氨基甲酸酯化合物 |
KR102014615B1 (ko) * | 2013-03-12 | 2019-08-27 | (주)바이오팜솔루션즈 | 페닐카바메이트 화합물 및 이를 포함하는 신경보호용 조성물 |
US10777330B2 (en) | 2014-12-26 | 2020-09-15 | Techno Eye Corporation | MgF2 system fluoride sintered body for radiation moderator and method for producing the same |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2884444A (en) * | 1956-01-13 | 1959-04-28 | Carter Prod Inc | 2-phenyl-1,3 propane diol dicarbamate |
US2937119A (en) * | 1959-06-11 | 1960-05-17 | Carter Prod Inc | Nu-monosubstituted-2, 2-dialkyl-1, 3-propanediol dicarbamates |
US3313692A (en) * | 1958-04-21 | 1967-04-11 | Armour Pharma | Method of inducing calming and muscle relaxation with carbamates |
US3313696A (en) * | 1962-06-26 | 1967-04-11 | Armour Pharmacentical Company | Carbamate sedative compositions and method of use |
US3313699A (en) * | 1962-06-26 | 1967-04-11 | Armour Pharma | Compositions for and method of treating the central nervous system |
US3313697A (en) * | 1962-06-26 | 1967-04-11 | Armour Pharma | Carbamate compositions for and methods of treating the central nervous system |
US3248418A (en) * | 1962-06-26 | 1966-04-26 | Charles D Bossinger | 2-hydroxy-2-phenyl alkyl carbamates |
US3265727A (en) * | 1962-06-26 | 1966-08-09 | Armour Pharma | Phenyl alkyl-1, 2 dicarbamates |
US3144389A (en) * | 1962-06-26 | 1964-08-11 | Armour Pharma | 2-hydroxy-2-phenyl-ethyl carbamate for muscle relaxation |
US3313700A (en) * | 1962-07-18 | 1967-04-11 | Armour Pharmacentical Company | Method of treating the central nervous system with substituted phenethyl carbamates and compositions therefor |
US3265728A (en) * | 1962-07-18 | 1966-08-09 | Armour Pharma | Substituted phenethyl carbamates |
FR5671M (es) * | 1965-04-23 | 1968-01-02 | ||
KR100197901B1 (ko) * | 1994-02-21 | 1999-06-15 | 남창우 | 페닐-1,2-에탄디올 광학이성체의 단일 카바메이트 |
US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
-
1996
- 1996-01-16 US US08/586,497 patent/US5698588A/en not_active Expired - Lifetime
-
1997
- 1997-01-09 US US08/781,101 patent/US5854283A/en not_active Expired - Lifetime
- 1997-01-16 EP EP97900794A patent/EP0907635B1/en not_active Expired - Lifetime
- 1997-01-16 DE DE69715847T patent/DE69715847T2/de not_active Expired - Lifetime
- 1997-01-16 ES ES97900794T patent/ES2184058T3/es not_active Expired - Lifetime
- 1997-01-16 AU AU13205/97A patent/AU724812B2/en not_active Expired
- 1997-01-16 JP JP52587897A patent/JP4023825B2/ja not_active Expired - Fee Related
- 1997-01-16 CN CN97191722A patent/CN1077567C/zh not_active Expired - Lifetime
- 1997-01-16 CA CA002242865A patent/CA2242865C/en not_active Expired - Lifetime
- 1997-01-16 WO PCT/KR1997/000006 patent/WO1997026241A1/en active IP Right Grant
- 1997-01-16 KR KR1019970001536A patent/KR100467760B1/ko not_active IP Right Cessation
-
1999
- 1999-07-08 US US09/349,852 patent/US6127412A/en not_active Expired - Lifetime
- 1999-07-08 US US09/349,850 patent/US6103759A/en not_active Expired - Lifetime
-
2007
- 2007-07-25 JP JP2007193230A patent/JP4740202B2/ja not_active Expired - Fee Related
-
2010
- 2010-11-10 JP JP2010251660A patent/JP2011037897A/ja active Pending
-
2014
- 2014-05-26 JP JP2014107729A patent/JP5831835B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2007314563A (ja) | 2007-12-06 |
US6103759A (en) | 2000-08-15 |
JP2002515029A (ja) | 2002-05-21 |
JP4023825B2 (ja) | 2007-12-19 |
US5698588A (en) | 1997-12-16 |
AU1320597A (en) | 1997-08-11 |
EP0907635A1 (en) | 1999-04-14 |
CN1208402A (zh) | 1999-02-17 |
DE69715847T2 (de) | 2003-05-28 |
US6127412A (en) | 2000-10-03 |
JP4740202B2 (ja) | 2011-08-03 |
AU724812B2 (en) | 2000-09-28 |
KR970059163A (ko) | 1997-08-12 |
JP2011037897A (ja) | 2011-02-24 |
DE69715847D1 (de) | 2002-10-31 |
JP5831835B2 (ja) | 2015-12-09 |
EP0907635B1 (en) | 2002-09-25 |
CA2242865C (en) | 2006-03-28 |
KR100467760B1 (ko) | 2005-04-19 |
CA2242865A1 (en) | 1997-07-24 |
JP2014193899A (ja) | 2014-10-09 |
US5854283A (en) | 1998-12-29 |
WO1997026241A1 (en) | 1997-07-24 |
CN1077567C (zh) | 2002-01-09 |
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